Joseph L. Goldstein

发表

SREBPs: transcriptional mediators of lipid homeostasis.

J. Horton, J. Goldstein, Michael S. Brown, 2002, Cold Spring Harbor symposia on quantitative biology.

Defective lipoprotein receptors and atherosclerosis. Lessons from an animal counterpart of familial hypercholesterolemia.

T. Kita, M. Brown, J. Goldstein, 1983, The New England journal of medicine.

Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi.

M. S. Brown, M. Brown, J. Goldstein, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Familial hypercholesterolemia. A genetic regulatory defect in cholesterol metabolism.

M. Brown, J. Goldstein, Michael S. Brown, 1975, The American journal of medicine.

The cholesteryl ester cycle in macrophage foam cells. Continual hydrolysis and re-esterification of cytoplasmic cholesteryl esters.

M. Brown, J. Goldstein, Michael S. Brown, 1980, The Journal of biological chemistry.

Multiple crm- mutations in familial hypercholesterolemia. Evidence for 13 alleles, including four deletions.

H. Hobbs, D. Russell, M. Brown, 1988, The Journal of clinical investigation.

Asparagine-proline sequence within membrane-spanning segment of SREBP triggers intramembrane cleavage by site-2 protease.

M. S. Brown, N. Grishin, J. Goldstein, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Synthesis of ubiquinone and cholesterol in human fibroblasts: regulation of a branched pathway.

M. Brown, J. Goldstein, Michael S. Brown, 1979, Archives of biochemistry and biophysics.

Receptor-mediated uptake of low density lipoprotein and utilization of its cholesterol for steroid synthesis in cultured mouse adrenal cells.

M. Brown, J. Goldstein, Michael S. Brown, 1977, The Journal of biological chemistry.

Assays for inhibitors of CAAX farnesyltransferase in vitro and in intact cells.

M. Brown, J. Goldstein, Michael S. Brown, 1995, Methods in enzymology.

Mouse macrophages synthesize and secrete a protein resembling apolipoprotein E.

R. Havel, M. Brown, J. Goldstein, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Familial hypercholesterolemia: identification of a defect in the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity associated with overproduction of cholesterol.

M. Brown, J. Goldstein, Michael S. Brown, 1973, Proceedings of the National Academy of Sciences of the United States of America.

Regulation of low density lipoprotein receptors by adrenocorticotropin in the adrenal gland of mice and rats in vivo.

M. Brown, P. Kovanen, J. Goldstein, 1980, The Journal of biological chemistry.

REP-2, a Rab escort protein encoded by the choroideremia-like gene.

S. Armstrong, F. Cremers, J. Goldstein, 1994, The Journal of biological chemistry.

Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptor.

M. S. Brown, M. Brown, J. Goldstein, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Proteolytic processing of the 600 kd low density lipoprotein receptor‐related protein (LRP) occurs in a trans‐Golgi compartment.

M. S. Brown, M. Brown, J. Goldstein, 1990, The EMBO journal.

Lowering plasma cholesterol by raising LDL receptors.

M. Brown, J. Goldstein, Michael S. Brown, 1981, The New England journal of medicine.

The LDL pathway in human fibroblasts: a receptor-mediated mechanism for the regulation of cholesterol metabolism.

M. Brown, J. Goldstein, Michael S. Brown, 1976, Current topics in cellular regulation.

Surviving starvation: essential role of the ghrelin-growth hormone axis.

Michael S. Brown, G. Liang, R. Li, 2011, Cold Spring Harbor symposia on quantitative biology.

Sterol regulatory element binding proteins (SREBPs): controllers of lipid synthesis and cellular uptake.

M. Brown, J. Goldstein, Michael S. Brown, 2009, Nutrition reviews.

Different combinations of cysteine-rich repeats mediate binding of low density lipoprotein receptor to two different proteins.

D. Russell, M. Brown, J. Goldstein, 1989, The Journal of biological chemistry.

Evidence for a dominant gene that suppresses hypercholesterolemia in a family with defective low density lipoprotein receptors.

H. Hobbs, M. Brown, J. Goldstein, 1989, The Journal of clinical investigation.

Binding and internalization of 125I-LDL in normal and mutant human fibroblasts. A quantitative autoradiographic study.

L. Orci, M. Brown, J. Carpentier, 1979, Experimental cell research.

Sequence requirement for peptide recognition by rat brain p21ras protein farnesyltransferase.

L. Gierasch, Y. Reiss, M. Brown, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Benzodiazepine peptidomimetic BZA-5B interrupts the MAP kinase activation pathway in H-Ras-transformed Rat-1 cells, but not in untransformed cells.

M. Cobb, M. Brown, J. Goldstein, 1994, The Journal of biological chemistry.

Visualization of acidic organelles in intact cells by electron microscopy.

M. Brown, J. Falck, J. Goldstein, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Partial deletion of membrane-bound domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase eliminates sterol-enhanced degradation and prevents formation of crystalloid endoplasmic reticulum

M. Brown, J. Goldstein, Michael S. Brown, 1987, The Journal of cell biology.

Rab geranylgeranyl transferase. A multisubunit enzyme that prenylates GTP-binding proteins terminating in Cys-X-Cys or Cys-Cys.

T. Südhof, M. Brown, J. Goldstein, 1992, The Journal of biological chemistry.

Surface distribution and recycling of the low density lipoprotein receptor as visualized with antireceptor antibodies

Richard G. W. Anderson, M. Brown, J. Goldstein, 1982, The Journal of cell biology.

Regulation of cholesterol synthesis by low density lipoprotein in isolated human lymphocytes

D. Bilheimer, Michael S. Brown, Y. Ho, 1977, The Journal of experimental medicine.

Multiple genes encode nuclear factor 1-like proteins that bind to the promoter for 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

J. R. Smith, C. Slaughter, T. Osborne, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Multiple mRNAs for 3-hydroxy-3-methylglutaryl coenzyme A reductase determined by multiple transcription initiation sites and intron splicing sites in the 5'-untranslated region.

M. Brown, J. Goldstein, Michael S. Brown, 1985, The Journal of biological chemistry.

Overexpression of human low density lipoprotein receptors leads to accelerated catabolism of Lp(a) lipoprotein in transgenic mice.

R. Hammer, M. Brown, J. Goldstein, 1990, The Journal of clinical investigation.

Occurrence of low density lipoprotein receptors within large pits on the surface of human fibroblasts as demonstrated by freeze-etching.

L Orci, L. Orci, M. Brown, 1978, Experimental cell research.

Regulation of low density lipoprotein receptor activity in freshly isolated human lymphocytes.

D. Bilheimer, Michael S. Brown, Y. Ho, 1976, The Journal of clinical investigation.

ENDOCYTOSIS: Concepts Emerging from the LDL Receptor System

Michael S. Brown, Joseph L. Goldstein, David W. Russell, 1985 .

Regulation of cholesterol synthesis in normal and malignant tissue.

M. Brown, J. Goldstein, M. Siperstein, 1973, Federation proceedings.

Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells.

M. Brown, J. Goldstein, Michael S. Brown, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Tetrapeptide inhibitors of protein farnesyltransferase: amino-terminal substitution in phenylalanine-containing tetrapeptides restores farnesylation.

Michael S. Brown, Joseph L. Goldstein, John Burnier, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Nonfarnesylated tetrapeptide inhibitors of protein farnesyltransferase.

L. Gierasch, Y. Reiss, M. Brown, 1991, The Journal of biological chemistry.

Targeted killing of cultured cells by receptor-dependent photosensitization.

M. Brown, J. Falck, J. Goldstein, 1981, Proceedings of the National Academy of Sciences of the United States of America.

Sterols accelerate degradation of hamster 3-hydroxy-3-methylglutaryl coenzyme A reductase encoded by a constitutively expressed cDNA.

M. Brown, J. Goldstein, Michael S. Brown, 1985, Molecular and cellular biology.

Overexpression of low density lipoprotein (LDL) receptor eliminates LDL from plasma in transgenic mice.

R. Hammer, D. Russell, M. Brown, 1988, Science.

Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in livers of mice treated with mevinolin, a competitive inhibitor of the reductase.

M. Brown, J. Goldstein, Michael S. Brown, 1980, The Journal of clinical investigation.

Inhibition of cholesterol synthesis with compactin renders growth of cultured cells dependent on the low density lipoprotein receptor.

M. Brown, J. Goldstein, Michael S. Brown, 1979, The Journal of biological chemistry.

Blunted feedback suppression of SREBP processing by dietary cholesterol in transgenic mice expressing sterol-resistant SCAP(D443N).

R. Hammer, I. Shimomura, M. Brown, 1998, The Journal of clinical investigation.

Sterols regulate processing of carbohydrate chains of wild-type SREBP cleavage-activating protein (SCAP), but not sterol-resistant mutants Y298C or D443N.

M. Brown, J. Goldstein, Michael S. Brown, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Receptor-mediated uptake of lipoprotein-cholesterol and its utilization for steroid synthesis in the adrenal cortex.

M. Brown, P. Kovanen, J. Goldstein, 1979, Recent progress in hormone research.

Diet-induced hypercholesterolemia in mice: prevention by overexpression of LDL receptors.

R. Hammer, M. Brown, J. Goldstein, 1990, Science.

Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance.

M. Brown, K. Orth, T. Willnow, 1992, The Journal of biological chemistry.

The Cholesterol Quartet

Joseph L. Goldstein, J. Goldstein, Michael S. Brown, 2001, Science.

cDNA cloning of MEV, a mutant protein that facilitates cellular uptake of mevalonate, and identification of the point mutation responsible for its gain of function.

M. Brown, J. Goldstein, Michael S. Brown, 1992, The Journal of biological chemistry.

Imaging of hepatic low density lipoprotein receptors by radionuclide scintiscanning in vivo.

J. Corbett, M. Brown, J. Goldstein, 1984, Proceedings of the National Academy of Sciences of the United States of America.

cDNA cloning and expression of the alpha and beta subunits of rat Rab geranylgeranyl transferase.

S. Armstrong, T. Südhof, M. Brown, 1993, The Journal of biological chemistry.

Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver.

Michael S. Brown, G. Liang, J. Ou, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Nonidentical subunits of p21H-ras farnesyltransferase. Peptide binding and farnesyl pyrophosphate carrier functions.

S. Armstrong, C. Slaughter, Y. Reiss, 1991, The Journal of biological chemistry.