D. Wolf

S. Ketover, E. Seidman, M. Crowell, 2014, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

What do we need to know prior to thinking about incorporating an epigenetic evaluation into safety assessments?

Y. Dragan, S. Pettit, D. Dixon, 2010, Toxicological sciences : an official journal of the Society of Toxicology.

Mutations in the VHL gene from potassium bromate-induced rat clear cell renal tumors.

L. Anderson, D. Wolf, M. Hooth, 2002, Cancer letters.

Predicting Outcomes and Tailoring Therapy in the Diagnosis and Treatment of IBD.

E. Seidman, D. Wolf, E. Scherl, 2007, Gastroenterology & hepatology.

Repifermin (keratinocyte growth factor‐2) for the treatment of active ulcerative colitis: a randomized, double‐blind, placebo‐controlled, dose‐escalation trial

B. Sands, D. Wolf, W. Sandborn, 2003, Alimentary pharmacology & therapeutics.

Paraquat pharmacokinetics in primates and extrapolation to humans.

Jerry L. Campbell, H. Clewell, D. Wolf, 2021, Toxicology and applied pharmacology.

Integration of paraquat pharmacokinetic data across species using PBPK modelling.

Jerry L. Campbell, M. Andersen, H. Clewell, 2021, Toxicology and applied pharmacology.

Adalimumab induces and maintains clinical remission in patients with moderate-to-severe ulcerative colitis.

G. D'Haens, G. Van Assche, D. Wolf, 2012, Gastroenterology.

Mode of action and human relevance analysis for nuclear receptor-mediated liver toxicity: A case study with phenobarbital as a model constitutive androstane receptor (CAR) activator

Wen Xie, Rita Schoeny, Douglas C Wolf, 2014, Critical reviews in toxicology.

Identification and characterization of adverse effects in 21st century toxicology.

Nancy G Doerrer, William H Farland, Daland R Juberg, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

Quantitative Relationship Between Transforming Growth Factor-Alpha and Hepatic Focal Phenotype and Progression in Female Mouse Liver

T. Goldsworthy, D. Wolf, G. Moser, 1997, Toxicologic pathology.

Loss of tumor-promoting activity of unleaded gasoline in N-nitrosodiethylamine-initiated ovariectomized B6C3F1 mouse liver.

T. Goldsworthy, D. Wolf, B. Wong, 1997, Carcinogenesis.

Crohn’s Colitis Presenting With Node-Negative Colon Cancer and Liver Metastasis After Therapy With Infliximab: Report of Two Cases

D. Wolf, G. Orangio, E. Pennington, 2005, Diseases of the colon and rectum.

Case Reports: Crohn’s Colitis Presenting With Node-Negative Colon Cancer and Liver Metastasis After Therapy With Infliximab: Report of Two Cases

D. Wolf, G. Orangio, E. Pennington, 2005 .

Human anti-tumor necrosis factor monoclonal antibody (adalimumab) in Crohn's disease: the CLASSIC-I trial.

P. Rutgeerts, S. Hanauer, D. Wolf, 2006, Gastroenterology.

Analysis of preneoplastic and neoplastic renal lesions in Tsc2 mutant Long-Evans (Eker) rats following exposure to a mixture of drinking water disinfection by-products.

T. Starr, D. Wolf, M. Hooth, 2003, Toxicology.

Induction of Transitional Cell Hyperplasia in the Urinary Bladder and Aberrant Crypt Foci in the Colon of Rats Treated with Individual and a Mixture of Drinking Water Disinfection By-Products

S. Hester, D. Wolf, M. Hooth, 2003, Toxicologic pathology.

The carcinogenic response of Tsc2 mutant Long-Evans (Eker) rats to a mixture of drinking water disinfection by-products was less than additive.

S. Hester, D. Wolf, A. Swank, 2002, Toxicological sciences : an official journal of the Society of Toxicology.

Tacrolimus for the treatment of fistulas in patients with Crohn's disease: a randomized, placebo-controlled trial.

Christopher F. Martin, R. Sandler, S. Hanauer, 2003, Gastroenterology.

Is the 90-day dog study necessary for pesticide toxicity testing?

Patricia L Bishop, V. Dellarco, D. Wolf, 2023, Critical reviews in toxicology.

Comparison of scheduled and episodic treatment strategies of infliximab in Crohn's disease.

P. Rutgeerts, S. Hanauer, D. Wolf, 2004, Gastroenterology.

A new approach to the classification of carcinogenicity

Samuel M. Cohen, A. Boobis, P. Fenner-Crisp, 2022, Archives of Toxicology.

A Tiered Approach to Systemic Toxicity Testing for Agricultural Chemical Safety Assessment

Angelo Moretto, Nancy G Doerrer, Roland Solecki, 2006, Critical reviews in toxicology.

Exposure Concentrations of Infants Breastfed by Women Receiving Biologic Therapies for Inflammatory Bowel Diseases and Effects of Breastfeeding on Infections and Development.

Christopher F. Martin, Samir A. Shah, D. Wolf, 2018, Gastroenterology.

Disruption of testosterone homeostasis as a mode of action for the reproductive toxicity of triazole fungicides in the male rat.

David J Dix, Douglas C Wolf, D. Dix, 2007, Toxicological sciences : an official journal of the Society of Toxicology.

Finfish and aquatic invertebrate pathology resources for now and the future.

D. Wolf, K. Cheng, J. Law, 2009, Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.

Concomitant human immunodeficiency virus protease inhibitor therapy markedly reduces tacrolimus metabolism and increases blood levels.

D. Wolf, H. Horowitz, E. Lebovics, 1999, Transplantation.

Pregnancy Outcomes in Subjects Exposed to Certolizumab Pegol

D. Wolf, M. Clowse, J. Cush, 2015, The Journal of Rheumatology.

Gene Profiling in the Livers of Wild-type and PPARα-Null Mice Exposed to Perfluorooctanoic Acid

J. Corton, M. Rosen, C. Lau, 2008, Toxicologic pathology.

Toxicity Profiles in Mice Treated with Hepatotumorigenic and Non-Hepatotumorigenic Triazole Conazole Fungicides: Propiconazole, Triadimefon, and Myclobutanil

Tanya Moore, Sheau-Fung Thai, Douglas C Wolf, 2006, Toxicologic pathology.

Toxicity Profiles in Rats Treated with Tumorigenic and Nontumorigenic Triazole Conazole Fungicides: Propiconazole, Triadimefon, and Myclobutanil

Tanya Moore, Sheau-Fung Thai, Douglas C Wolf, 2006, Toxicologic pathology.

Clinical Outcomes Associated with Switching or Discontinuation from Anti-TNF Inhibitors for Nonmedical Reasons.

M. Lebwohl, M. Skup, D. Wolf, 2017, Clinical therapeutics.

Fluconazole-induced hepatic cytochrome P450 gene expression and enzymatic activities in rats and mice.

S. Nesnow, D. Dix, D. Wolf, 2006, Toxicology letters.

Propiconazole-induced cytochrome P450 gene expression and enzymatic activities in rat and mouse liver.

S. Nesnow, D. Dix, D. Wolf, 2005, Toxicology letters.

Atrazine-induced reproductive tract alterations after transplacental and/or lactational exposure in male Long-Evans rats.

Douglas C Wolf, D. Wolf, S. Fenton, 2007, Toxicology and applied pharmacology.

Peritoneovenous shunting as compared with medical treatment in patients with alcoholic cirrhosis and massive ascites. Veterans Administration Cooperative Study on Treatment of Alcoholic Cirrhosis with Ascites.

E. Schiff, T. Gadacz, H. Greenlee, 1989, The New England journal of medicine.

Four-Year Maintenance Treatment With Adalimumab in Patients with Moderately to Severely Active Ulcerative Colitis: Data from ULTRA 1, 2, and 3

M. Skup, D. Wolf, W. Sandborn, 2014, The American Journal of Gastroenterology.

Transcriptional Profiles in Liver from Mice Treated with Hepatotumorigenic and Nonhepatotumorigenic Triazole Conazole Fungicides: Propiconazole, Triadimefon, and Myclobutanil

Susan D. Hester, Douglas C. Wolf, Sheau-Fung Thai, 2006, Toxicologic pathology.

Transcriptional Profiles in Liver from Rats Treated with Tumorigenic and Non-tumorigenic Triazole Conazole Fungicides: Propiconazole, Triadimefon, and Myclobutanil

S. Nesnow, S. Hester, D. Wolf, 2006, Toxicologic pathology.

Etrasimod as induction and maintenance therapy for ulcerative colitis (ELEVATE): two randomised, double-blind, placebo-controlled, phase 3 studies

S. Vermeire, B. Sands, G. D'Haens, 2023, The Lancet.

Ozanimod as a novel oral small molecule therapy for the treatment of Crohn's disease: The YELLOWSTONE clinical trial program

D. Wolf, B. Feagan, F. Rieder, 2022, Contemporary clinical trials.

Certolizumab pegol in patients with moderate to severe Crohn's disease and secondary failure to infliximab.

P. Rutgeerts, S. Vermeire, M. Spehlmann, 2010, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

Choline may be an essential nutrient in malnourished patients with cirrhosis.

M. Kutner, H. Bonkovsky, D. Wolf, 1989, Gastroenterology.

The transcriptional profile of the kidney in Tsc2 heterozygous mutant Long Evans (Eker) rats compared to wild-type.

S. Hester, D. Wolf, Banalata Sen, 2004, Mutation research.

Use of the Spontaneous Tsc2 Knockout (Eker) Rat Model of Hereditary Renal Cell Carcinoma for the Study of Renal Carcinogens

D. Wolf, K. McDorman, K. Mcdorman, 2002, Toxicologic pathology.

Effects of prenatal exposure to a low dose atrazine metabolite mixture on pubertal timing and prostate development of male Long-Evans rats.

Douglas C Wolf, D. Wolf, S. Fenton, 2010, Reproductive toxicology.

Rodent model of reproductive tract leiomyomata. Establishment and characterization of tumor-derived cell lines.

T. Goldsworthy, C. Walker, D. Wolf, 1995, The American journal of pathology.

Cell proliferation and regulation of negative growth factors in mouse liver foci.

R. Jirtle, T. Goldsworthy, D. Wolf, 1996, Carcinogenesis.

Hereditary renal cell carcinoma in the Eker rat: a rodent familial cancer syndrome.

T. Goldsworthy, C. Walker, D. Wolf, 1992, The Journal of urology.

Toxicogenomics and the Regulatory Framework

D. Dix, K. Gallagher, F. Goodsaid, 2011 .

Gene expression profiling in the liver of CD-1 mice to characterize the hepatotoxicity of triazole fungicides.

S. Nesnow, D. Dix, Hongzu Ren, 2006, Toxicology and applied pharmacology.

Absence of p53 gene mutations in rat colon carcinomas induced by azoxymethane.

S. Belinsky, D. Wolf, N. Shivapurkar, 1995, Cancer letters.

Gene expression profiling in liver and testis of rats to characterize the toxicity of triazole fungicides.

D. Dix, Hongzu Ren, C. Wood, 2006, Toxicology and applied pharmacology.

Placental transfer of anti-tumor necrosis factor agents in pregnant patients with inflammatory bowel disease.

M. Dubinsky, D. Rubin, D. Wolf, 2013, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

Predisposition to renal cell carcinoma due to alteration of a cancer susceptibility gene.

T. Goldsworthy, C. Walker, D. Wolf, 1992, Science.

An evaluation framework for new approach methodologies (NAMs) for human health safety assessment.

Alan Boobis, Marco Corvaro, Suzanne Fitzpatrick, 2020, Regulatory toxicology and pharmacology : RTP.

Preneoplastic and Neoplastic Lesions of Rat Hereditary Renal Cell Tumors Express Markers of Proximal and Distal Nephron

D. Wolf, J. Everitt, H. Whiteley, 1995, Veterinary pathology.

Best Practices for Use of Historical Control Data of Proliferative Rodent Lesions

Douglas C. Wolf, S. Elmore, S. Peddada, 2009, Toxicologic pathology.

Potential for a Global Historical Control Database for Proliferative Rodent Lesions

S. Elmore, S. Peddada, C. Keenan, 2009, Toxicologic pathology.

Acute hepatotoxic and nephrotoxic effects of chloroform in male F-344 rats and female B6C3F1 mice

D. Wolf, J. Larson, B. Butterworth, 1993 .

What do we need to know prior to thinking about incorporating an epigenetic evaluation into safety assessments?

Y. Dragan, S. Pettit, D. Dixon, 2010, Toxicological sciences : an official journal of the Society of Toxicology.

Reproductive and Developmental Toxicity of Arsenic in Rodents: A Review

D. Wolf, S. Ahmed, J. Robertson, 2006, International journal of toxicology.

Transcriptional Modulation of the ERK1/2 MAPK and NF-κB Pathways in Human Urothelial Cells After Trivalent Arsenical Exposure: Implications for Urinary Bladder Cancer.

Stephen W. Edwards, R. Fry, D. Wolf, 2012, Journal of cancer research updates.

Comparative Hepatic Effects of Perfluorooctanoic Acid and WY 14,643 in PPAR-α Knockout and Wild-type Mice

M. Rosen, C. Lau, D. Wolf, 2008, Toxicologic pathology.

Long-Term Efficacy and Safety of Ozanimod in Moderately to Severely Active Ulcerative Colitis: Results From the Open-Label Extension of the Randomized, Phase 2 TOUCHSTONE Study

S. Vermeire, S. Hanauer, G. D'Haens, 2021, Journal of Crohn's & colitis.

Metamorphic inhibition of Xenopus laevis by sodium perchlorate: Effects on development and thyroid histology

P. Kosian, S. Degitz, J. Korte, 2005, Environmental toxicology and chemistry.

Highlights of Prescribing Information

D. Wolf, J. Mordenti, W. Tremaine, 2022 .

Altered expression of transforming growth factor‐α: An early event in renal cell carcinoma development

C. Walker, D. Wolf, J. Everitt, 1997, Molecular carcinogenesis.

Methyltert-Butyl Ether Causes α2u-Globulin Nephropathy and Enhanced Renal Cell Proliferation in Male Fischer-344 Rats

D. Wolf, S. Borghoff, B. Wong, 1997 .

Hereditary renal cell carcinoma in the Eker rat: a unique animal model for the study of cancer susceptibility.

T. Goldsworthy, C. Walker, D. Wolf, 1995, Toxicology Letters.

Methyl tert-butyl ether causes alpha2u-globulin nephropathy and enhanced renal cell proliferation in male Fischer-344 rats.

D. Wolf, S. Borghoff, B. Wong, 1997, Toxicology and applied pharmacology.

Oxidative DNA damage from potassium bromate exposure in Long-Evans rats is not enhanced by a mixture of drinking water disinfection by-products.

B. Pachkowski, J. Swenberg, D. Wolf, 2005, Chemico-biological interactions.

Estrogen treatment enhances hereditary renal tumor development in Eker rats.

T. Goldsworthy, E. Donner, D. Wolf, 1998, Carcinogenesis.

Induced Cytotoxicity and Cell Proliferation in the Hepatocarcinogenicity of Chloroform in Female B6C3F1 Mice: Comparison of Administration by Gavage in Corn Oil vs ad Libitum in Drinking Water

Douglas C. Wolf, D. Wolf, B. Butterworth, 1994 .

Dimethylarsinic Acid in Drinking Water Changed the Morphology of Urinary Bladder but Not the Expression of DNA Repair Genes of Bladder Transitional Epithelium in F344 Rats

J. Robertson, S. Holladay, W. Huckle, 2009, Toxicologic pathology.

The Effect of Chronic Progressive Nephropathy on the Incidence of Renal Tubule Cell Neoplasms in Control Male F344 Rats

J. Haseman, D. Wolf, J. Everitt, 2002, Toxicologic pathology.

Sustained Clinical Remission With Vedolizumab in Patients With Moderate-to-Severe Ulcerative Colitis

D. Wolf, B. Feagan, R. Ehehalt, 2018, Inflammatory bowel diseases.

Lack of effect of intravenous administration on time to respond to azathioprine for steroid-treated Crohn's disease. North American Azathioprine Study Group.

S. Targan, S. Hanauer, D. Wolf, 1999, Gastroenterology.

One‐year maintenance outcomes among patients with moderately‐to‐severely active ulcerative colitis who responded to induction therapy with adalimumab: subgroup analyses from ULTRA 2

G. D'Haens, G. Van Assche, D. Wolf, 2013, Alimentary pharmacology & therapeutics.

ALIMENTARY TRACT Lack of Effect of Intravenous Administration on Time to Respond to Azathioprine for Steroid-Treated Crohn’s Disease

S. Targan, S. Hanauer, D. Wolf, 1999 .

Adherence rates and health care costs in Crohn’s disease patients receiving certolizumab pegol with and without home health nurse assistance: results from a retrospective analysis of patient claims and home health nurse data

D. Schwartz, D. Wolf, R. Low, 2018, Patient preference and adherence.

Escalation to weekly dosing recaptures response in adalimumab‐treated patients with moderately to severely active ulcerative colitis

G. D'Haens, G. Van Assche, D. Wolf, 2014, Alimentary Pharmacology and Therapeutics.

Reduced Steroid Usage in Ulcerative Colitis Patients With Week 8 Response to Adalimumab: Subanalysis of ULTRA 2: P‐21

G. D'Haens, G. Van Assche, W. Sandborn, 2012 .

Scheduled maintenance treatment with infliximab is superior to episodic treatment for the healing of mucosal ulceration associated with Crohn's disease

M. Bala, S. Hanauer, P. Rutgeerts, 2006 .

Quality Indicators for Inflammatory Bowel Disease: Development of Process and Outcome Measures

T. Dassopoulos, B. Spiegel, D. Rubin, 2013, Inflammatory bowel diseases.

A randomised, double-blind, sham-controlled study of granulocyte/monocyte apheresis for moderate to severe Crohn's disease

S. Hanauer, B. Sands, M. Vandervoort, 2012, Gut.

Pilot Feasibility Studies of Leukocytapheresis With the Adacolumn Apheresis System in Patients With Active Ulcerative Colitis or Crohn Disease

D. Schwartz, S. Hanauer, B. Sands, 2006, Journal of clinical gastroenterology.

Gene expression profiling of responses to dimethylarsinic acid in female F344 rat urothelium.

Douglas C Wolf, S. Hester, D. Wolf, 2005, Toxicology.

Conazole Fungicides : Propiconazole , Triadimefon , and Myclobutanil Transcriptional Profiles in Liver from Rats Treated with Tumorigenic and Non-tumorigenic Triazole

S. Nesnow, S. Hester, D. Wolf, 2006 .

Rethinking chronic toxicity and carcinogenicity assessment for agrochemicals project (ReCAAP): A reporting framework to support a weight of evidence safety assessment without long-term rodent bioassays.

W. Casey, D. Wolf, A. Hayes, 2022, Regulatory toxicology and pharmacology : RTP.

Chemical carcinogenicity revisited 3: Risk assessment of carcinogenic potential based on the current state of knowledge of carcinogenesis in humans.

Alan R. Boobis, Angelo Moretto, Rita S. Schoeny, 2019, Regulatory toxicology and pharmacology : RTP.

Chemical carcinogenicity revisited 2: Current knowledge of carcinogenesis shows that categorization as a carcinogen or non-carcinogen is not scientifically credible.

A. Boobis, P. Fenner-Crisp, D. Wolf, 2019, Regulatory toxicology and pharmacology : RTP.

A simple problem formulation framework to create the right solution to the right problem.

Alan Raybould, Justin McDonald, Alaina Sauve-Ciencewicki, 2019, Regulatory toxicology and pharmacology : RTP.

Classification schemes for carcinogenicity based on hazard-identification have become outmoded and serve neither science nor society.

Angelo Moretto, Vicki L Dellarco, Alan R Boobis, 2016, Regulatory toxicology and pharmacology : RTP.

Transcriptional profile of diuron-induced toxicity on the urinary bladder of male Wistar rats to inform mode of action.

S. Hester, J. D. de Camargo, Carlton P. Jones, 2011, Toxicological Sciences.

Two-year inhalation exposure of female and male B6C3F1 mice and F344 rats to chlorine gas induces lesions confined to the nose.

C. Barrow, D. Wolf, J. Popp, 1995, Fundamental and applied toxicology : official journal of the Society of Toxicology.

Dose and temporal effects on gene expression profiles of urothelial cells from rats exposed to diuron.

Hongzu Ren, R. Fry, D. Wolf, 2014, Toxicology.

Identification of interspecies concordance of mechanisms of arsenic-induced bladder cancer.

Andrej Bugrim, Douglas C Wolf, S. Hester, 2007, Toxicology in vitro : an international journal published in association with BIBRA.

Workshop overview: arsenic research and risk assessment.

D. Wolf, A. Lowit, E. Ohanian, 2007, Toxicology and applied pharmacology.

A predictive data-driven framework for endocrine prioritization: a triazole fungicide case study

D. Wolf, A. Goetz, M. S. Marty, 2016, Critical reviews in toxicology.

W1325 Persistency Equals Efficacy in Adalimumab Patients: Preliminary Report of a Large Single Site Experience

C. Wolf, D. Wolf, 2010 .

Therapeutic Drug Monitoring of Tumor Necrosis Factor Antagonists in Crohn Disease: A Theoretical Construct to Apply Pharmacokinetics and Guidelines to Clinical Practice

D. Wolf, W. Sandborn, B. Feagan, 2020, Inflammatory bowel diseases.

Tissue distribution and urinary excretion of dimethylated arsenic and its metabolites in dimethylarsinic acid- or arsenate-treated rats.

D. Wolf, David J. Thomas, J. Creed, 2007, Toxicology and applied pharmacology.

Promotion by sodium barbital induces early development but does not increase the multiplicity of hereditary renal tumors in Eker rats.

T. Goldsworthy, E. Donner, D. Wolf, 2000, Carcinogenesis.

Hereditary Renal Cell Adenoma and Carcinoma, Rat

T. Goldsworthy, C. Walker, D. Wolf, 1998 .

Bioavailability of the genotoxic components in coal tar contaminated soils in Fischer 344 rats.

D. Wolf, K. Donnelly, L. King, 2000, Toxicological sciences : an official journal of the Society of Toxicology.

Eight Cases of Canine Lymphomatoid Granulomatosis

D. Wolf, W. Carlton, S. Fitzgerald, 1991, Veterinary pathology.

Capsule Retention in Crohn's Disease: A Meta-analysis.

D. Rubin, J. Leighton, G. D'Haens, 2019, Inflammatory bowel diseases.

Capsule endoscopy is superior to small-bowel follow-through and equivalent to ileocolonoscopy in suspected Crohn's disease.

S. Ketover, E. Seidman, M. Crowell, 2014, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

751e Adalimumab Induces and Maintains Mucosal Healing in Patients with Moderate to Severe Ileocolonic Crohn's Disease – First Results of the Extend Trial

P. Rutgeerts, G. D'Haens, D. Wolf, 2009 .

D. Wolf, D. Wolf, 2016, Inflammatory bowel diseases.

Four-Year Maintenance Treatment With Adalimumab in Patients with Moderately to Severely Active Ulcerative Colitis: Data from ULTRA 1, 2, and 3

M. Skup, W. Sandborn, W. Reinisch, 2014, The American Journal of Gastroenterology.

A Data-Based Assessment of Alternative Strategies for Identification of Potential Human Cancer Hazards

A. Boobis, S. Galloway, D. Wolf, 2009, Toxicologic pathology.

Tu1725 EFFECTS OF OZANIMOD ON HISTOLOGIC REMISSION AND MUCOSAL HEALING OVER 3 YEARS OF CONTINUOUS TREATMENT IN PATIENTS WITH ULCERATIVE COLITIS

R. Panaccione, S. Danese, M. Abreu, 2023, Gastroenterology.

Efficacy and Safety of Approximately 3 Years of Continuous Ozanimod in Moderately to Severely Active Ulcerative Colitis: Interim Analysis of the True North Open-label Extension

S. Vermeire, R. Panaccione, S. Danese, 2023, Journal of Crohn's & colitis.

Use of the MucilAir Airway Assay, a New Approach Methodology, for Evaluating the Safety and Inhalation Risk of Agrochemicals