Jeffery W. Kelly

发表

D18G transthyretin is monomeric, aggregation prone, and not detectable in plasma and cerebrospinal fluid: a prescription for central nervous system amyloidosis?

Joleen T White, H. Budka, J. Kelly, 2003, Biochemistry.

Rational design of potent human transthyretin amyloid disease inhibitors

James C. Sacchettini, H. M. Petrassi, T. Klabunde, 2000, Nature Structural Biology.

Quantification of Transthyretin Kinetic Stability in Human Plasma Using Subunit Exchange

M. Maurer, J. Kelly, E. Powers, 2014, Biochemistry.

The acid-mediated denaturation pathway of transthyretin yields a conformational intermediate that can self-assemble into amyloid.

J. Kelly, W. Colón, Z. Lai, 1996, Biochemistry.

Transthyretin mutation Leu-55-Pro significantly alters tetramer stability and increases amyloidogenicity.

J. Kelly, W. Colón, S. L. McCutchen, 1993, Biochemistry.

The most pathogenic transthyretin variant, L55P, forms amyloid fibrils under acidic conditions and protofilaments under physiological conditions.

C. Wurth, J. Kelly, H. Lashuel, 1999, Biochemistry.

Characterization of the transthyretin acid denaturation pathways by analytical ultracentrifugation: implications for wild-type, V30M, and L55P amyloid fibril formation.

J. Kelly, H. Lashuel, Z. Lai, 1998, Biochemistry.

The alternative conformations of amyloidogenic proteins and their multi-step assembly pathways.

J. Kelly, Jeffery W. Kelly, Jeffery W. Kelly, 1998, Current opinion in structural biology.

Comparison of lethal and nonlethal transthyretin variants and their relationship to amyloid disease.

J. Kelly, W. Colón, Z. Lai, 1995, Biochemistry.

An engineered transthyretin monomer that is nonamyloidogenic, unless it is partially denatured.

H. M. Petrassi, J. Sacchettini, J. Kelly, 2001, Biochemistry.

Discovering transthyretin amyloid fibril inhibitors by limited screening.

Scott A. Peterson, J. Kelly, P. Baures, 1998, Bioorganic & medicinal chemistry.

Protein subunit interactions and structural integrity of amyloidogenic transthyretins: evidence from electrospray mass spectrometry.

C. Dobson, C. Robinson, J. Kelly, 1998, Journal of molecular biology.

Localized structural fluctuations promote amyloidogenic conformations in transthyretin.

H. Dyson, P. Wright, J. Kelly, 2013, Journal of molecular biology.