Hiroshi Yoshino

Discovery of novel antitumor sulfonamides targeting G1 phase of the cell cycle.

T. Owa, T. Nagasu, N. Koyanagi, 1999, Journal of medicinal chemistry.

In vivo tumor growth inhibition produced by a novel sulfonamide, E7010, against rodent and human tumors.

T. Nagasu, T. Taguchi, Y. Funahashi, 1994, Cancer research.

Mechanism of action of E7010, an orally active sulfonamide antitumor agent: inhibition of mitosis by binding to the colchicine site of tubulin.

A. Yamaguchi, N. Koyanagi, K. Kitoh, 1997, Cancer research.

A focused compound library of novel N-(7-indolyl)benzenesulfonamides for the discovery of potent cell cycle inhibitors.

T. Owa, T. Nagasu, N. Koyanagi, 2000, Bioorganic & medicinal chemistry letters.

Cell cycle regulation in the G1 phase: a promising target for the development of new chemotherapeutic anticancer agents.

T. Owa, T. Nagasu, K. Yoshimatsu, 2001, Current medicinal chemistry.