Anke Jakobs

Targeting acute myeloid leukemia with a small molecule inhibitor of the Myb/p300 interaction.

A. Coulibaly, K. Klempnauer, W. Berdel, 2016, Blood.

A novel cell-based screening assay for small-molecule MYB inhibitors identifies podophyllotoxins teniposide and etoposide as inhibitors of MYB activity

K. Klempnauer, M. Yusenko, A. Jakobs, 2018, Scientific Reports.

Monensin, a novel potent MYB inhibitor, suppresses proliferation of acute myeloid leukemia and adenoid cystic carcinoma cells.

K. Klempnauer, M. Yusenko, G. Stenman, 2020, Cancer letters.

The natural anti-tumor compound Celastrol targets a Myb-C/EBPβ-p300 transcriptional module implicated in myeloid gene expression

A. Coulibaly, K. Klempnauer, T. Schmidt, 2018, PloS one.

Withaferin A, a natural compound with anti-tumor activity, is a potent inhibitor of transcription factor C/EBPβ.

H. Mootz, A. Coulibaly, K. Klempnauer, 2017, Biochimica et biophysica acta. Molecular cell research.

An isoform-specific C/EBPβ inhibitor targets acute myeloid leukemia cells

A. Coulibaly, K. Klempnauer, W. Berdel, 2016, Leukemia.

Interaction and Cooperation of the CCAAT-box Enhancer-binding Protein β (C/EBPβ) with the Homeodomain-interacting Protein Kinase 2 (Hipk2)*

A. Coulibaly, K. Klempnauer, S. Steinmann, 2013, The Journal of Biological Chemistry.

Helenalin Acetate, a Natural Sesquiterpene Lactone with Anti-inflammatory and Anti-cancer Activity, Disrupts the Cooperation of CCAAT Box/Enhancer-binding Protein β (C/EBPβ) and Co-activator p300*

K. Klempnauer, T. Schmidt, S. Steinmann, 2016, The Journal of Biological Chemistry.