Linghang Zhuang

发表

Structure-based design and synthesis of 1,3-oxazinan-2-one inhibitors of 11β-hydroxysteroid dehydrogenase type 1.

Suresh B. Singh, P. Carroll, D. Claremon, 2011, Journal of medicinal chemistry.

A naphthyridine carboxamide provides evidence for discordant resistance between mechanistically identical inhibitors of HIV-1 integrase.

Mark Embrey, Samson M Jolly, Wei Xu, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Discovery of novel spiro compound as RAF kinase inhibitor with in vitro potency against KRAS mutant cancer.

Suxing Liu, Weikang Tao, Rumin Zhang, 2022, Bioorganic & medicinal chemistry letters.

Discovery of spiro amide SHR902275: A potent, selective, and efficacious RAF inhibitor targeting RAS mutant cancers.

Yu Zhou, Suxing Liu, Weikang Tao, 2021, European journal of medicinal chemistry.

4-Aryl-2,4-dioxobutanoic acid inhibitors of HIV-1 integrase and viral replication in cells.

H. M. Langford, D. Hazuda, W. Schleif, 2000, Journal of medicinal chemistry.

Liver X receptor

Suresh B. Singh, Yajun Zheng, K. Leftheris, 2013 .

Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core.

K. Fan, R. Gregg, Suresh B. Singh, 2016, Bioorganic & medicinal chemistry letters.

A CARBONYL-YLIDE APPROACH TO THE TIGLIANE DITERPENES

W. Watt, D. Wright, L. Zhuang, 1994 .

Discovery of Isoindoline Amide Derivatives as Potent and Orally Bioavailable ADAMTS-4/5 Inhibitors for the Treatment of Osteoarthritis.

Suxing Liu, Weikang Tao, Chunying Song, 2022, ACS pharmacology & translational science.

Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR) β Agonist.

K. Fan, R. Gregg, Zhijie Liu, 2016, Journal of medicinal chemistry.

A Novel CD73 Inhibitor SHR170008 Suppresses Adenosine in Tumor and Enhances Anti-Tumor Activity with PD-1 Blockade in a Mouse Model of Breast Cancer

Suxing Liu, Weikang Tao, Rumin Zhang, 2021, OncoTargets and therapy.

Novel Small Molecule Tyrosine Kinase 2 Pseudokinase Ligands Block Cytokine-Induced TYK2-Mediated Signaling Pathways

Suxing Liu, Weikang Tao, R. Chowdhury, 2022, Frontiers in Immunology.

The medicinal chemistry of liver X receptor (LXR) modulators.

K. Fan, Suresh B. Singh, D. Lala, 2014, Journal of medicinal chemistry.

Dihydroxypyridopyrazine-1,6-dione HIV-1 integrase inhibitors.

D. Hazuda, W. Schleif, L. Gabryelski, 2007, Bioorganic & medicinal chemistry letters.

Discovery and optimization of adamantyl carbamate inhibitors of 11β-HSD1.

R. Gregg, Suresh B. Singh, H. Nar, 2010, Bioorganic & medicinal chemistry letters.

Pharmacological characterization of the selective 11β-hydroxysteroid dehydrogenase 1 inhibitor, BI 135585, a clinical candidate for the treatment of type 2 diabetes.

H. Nar, B. Hamilton, D. Lala, 2015, European journal of pharmacology.

Spongipyran Synthetic Studies. Total Synthesis of (+)-Spongistatin 2.

Clay S. Bennett, Mark D. McBriar, A. M. Boldi, 2009, Tetrahedron.

SHR1032, a novel STING agonist, stimulates anti-tumor immunity and directly induces AML apoptosis

Suxing Liu, Weikang Tao, M. Miller, 2022, Scientific Reports.

Spirocyclic ureas: orally bioavailable 11 beta-HSD1 inhibitors identified by computer-aided drug design.

Suresh B. Singh, D. Claremon, C. Tice, 2010, Bioorganic & medicinal chemistry letters.

Design and synthesis of 8-hydroxy-[1,6]naphthyridines as novel inhibitors of HIV-1 integrase in vitro and in infected cells.

Linghang Zhuang, D. Hazuda, W. Schleif, 2003, Journal of medicinal chemistry.