Raphaël Matusiak

Spatacsin regulates directionality of lysosome trafficking

F. Darios, Maxime Boutry, Julien Branchu, 2022, bioRxiv.

Loss of spatacsin function alters lysosomal lipid clearance leading to upper and lower motor neuron degeneration

A. Brice, G. Stevanin, F. Santorelli, 2017, Neurobiology of Disease.

Spatacsin regulates directionality of lysosome trafficking by promoting the degradation of its partner AP5Z1

L. Danglot, F. Darios, Maxime Boutry, 2023, PLoS biology.

Loss of spatacsin impairs cholesterol trafficking and calcium homeostasis

A. Brice, G. Stevanin, F. Darios, 2019, Communications Biology.

Alteration of ornithine metabolism leads to dominant and recessive hereditary spastic paraplegia.

A. Durr, C. Depienne, A. Brice, 2015, Brain : a journal of neurology.

Inhibition of Lysosome Membrane Recycling Causes Accumulation of Gangliosides that Contribute to Neurodegeneration

A. Durr, B. Colsch, A. Brice, 2003, Cell reports.