Hans-Dieter Gerber

发表

Facile synthesis of substituted 2,3,4,7-tetrahydro-1H-azepines via ring-closing metathesis

S. Brass, H. Gerber, W. Diederich, 2006 .

Surprising Non-Additivity of Methyl-Groups in Drug-Kinase Interaction.

G. Klebe, A. Heine, H. Gohlke, 2019, ACS chemical biology.

Paradoxically, Most Flexible Ligand Binds Most Entropy-Favored: Intriguing Impact of Ligand Flexibility and Solvation on Drug-Kinase Binding.

G. Klebe, K. Saxena, H. Schwalbe, 2018, Journal of medicinal chemistry.

Structural insights into the stimulation of S. pombe Dnmt2 catalytic efficiency by the tRNA nucleoside queuosine

H. Urlaub, P. Neumann, R. Ficner, 2018, Scientific Reports.

Virtual screening for submicromolar leads of tRNA-guanine transglycosylase based on a new unexpected binding mode detected by crystal structure analysis.

Gerhard Klebe, Klaus Reuter, Hans-Dieter Gerber, 2003, Journal of medicinal chemistry.

A new target for shigellosis: rational design and crystallographic studies of inhibitors of tRNA-guanine transglycosylase.

G Klebe, G. Klebe, K. Reuter, 2000, Journal of molecular biology.

Concise and efficient syntheses of preQ1 base, Q base, and (ent)-Q base.

G. Klebe, H. Gerber, Hans-Dieter Gerber, 2012, Organic & biomolecular chemistry.

Frag4Lead: growing crystallographic fragment hits by catalog using fragment-guided template docking

G. Klebe, A. Heine, M. Weiss, 2021, Acta crystallographica. Section D, Structural biology.

Kinetic and Structural Insights into the Mechanism of Binding of Sulfonamides to Human Carbonic Anhydrase by Computational and Experimental Studies.

G. Klebe, A. Cavalli, G. Bottegoni, 2016, Journal of medicinal chemistry.

Structural and Biochemical Investigation of the Heterodimeric Murine tRNA-Guanine Transglycosylase.

G. Klebe, A. Heine, S. Cianférani, 2022, ACS chemical biology.

Investigation of Specificity Determinants in Bacterial tRNA-Guanine Transglycosylase Reveals Queuine, the Substrate of Its Eucaryotic Counterpart, as Inhibitor

G. Klebe, A. Heine, K. Reuter, 2013, PloS one.

Fragment‐Based Lead Discovery: Screening and Optimizing Fragments for Thermolysin Inhibition

Gerhard Klebe, Katrin Silber, Hans-Dieter Gerber, 2010, ChemMedChem.

From Hit to Lead: De Novo Design Based on Virtual Screening Hits of Inhibitors of tRNA‐Guanine Transglycosylase, a Putative Target of Shigellosis Therapy

Gerhard Klebe, Klaus Reuter, Ruth Brenk, 2003 .