M. P. Longhese

发表

Mechanisms and regulation of DNA end resection

N. Manfrini, Maria Pia Longhese, M. Longhese, 2010, The EMBO journal.

Processing of DNA Double-Strand Breaks by the MRX Complex in a Chromatin Context

M. Longhese, Diego Bonetti, Erika Casari, 2019, Front. Mol. Biosci..

The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast.

G. Lucchini, M. Longhese, M. Clerici, 2000, Genes & development.

DNA damage checkpoint in budding yeast

G. Lucchini, P. Plevani, M. Muzi-Falconi, 1998, The EMBO journal.

Mec1p is essential for phosphorylation of the yeast DNA damage checkpoint protein Ddc1p, which physically interacts with Mec3p

G. Lucchini, P. Plevani, M. Longhese, 1998, The EMBO journal.

The novel DNA damage checkpoint protein Ddc1p is phosphorylated periodically during the cell cycle and in response to DNA damage in budding yeast

G. Lucchini, P. Plevani, R. Fraschini, 1997, The EMBO journal.

Mec 1 p is essential for phosphorylation of the yeast DNA damage checkpoint protein Ddc 1 p , which physically interacts with Mec 3 p

G. Lucchini, P. Plevani, M. Longhese, 2013 .

EMBO MEMBER'S REVIEW DNA damage checkpoint in budding yeast

G. Lucchini, P. Plevani, M. Muzi-Falconi, 1998 .

Purification and characterization of a new DNA polymerase from budding yeast Saccharomyces cerevisiae. A probable homolog of mammalian DNA polymerase beta.

G. Lucchini, P. Plevani, C. Santocanale, 1993, The Journal of biological chemistry.

The Ku complex promotes DNA end-bridging and this function is antagonized by Tel1/ATM kinase

R. Tisi, Erika Casari, M. Mangiagalli, 2023, Nucleic acids research.

How do cells sense DNA lesions?

M. Longhese, E. Gobbini, M. Gnugnoli, 2020, Biochemical Society transactions.

Uncoupling Sae2 Functions in Downregulation of Tel1 and Rad53 Signaling Activities

R. Ranieri, M. Longhese, Diego Bonetti, 2018, Genetics.

Processing of DNA Ends in the Maintenance of Genome Stability

M. Longhese, Diego Bonetti, M. Clerici, 2018, Front. Genet..

Local unwinding of double-strand DNA ends by the MRX complex promotes Exo1 processing activity

J. Vertemara, M. Longhese, E. Gobbini, 2018, Molecular & cellular oncology.

The MRX complex regulates Exo1 resection activity by altering DNA end structure

P. Sung, J. Vertemara, Giuseppe Zampella, 2018, The EMBO journal.

Tel1/ATM prevents degradation of replication forks that reverse after topoisomerase poisoning

M. Lopes, M. Longhese, M. Clerici, 2018, EMBO reports.

Rad9/53BP1 protects stalled replication forks from degradation in Mec1/ATR‐defective cells

M. Longhese, Diego Bonetti, M. Villa, 2018, EMBO reports.

The RNA binding protein Npl3 promotes resection of DNA double-strand breaks by regulating the levels of Exo1

M. Longhese, M. Clerici, C. Colombo, 2017, Nucleic acids research.

Coupling end resection with the checkpoint response at DNA double-strand breaks

M. Longhese, Diego Bonetti, E. Gobbini, 2016, Cellular and Molecular Life Sciences.

Sae2 Function at DNA Double-Strand Breaks Is Bypassed by Dampening Tel1 or Rad53 Activity

M. Longhese, M. Clerici, E. Gobbini, 2015, PLoS genetics.

Mec1/ATR regulates the generation of single‐stranded DNA that attenuates Tel1/ATM signaling at DNA ends

G. Lucchini, A. Galbiati, M. Longhese, 2013, The EMBO journal.

Interplays between ATM/Tel1 and ATR/Mec1 in sensing and signaling DNA double-strand breaks.

A. Galbiati, M. Longhese, E. Gobbini, 2013, DNA repair.

G1/S and G2/M Cyclin-Dependent Kinase Activities Commit Cells to Death in the Absence of the S-Phase Checkpoint

G. Lucchini, N. Manfrini, M. Longhese, 2012, Molecular and Cellular Biology.

Resection is responsible for loss of transcription around a double-strand break in Saccharomyces cerevisiae

F. d’Adda di Fagagna, A. Morillon, M. Wery, 2015, eLife.

Yeast pip3/mec3 mutants fail to delay entry into S phase and to slow DNA replication in response to DNA damage, and they define a functional link between Mec3 and DNA primase

G. Lucchini, P. Plevani, R. Fraschini, 1996, Molecular and cellular biology.

Dominant TEL1-hy Mutations Compensate for Mec1 Lack of Functions in the DNA Damage Response

G. Lucchini, M. Longhese, V. Baldo, 2007, Molecular and Cellular Biology.

Budding Yeast Sae2 is an In Vivo Target of the Mec1 and Tel1 Checkpoint Kinases During Meiosis

G. Lucchini, I. Guerini, M. Longhese, 2006, Cell cycle.

Responses to Replication of DNA Damage

M. Foiani, M. Longhese, M. P. Longhese, 2005 .

A Tel1/MRX-Dependent Checkpoint Inhibits the Metaphase-to-Anaphase Transition after UV Irradiation in the Absence of Mec1

G. Lucchini, Davide Mantiero, M. Longhese, 2004, Molecular and Cellular Biology.

The Functions of Budding Yeast Sae2 in the DNA Damage Response Require Mec1- and Tel1-Dependent Phosphorylation

G. Lucchini, M. Longhese, V. Viscardi, 2004, Molecular and Cellular Biology.

Functions of Saccharomyces cerevisiae 14-3-3 proteins in response to DNA damage and to DNA replication stress.

G. Lucchini, M. Longhese, Francisca Lottersberger, 2003, Genetics.

The S-phase checkpoint and its regulation in Saccharomyces cerevisiae.

G. Lucchini, M. Longhese, M. Clerici, 2003, Mutation research.

Interaction between Set1p and checkpoint protein Mec3p in DNA repair and telomere functions

E. Gilson, V. Géli, Y. Corda, 1999, Nature Genetics.

The 70 kDa subunit of replication protein A is required for the G1/S and intra-S DNA damage checkpoints in budding yeast.

G. Lucchini, P. Plevani, M. Longhese, 1996, Nucleic acids research.

A central role for DNA replication forks in checkpoint activation and response.

J. Diffley, J. A. Tercero, M. Longhese, 2003, Molecular cell.

Regulation of the DNA damage response by cyclin-dependent kinases.

N. Manfrini, M. Longhese, M. Falcettoni, 2013, Journal of molecular biology.

Checkpoint proteins influence telomeric silencing and length maintenance in budding yeast.

G. Lucchini, M. Longhese, V. Paciotti, 2000, Genetics.

Physical and functional interactions between nucleotide excision repair and DNA damage checkpoint

P. Plevani, Federico Lazzaro, M. Muzi-Falconi, 2004, The EMBO journal.

To Fix or Not to Fix: Maintenance of Chromosome Ends Versus Repair of DNA Double-Strand Breaks

M. Longhese, Diego Bonetti, Erika Casari, 2022, Cells.

The DNA damage checkpoint: A tale from budding yeast

M. Longhese, Erika Casari, M. Gnugnoli, 2022, Frontiers in Genetics.

Functional and structural insights into the MRX/MRN complex, a key player in recognition and repair of DNA double-strand breaks

J. Vertemara, Giuseppe Zampella, M. Longhese, 2020, Computational and structural biotechnology journal.

DNA binding modes influence Rap1 activity in the regulation of telomere length and MRX functions at DNA ends

J. Vertemara, Giuseppe Zampella, M. Notaro, 2019, Nucleic acids research.

The ATP-bound conformation of the Mre11–Rad50 complex is essential for Tel1/ATM activation

J. Vertemara, Giuseppe Zampella, M. Longhese, 2019, Nucleic acids research.

Structure–function relationships of the Mre11 protein in the control of DNA end bridging and processing

M. Longhese, Corinne Cassani, R. Tisi, 2018, Current Genetics.

Structurally distinct Mre11 domains mediate MRX functions in resection, end-tethering and DNA damage resistance

P. Sung, J. Vertemara, Giuseppe Zampella, 2018, Nucleic acids research.

Functions and regulation of the MRX complex at DNA double-strand breaks

M. Longhese, Diego Bonetti, E. Gobbini, 2016, Microbial cell.

Tel1 and Rif2 Regulate MRX Functions in End-Tethering and Repair of DNA Double-Strand Breaks

P. Sung, H. Niu, Patrick Sung, 2016, PLoS biology.

The MRX Complex Plays Multiple Functions in Resection of Yku- and Rif2-Protected DNA Ends

G. Lucchini, N. Manfrini, M. Longhese, 2010, PloS one.

Surveillance mechanisms monitoring chromosome breaks during mitosis and meiosis.

I. Guerini, M. Longhese, M. Clerici, 2008, DNA repair.

The cellular response to chromosome breakage

Davide Mantiero, Maria Pia Longhese, Davide Mantiero, 2006, Molecular microbiology.

The Saccharomyces cerevisiae Sae2 protein negatively regulates DNA damage checkpoint signalling

G. Lucchini, Davide Mantiero, M. Longhese, 2006, EMBO reports.

The Saccharomyces cerevisiae Sae2 Protein Promotes Resection and Bridging of Double Strand Break Ends*

G. Lucchini, Davide Mantiero, M. Longhese, 2005, Journal of Biological Chemistry.

Characterization of mec1Kinase-Deficient Mutants and of New Hypomorphic mec1Alleles Impairing Subsets of the DNA Damage Response Pathway

G. Lucchini, M. Longhese, M. Clerici, 2001, Molecular and Cellular Biology.

DNA double-strand breaks in meiosis: checking their formation, processing and repair.

N. Manfrini, I. Guerini, M. Longhese, 2009, DNA repair.

Replication factor A is required in vivo for DNA replication, repair, and recombination

G. Lucchini, P. Plevani, M. Longhese, 1994, Molecular and cellular biology.

The Plasticity of Dendritic Cell Responses to Pathogens and Their Components

Giovanna Lucchini, Paolo Plevani, G. Lucchini, 2001 .

Sae2 and Rif2 regulate MRX endonuclease activity at DNA double-strand breaks in opposite manners

P. Cejka, E. Cannavó, M. Longhese, 2021, Cell reports.

Sensing R-Loop-Associated DNA Damage to Safeguard Genome Stability

M. Longhese, Diego Bonetti, C. Rinaldi, 2021, Frontiers in Cell and Developmental Biology.

Telomere uncapping at the crossroad between cell cycle arrest and carcinogenesis

M. Longhese, E. Gobbini, Corinne Cassani, 2014, Molecular & cellular oncology.

The novel DNA damage checkpoint protein Ddc 1 p is phosphorylated periodically during the cell cycle and in response to DNA damage in budding yeast human cells

G. Lucchini, P. Plevani, R. Fraschini, 2013 .

Irreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing

F. d’Adda di Fagagna, F. Rossiello, M. Fumagalli, 2014, Current opinion in genetics & development.

PP2A Controls Genome Integrity by Integrating Nutrient-Sensing and Metabolic Pathways with the DNA Damage Response

S. Minucci, M. Varasi, M. Elgendy, 2017, Molecular cell.

Tel1/ATM Signaling to the Checkpoint Contributes to Replicative Senescence in the Absence of Telomerase

M. Longhese, M. Clerici, C. Colombo, 2019, Genetics.

MRX-dependent DNA damage response to short telomeres.

G. Lucchini, M. Longhese, Diego Bonetti, 2007, Molecular biology of the cell.

Telomeres and DNA damage checkpoints.

M. Longhese, M. Clerici, V. Viscardi, 2005, Biochimie.

RPA regulates telomerase action by providing Est1p access to chromosome ends

E. Gilson, V. Géli, Y. Corda, 2004, Nature Genetics.

Multiple pathways regulate 3' overhang generation at S. cerevisiae telomeres.

G. Lucchini, M. Longhese, Diego Bonetti, 2009, Molecular cell.

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

F. D. D. Fagagna, Davide Cittaro, F. Rossiello, 2012, Nature Cell Biology.

Mutations in conserved yeast DNA primase domains impair DNA replication in vivo.

G. Lucchini, P. Plevani, S. Francesconi, 1991, Proceedings of the National Academy of Sciences of the United States of America.

The Saccharomyces cerevisiae 14-3-3 Proteins Are Required for the G1/S Transition, Actin Cytoskeleton Organization and Cell Wall Integrity

Giovanna Lucchini, G. Lucchini, S. Piatti, 2006, Genetics.

Mutants with changes in different domains of yeast replication protein A exhibit differences in repairing the control region, the transcribed strand and the non-transcribed strand of the Saccharomyces cerevisiae MFA2 gene.

R. Waters, Y. Teng, M. Longhese, 1998, Journal of molecular biology.

DNA damage response at functional and dysfunctional telomeres.

Maria Pia Longhese, M. Longhese, M. P. Longhese, 2008, Genes & development.

The role of shelterin in maintaining telomere integrity.

S. Anbalagan, M. Longhese, Diego Bonetti, 2012, Frontiers in bioscience.

Dual role for Saccharomyces cerevisiae Tel1 in the checkpoint response to double‐strand breaks

G. Lucchini, Davide Mantiero, M. Longhese, 2007, EMBO reports.

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

F. D. D. Fagagna, Davide Cittaro, F. Rossiello, 2012, Nature Cell Biology.

Rif1 Supports the Function of the CST Complex in Yeast Telomere Capping

G. Lucchini, S. Anbalagan, M. Longhese, 2011, PLoS genetics.

Hyperactivation of the yeast DNA damage checkpoint by TEL1 and DDC2 overexpression

G. Lucchini, M. Longhese, M. Clerici, 2001, The EMBO journal.

The Mec1p and Tel1p checkpoint kinases allow humanized yeast to tolerate chronic telomere dysfunctions by suppressing telomere fusions.

E. Gilson, E. D. Di Domenico, F. Ascenzioni, 2009, DNA Repair.

Regulation of telomere metabolism by the RNA processing protein Xrn1

M. Lisby, M. Longhese, Diego Bonetti, 2017, Nucleic acids research.

RNA‐processing proteins regulate Mec1/ATR activation by promoting generation of RPA‐coated ssDNA

F. d’Adda di Fagagna, A. Morillon, M. Wery, 2015, EMBO reports.

Dpb4 promotes resection of DNA double-strand breaks and checkpoint activation by acting in two different protein complexes

M. Longhese, M. Clerici, E. Gobbini, 2021, Nature Communications.

Role of the Saccharomyces cerevisiae Rad53 Checkpoint Kinase in Signaling Double-Strand Breaks during the Meiotic Cell Cycle

G. Lucchini, N. Manfrini, I. Guerini, 2008, Molecular and Cellular Biology.

The chromatin remodeler Chd1 supports MRX and Exo1 functions in resection of DNA double-strand breaks

M. Longhese, Erika Casari, M. Gnugnoli, 2021, PLoS genetics.

The 9-1-1 Complex Controls Mre11 Nuclease and Checkpoint Activation during Short-Range Resection of DNA Double-Strand Breaks.

M. Longhese, Diego Bonetti, E. Gobbini, 2020, Cell reports.

Escape of Sgs1 from Rad9 inhibition reduces the requirement for Sae2 and functional MRX in DNA end resection

M. Longhese, Diego Bonetti, E. Gobbini, 2015, EMBO reports.

Saccharomyces cerevisiae Rif1 cooperates with MRX‐Sae2 in promoting DNA‐end resection

Giovanna Lucchini, G. Lucchini, M. Longhese, 2014, EMBO reports.

Tbf1 and Vid22 promote resection and non‐homologous end joining of DNA double‐strand break ends

G. Lucchini, S. Anbalagan, Diego Bonetti, 2012, The EMBO journal.

Shelterin-Like Proteins and Yku Inhibit Nucleolytic Processing of Saccharomyces cerevisiae Telomeres

G. Lucchini, S. Anbalagan, M. Longhese, 2010, PLoS genetics.

Processing of Meiotic DNA Double Strand Breaks Requires Cyclin-dependent Kinase and Multiple Nucleases*

G. Lucchini, N. Manfrini, A. Citterio, 2010, The Journal of Biological Chemistry.

Functional and Physical Interactions between Yeast 14-3-3 Proteins, Acetyltransferases, and Deacetylases in Response to DNA Replication Perturbations

Giovanna Lucchini, G. Lucchini, Francisca Lottersberger, 2007, Molecular and Cellular Biology.

Escape of Sgs1 from Rad9 inhibition reduces the requirement for Sae2 and functional MRX in DNA end resection

Diego Bonetti, E. Gobbini, Corinne Cassani, 2015, EMBO reports.

The Yku70–Yku80 complex contributes to regulate double‐strand break processing and checkpoint activation during the cell cycle

G. Lucchini, Davide Mantiero, I. Guerini, 2008, EMBO reports.

Sudden telomere lengthening triggers a Rad53-dependent checkpoint in Saccharomyces cerevisiae.

G. Lucchini, M. Longhese, V. Viscardi, 2003, Molecular biology of the cell.

Telomere-end processing: mechanisms and regulation

M. Longhese, Diego Bonetti, Marina Martina, 2013, Chromosoma.

The regulation of the DNA damage response at telomeres: focus on kinases.

M. Longhese, M. Clerici, Michela Galli, 2021, Biochemical Society transactions.

Resection of a DNA Double-Strand Break by Alkaline Gel Electrophoresis and Southern Blotting.

M. Longhese, M. Clerici, E. Gobbini, 2021, Methods in molecular biology.

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

F. D. D. Fagagna, Davide Cittaro, F. Rossiello, 2012, Nature Cell Biology.

Mec1/ATR regulates the generation of single‐stranded DNA that attenuates Tel1/ATM signaling at DNA ends

G. Lucchini, A. Galbiati, Michela Clerici, 2013, The EMBO journal.

A Balance between Tel1 and Rif2 Activities Regulates Nucleolytic Processing and Elongation at Telomeres

G. Lucchini, M. Longhese, Diego Bonetti, 2012, Molecular and Cellular Biology.

Structure–function relationships of the Mre11 protein in the control of DNA end bridging and processing

M. Longhese, A. Marsella, Corinne Cassani, 2018, Current Genetics.

The set1Delta mutation unveils a novel signaling pathway relayed by the Rad53-dependent hyperphosphorylation of replication protein A that leads to transcriptional activation of repair genes.

G. Lucchini, E. Gilson, V. Géli, 2001, Genes & development.

Rif2 interaction with Rad50 counteracts Tel1 functions in checkpoint signalling and DNA tethering by releasing Tel1 from MRX binding

R. Tisi, Erika Casari, M. Gnugnoli, 2024, Nucleic acids research.

The PP2A phosphatase counteracts the function of the 9-1-1 axis in checkpoint activation.

Erika Casari, M. Gnugnoli, Paolo Pizzul, 2023, Cell reports.

The Ku complex promotes DNA end-bridging and this function is antagonized by Tel1/ATM kinase

M. Longhese, R. Tisi, Erika Casari, 2023, Nucleic acids research.

Coupling end resection with the checkpoint response at DNA double-strand breaks

M. Longhese, Diego Bonetti, E. Gobbini, 2016, Cellular and Molecular Life Sciences.

Regulation of the DNA damage response by cyclin-dependent kinase in "Saccharomyces cerevisiae ”

C. Trovesi, M. P. Longhese, Camilla Trovesi, 2013 .

Genetic Control of the DNA Polymerase α -Primase complex in the Yeast Saccharomyces cerevisiae

G. Lucchini, P. Plevani, S. Francesconi, 1992 .

Conditional mutations in the yeast DNA primase genes affect different aspects of DNA metabolism and interactions in the DNA polymerase alpha-primase complex.

G. Lucchini, P. Plevani, L. Jovine, 1993, Genetics.

Dephosphorylation of γH2A by Glc7/Protein Phosphatase 1 Promotes Recovery from Inhibition of DNA Replication

G. Lucchini, Davide Mantiero, M. Longhese, 2009, Molecular and Cellular Biology.

G1/S and G2/M Cyclin-Dependent Kinase Activities Commit Cells to Death in the Absence of the S-Phase Checkpoint

G. Lucchini, N. Manfrini, E. Gobbini, 2012, Molecular and Cellular Biology.

The Rad53CHK1/CHK2-Spt21NPAT and Tel1ATM axes couple glucose tolerance to histone dosage and subtelomeric silencing

M. Smolka, Adhish S. Walvekar, Sunil Laxman, 2020, Nature Communications.