B. Büttelmann

发表

CTEP: A Novel, Potent, Long-Acting, and Orally Bioavailable Metabotropic Glutamate Receptor 5 Inhibitor

W. Spooren, T. Hartung, Aubin Michalon, 2011, Journal of Pharmacology and Experimental Therapeutics.

1-Benzyloxy-4,5-dihydro-1H-imidazol-2-yl-amines, a novel class of NR1/2B subtype selective NMDA receptor antagonists.

E. Pinard, V. Mutel, G. Trube, 2003, Bioorganic & medicinal chemistry letters.

4-(3,4-dihydro-1H-isoquinolin-2yl)-pyridines and 4-(3,4-dihydro-1H-isoquinolin-2-yl)-quinolines as potent NR1/2B subtype selective NMDA receptor antagonists.

E. Pinard, V. Mutel, G. Trube, 2003, Bioorganic & medicinal chemistry letters.

2-(3,4-Dihydro-1H-isoquinolin-2yl)-pyridines as a novel class of NR1/2B subtype selective NMDA receptor antagonists.

E. Pinard, V. Mutel, G. Trube, 2003, Bioorganic & medicinal chemistry letters.

4-Aminoquinolines as a novel class of NR1/2B subtype selective NMDA receptor antagonists.

E. Pinard, G. Trube, A. Bourson, 2002, Bioorganic & medicinal chemistry letters.

Discovery of (R)-1-[2-hydroxy-3-(4-hydroxy-phenyl)-propyl]-4-(4-methyl-benzyl)-piperidin-4-ol: a novel NR1/2B subtype selective NMDA receptor antagonist.

E. Pinard, V. Mutel, G. Trube, 2001, Bioorganic & medicinal chemistry letters.

Fenobam: A Clinically Validated Nonbenzodiazepine Anxiolytic Is a Potent, Selective, and Noncompetitive mGlu5 Receptor Antagonist with Inverse Agonist Activity

Jens-Uwe Peters, Richard H. P. Porter, W. Spooren, 2005, Journal of Pharmacology and Experimental Therapeutics.

Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases.

W. Guba, W. Spooren, J. Peters, 2015, Journal of medicinal chemistry.

Synthesis and biological evaluation of fenobam analogs as mGlu5 receptor antagonists.

W. Guba, B. Kuhn, W. Spooren, 2007, Bioorganic & medicinal chemistry letters.

Discovery of the imidazo[1,5-a][1,2,4]-triazolo[1,5-d][1,4]benzodiazepine scaffold as a novel, potent and selective GABA(A) alpha5 inverse agonist series.

F. Blasco, F. Knoflach, G. Trube, 2009, Bioorganic & Medicinal Chemistry Letters.

Arylmethoxypyridines as novel, potent and orally active mGlu5 receptor antagonists.

W. Spooren, J. Peters, S. Ceccarelli, 2006, Bioorganic & medicinal chemistry letters.

Pharmacological Characterization of Ro 63-1908 (1-[2-(4-Hydroxy-phenoxy)-ethyl]-4-(4-methyl-benzyl)-piperidin-4-ol), a Novel Subtype-SelectiveN-Methyl-d-Aspartate Antagonist

J. Kemp, J. Kew, E. Pinard, 2002, Journal of Pharmacology and Experimental Therapeutics.