J. Heads

发表

Fab-dsFv: A bispecific antibody format with extended serum half-life through albumin binding

A. Lawson, A. Turner, R. Adams, 2016, mAbs.

Towards a universal disulphide stabilised single chain Fv format: importance of interchain disulphide bond location and vL-vH orientation.

R. Adams, D. Humphreys, S. Heywood, 2012, Protein engineering, design & selection : PEDS.

A Mixture of Functionally Oligoclonal Humanized Monoclonal Antibodies That Neutralize Clostridium difficile TcdA and TcdB with High Levels of In Vitro Potency Shows In Vivo Protection in a Hamster Infection Model

A. Turner, M. Ellis, D. Humphreys, 2013, Clinical and Vaccine Immunology.

A computational method for predicting the aggregation propensity of IgG1 and IgG4(P) mAbs in common storage buffers

Alastair D G Lawson, S. Kelm, K. Tyson, 2022, mAbs.

Infection Model Protection in a Hamster In Vivo Shows Potency In Vitro TcdB with High Levels of Neutralize Clostridium difficile TcdA and Humanized Monoclonal Antibodies That A Mixture of Functionally Oligoclonal

M. Ellis, A. Oxbrow, K. Sarkar, 2014 .

Electrostatic interactions modulate the differential aggregation propensities of IgG1 and IgG4P antibodies and inform charged residue substitutions for improved developability

A. Lawson, S. Kelm, A. Turner, 2019, Protein engineering, design & selection : PEDS.

A CHO cell line engineered to express XBP1 and ERO1‐Lα has increased levels of transient protein expression

A. Dickson, P. Stephens, A. Ventom, 2013, Biotechnology progress.

An affinity-enhanced, broadly neutralizing heavy chain–only antibody protects against SARS-CoV-2 infection in animal models

P. Maes, N. Callewaert, B. Weynand, 2021, Science Translational Medicine.

Drug development of an affinity enhanced, broadly neutralizing heavy chain-only antibody that restricts SARS-CoV-2 in rodents

P. Maes, N. Callewaert, B. Weynand, 2021, bioRxiv.

Loss of Protein Kinase Novel 1 (PKN1) is Associated with Mild Systolic and Diastolic Contractile Dysfunction, Increased Phospholamban Thr Phosphorylation and Exacerbated Ischaemia-Reperfusion Injury

P. Parker, M. Marber, R. Heads, 2017 .

Engineering the Fab fragment of the anti-IgE omalizumab to prevent Fab crystallization and permit IgE-Fc complex crystallization

T. Ceska, A. Beavil, B. Sutton, 2020, Acta crystallographica. Section F, Structural biology communications.