April L. Risinger

发表

Didemnaketals F and G, New Bioactive Spiroketals from a Red Sea Ascidian Didemnum Species

G. Mohamed, S. Ibrahim, D. Youssef, 2014, Marine drugs.

Synthesis and discovery of water-soluble microtubule targeting agents that bind to the colchicine site on tubulin and circumvent Pgp mediated resistance.

E. Hamel, S. Mooberry, Sudhir Raghavan, 2010, Journal of medicinal chemistry.

α- and β-Santalols Directly Interact with Tubulin and Cause Mitotic Arrest and Cytotoxicity in Oral Cancer Cells.

C. Levenson, A. L. Risinger, J. Bohmann, 2015, Journal of natural products.

Janus Compounds, 5-Chloro-N4-methyl-N4-aryl-9H-pyrimido[4,5-b]indole-2,4-diamines, Cause Both Microtubule Depolymerizing and Stabilizing Effects

S. Mooberry, A. Gangjee, S. Choudhary, 2016, Molecules.

Gatorbulin-1, a distinct cyclodepsipeptide chemotype, targets a seventh tubulin pharmacological site

S. Matthew, D. Lucena‐Agell, A. Prota, 2021, Proceedings of the National Academy of Sciences.

Taccalonolide binding to tubulin imparts microtubule stability and potent in vivo activity.

D. Schriemer, A. L. Risinger, S. Mooberry, 2013, Cancer research.

Microtubules as a Target in Cancer Therapy

A. L. Risinger, S. Mooberry, A. Risinger, 2012 .

Taccalonolides: Novel microtubule stabilizers with clinical potential.

A. L. Risinger, S. Mooberry, A. Risinger, 2010, Cancer letters.

In Situ Ring Contraction and Transformation of the Rhizoxin Macrocycle through an Abiotic Pathway.

R. Cichewicz, A. L. Risinger, S. Mooberry, 2019, Journal of natural products.

Efficacy of a Covalent Microtubule Stabilizer in Taxane-Resistant Ovarian Cancer Models

Samantha S. Yee, A. Risinger, April L. Risinger, 2021, Molecules.

Regulation of E-cadherin localization by microtubule targeting agents: rapid promotion of cortical E-cadherin through p130Cas/Src inhibition by eribulin

A. L. Risinger, S. Mooberry, Nicholas F. Dybdal-Hargreaves, 2017, Oncotarget.

One- and Two-Photon Activated Release of Oxaliplatin from a Pt(IV)-Functionalized Poly(phenylene ethynylene).

K. Schanze, Samantha S. Yee, H. Gobeze, 2022, ACS applied materials & interfaces.

Targeting and extending the eukaryotic druggable genome with natural products: cytoskeletal targets of natural products.

L. Du, A. L. Risinger, A. Risinger, 2019, Natural product reports.

Structure-activity relationships of retro-dihydrochalcones isolated from Tacca sp.

G. Kellogg, S. Mooberry, Chenxiao Da, 2013, Journal of natural products.

The bat flower: a source of microtubule-destabilizing and -stabilizing compounds with synergistic antiproliferative actions.

A. L. Risinger, S. Mooberry, D. Frantz, 2013, Journal of natural products.

Evelynin, a cytotoxic benzoquinone-type Retro-dihydrochalcone from Tacca chantrieri.

G. Helms, S. Mooberry, D. Frantz, 2010, Journal of natural products.

Microtubule dynamics as a target in oncology.

F. Giles, A. L. Risinger, S. Mooberry, 2009, Cancer treatment reviews.

Pharmacological augmentation of nicotinamide phosphoribosyltransferase (NAMPT) protects against paclitaxel-induced peripheral neuropathy

K. Berg, W. Clarke, Teresa S. Chavera, 2017, eLife.

Fluorescence spectral shape analysis for nucleotide identification

Charles J. Zeman, K. Schanze, Zhiliang Li, 2019, Proceedings of the National Academy of Sciences.

Eribulin Activates the cGAS-STING Pathway via the Cytoplasmic Accumulation of Mitochondrial DNA

Huiyun Liang, S. Mooberry, Leila Takahashi-Ruiz, 2021, Molecular Pharmacology.

Unique amalgamation of primary and secondary structural elements transform peptaibols into potent bioactive cell-penetrating peptides

R. Cichewicz, B. Stevenson, B. Stamps, 2017, Proceedings of the National Academy of Sciences.

Elucidating target specificity of the taccalonolide covalent microtubule stabilizers employing a combinatorial chemical approach

Samantha S. Yee, L. Du, Karthik Ramachandran, 2020, Nature Communications.

CRISPR-Cas9 Genome-Wide Knockout Screen Identifies Mechanism of Selective Activity of Dehydrofalcarinol in Mesenchymal Stem-like Triple-Negative Breast Cancer Cells.

J. Doench, Huiyun Liang, R. Cichewicz, 2020, Journal of natural products.

Amino acids regulate the transcription, internal sorting, and intrinsic activity of the general amino acid permease (GAP1) in S. cerevisiae

A. L. Risinger, A. Risinger, April L. Risinger, 2007 .

Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands

M. Steinmetz, K. Altmann, A. Prota, 2019, International journal of molecular sciences.

Vortioxetine reverses medial prefrontal cortex-mediated cognitive deficits in male rats induced by castration as a model of androgen deprivation therapy for prostate cancer

D. Morilak, I. Thompson, T. Johnson-Pais, 2019, Psychopharmacology.

The taccalonolides and paclitaxel cause distinct effects on microtubule dynamics and aster formation

M. Jordan, L. Wilson, S. Mooberry, 2014, Molecular Cancer.

Triple-negative breast cancer cell line sensitivity to englerin A identifies a new, targetable subtype

J. Beutler, Karthik Ramachandran, S. Mooberry, 2019, Breast Cancer Research and Treatment.

Identification of C-6 as a New Site for Linker Conjugation to the Taccalonolide Microtubule Stabilizers.

Samantha S. Yee, R. Cichewicz, L. Du, 2019, Journal of natural products.

Taccalonolide Microtubule Stabilizers.

Samantha S. Yee, L. Du, A. Risinger, 2020, Progress in the chemistry of organic natural products.

Taccalonolide microtubule stabilizers.

S. Mooberry, Jing Li, A. Risinger, 2014, Bioorganic & medicinal chemistry.

The taccalonolides and paclitaxel cause distinct effects on microtubule dynamics and aster formation

M. Jordan, L. Wilson, A. L. Risinger, 2014, Molecular Cancer.

Potent taccalonolides, AF and AJ, inform significant structure-activity relationships and tubulin as the binding site of these microtubule stabilizers.

Lihong Hu, A. L. Risinger, S. Mooberry, 2011, Journal of the American Chemical Society.

The taccalonolides, novel microtubule stabilizers, and γ-radiation have additive effects on cellular viability.

A. L. Risinger, S. Mooberry, M. Natarajan, 2011, Cancer letters.

Cellular studies reveal mechanistic differences between taccalonolide A and paclitaxel

A. L. Risinger, S. Mooberry, A. Risinger, 2011, Cell cycle.

The taccalonolides: microtubule stabilizers that circumvent clinically relevant taxane resistance mechanisms.

G. Kruh, G. Helms, S. Mooberry, 2008, Cancer research.

Eribulin rapidly inhibits TGF-β-induced Snail expression and can induce Slug expression in a Smad4-dependent manner

S. Mooberry, R. Kaul, A. Risinger, 2019, British Journal of Cancer.

The Microtubule Destabilizer Eribulin Synergizes with STING Agonists to Promote Antitumor Efficacy in Triple-Negative Breast Cancer Models

S. Mooberry, Leila Takahashi-Ruiz, Peter Y. W. Chan, 2022, Cancers.

Identification and biological activities of new taccalonolide microtubule stabilizers.

G. Helms, A. L. Risinger, S. Mooberry, 2011, Journal of medicinal chemistry.

Breast Cancer Cell Lines Exhibit Differential Sensitivities to Microtubule-targeting Drugs Independent of Doubling Time.

S. Mooberry, Nicholas F. Dybdal-Hargreaves, A. Risinger, 2015, Anticancer research.

Identification of Compounds with Efficacy against Malaria Parasites from Common North American Plants.

D. Powell, T. Anderson, R. Cichewicz, 2016, Journal of natural products.

Different ubiquitin signals act at the Golgi and plasma membrane to direct GAP1 trafficking.

C. Kaiser, A. L. Risinger, A. Risinger, 2008, Molecular biology of the cell.

Targeting the tubulin C-terminal tail by charged small molecules.

M. Mori, Mingyan Yang, R. Hortigüela, 2022, Organic & biomolecular chemistry.

Pharmacological augmentation of nicotinamide phosphoribosyltransferase (NAMPT) protects against paclitaxel-induced peripheral neuropathy

K. Berg, W. Clarke, Teresa S. Chavera, 2017, eLife.

Mapping chromatin structure in vivo using DNA methyltransferases.

Archana Dhasarathy, Archana Dhasarathy, Scott A. Hoose, 2004, Methods.

A Potent HDAC Inhibitor, 1-Alaninechlamydocin, from a Tolypocladium sp. Induces G2/M Cell Cycle Arrest and Apoptosis in MIA PaCa-2 Cells

D. Powell, R. Cichewicz, L. Du, 2014, Journal of natural products.

Pharmacokinetic Analysis and in Vivo Antitumor Efficacy of Taccalonolides AF and AJ.

Andrew J. Robles, R. Cichewicz, L. Du, 2017, Journal of natural products.

Activity-dependent reversible inactivation of the general amino acid permease.

C. Kaiser, Chris A Kaiser, April L Risinger, 2006, Molecular biology of the cell.

Altertoxin II, a Highly Effective and Specific Compound against Ewing Sarcoma

Andrew J. Robles, P. Houghton, R. Cichewicz, 2021, Cancers.

Eribulin Mesylate: Mechanism of Action of a Unique Microtubule-Targeting Agent

A. L. Risinger, S. Mooberry, Nicholas F. Dybdal-Hargreaves, 2015, Clinical Cancer Research.

Design, synthesis, and biological evaluations of 2,5-diaryl-2,3-dihydro-1,3,4-oxadiazoline analogs of combretastatin-A4.

Ryan S. Davis, S. Mooberry, Erin O'Brien, 2010, Journal of medicinal chemistry.

Microtubule-Targeting Drugs: More than Antimitotics.

A. L. Risinger, S. Mooberry, R. Kaul, 2019, Journal of natural products.

Sterically induced conformational restriction: Discovery and preclinical evaluation of novel pyrrolo[3,2-d]pyrimidines as microtubule targeting agents.

Taylor A. Gentile, E. Hamel, S. Mooberry, 2018, Bioorganic & medicinal chemistry.

In Vivo Evaluation of (−)-Zampanolide Demonstrates Potent and Persistent Antitumor Efficacy When Targeted to the Tumor Site

Tyler A. Johnson, P. Crews, A. L. Risinger, 2022, Molecules.

Yuanhuacine Is a Potent and Selective Inhibitor of the Basal-Like 2 Subtype of Triple Negative Breast Cancer with Immunogenic Potential

R. Cichewicz, S. Cai, A. L. Risinger, 2021, Cancers.