Nilay S. Sethi

发表

Aberrant cell state plasticity mediated by developmental reprogramming precedes colorectal cancer initiation

J. Hornick, M. Yurgelun, Xiaoyan Liang, 2022, bioRxiv.

Developmental reprogramming mediates aberrant cell state plasticity in colorectal cancer initiation

W. Hahn, J. Hornick, M. Yurgelun, 2022 .

Comparative Molecular Analysis of Gastrointestinal Adenocarcinomas.

Chandra Sekhar Pedamallu, Farshad Farshidfar, Rehan Akbani, 2018, Cancer cell.

Tumor-derived JAGGED1 promotes osteolytic bone metastasis of breast cancer by engaging notch signaling in bone cells.

Yibin Kang, C. Winter, N. Sethi, 2011, Cancer cell.

Rabconnectin-3 Is a Functional Regulator of Mammalian Notch Signaling*

Yibin Kang, T. Schupbach, N. Sethi, 2010, The Journal of Biological Chemistry.

Early TP53 Alterations Shape Gastric and Esophageal Cancer Development

W. Chatila, R. Yaeger, Deepa T. Patil, 2021, Cancers.

Replicative stress in gastroesophageal adenocarcinoma is associated with chromosomal instability and sensitivity to DNA damage response inhibitors

Z. Szallasi, Deepa T. Patil, Harshabad Singh, 2023, bioRxiv.

Early TP53 Alterations Engage Environmental Exposures to Promote Gastric Premalignancy in an Integrative Mouse Model

James M. McFarland, R. Beroukhim, K. Ligon, 2019, Nature Genetics.

Utilizing a dual endogenous reporter system to identify functional regulators of aberrant stem cell and differentiation activity in colorectal cancer

B. Wolpin, N. Sethi, Zhixin Li, 2024, bioRxiv.

Notch signaling: mediator and therapeutic target of bone metastasis.

Yibin Kang, N. Sethi, Nilay S. Sethi, 2012, BoneKEy reports.

Notch signalling in cancer progression and bone metastasis

N. Sethi, Y. Kang, Nilay S. Sethi, 2011, British Journal of Cancer.

A novel β-catenin/BCL9 complex inhibitor blocks oncogenic Wnt signaling and disrupts cholesterol homeostasis in colorectal cancer

J. Bradner, H. Seo, R. Carrasco, 2022, Science advances.

Unravelling the complexity of metastasis — molecular understanding and targeted therapies

Yibin Kang, N. Sethi, Nilay S. Sethi, 2011, Nature Reviews Cancer.

Programmatic Precision Oncology Decision Support for Patients With Gastrointestinal Cancer

Rachel B. Keller, E. Cerami, J. Meyerhardt, 2023, JCO precision oncology.

Interaction of Variable Bacterial Outer Membrane Lipoproteins with Brain Endothelium

K. Kim, N. Sethi, D. Cadavid, 2010, PloS one.

Interaction of a Neurotropic Strain of Borrelia turicatae with the Cerebral Microcirculation System

K. Kim, N. Sethi, D. Cadavid, 2006, Infection and Immunity.

YAP1 and PRDM14 converge to promote cell survival and tumorigenesis.

Henry W. Long, John G Doench, J. Doench, 2021, Developmental cell.

Diagnostic tool to identify and treat DNA repair deficient gastroesophageal adenocarcinomas

Z. Szallasi, I. Csabai, Harshabad Singh, 2022, bioRxiv.

Oesophageal adenocarcinoma and gastric cancer: should we mind the gap?

A. Bass, A. Sepulveda, T. Wang, 2016, Nature Reviews Cancer.

Integrated clinical and genomic analysis identifies driver events and molecular evolution of colitis-associated cancers

N. Schultz, R. Yantiss, A. Bass, 2023, Nature Communications.

Opportunities for Utilization of DNA Repair Inhibitors in Homologous Recombination Repair-Deficient and Proficient Pancreatic Adenocarcinoma

G. Shapiro, A. D’Andrea, B. Wolpin, 2021, Clinical Cancer Research.

Emerging Role of Targeted Therapy in Metastatic Pancreatic Adenocarcinoma

H. Ellis, B. Wolpin, A. Aguirre, 2022, Cancers.

Mutant p53 induces a hypoxia transcriptional program in gastric and esophageal adenocarcinoma.

James M. McFarland, A. Bass, W. Kaelin, 2019, JCI insight.

Mutant p 53 induces a hypoxia transcriptional program in gastric and esophageal adenocarcinoma

James M. McFarland, A. Bass, W. Kaelin, 2019 .

Dysregulation of developmental pathways in bone metastasis.

Yibin Kang, N. Sethi, Nilay S. Sethi, 2011, Bone.

An enhancer-driven stem cell-like program mediated by SOX9 blocks intestinal differentiation in colorectal cancer.

Henry W. Long, A. Bass, Harshabad Singh, 2021, Gastroenterology.

Early TP53 alterations engage environmental exposures to promote gastric premalignancy in an integrative mouse model

James M. McFarland, R. Beroukhim, K. Ligon, 2020, Nature Genetics.

toutvelu, a Regulator of Heparan Sulfate Proteoglycan Biosynthesis, Controls Guidance Cues for Germ-Cell Migration

P. Schedl, G. Deshpande, N. Sethi, 2007, Genetics.

Factoring in the missing link

A. Sperling, N. Sethi, L. Tierney, 2017, American journal of hematology.

Identifying regulators of aberrant stem cell and differentiation activity in colorectal cancer using a dual endogenous reporter system

M. Giannakis, S. Spisák, P. De Silva, 2024, Nature communications.

Tumor control with PD-1 inhibition in a patient with concurrent metastatic melanoma and renal cell carcinoma

T. Choueiri, P. Ott, N. Sethi, 2016, Journal of Immunotherapy for Cancer.

Nucleotide excision repair deficiency is a targetable therapeutic vulnerability in clear cell renal cell carcinoma

Z. Szallasi, I. Csabai, G. Klus, 2023, bioRxiv.

Mutational signature-based identification of DNA repair deficient gastroesophageal adenocarcinomas for therapeutic targeting

Harshabad Singh, Z. Sztupinszki, S. Spisák, 2024, NPJ precision oncology.

Cell states and neighborhoods in distinct clinical stages of primary and metastatic esophageal adenocarcinoma

E. V. Van Allen, Josephine Yates, Agnieszka Kraft, 2024, bioRxiv.