Josefa dela Cruz-Chuh

Modulating Antibody-Drug Conjugate Payload Metabolism by Conjugation Site and Linker Modification.

Yichin Liu, Ely Cosino, R. Vandlen, 2018, Bioconjugate chemistry.

Systematic Variation of Pyrrolobenzodiazepine (PBD)-dimer Payload Physicochemical Properties Impacts Efficacy and Tolerability of the Corresponding Antibody-Drug Conjugates.

R. Rowntree, BinQing Wei, P. Dragovich, 2020, Journal of medicinal chemistry.

Exploration of Pyrrolobenzodiazepine (PBD)-Dimers Containing Disulfide-Based Prodrugs as Payloads for Antibody-Drug Conjugates.

R. Rowntree, James Lee, D. Stokoe, 2018, Molecular pharmaceutics.

Linker Immolation Determines Cell Killing Activity of Disulfide-Linked Pyrrolobenzodiazepine Antibody-Drug Conjugates.

P. Dragovich, C. Hop, J. Wai, 2016, ACS medicinal chemistry letters.

Development of a cysteine-conjugatable disulfide FRET probe: Influence of Charge on Linker Cleavage and Payload Trafficking for an anti-HER2 antibody conjugate.

S. Scales, Julie Chang, J. Sadowsky, 2019, Bioconjugate chemistry.

Stabilizing a Tubulysin Antibody-Drug Conjugate To Enable Activity Against Multidrug-Resistant Tumors.

Jeffrey T. Lau, J. Wai, G. L. Lewis Phillips, 2017, ACS medicinal chemistry letters.

is not an appropriate payload of antibody-drug conjugates as rapid inactivation by lysosomal enzymes

P. Dragovich, Thomas H. Pillow, Josefa dela Cruz-Chuh, 2019 .