Ouyang Zhen

发表

A Huntingtin Knockin Pig Model Recapitulates Features of Selective Neurodegeneration in Huntington’s Disease

Shihua Li, Xiao-Jiang Li, He Zhao, 2018, Cell.

Piglets cloned from induced pluripotent stem cells

Huanming Yang, Zhenzhen Yang, Jing Li, 2012, Cell Research.

Cytoplasmic mislocalization of RNA splicing factors and aberrant neuronal gene splicing in TDP-43 transgenic pig brain

Chuan-en Wang, Shihua Li, Xiao-Jiang Li, 2015, Molecular Neurodegeneration.

Species-dependent neuropathology in transgenic SOD1 pigs

Chuan-en Wang, Shihua Li, Xiao-Jiang Li, 2014, Cell Research.

Double knock-in pig models with elements of binary Tet-On and phiC31 integrase systems for controllable and switchable gene expression

L. Lai, Yanhui Liang, Zhaoming Liu, 2022, Science China Life Sciences.

Use of the 2A Peptide for Generation of Multi-Transgenic Pigs through a Single Round of Nuclear Transfer

Dongshan Yang, L. Lai, Zhenfang Wu, 2011, PloS one.

Generation of Hoxc13 knockout pigs recapitulates human ectodermal dysplasia–9

K. Zeng, L. Lai, Nana Fan, 2016, Human molecular genetics.

Highly Efficient Generation of GGTA1 Biallelic Knockout Inbred Mini-Pigs with TALENs

L. Lai, Nana Fan, Huaqiang Yang, 2013, PloS one.

Engineered Pigs Carrying a Gain-of-Function NLRP3 Homozygous Mutation Can Survive to Adulthood and Accurately Recapitulate Human Systemic Spontaneous Inflammatory Responses

Lei Xiao, L. Lai, Guangxun Meng, 2020, The Journal of Immunology.

Doxycycline-dependent Cas9-expressing pig resources for conditional in vivo gene nullification and activation

L. Lai, Ren Huang, Zhaoming Liu, 2023, Genome Biology.

Efficient base editing for multiple genes and loci in pigs using base editors

Yu Zhao, L. Lai, Han Wu, 2019, Nature Communications.

XIST Derepression in Active X Chromosome Hinders Pig Somatic Cell Nuclear Transfer

Xiaoshan Wang, Hong Song, Jiekai Chen, 2018, Stem cell reports.

Generation of CRISPR/Cas9-mediated gene-targeted pigs via somatic cell nuclear transfer

L. Lai, M. Esteban, Nana Fan, 2015, Cellular and Molecular Life Sciences.

Genetically humanized pigs exclusively expressing human insulin are generated through custom endonuclease-mediated seamless engineering.

Xiaofang Sun, L. Lai, Yong Fan, 2016, Journal of molecular cell biology.

Rosa26-targeted swine models for stable gene over-expression and Cre-mediated lineage tracing

H. Ouyang, L. Lai, Songcai Liu, 2014, Cell Research.

RAG1/2 Knockout Pigs with Severe Combined Immunodeficiency

A. Schambach, J. Frampton, Dongshan Yang, 2014, The Journal of Immunology.

Combined Immunodeficiency Rag1/2 Knockout Pigs with Severe

Dongshan Yang, Nana Fan, Zhaoming Liu, 2022 .

Combined Immunodeficiency Rag1/2 Knockout Pigs with Severe

A. Schambach, J. Frampton, Dongshan Yang, 2022 .

Generation of CRISPR/Cas9-mediated gene-targeted pigs via somatic cell nuclear transfer

L. Lai, M. Esteban, Nana Fan, 2014, Cellular and Molecular Life Sciences.

Cre-dependent Cas9-expressing pigs enable efficient in vivo genome editing

P. Doevendans, J. Sluijter, L. Lai, 2017, Genome research.

Evaluation of guide-free Cas9-induced genomic damage and transcriptome changes in pig embryos

Tao Chen, Yanhui Liang, Han Wu, 2023, Molecular therapy. Nucleic acids.

AGBE: a dual deaminase-mediated base editor by fusing CGBE with ABE for creating a saturated mutant population with multiple editing patterns

L. Lai, Yanhui Liang, Zhenpeng Zhuang, 2022, Nucleic acids research.

ACBE, a new base editor for simultaneous C-to-T and A-to-G substitutions in mammalian systems

L. Lai, Yanhui Liang, Zhenpeng Zhuang, 2020, BMC Biology.

CRISPR/Cas9-mediated gene correction in newborn rabbits with hereditary tyrosinemia type I.

L. Lai, Yanhui Liang, Zhenpeng Zhuang, 2020, Molecular therapy : the journal of the American Society of Gene Therapy.

Establishment of a porcine Oct-4 promoter-driven EGFP reporter system for monitoring pluripotency of porcine stem cells.

Dongshan Yang, L. Lai, J. Cai, 2011, Cellular reprogramming.