Jenna M. Gregory

发表

Reactive astrocytes acquire neuroprotective as well as deleterious signatures in response to Tau and Aß pathology

P. Kind, J. Tulloch, S. Chandran, 2022, Nature Communications.

The Aggregation and Neurotoxicity of TDP-43 and Its ALS-Associated 25 kDa Fragment Are Differentially Affected by Molecular Chaperones in Drosophila

C. Dobson, Sarah Meehan, L. Luheshi, 2012, PloS one.

Mitochondrial bioenergetic deficits in C9orf72 amyotrophic lateral sclerosis motor neurons cause dysfunctional axonal homeostasis

Colin Smith, S. Chandran, G. Hardingham, 2021, Acta Neuropathologica.

Clusterin protects neurons against intracellular proteotoxicity

C. Dobson, Colin Smith, Mark R. Wilson, 2017, Acta Neuropathologica Communications.

The chaperone HSPB8 reduces the accumulation of truncated TDP-43 species in cells and protects against TDP-43-mediated toxicity

C. Dobson, U. Pandey, V. Crippa, 2016, Human molecular genetics.

pTDP‐43 aggregates accumulate in non‐central nervous system tissues prior to symptom onset in amyotrophic lateral sclerosis: a case series linking archival surgical biopsies with clinical phenotypic data

M. Horrocks, M. Arends, Fergal M. Waldron, 2022, The journal of pathology. Clinical research.

Clinical trials in amyotrophic lateral sclerosis: a systematic review and perspective

M. Macleod, S. Chandran, J. Chataway, 2021, Brain communications.

C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity

P. Kind, C. Shaw, Colin Smith, 2018, Nature Communications.

Random forest modelling of neuropathological features identifies microglial activation as an accurate pathological classifier of C9orf72-related amyotrophic lateral sclerosis

Christopher R. Sibley, B. McColl, S. Chandran, 2021, bioRxiv.

Dysregulation of AMPA receptor subunit expression in sporadic ALS post‐mortem brain

Colin Smith, S. Chandran, Samantha K. Barton, 2019, The Journal of pathology.

Genotype–phenotype characterisation of long survivors with motor neuron disease in Scotland

I. Deary, S. Chandran, J. Prendergast, 2022, Journal of Neurology.

Genetics of Amyotrophic Lateral Sclerosis

H. Phatnani, D. Fagegaltier, M. Harms, 2020, Current Genetic Medicine Reports.

Targeting mitochondrial dysfunction in amyotrophic lateral sclerosis: a systematic review and meta-analysis

M. Macleod, S. Chandran, G. Hardingham, 2019, Brain communications.

NLRP3 inflammasome as a key molecular target underlying cognitive resilience in amyotrophic lateral sclerosis

Colin Smith, S. Chandran, S. Abrahams, 2021, The Journal of pathology.

Improved detection of RNA foci in C9orf72 amyotrophic lateral sclerosis post-mortem tissue using BaseScope™ shows a lack of association with cognitive dysfunction

Colin Smith, S. Chandran, S. Abrahams, 2020, Brain communications.

Executive, language and fluency dysfunction are markers of localised TDP-43 cerebral pathology in non-demented ALS

Colin Smith, S. Chandran, T. Bak, 2019, Journal of Neurology, Neurosurgery, and Psychiatry.

Neuronal clusterin expression is associated with cognitive protection in amyotrophic lateral sclerosis

S. Chandran, T. Bak, S. Abrahams, 2019, Neuropathology and applied neurobiology.

Distinct neuroinflammatory signatures exist across genetic and sporadic ALS cohorts

S. Abrahams, A. Munro, Fergal M. Waldron, 2023, bioRxiv.

Systematic, comprehensive, evidence-based approach to identify neuroprotective interventions for motor neuron disease: using systematic reviews to inform expert consensus

Ashutosh Kumar Singh, S. Chandran, J. Chataway, 2023, BMJ Open.

Motor Neuron Disease Systematic Multi-Arm Adaptive Randomised Trial (MND-SMART): a multi-arm, multi-stage, adaptive, platform, phase III randomised, double-blind, placebo-controlled trial of repurposed drugs in motor neuron disease

S. Chandran, J. Chataway, M. Parmar, 2022, BMJ Open.

A Systematic Approach to Identify Neuroprotective Interventions for Motor Neuron Disease

Ashutosh Kumar Singh, S. Chandran, J. Chataway, 2022, medRxiv.

TDP-43 as a potential biomarker for amyotrophic lateral sclerosis: a systematic review and meta-analysis

S. Pal, A. Green, M. Barria, 2018, BMC Neurology.

pTDP-43 aggregates accumulate in the gut and other non-central nervous system tissues prior to symptom onset in amyotrophic lateral sclerosis

M. Arends, Fergal M. Waldron, Olivia M. Rifai, 2022, bioRxiv.

Therapeutic Targeting of Proteostasis in Amyotrophic Lateral Sclerosis—a Systematic Review and Meta-Analysis of Preclinical Research

S. Chandran, G. Hardingham, Fergal M. Waldron, 2020, Frontiers in Neuroscience.

Transactive response DNA-binding protein-43 proteinopathy in oligodendrocytes revealed using an induced pluripotent stem cell model

S. Chandran, G. Hardingham, D. Wyllie, 2021, Brain communications.

Dysregulation in Subcellular Localization of Myelin Basic Protein mRNA Does Not Result in Altered Myelination in Amyotrophic Lateral Sclerosis

Colin Smith, S. Chandran, T. Spires-Jones, 2021, Frontiers in Neuroscience.

Spatial transcriptomics identifies spatially dysregulated expression of GRM3 and USP47 in amyotrophic lateral sclerosis

Colin Smith, S. Chandran, T. Aitman, 2020, Neuropathology and applied neurobiology.

Random forest modelling demonstrates microglial and protein misfolding features to be key phenotypic markers in C9orf72‐ALS

B. McColl, S. Chandran, S. Abrahams, 2022, The Journal of pathology.

Cerebrospinal fluid cytotoxicity in amyotrophic lateral sclerosis: a systematic review of in vitro studies

S. Chandran, S. Pal, A. Mehta, 2020, Brain communications.

Could an Impairment in Local Translation of mRNAs in Glia be Contributing to Pathogenesis in ALS?

S. Chandran, B. J. Turner, Samantha K. Barton, 2019, Front. Mol. Neurosci..

40 Years of CSF Toxicity Studies in ALS: What Have We Learnt About ALS Pathophysiology?

S. Chandran, G. Hardingham, S. Pal, 2021, Frontiers in Molecular Neuroscience.

Probing TDP-43 condensation using an in silico designed aptamer

S. Gustincich, S. Chandran, G. Ruocco, 2022, Nature Communications.

ALS and the Gut-Brain Axis: A protocol for a systematic review and meta-analysis assessing the relationship between amyotrophic lateral sclerosis, the gut and its microbiome.

Fergal M. Waldron, Jenna M. Gregory, Alexander T Jackson, 2023 .

RNA aptamer reveals nuclear TDP-43 pathology is an early aggregation event that coincides with STMN-2 cryptic splicing and precedes clinical manifestation in ALS

M. Horrocks, G. Tartaglia, E. Zacco, 2023, bioRxiv.

An epidemiological profile of dysarthria incidence and assistive technology use in the living population of people with MND in Scotland

S. Chandran, S. Colville, S. Pal, 2019, Amyotrophic lateral sclerosis & frontotemporal degeneration.