Natasha Zarich

发表

Plitidepsin Cellular Binding and Rac1/JNK Pathway Activation Depend on Membrane Cholesterol Content

M. A. Lasunción, A. Dávalos, Y. Suárez, 2006, Molecular Pharmacology.

membrane cholesterol content

M. A. Lasunción, A. Dávalos, Y. Suárez, 2006 .

SOS GEFs IN HEALTH AND DISEASE.

E. Santos, N. Zarich, F. Baltanás, 2020, Biochimica et biophysica acta. Reviews on cancer.

The CSN3 subunit of the COP9 signalosome interacts with the HD region of Sos1 regulating stability of this GEF protein

A. Fernández-Medarde, E. Santos, A. Ballester, 2019, Oncogenesis.

hSos1 Contains a New Amino-terminal Regulatory Motif with Specific Binding Affinity for Its Pleckstrin Homology Domain*

Xavier de la Cruz, X. de la Cruz, N. Martínez, 2002, The Journal of Biological Chemistry.

Grb2 is a negative modulator of the intrinsic Ras-GEF activity of hSos1.

N. Martínez, J. Rojas, A. Ballester, 2006, Molecular biology of the cell.

Shoc2/Sur8 Protein Regulates Neurite Outgrowth

T. Iglesias, N. Martínez, J. Rojas, 2014, PloS one.

The isoform-specific stretch of hSos1 defines a new Grb2-binding domain

J. Rojas, N. Zarich, J. L. Oliva, 2000, Oncogene.

Isoform-specific insertion near the Grb2-binding domain modulates the intrinsic guanine nucleotide exchange activity of hSos1

J. Rojas, N. Zarich, E. Santos, 1999, Oncogene.

Plitidepsin Has a Dual Effect Inhibiting Cell Cycle and Inducing Apoptosis via Rac1/c-Jun NH2-Terminal Kinase Activation in Human Melanoma Cells

J. Rojas, T. Martínez, A. Muñoz, 2008, Journal of Pharmacology and Experimental Therapeutics.

Plitidepsin has a dual effect inhibiting cell cycle and inducing apoptosis via Rac1/JNK activation in human melanoma cells

J. Rojas, A. Muñoz, N. Zarich, 2007 .

Aplidin® induces JNK-dependent apoptosis in human breast cancer cells via alteration of glutathione homeostasis, Rac1 GTPase activation, and MKP-1 phosphatase downregulation

Y. Suárez, A. Cuadrado, J. Rojas, 2005, Cell Death and Differentiation.

Discovery of mitogen-activated protein kinase-interacting kinase 1 inhibitors by a comprehensive fragment-oriented virtual screening approach.

O. Rabal, J. Oyarzábal, Manuel Urbano-Cuadrado, 2010, Journal of medicinal chemistry.

Sprouty2 binds Grb2 at two different proline-rich regions, and the mechanism of ERK inhibition is independent of this interaction.

N. Martínez, J. Rojas, B. Domingo, 2007, Cellular signalling.

Potentiation of tumor formation by topical administration of 15-deoxy-delta12,14-prostaglandin J2 in a model of skin carcinogenesis.

K. Stamatakis, J. Rojas, L. Boscá, 2006, Carcinogenesis.

The P34G Mutation Reduces the Transforming Activity of K-Ras and N-Ras in NIH 3T3 Cells but Not of H-Ras*

Á. Juarranz, J. Gutkind, N. Martínez, 2004, Journal of Biological Chemistry.

PKD phosphorylation and COP9/Signalosome modulate intracellular Spry2 protein stability

E. Santos, T. Iglesias, N. Martínez, 2023, Oncogenesis.