L. Dong

发表

Adiponectin Sensitizes Insulin Signaling by Reducing p70 S6 Kinase-mediated Serine Phosphorylation of IRS-1*

F. Liu, K. Guan, Changhua Wang, 2007, Journal of Biological Chemistry.

APPL1 Potentiates Insulin Sensitivity by Facilitating the Binding of IRS1/2 to the Insulin Receptor

Feng Dong, Steven N. Austad, Feng Liu, 2014, Cell reports.

Deficiency of APPL1 in mice impairs glucose-stimulated insulin secretion through inhibition of pancreatic beta cell mitochondrial function

W. Jia, Dongyun Shi, Ling Li, 2013, Diabetologia.

Adiponectin and Adiponectin Signaling

J. Ryu, Lily Q. Dong, Jason T. Hadley, 2021 .

Yin-Yang Regulation of Adiponectin Signaling by APPL Isoforms in Muscle Cells*

Feng Liu, Hongzhi Chen, Feng Liu, 2009, The Journal of Biological Chemistry.

Crystal structures of the BAR-PH and PTB domains of human APPL1.

L. Tong, Lily Q. Dong, F. Liu, 2007, Structure.

APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function

Feng Liu, F. Liu, Lily Q. Dong, 2006, Nature Cell Biology.

Peripheral Disruption of the Grb10 Gene Enhances Insulin Signaling and Sensitivity In Vivo

F. Liu, R. DeFronzo, N. Musi, 2007, Molecular and Cellular Biology.

Grb10 Inhibits Insulin-stimulated Insulin Receptor Substrate (IRS)-Phosphatidylinositol 3-Kinase/Akt Signaling Pathway by Disrupting the Association of IRS-1/IRS-2 with the Insulin Receptor*

F. Liu, S. Shoelson, Lily Q. Dong, 2003, The Journal of Biological Chemistry.

Insulin Receptor-mediated p62dok Tyrosine Phosphorylation at Residues 362 and 398 Plays Distinct Roles for Binding GTPase-activating Protein and Nck and Is Essential for Inhibiting Insulin-stimulated Activation of Ras and Akt*

Fenglin Liu, M. Wick, Lily Q. Dong, 2001, The Journal of Biological Chemistry.

Nuclear translocation of 3′-phosphoinositide-dependent protein kinase 1 (PDK-1): A potential regulatory mechanism for PDK-1 function

M. Wick, Lily Q. Dong, Chintan K. Kikani, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Hepatic ATF6 Increases Fatty Acid Oxidation to Attenuate Hepatic Steatosis in Mice Through Peroxisome Proliferator–Activated Receptor α

Lily Q. Dong, Yixuan Sun, Aoyuan Cui, 2016, Diabetes.

Proliferative and Antiapoptotic Signaling Stimulated by Nuclear-Localized PDK1 Results in Oncogenesis

F. Liu, Luzhe Sun, W. Ogawa, 2012, Science Signaling.

DsbA-L ameliorates high glucose induced tubular damage through maintaining MAM integrity

Lin Sun, Fuyou Liu, Lily Q. Dong, 2019, EBioMedicine.

Disulfide-bond A oxidoreductase-like protein protects against ectopic fat deposition and lipid-related kidney damage in diabetic nephropathy.

F. Liu, Lin Sun, Guochun Chen, 2019, Kidney international.

APPL1 negatively regulates bone mass, possibly by controlling the fate of bone marrow mesenchymal progenitor cells

Lily Q. Dong, Yuan-Yu Lin, L. Dong, 2020, Proceedings of the Japan Academy. Series B, Physical and biological sciences.

Adiponectin Inhibits Osteoclastogenesis and Bone Resorption via APPL1-mediated Suppression of Akt1*

Lily Q. Dong, E. Luo, Jin Zhang, 2011, The Journal of Biological Chemistry.

Primary Structure, Tissue Distribution, and Expression of Mouse Phosphoinositide-dependent Protein Kinase-1, a Protein Kinase That Phosphorylates and Activates Protein Kinase Cζ*

Feng Liu, L. Zhu, Lily Q. Dong, 1999, The Journal of Biological Chemistry.

Cloning and characterization of a testis and brain-specific isoform of mouse 3'-phosphoinositide-dependent protein kinase-1, mPDK-1 beta.

M. Wick, A. Richardson, R. Strong, 2002, Biochemical and biophysical research communications.

PDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle.

F. Liu, Lily Q. Dong, Feng Liu, 2005, American journal of physiology. Endocrinology and metabolism.

Grb 10 Promotes Lipolysis and Thermogenesis by Phosphorylation-Dependent Feedback Inhibition of mTORC 1

T. Slaga, J. Blenis, Huiyun Liang, 2014 .

Negative regulation of insulin-stimulated mitogen-activated protein kinase signaling by Grb10.

F. Liu, M. Quon, Lily Q. Dong, 2004, Molecular endocrinology.

Receptor Interacting Protein Kinase Pathways Regulate Innate B Cell Developmental Checkpoints But Not Effector Function in Mice

A. McLennan, Lily Q. Dong, Thomas Hägglöf, 2021, Frontiers in Immunology.

DsbA-L prevents obesity-induced inflammation and insulin resistance by suppressing the mtDNA release-activated cGAS-cGAMP-STING pathway

F. Liu, Huan Cai, Lily Q. Dong, 2017, Proceedings of the National Academy of Sciences.

Inhibition of hGrb10 Binding to the Insulin Receptor by Functional Domain-mediated Oligomerization*

Lily Q. Dong, S. Porter, Feng Liu, 1998, The Journal of Biological Chemistry.

LRG1 is an adipokine that mediates obesity-induced hepatosteatosis and insulin resistance.

R. Duggirala, Mengwei Zang, J. Ryu, 2021, The Journal of clinical investigation.

Adiponectin Alleviates Diet-Induced Inflammation in the Liver by Suppressing MCP-1 Expression and Macrophage Infiltration

R. DeFronzo, Fenglin Liu, J. Ryu, 2021, Diabetes.

Identification and characterization of a novel adiponectin receptor agonist adipo anti‐inflammation agonist and its anti‐inflammatory effects in vitro and in vivo

Xuedong Zhou, Lily Q. Dong, W. Qiu, 2020, British journal of pharmacology.

A disulfide-bond A oxidoreductase-like protein (DsbA-L) regulates adiponectin multimerization

Feng Liu, F. Liu, A. Xu, 2008, Proceedings of the National Academy of Sciences.

Mouse 3-Phosphoinositide-dependent Protein Kinase-1 Undergoes Dimerization and trans-Phosphorylation in the Activation Loop*

F. Liu, Hui Chen, M. Quon, 2003, Journal of Biological Chemistry.

Anti-inflammatory and anti-proliferative action of adiponectin mediated by insulin signaling cascade in human vascular smooth muscle cells

Lily Q. Dong, Xiaojing Xu, E. Cersosimo, 2020, Molecular Biology Reports.

Identification of Grb10 as a direct substrate for members of the Src tyrosine kinase family

F. Liu, Lily Q. Dong, P. Langlais, 2000, Oncogene.

Recent Advances in Adipose mTOR Signaling and Function: Therapeutic Prospects.

F. Liu, Huan Cai, Lily Q. Dong, 2016, Trends in pharmacological sciences.

Up-regulation of Adiponectin by Resveratrol

T. Slaga, F. Liu, Lily Q. Dong, 2010, The Journal of Biological Chemistry.

Hepatic DsbA‐L protects mice from diet‐induced hepatosteatosis and insulin resistance

F. Liu, Feng Dong, M. Abdul-Ghani, 2017, The FASEB Journal.

The tumor suppressor TMEM127 regulates insulin sensitivity in a tissue-specific manner

S. Srikantan, R. Aguiar, P. Dahia, 2019, Nature Communications.

Identification of insulin receptor substrate 1 serine/threonine phosphorylation sites using mass spectrometry analysis: regulatory role of serine 1223.

L. Mandarino, S. Weintraub, Lily Q. Dong, 2005, Endocrinology.

Phosphorylation of Adaptor Protein Containing Pleckstrin Homology Domain, Phosphotyrosine Binding Domain, and Leucine Zipper Motif 1 (APPL1) at Ser430 Mediates Endoplasmic Reticulum (ER) Stress-induced Insulin Resistance in Hepatocytes*

Lijun Zhou, Bekke M. Holmes, Lily Q. Dong, 2012, The Journal of Biological Chemistry.

Cloning, Chromosome Localization, Expression, and Characterization of an Src Homology 2 and Pleckstrin Homology Domain-containing Insulin Receptor Binding Protein hGrb10γ*

Adrian V. Lee, L. F. Kolakowski, D. Yee, 1997, Journal of Biological Chemistry.

Upregulated TGF-β1 contributes to hyperglycaemia in type 2 diabetes by potentiating glucagon signalling

W. Liu, J. Ryu, Lily Q. Dong, 2023, Diabetologia.

Cloning and characterization of a testis and brain-specific isoform of mouse 3′-phosphoinositide-dependent protein kinase-1, mPDK-1β

M. Wick, A. Richardson, R. Strong, 2002 .

DsbA-L Alleviates Endoplasmic Reticulum Stress–Induced Adiponectin Downregulation

F. Liu, Lijun Zhou, Lily Q. Dong, 2010, Diabetes.

APPL1 mediates adiponectin-induced LKB1 cytosolic localization through the PP2A-PKCzeta signaling pathway.

F. Liu, R. DeFronzo, N. Musi, 2011, Molecular endocrinology.

Downregulation of Grb2 contributes to the insulin-sensitizing effect of calorie restriction.

A. Richardson, Lily Q. Dong, H. Van Remmen, 2009, American Journal of Physiology. Endocrinology and Metabolism.