R. Hill

发表

Zoniporide: a potent and highly selective inhibitor of human Na(+)/H(+) exchanger-1.

R. J. Hill, D. Knight, Janice A. Brown, 2002, European journal of pharmacology.

Evidence for a role for both the adenosine A1 and A3 receptors in protection of isolated human atrial muscle against simulated ischaemia.

R. J. Hill, D. Knight, D. Yellon, 1997, Cardiovascular research.

3'-Aminoadenosine-5'-uronamides: discovery of the first highly selective agonist at the human adenosine A3 receptor.

R. J. Hill, D. Knight, J. Oleynek, 2003, Journal of medicinal chemistry.

Selective activation of adenosine A3 receptors with N6-(3-chlorobenzyl)-5'-N-methylcarboxamidoadenosine (CB-MECA) provides cardioprotection via KATP channel activation.

R. J. Hill, J. Oleynek, H. Masamune, 1998, Cardiovascular research.

Aminoalkyl structural requirements for interaction of lidocaine with the class I antiarrhythmic drug receptor on rat cardiac myocytes.

M. Taouis, R. J. Hill, R. Sheldon, 1991, Molecular pharmacology.

Selective adenosine A3 receptor stimulation reduces ischemic myocardial injury in the rabbit heart.

R. J. Hill, D. Knight, S. Kennedy, 1997, Cardiovascular research.

Structure-based drug design of RN486, a potent and selective Bruton's tyrosine kinase (BTK) inhibitor, for the treatment of rheumatoid arthritis.

A. Kuglstatter, D. Davis, Jaehyeon Park, 2015, Journal of medicinal chemistry.

Relative Selectivity of Covalent Inhibitors Requires Assessment of Inactivation Kinetics and Cellular Occupancy: A Case Study of Ibrutinib and Acalabrutinib

J. Dean, T. Kinoshita, R. J. Hill, 2019, The Journal of Pharmacology and Experimental Therapeutics.

Discovery of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (pamapimod) and 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (R1487) as orally bioavailable and highly selective inhibitors

B. Graves, A. Kuglstatter, M. Stahl, 2011, Journal of medicinal chemistry.

Determinants of stereospecific binding of type I antiarrhythmic drugs to cardiac sodium channels.

H. Duff, R. J. Hill, R. Sheldon, 1988, Molecular pharmacology.

Class I antiarrhythmic drugs: allosteric inhibitors of [3H] batrachotoxinin binding to rat cardiac sodium channels.

H. Duff, R. J. Hill, R. Sheldon, 1994, The Journal of pharmacology and experimental therapeutics.

Discovery of zoniporide: a potent and selective sodium-hydrogen exchanger type 1 (NHE-1) inhibitor with high aqueous solubility.

R. J. Hill, D. Knight, A. Guzman-Perez, 2001, Bioorganic & medicinal chemistry letters.

Cloning, expression and pharmacological characterization of rabbit adenosine A1 and A3 receptors.

R. J. Hill, D. Knight, J. Oleynek, 1997, The Journal of pharmacology and experimental therapeutics.

Optimizing circadian drug infusion schedules towards personalized cancer chronotherapy

Francis Lévi, Pasquale F Innominato, Annabelle Ballesta, 2020, PLoS Comput. Biol..

Amiodarone: biochemical evidence for binding to a receptor for class I drugs associated with the rat cardiac sodium channel.

H. Duff, R. J. Hill, R. Sheldon, 1989, Circulation research.

Cloning , Expression and Pharmacological Characterization of Rabbit Adenosine A 1 and A 3 Receptors

R. J. Hill, D. Knight, J. Oleynek, 1997 .

The synthesis of highly potent, selective, and water-soluble agonists at the human adenosine A3 receptor.

R. J. Hill, D. Knight, J. Oleynek, 2006, Bioorganic & medicinal chemistry letters.

JPET #187740 RN486 [6-Cyclopropyl-8-fluoro-2-(2-hydroxymethyl-3-{1-methyl-5-[5-(4-methyl- piperazin-1-yl)-pyridin-2-ylamino]-6-oxo-1,6-dihydro-pyridin-3-yl}-phenyl)-2H- isoquinolin-1-one], a Selective Bruton’s Tyrosine Kinase (Btk) Inhibitor, Abrogates Immune Hypersensitivity Responses and Arthritis

Daigen Xu, J. Demartino, S. Narula, 2011 .

Optimizing drug infusion schedules towards personalized cancer chronotherapy

F. Lévi, P. Innominato, R. J. Hill, 2019, bioRxiv.

Novel N6-substituted adenosine 5'-N-methyluronamides with high selectivity for human adenosine A3 receptors reduce ischemic myocardial injury.

R. J. Hill, D. Flynn, D. Knight, 2003, American journal of physiology. Heart and circulatory physiology.

Identification of a specific radioligand for the cardiac rapidly activating delayed rectifier K+ channel.

G M Briggs, P J Silver, C C Chadwick, 1993, Circulation research.

Transcainide: biochemical evidence for state-dependent interaction with the class I antiarrhythmic drug receptor.

H. Duff, M. Taouis, R. J. Hill, 1990, European journal of pharmacology.