H. Saito

发表

Aging and plasminogen activator inhibitor-1 (PAI-1) regulation: implication in the pathogenesis of thrombotic disorders in the elderly.

Koji Yamamoto, J. Takamatsu, H. Saito, 2005, Cardiovascular research.

Plasminogen Activator Inhibitor-1 in Aging

Koji Yamamoto, H. Saito, K. Takeshita, 2014, Seminars in Thrombosis & Hemostasis.

Increased expression of plasminogen activator inhibitor-1 in cardiomyocytes contributes to cardiac fibrosis after myocardial infarction.

M. Hirai, M. Hayashi, T. Murohara, 2004, The American journal of pathology.

Increased Expression of Plasminogen Activator Inhibitor-1 with Fibrin Deposition in a Murine Model of Aging, "Klotho" Mouse

M. Hirai, Y. Nabeshima, T. Murohara, 2002, Seminars in thrombosis and hemostasis.

Aging and obesity augment the stress-induced expression of tissue factor gene in the mouse.

K. Isobe, D. Loskutoff, Koji Yamamoto, 2002, Blood.

Aging accelerates endotoxin-induced thrombosis : increased responses of plasminogen activator inhibitor-1 and lipopolysaccharide signaling with aging.

K. Isobe, D. Loskutoff, Koji Yamamoto, 2002, The American journal of pathology.

Plasminogen activator inhibitor-1 is a major stress-regulated gene: Implications for stress-induced thrombosis in aged individuals

K. Isobe, D. Loskutoff, Koji Yamamoto, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Protein S Deficiency: A Database of Mutations

P. Reitsma, D. Cooper, F. Bernardi, 1997, Thrombosis and Haemostasis.

Identification of six novel MYH9 mutations and genotype-phenotype relationships in autosomal dominant macrothrombocytopenia with leukocyte inclusions

H. Saito, T. Matsushita, T. Kojima, 2001, Journal of Human Genetics.

Recent advances in thrombosis and hemostasis 2008

K. Sueishi, E. Davie, S. Iwanaga, 2008 .

Congenital Deficiency of α2-Plasmin Inhibitor Associated with Severe Hemorrhagic Tendency

Y. Sakata, H. Saito, T. Kamiya, 1979 .

FITZGERALD FACTOR: A HITHERTO UNRECOGNISED COAGULATION FACTOR

R. Waldmann, H. Saito, J. Rebuck, 1975, The Lancet.

Immunofluorescence Analysis of Neutrophil Nonmuscle Myosin Heavy Chain-A in MYH9 Disorders: Association of Subcellular Localization with MYH9 Mutations

H. Saito, Eun-Kyeong Jo, T. Matsushita, 2003, Laboratory Investigation.

Heterozygous ITGA2B R995W mutation inducing constitutive activation of the αIIbβ3 receptor affects proplatelet formation and causes congenital macrothrombocytopenia.

Y. Tomiyama, H. Saito, N. Takayama, 2011, Blood.

Novel heterozygous missense mutation in the second leucine rich repeat of GPIbα affects GPIb/IX/V expression and results in macrothrombocytopenia in a patient initially misdiagnosed with idiopathic thrombocytopenic purpura

H. Saito, M. Hamaguchi, S. Kunishima, 2006, European journal of haematology.

Nuclear Targeting by the Growth Factor Midkine

M. Hirai, G. Bu, H. Saito, 2002, Molecular and Cellular Biology.

Obesity enhances the induction of plasminogen activator inhibitor‐1 by restraint stress: a possible mechanism of stress‐induced renal fibrin deposition in obese mice

M. Hayashi, D. Loskutoff, J. Takamatsu, 2005, Journal of thrombosis and haemostasis : JTH.

Identification of the Amino Acid Residues of the Platelet Glycoprotein Ib (GPIb) Essential for the von Willebrand Factor Binding by Clustered Charged-to-Alanine Scanning Mutagenesis*

M. Hirai, T. Kondo, Y. Inden, 2004, Journal of Biological Chemistry.

Historical perspective and future direction of coagulation research

H. Saito, T. Matsushita, T. Kojima, 2011, Journal of thrombosis and haemostasis : JTH.

A novel missense mutation causing abnormal LMAN1 in a Japanese patient with combined deficiency of factor V and factor VIII

T. Murate, H. Saito, T. Matsushita, 2009, American journal of hematology.

and VIII Deficiency Families ERGIC-53 Gene Structure and Mutation Analysis in 19 Combined Factors V

R. Kaufman, C. Négrier, H. Saito, 2013 .

Effects of coagulation Factor VII polymorphisms on the coronary artery disease in Japanese: Factor VII polymorphism and coronary disease.

M. Hirai, T. Kondo, Y. Inden, 2002, Thrombosis research.

Long-term Results of a Multicenter Randomized, Comparative Trial of Modified CHOP versus THP-COP versus THP-COPE Regimens in Elderly Patients with Non-Hodgkin’s Lymphoma

T. Miyazaki, M. Mori, H. Mizoguchi, 2005, International journal of hematology.

Genetic Abnormalities of Bernard-Soulier Syndrome

H. Saito, T. Kamiya, S. Kunishima, 2002, International journal of hematology.

The Carboxyl-Terminal Region of Protein C Is Essential for Its Secretion

H. Saito, T. Senda, H. Umeyama, 1998 .

Molecular Pathogenesis of Protein C-Nagoya, a Hereditary Type I Protein C Deficiency

H. Saito, T. Kojima, I. Sugiura, 1996 .

Mutation of the beta1-tubulin gene associated with congenital macrothrombocytopenia affecting microtubule assembly.

H. Saito, T. Itoh, M. Hamaguchi, 2009, Blood.

TUBB1 mutation disrupting microtubule assembly impairs proplatelet formation and results in congenital macrothrombocytopenia

S. Nishimura, H. Saito, M. Imaizumi, 2014, European journal of haematology.

ACTN1 mutations cause congenital macrothrombocytopenia.

Satoru Miyano, Yuichi Shiraishi, Ryoji Kobayashi, 2013, American journal of human genetics.

Syndecan-4 expression is associated with follicular atresia in mouse ovary

H. Saito, K. Ishiguro, T. Muramatsu, 1999, Histochemistry and Cell Biology.

Down-regulation of murine tissue factor pathway inhibitor mRNA by endotoxin and tumor necrosis factor-alpha in vitro and in vivo.

H. Saito, K. Yamamoto, T. Kojima, 2000, Thrombosis research.

Congenital deficiency of alpha 2-plasmin inhibitor associated with severe hemorrhagic tendency.

Y. Sakata, H. Saito, T. Kamiya, 1979, The Journal of clinical investigation.

Effect of a Recombinant Human Soluble Thrombomodulin on Mortality in Patients With Sepsis-Associated Coagulopathy: The SCARLET Randomized Clinical Trial.

P. Barie, S. Opal, J. Vincent, 2019, JAMA.

Biosynthesis and secretion of functional protein S by a human megakaryoblastic cell line (MEG-01)

M. Ogura, J. Nishioka, Koji Suzuki, 1987 .

Patients with Epstein-Fechtner syndromes owing to MYH9 R702 mutations develop progressive proteinuric renal disease.

H. Kanegane, M. Hattori, H. Saito, 2010, Kidney international.

Increased incidence of thromboembolism in stage IV breast cancer patients treated with a five‐drug chemotherapy regimen

H. Saito, A. Manni, L. Goodnough, 1984, Cancer.

Detailed characterization of an anti-factor IX monoclonal antibody that neutralizes the prolonged ox brain prothrombin time of hemophilia BM by synthetic peptides

H. Saito, T. Kojima, I. Takahashi, 2000, Peptides.

Blood clotting factor IX BM Nagoya. Substitution of arginine 180 by tryptophan and its activation by alpha-chymotrypsin and rat mast cell chymase.

J. Takamatsu, S. Kawabata, H. Saito, 1989, The Journal of biological chemistry.

Mutations in KaiA, a clock protein, extend the period of circadian rhythm in the cyanobacterium Synechococcus elongatus PCC 7942.

Y. Nakahira, M. Hirai, H. Hayashi, 2002, Microbiology.

Normal function levels of protein C inhibitor in two groups with different inheritance modes of congenital combined factor V/VIII deficiency

J. Nishioka, Koji Suzuki, J. Takamatsu, 1984 .

Congenital Combined Deficiency of Factor V and Factor VIII

T. Kamiya, K. Koie, O. Katsumi, 1969, Thrombosis and Haemostasis.

Genotype establishments for protein C deficiency by use of a DNA polymorphism in the gene.

M. Tanimoto, J. Takamatsu, H. Saito, 1991, Blood.

Effects of thrombomodulin alfa on hemostatic parameters in disseminated intravascular coagulation: Post hoc analysis of a phase 3 randomized controlled trial

Takashi Ito, I. Maruyama, N. Aikawa, 2020, Research and practice in thrombosis and haemostasis.

Identification of amino acid residues essential for heparin binding by the A1 domain of human von Willebrand factor.

T. Naoe, H. Saito, T. Matsushita, 2006, Biochemical and biophysical research communications.

Bernard–Soulier syndrome caused by a hemizygous GPIbβ mutation and 22q11.2 deletion

S. Ogawa, S. Kunishima, R. Kobayashi, 2013, Pediatrics international : official journal of the Japan Pediatric Society.

Novel nonsense mutation in the platelet glycoprotein Ibβ gene associated with Bernard‐Soulier syndrome

H. Saito, T. Matsushita, T. Kamiya, 2002, American journal of hematology.

Ribavirin-induced intracellular GTP depletion activates transcription elongation in coagulation factor VII gene expression.

T. Murate, H. Saito, A. Takagi, 2013, The Biochemical journal.

Advances in the understanding of MYH9 disorders

H. Saito, S. Kunishima, H. Saito, 2010, Current opinion in hematology.

Targeted disruption of mouse ortholog of the human MYH9 responsible for macrothrombocytopenia with different organ involvement: hematological, nephrological, and otological studies of heterozygous KO mice.

T. Naoe, Masahide Takahashi, M. Hayashi, 2004, Biochemical and biophysical research communications.

Enzyme immunoassay for measurement of murine plasminogen activator inhibitor-1, employing a specific antibody produced by the DNA vaccine method.

T. Murate, Koji Yamamoto, H. Saito, 2003, Thrombosis research.

Direct carrier detection in hemophilia B kindreds: use of modified primers (mutagenic primers) for enzymatic amplification of the factor IX gene.

M. Tanimoto, J. Takamatsu, H. Saito, 1991, Thrombosis research.

Response:W318 β1-tubulin and macrothrombocytopenia

H. Saito, S. Kunishima, H. Saito, 2009 .

Differential expression of wild-type and mutant NMMHC-IIA polypeptides in blood cells suggests cell-specific regulation mechanisms in MYH9 disorders.

H. Saito, M. Hamaguchi, S. Kunishima, 2008, Blood.

Congenital macrothrombocytopenias.

H. Saito, S. Kunishima, H. Saito, 2006, Blood reviews.

Mutation of the beta1-tubulin gene associated with congenital macrothrombocytopenia affecting microtubule assembly.

T. Itoh, M. Hamaguchi, S. Kunishima, 2009, Blood.

Identification of protein Sα gene mutations including four novel mutations in eight unrelated patients with protein S deficiency

T. Murate, Koji Yamamoto, J. Takamatsu, 2004 .

Inherited deficiency of protein S in a Japanese family with recurrent venous thrombosis: a study of three generations.

J. Nishioka, H. Saito, K. Ogata, 1986, Blood.

Histidine‐rich glycoprotein and changes in the components of the fibrinolytic system after streptokinase therapy in patients with pulmonary thromboembolism

H. Saito, W. Bell, L. Tim Goodnough, 1985, American journal of hematology.

Identification of the regulatory elements of the human von Willebrand factor for binding to platelet GPIb. Importance of structural integrity of the regions flanked by the CYS1272-CYS1458 disulfide bond

T. Matsushita, T. Kojima, T. Nakayama, 2003 .

Development of a new laboratory test to evaluate antithrombin resistance in plasma.

T. Murate, H. Saito, T. Matsushita, 2014, Thrombosis research.

The status of antithymocyte globulin therapy for adult patients in Japan: retrospective analysis of a nationwide survey

T. Terasawa, H. Saito, F. Kawano, 2008, International journal of hematology.

Thrombosis from a prothrombin mutation conveying antithrombin resistance.

T. Naoe, T. Murate, T. Matsushita, 2012, The New England journal of medicine.

3 Megakaryocytic cell lines

H. Saito, H. Saito, 1997 .

Intravenous Immunoglobulin Therapy for Acquired Coagulation Inhibitors: A Critical Review

Koji Yamamoto, J. Takamatsu, H. Saito, 2007, International journal of hematology.

Giant platelet syndrome

H. Saito, T. Matsushita, K. Yamamoto, 2005, Hematology.

Syndecan-4 Deficiency Increases Susceptibility to κ-Carrageenan–Induced Renal Damage

H. Saito, K. Ishiguro, T. Muramatsu, 2001, Laboratory Investigation.

Mutations in MYH9 exons 1, 16, 26, and 30 are infrequently found in Japanese patients with nonsyndromic deafness.

H. Saito, S. Kunishima, T. Matsunaga, 2009, Genetic testing and molecular biomarkers.

Establishment of Mouse Model of MYH9 Disorders: Heterozygous R702C Mutation Provokes Macrothrombocytopenia with Leukocyte Inclusion Bodies, Renal Glomerulosclerosis and Hearing Disability

T. Naoe, M. Ikawa, M. Okabe, 2013, PloS one.

First description of somatic mosaicism in MYH9 disorders

Kentaro Yokoi, H. Saito, T. Matsushita, 2005, British journal of haematology.

Detection of unique neutrophil non‐muscle myosin heavy chain‐A localization by immunofluorescence analysis in MYH9 disorder presented with macrothrombocytopenia without leukocyte inclusions and deafness

T. Naoe, H. Saito, T. Matsushita, 2005, European journal of haematology.

Comparison of accelerometry and oxymetry for measuring daily physical activity.

Akiko Noda, Makoto Hirai, Takashi Kawamura, 2002, Circulation journal : official journal of the Japanese Circulation Society.

Changes in Repolarization Properties with Long‐Term Cardiac Memory Modify Dispersion of Repolarization in Patients with Wolff‐Parkinson‐White Syndrome

M. Hirai, T. Kondo, Y. Inden, 2002, Journal of cardiovascular electrophysiology.

R702C Mutation of the MYH9 Gene Provokes Impaired Platelet Formation, Renal Focal Segmental Glomerulosclerosis, and Hearing Disability In the Mice Model

T. Naoe, M. Ikawa, M. Okabe, 2010 .

Impact of antithrombin deficiency in thrombogenesis: lipopolysaccharide and stress-induced thrombus formation in heterozygous antithrombin-deficient mice.

M. Nishimura, Koji Yamamoto, H. Saito, 2002, Blood.

Molecular defects associated with antithrombin deficiency and dilated cardiomyopathy in a Japanese patient.

K. Node, K. Nagata, T. Murate, 2008, Internal medicine.

ISTH and SSC MEETINGS Second Announcement of the XVIth Congress of the ISTH

Secretary, President, P. Mannucci, 2010 .

Studies on Fletcher trait and Fitzgerald trait

H. Saito, H. Saito, 2010, Thrombosis and Haemostasis.

PREKALLIKREIN (FLETCHER FACTOR) BY RADIOIMMUNOASSAY

H. Saito, H. Saito, 1979 .

Some reminiscences in Nagoya and Cleveland

H. Saito, H. Saito, 2013 .

Molecular hetergeneity of blood coagulation factor deficiency and plasma inhibitor deficiency

H. Saito, H. Saito, 1984 .

Compound heterozygosity for two novel mutations in a severe factor XI deficiency

T. Murate, H. Saito, T. Matsushita, 2003, American journal of hematology.

Classic Polyarteritis Nodosa Presenting Rare Clinical Manifestations in a Patient with Hemophilia A

T. Naoe, G. Sobue, H. Saito, 2006, International journal of hematology.

mice stress-induced thrombus formation in heterozygous antithrombin-deficient Impact of antithrombin deficiency in thrombogenesis: lipopolysaccharide and

M. Nishimura, K. Ishiguro, T. Muramatsu, 2013 .

Immunoglobulin Analysis and Epitope Mapping of F VIII Inhibitor Antibodies Developed in Two Nonhemophilic Patients Determined by Immunoblotting

J. Takamatsu, T. Matsushita, M. Shima, 1991 .

Haematological characteristics of MYH9 disorders due to MYH9 R702 mutations

H. Saito, T. Matsushita, M. Hamaguchi, 2007, European journal of haematology.

Down-regulation of PROS1 Gene Expression by 17β-Estradiol via Estrogen Receptor α (ERα)-Sp1 Interaction Recruiting Receptor-interacting Protein 140 and the Corepressor-HDAC3 Complex*

T. Murate, H. Saito, A. Takagi, 2010, The Journal of Biological Chemistry.

Hepatitis C antibody and posttransfusion hepatitis in hemophiliacs.

J. Takamatsu, K. Ogata, T. Kamiya, 1991 .

Historical hematology: May–Hegglin anomaly

H. Saito, S. Kunishima, H. Saito, 2008, American journal of hematology.