James A Root

发表

Pyrimido[4,5-d]azepines as potent and selective 5-HT2C receptor agonists: design, synthesis, and evaluation of PF-3246799 as a treatment for urinary incontinence.

M. Andrews, A. Brown, P. Fish, 2011, Bioorganic & medicinal chemistry letters.

In vitro and in vivo characterization of PF‐04418948, a novel, potent and selective prostaglandin EP2 receptor antagonist

N. Pullen, K. Dack, Nicholas Pullen, 2011, British journal of pharmacology.

Linking increased airway hydration, ciliary beating, and mucociliary clearance through ENaC inhibition.

A. Åstrand, Alaina L. Garland, R. Tarran, 2015, American journal of physiology. Lung cellular and molecular physiology.

Linking Increased Airway Hydration, Ciliary Beating

A. Åstrand, R. Tarran, Arunava Ghosh, 2014 .

Targets of Neutrophil Influx and Weaponry: Therapeutic Opportunities for Chronic Obstructive Airway Disease

M. Uddin, K. Karabelas, J. Root, 2017, Journal of immunology research.

Attached stratified mucus separates bacteria from the epithelial cells in COPD lungs.

Dave Singh, A. Åstrand, C. McCrae, 2018, JCI insight.

Dipeptidyl Peptidase 1 Inhibitor AZD7986 Induces a Sustained, Exposure‐Dependent Reduction in Neutrophil Elastase Activity in Healthy Subjects

A. Jauhiainen, P. Forte, J. Mäenpää, 2018, Clinical pharmacology and therapeutics.

Discovery of Second Generation Reversible Covalent DPP1 Inhibitors Leading to an Oxazepane Amidoacetonitrile Based Clinical Candidate (AZD7986).

S. Connolly, S. Swallow, H. Käck, 2016, Journal of medicinal chemistry.

Target engagement confirmed in man with a dipeptidyl peptidase 1 inhibitor

A. Jauhiainen, J. Mäenpää, P. Gardiner, 2017 .

Prostanoid receptors mediating contraction in rat, macaque and human bladder smooth muscle in vitro.

J. Root, Dorren A Davey, K. af Forselles, 2015, European journal of pharmacology.

Attached stratified mucus separates bacteria from the epithelial cells in COPD lungs.

Dave Singh, A. Åstrand, C. McCrae, 2018, JCI insight.

COPD lungs show an attached stratified mucus layer resembling the protective colonic mucus

Dave Singh, A. Åstrand, C. McCrae, 2017, bioRxiv.

In vitro and in vivo characterization of PF‐04418948, a novel, potent and selective prostaglandin EP2 receptor antagonist

K. Dack, Nicholas Pullen, T. Clarke, 2011, British Journal of Pharmacology.

Multiparameter optimization in CNS drug discovery: design of pyrimido[4,5-d]azepines as potent 5-hydroxytryptamine 2C (5-HT₂C) receptor agonists with exquisite functional selectivity over 5-HT₂A and 5-HT₂B receptors.

Robert P. DePianta, V. Shanmugasundaram, A. Brown, 2014, Journal of medicinal chemistry.

Safety of medicine and the use of animals in research

I. Wilmut, Kathy Archibald, B. Pierscionek, 2011, The Lancet.