S. Hecht

S. Hecht, S. Carmella, J. Richie, 1995, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

Reduced nicotine content cigarettes: effects on toxicant exposure, dependence and cessation.

D. Hatsukami, P. Shields, S. Hecht, 2010, Addiction.

Biomarkers of exposure to new and emerging tobacco delivery products.

P. Jatlow, P. Lorkiewicz, N. Benowitz, 2017, American journal of physiology. Lung cellular and molecular physiology.

Developing the science base for reducing tobacco harm.

E. Borgida, D. Hatsukami, S. Hecht, 2007, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

Smokers with the CHRNA lung cancer-associated variants are exposed to higher levels of nicotine equivalents and a carcinogenic tobacco-specific nitrosamine.

Maarit Tiirikainen, Stephen S Hecht, L. Le Marchand, 2008, Cancer research.

Time course of DNA adduct formation in peripheral blood granulocytes and lymphocytes after drinking alcohol.

D. Hatsukami, S. Hecht, S. Balbo, 2012, Mutagenesis.

Research on cruciferous vegetables, indole-3-carbinol, and cancer prevention: A tribute to Lee W. Wattenberg.

Stephen S Hecht, S. Hecht, V. Fritz, 2016, Molecular nutrition & food research.

Effects of phenethyl isothiocyanate and benzyl isothiocyanate, individually and in combination, on lung tumorigenesis induced in A/J mice by benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

S. Hecht, P. Upadhyaya, M. Wang, 2000, Cancer letters.

Tobacco smoke carcinogens and lung cancer.

S. Hecht, S. Hecht, 1999, Journal of the National Cancer Institute.

Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone mouse lung tumorigenesis by arylalkynes, mechanism-based inactivators of cytochrome P450.

S. Hecht, W. Alworth, R. Young-Sciame, 1993, Carcinogenesis.

Inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone pulmonary metabolism and tumorigenicity in mice by analogues of the investigational chemotherapeutic drug 4-ipomeanol.

S. Amin, D. Desai, S. Hecht, 1992, Chemical research in toxicology.

Structure-activity relationships for inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone lung tumorigenesis by arylalkyl isothiocyanates in A/J mice.

S. Amin, D. Desai, S. Hecht, 1991, Cancer research.

Effects of alkyl chain length on the inhibition of NNK-induced lung neoplasia in A/J mice by arylalkyl isothiocyanates.

S. Amin, S. Hecht, F. Chung, 1989, Carcinogenesis.

Effects of aromatic isothiocyanates on tumorigenicity, O6-methylguanine formation, and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung.

S. Amin, S. Hecht, F. Chung, 1989, Cancer research.

Liquid chromatography--electrospray ionization mass spectrometric detection of an ethenodeoxyguanosine adduct and its hemiaminal precursors in DNA reacted with alpha-acetoxy-N-nitrosopiperidine and cis-4-Oxo-2-pentenal.

S. Hecht, R. Young-Sciame, Z. Liu, 1996, Chemical research in toxicology.

Reaction of alpha-acetoxy-N-nitrosopiperidine with deoxyguanosine: oxygen-dependent formation of 4-oxo-2-pentenal and a 1,N2-ethenodeoxyguanosine adduct.

S. Hecht, F. Chung, R. Young-Sciame, 1992, Chemical research in toxicology.

Formation of cyclic 1,N2-propanodeoxyguanosine adducts in DNA upon reaction with acrolein or crotonaldehyde.

S. Hecht, F. Chung, R. Young, 1984, Cancer research.

Association of CYP2A6 activity with lung cancer incidence in smokers: The multiethnic cohort study

L. Le Marchand, D. Stram, L. Wilkens, 2017, PloS one.

Detection of 7-(2'-carboxyethyl)guanine but not 7-carboxymethylguanine in human liver DNA.

S. Hecht, P. Villalta, G. Cheng, 2010, Chemical research in toxicology.

Analysis of crotonaldehyde- and acetaldehyde-derived 1,n(2)-propanodeoxyguanosine adducts in DNA from human tissues using liquid chromatography electrospray ionization tandem mass spectrometry.

S. Hecht, P. Villalta, Siyi Zhang, 2006, Chemical research in toxicology.

Replication-coupled repair of crotonaldehyde/acetaldehyde-induced guanine-guanine interstrand cross-links and their mutagenicity.

S. Hecht, M. Moriya, I. Yang, 2006, Biochemistry.

Genotoxicity of acetaldehyde- and crotonaldehyde-induced 1,N2-propanodeoxyguanosine DNA adducts in human cells.

S. Hecht, M. Moriya, I. Yang, 2006, Mutation research.

Analysis of N'-nitrosonornicotine enantiomers in human urine by chiral stationary phase liquid chromatography-nanoelectrospray ionization-high resolution tandem mass spectrometry.

S. Hecht, S. Carmella, Jing Yang, 2017, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Combined analysis of N'-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in the urine of cigarette smokers and e-cigarette users.

Delshanee Kotandeniya, S. Hecht, S. Carmella, 2015, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Comprehensive analysis of urinary metabolites of N'-nitrosonornicotine.

S. Hecht, C. B. Chen, C. H. B. Chen, 1981, Carcinogenesis.

Transcriptome profiling in oral cavity and esophagus tissues from (S)‐N′‐nitrosonornicotine‐treated rats reveals candidate genes involved in human oral cavity and esophageal carcinogenesis

S. Balbo, E. Dickerson, F. Kassie, 2016, Molecular carcinogenesis.

Dihydromethysticin from kava blocks tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis and differentially reduces DNA damage in A/J mice.

S. Hecht, M. G. O’Sullivan, S. Balbo, 2014, Carcinogenesis.

Kava Blocks 4-(Methylnitrosamino)-1-(3-pyridyl)-1-Butanone–Induced Lung Tumorigenesis in Association with Reducing O6-methylguanine DNA Adduct in A/J Mice

S. Hecht, M. G. O’Sullivan, S. Balbo, 2014, Cancer Prevention Research.

Evidence for endogenous formation of the hepatocarcinogen N-nitrosodihydrouracil in rats treated with dihydrouracil and sodium nitrite: a potential source of human hepatic DNA carboxyethylation.

P. Villalta, S. Balbo, S. Khariwala, 2013, Chemico-biological interactions.

Lung carcinogenesis by tobacco smoke

Stephen S Hecht, S. Hecht, S. Hecht, 2012, International journal of cancer.

Inhibition of lung carcinogenesis and critical cancer-related signaling pathways by N-acetyl-S-(N-2-phenethylthiocarbamoyl)-l-cysteine, indole-3-carbinol and myo-inositol, alone and in combination.

F. Kassie, Xianghua Luo, P. Upadhyaya, 2010, Carcinogenesis.

Potential contributions of the tobacco nicotine-derived nitrosamine ketone (NNK) in the pathogenesis of steatohepatitis in a chronic plus binge rat model of alcoholic liver disease.

S. Hecht, S. M. de la Monte, S. Balbo, 2015, Alcohol and alcoholism.

Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogenesis

Ivan Rusyn, Stephen S. Hecht, Robert J. Kavlock, 2015, Environmental health perspectives.

Biochemistry, biology, and carcinogenicity of tobacco-specific N-nitrosamines.

S. Hecht, S. Hecht, 1998, Chemical research in toxicology.

Induction of lung and exocrine pancreas tumors in F344 rats by tobacco-specific and Areca-derived N-nitrosamines.

S. Amin, S. Hecht, D. Hoffmann, 1988, Cancer research.

Formaldehyde and leukemia: Epidemiology, potential mechanisms, and implications for risk assessment

B. Sonawane, Luoping Zhang, Martyn T. Smith, 2009, Environmental and molecular mutagenesis.

Large Differences in Urinary Benzene Metabolite S-Phenylmercapturic Acid Quantitation: A Comparison of Five LC-MS-MS Methods.

B. Blount, S. Hecht, P. Jacob, 2020, Journal of analytical toxicology.

Chemical biomarkers of exposure and early damage from potentially carcinogenic airborne pollutants

K. Luo, S. Hecht, I. Stepanov, 2019, Annals of Cancer Epidemiology.

Assessing secondhand smoke using biological markers

J. Samet, N. Benowitz, Sungroul Kim, 2012, Tobacco Control.

CYP2A6 genetic polymorphisms and biomarkers of tobacco smoke constituents in relation to risk of lung cancer in the Singapore Chinese Health Study

Woon-Puay Koh, Stephen S Hecht, Jian-Min Yuan, 2017, Carcinogenesis.

Evaluation of carcinogen exposure in people who used "reduced exposure" tobacco products.

D. Hatsukami, S. Hecht, S. Murphy, 2004, Journal of the National Cancer Institute.

Analysis of 23 polycyclic aromatic hydrocarbons in smokeless tobacco by gas chromatography-mass spectrometry.

D. Hatsukami, S. Hecht, P. Villalta, 2010, Chemical research in toxicology.

Nicotine-derived N-nitrosamines (TSNA) and their relevance in tobacco carcinogenesis.

S. Hecht, F. Chung, D. Hoffmann, 1991, Critical reviews in toxicology.

O6-methylguanine is a critical determinant of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone tumorigenesis in A/J mouse lung.

S. Hecht, L. Peterson, S. Hecht, 1991, Cancer research.

A review: dietary and endogenously formed N-nitroso compounds and risk of childhood brain tumors

G. Block, P. Buffler, S. Hecht, 2005, Cancer Causes & Control.

Effects of immediate versus gradual nicotine reduction in cigarettes on biomarkers of biological effects.

Jason D. Robinson, M. al’Absi, J. Koopmeiners, 2019, Addiction.

Comparison of Polymorphisms in Genes Involved in Polycyclic Aromatic Hydrocarbon Metabolism with Urinary Phenanthrene Metabolite Ratios in Smokers

D. Hatsukami, S. Hecht, S. Carmella, 2006, Cancer Epidemiology Biomarkers & Prevention.

Human Phenanthrene Metabolites as Probes for the Metabolic Activation and Detoxification of Carcinogenic Polycyclic Aromatic Hydrocarbons

S. Hecht, S. Hecht, 2008 .

Quantitative analysis of catechol and 4-methylcatechol in human urine.

S. Hecht, S. Carmella, E. J. La Voie, 1982, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Tobacco-specific nitrosamines, an important group of carcinogens in tobacco and tobacco smoke.

S. Hecht, D. Hoffmann, S. Hecht, 1988, Carcinogenesis.

The safety evaluation of food flavoring substances: the role of genotoxicity studies

Sean V. Taylor, Samuel M. Cohen, S. Fukushima, 2020, Critical reviews in toxicology.

Original Contribution Associations between Genetic Ancestries and Nicotine Metabolism Biomarkers in the Multiethnic Cohort Study

C. Haiman, L. Kolonel, L. Marchand, 2022 .

Metabolites of a tobacco-specific carcinogen in urine from newborns.

U. Töllner, S. Hecht, S. Carmella, 1999, Journal of the National Cancer Institute.

Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers

N. Tretyakova, M. Olivier, P. Hainaut, 2002, Oncogene.

Reduced Nicotine Content Cigarettes and Nicotine Patch

M. al’Absi, D. Hatsukami, S. Hecht, 2013, Cancer Epidemiology, Biomarkers & Prevention.

Effect of Oral Snus and Medicinal Nicotine in Smokers on Toxicant Exposure and Withdrawal Symptoms: A Feasibility Study

B. Lindgren, D. Hatsukami, S. Hecht, 2010, Cancer Epidemiology, Biomarkers & Prevention.

Smokeless tobacco topography and toxin exposure.

D. Hatsukami, S. Hecht, S. Murphy, 2005, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

Cigarette smoking and adenocarcinoma of the lung: The relevance of nicotine-derived N-nitrosamines

S. Amin, S. Hecht, F. Chung, 1993 .

Effects of Glucosinolate-Rich Broccoli Sprouts on Urinary Levels of Aflatoxin-DNA Adducts and Phenanthrene Tetraols in a Randomized Clinical Trial in He Zuo Township, Qidong, People's Republic of China

S. Gange, J. Groopman, S. Hecht, 2005, Cancer Epidemiology Biomarkers & Prevention.

Phenethyl isothiocyanate and sulforaphane and their N-acetylcysteine conjugates inhibit malignant progression of lung adenomas induced by tobacco carcinogens in A/J mice.

S. Hecht, Chung-Xiou Wang, B. Pittman, 2005, Cancer research.

Environmental and chemical carcinogenesis.

L. Loeb, A. Conney, S. Hecht, 2004, Seminars in cancer biology.

Modulation of the metabolism of airborne pollutants by glucoraphanin-rich and sulforaphane-rich broccoli sprout beverages in Qidong, China.

A. Muñoz, Jian-Min Yuan, J. Groopman, 2012, Carcinogenesis.

Tobacco carcinogen metabolites and DNA adducts as biomarkers in Head and Neck cancer: Potential screening tools and prognostic indicators

D. Hatsukami, S. Hecht, S. Khariwala, 2012, Head & neck.

Evolution of research on the DNA adduct chemistry of N-nitrosopyrrolidine and related aldehydes.

S. Hecht, P. Upadhyaya, Mingyao Wang, 2011, Chemical research in toxicology.

Carcinogenic Effects of Cigarette Smoke on the Respiratory Tract

S. Hecht, L. Peterson, Anna M. Urban, 2010 .

Chemoprevention of lung carcinogenesis in addicted smokers and ex-smokers

Stephen S. Hecht, Dorothy K. Hatsukami, D. Hatsukami, 2009, Nature Reviews Cancer.

A comparison of urinary biomarkers of tobacco and carcinogen exposure in smokers.

D. Hatsukami, S. Hecht, S. Murphy, 2004, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

Synthesis and properties of an acetaldehyde-derived oligonucleotide interstrand cross-link.

S. Hecht, Y. Lao, S. Hecht, 2005, Chemical research in toxicology.

Elevated Levels of Volatile Organic Carcinogen and Toxicant Biomarkers in Chinese Women Who Regularly Cook at Home

Stephen S. Hecht, Woon-Puay Koh, Jian-Min Yuan, 2010, Cancer Epidemiology, Biomarkers & Prevention.

Urinary metabolites of a polycyclic aromatic hydrocarbon and volatile organic compounds in relation to lung cancer development in lifelong never smokers in the Shanghai Cohort Study.

Jian-Min Yuan, Renwei Wang, H. Nelson, 2014, Carcinogenesis.

Cigarette smoking and lung cancer: chemical mechanisms and approaches to prevention.

Stephen S Hecht, S. Hecht, S. Hecht, 2002, The Lancet. Oncology.

Genetic determinants of cytochrome P450 2A6 activity and biomarkers of tobacco smoke exposure in relation to risk of lung cancer development in the Shanghai cohort study

Jian-Min Yuan, Renwei Wang, H. Nelson, 2016, International journal of cancer.

Urinary levels of cigarette smoke constituent metabolites are prospectively associated with lung cancer development in smokers.

Jian-Min Yuan, Renwei Wang, H. Nelson, 2011, Cancer research.

Applying tobacco carcinogen and toxicant biomarkers in product regulation and cancer prevention.

Jian-Min Yuan, D. Hatsukami, S. Hecht, 2010, Chemical research in toxicology.

Identification of adducts formed in the reactions of 5'-acetoxy-N'-nitrosonornicotine with deoxyadenosine, thymidine, and DNA.

S. Hecht, P. Upadhyaya, S. Hecht, 2008, Chemical research in toxicology.

Comparison of Nicotine and Toxicant Exposure in Users of Electronic Cigarettes and Combustible Cigarettes

A. Hyland, D. Hatsukami, R. Niaura, 2018, JAMA network open.

Deoxygenated phosphorothioate inositol phosphate analogs: synthesis, phosphatase stability, and binding affinity.

Shana J Sturla, Stephen S Hecht, S. Hecht, 2008, Bioorganic & medicinal chemistry.

Evaluation of butylated hydroxyanisole, myo-inositol, curcumin, esculetin, resveratrol and lycopene as inhibitors of benzo[a]pyrene plus 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in A/J mice.

S. Hecht, A. Rao, P. Upadhyaya, 1999, Cancer letters.

Transport of the b-O-Glucuronide Conjugate of the Tobacco-specific Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by the Multidrug Resistance Protein 1 (MRP1) REQUIREMENT FOR GLUTATHIONE OR A NON-SULFUR-CONTAINING ANALOG*

S. Hecht, S. Cole, R. Deeley, 2001 .

Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1.

H. Yamazaki, T. Shimada, S. Amin, 1996, Cancer research.

Effects of smoking cessation on eight urinary tobacco carcinogen and toxicant biomarkers.

D. Hatsukami, S. Carmella, Menglan Chen, 2009, Chemical research in toxicology.

Smokeless tobacco and cancer.

K. Straif, P. Gupta, P. Boffetta, 2008, The Lancet. Oncology.

Eukaryotic initiation factor 4E binding protein family of proteins: sentinels at a translational control checkpoint in lung tumor defense.

S. Hecht, O. Larsson, M. Peterson, 2009, Cancer research.

Biomarkers to assess the utility of potential reduced exposure tobacco products.

D. Hatsukami, N. Benowitz, S. Rennard, 2006, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

Dietary Consumption of Black Raspberries or Their Anthocyanin Constituents Alters Innate Immune Cell Trafficking in Esophageal Cancer

S. Hecht, G. Stoner, Li‐Shu Wang, 2015, Cancer Immunology Research.

DietaryConsumptionofBlackRaspberriesorTheir Anthocyanin Constituents Alters Innate Immune Cell Traf fi cking in Esophageal Cancer

S. Hecht, G. Stoner, Li‐Shu Wang, 2015 .

Benzene Uptake and Glutathione S-transferase T1 Status as Determinants of S-Phenylmercapturic Acid in Cigarette Smokers in the Multiethnic Cohort

C. Haiman, L. Le Marchand, D. Stram, 2016, PloS one.

Analysis of the benzene oxide-DNA adduct 7-phenylguanine by liquid chromatography-nanoelectrospray ionization-high resolution tandem mass spectrometry-parallel reaction monitoring: application to DNA from exposed mice and humans.

S. Hecht, P. Villalta, S. Balbo, 2014, Chemico-biological interactions.

Tumor promoters and cocarcinogens in tobacco carcinogenesis.

E. Wynder, S. Hecht, D. Hoffmann, 1983, Environmental health perspectives.

Interaction of CYP1B1, cigarette-smoke carcinogen metabolism, and lung cancer risk.

M. Haznadar, M. Oken, T. Church, 2010, International journal of molecular epidemiology and genetics.

Identification of cyanidin glycosides as constituents of freeze-dried black raspberries which inhibit anti-benzo[a]pyrene-7,8-diol-9,10-epoxide induced NFkappaB and AP-1 activity.

Jingxia Li, Chuanshu Huang, S. Hecht, 2005, Carcinogenesis.

Analysis of acrolein-derived 1,N2-propanodeoxyguanosine adducts in human leukocyte DNA from smokers and nonsmokers.

S. Hecht, S. Balbo, Siyi Zhang, 2011, Chemical research in toxicology.

Detection and quantitation of acrolein-derived 1,N2-propanodeoxyguanosine adducts in human lung by liquid chromatography-electrospray ionization-tandem mass spectrometry.

S. Hecht, P. Villalta, Siyi Zhang, 2007, Chemical research in toxicology.

FEMA GRAS assessment of natural flavor complexes: Sage oil, Orris Root Extract and Tagetes Oil and related flavoring ingredients.

Sean V. Taylor, Jeanne M. Davidsen, Christie L Harman, 2023, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

FEMA GRAS assessment of natural flavor complexes: Lemongrass oil, chamomile oils, citronella oil and related flavoring ingredients.

Sean V. Taylor, Jeanne M. Davidsen, Christie L Harman, 2023, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Applying Tobacco, Environmental, and Dietary-Related Biomarkers to Understand Cancer Etiology and Evaluate Prevention Strategies

N. Tretyakova, D. Hatsukami, S. Hecht, 2020, Cancer Epidemiology, Biomarkers & Prevention.

Recent Studies on DNA Adducts Resulting from Human Exposure to Tobacco Smoke

S. Hecht, I. Stepanov, Bin Ma, 2019, Toxics.

New DNA adducts of crotonaldehyde and acetaldehyde.

S. Hecht, E. McIntee, M. Wang, 2001, Toxicology.

A Schiff base is a major DNA adduct of crotonaldehyde.

S. Hecht, P. Villalta, Yongli Shi, 2001, Chemical research in toxicology.

A cyclic N7,C-8 guanine adduct of N-nitrosopyrrolidine (NPYR): formation in nucleic acids and excretion in the urine of NPYR-treated rats.

S. Hecht, M. Wang, S. Hecht, 1997, Chemical research in toxicology.

Formation of cyclic 1,N2--adducts by reaction of deoxyguanosine with alpha-acetoxy-N-nitrosopyrrolidine, 4-(carbethoxynitrosamino)butanal, or crotonaldehyde.

S. Hecht, F. Chung, S. Hecht, 1983, Cancer research.

A Study of Reactions of α,β-Unsaturated Carbonyl Compounds with Deoxyguanosine

S. Hecht, F. Chung, K. R. Roy, 1988 .

Characterization of amino acid and glutathione adducts of cis-2-butene-1,4-dial, a reactive metabolite of furan.

L. J. Chen, S. Hecht, L. Peterson, 1997, Chemical research in toxicology.

Identification of cis-2-butene-1,4-dial as a microsomal metabolite of furan.

L A Peterson, L. J. Chen, S. Hecht, 1995, Chemical research in toxicology.

Quantitation of acrolein-derived (3-hydroxypropyl)mercapturic acid in human urine by liquid chromatography-atmospheric pressure chemical ionization tandem mass spectrometry: effects of cigarette smoking.

D. Hatsukami, S. Hecht, Yan Zhang, 2007, Chemical research in toxicology.

FEMA GRAS assessment of derivatives of basil, nutmeg, parsley, tarragon and related allylalkoxybenzene-containing natural flavor complexes.

Sean V. Taylor, Jeanne M. Davidsen, Christie L Harman, 2023, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Quantitation of phenanthrene dihydrodiols in the urine of smokers and non-smokers by gas chromatography-negative ion chemical ionization-tandem mass spectrometry.

K. Luo, S. Hecht, S. Carmella, 2020, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Cigarette smoking: cancer risks, carcinogens, and mechanisms

S. Hecht, S. Hecht, 2006, Langenbeck's Archives of Surgery.

Metabolism of benzo[a]pyrene and 7β,8α-dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene in lung and liver of newborn mice

S. Hecht, D. Hoffmann, A. Melikian, 1989 .

Effects of the co-carcinogen catechol on benzo[a]pyrene metabolism and DNA adduct formation in mouse skin.

S. Hecht, D. Hoffmann, A. Melikian, 1986, Carcinogenesis.

5-Methylchrysene metabolism in mouse epidermis in vivo, diol epoxide--DNA adduct persistence, and diol epoxide reactivity with DNA as potential factors influencing the predominance of 5-methylchrysene-1,2-diol-3,4-epoxide--DNA adducts in mouse epidermis.

E. LaVoie, S. Hecht, D. Hoffmann, 1983, Carcinogenesis.

FEMA GRAS assessment of natural flavor complexes: Allspice, anise, fennel-derived and related flavoring ingredients.

Sean V. Taylor, Jeanne M. Davidsen, Christie L Harman, 2023, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Effects of 6-Week Use of Very Low Nicotine Content Cigarettes in Smokers With Serious Mental Illness

B. Lindgren, D. Hatsukami, S. Hecht, 2019, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

Tumorigenicity of the tobacco-specific carcinogen 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone in infant mice.

S. Amin, L. Anderson, S. Hecht, 1991, Cancer letters.

Comparative carcinogenicity in A/J mice and metabolism by cultured mouse peripheral lung of N'-nitrosonornicotine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, and their analogues.

S. Hecht, G. Stoner, J. Klaunig, 1983, Cancer research.

Contrasting Disposition and Metabolism of Topically Applied Benzo(a)pyrene, trans-7,8-Dihydroxy-7,8-dihydrobenzo(a)pyrene, and 7β,8α-Dihydroxy-9α,10α-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene in Mouse Epidermis in Vivo

S. Hecht, A. Melikian, K. Bagheri, 1987 .

Contrasting disposition and metabolism of topically applied benzo(a)pyrene, trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene, and 7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene in mouse epidermis in vivo.

A. Melikian, K. Bagheri, S. Hecht, 1987, Cancer research.

Chemoprevention of Esophageal Cancer with Black Raspberries, Their Component Anthocyanins, and a Major Anthocyanin Metabolite, Protocatechuic Acid

S. Hecht, G. Stoner, Li‐Shu Wang, 2014, Cancer Prevention Research.

Tobacco addiction: implications for treatment and cancer prevention.

B. Kramer, S. Hecht, J. Henningfield, 1997, Journal of the National Cancer Institute.

SPECIAL ARTICLE Tobacco Addiction: Implications for Treatment and Cancer Prevention

B. Kramer, S. Hecht, J. Henningfield, 1997 .

Toxicant Exposure in Cigarette Reducers versus Light Smokers

D. Hatsukami, S. Hecht, A. Joseph, 2006, Cancer Epidemiology Biomarkers & Prevention.

Effects of reduced cigarette smoking on the uptake of a tobacco-specific lung carcinogen.

D. Hatsukami, S. Hecht, S. Murphy, 2004, Journal of the National Cancer Institute.

Comparative tumorigenicity of 1-nitropyrene, 1-nitrosopyrene, and 1-aminopyrene administered by gavage to Sprague-Dawley rats.

S. Hecht, K. El-Bayoumy, A. Rivenson, 1988, Cancer research.

Mutagenicity of K-region derivatives of 1-nitropyrene; remarkable activity of 1- and 3-nitro-5H-phenanthro[4,5-bcd]pyran-5-one.

S. Hecht, K. El-Bayoumy, S. Hecht, 1986, Mutation research.

Nitroarenes : occurrence, metabolism, and biological impact

S. Hecht, P. Howard, F. A. Beland, 1990 .

Comparative tumor initiating activity on mouse skin of 6-nitrobenzo[a]pyrene, 6-nitrochrysene, 3-nitroperylene, 1-nitropyrene and their parent hydrocarbons.

S. Hecht, D. Hoffmann, K. El-Bayoumy, 1982, Cancer letters.

Smokeless tobacco and cigarette smoking: chemical mechanisms and cancer prevention

D. Hatsukami, S. Hecht, S. Hecht, 2022, Nature Reviews Cancer.

Differences in exposure to toxic and/or carcinogenic volatile organic compounds between Black and White cigarette smokers

S. Gregorich, E. Perez-stable, D. Hatsukami, 2019, Journal of Exposure Science & Environmental Epidemiology.

The sphingolipid degradation product trans-2-hexadecenal forms adducts with DNA.

Ashok Kumar, S. Hecht, R. Bittman, 2012, Biochemical and biophysical research communications.

NIH electronic cigarette workshop: developing a research agenda.

W. Bailey, M. Fiore, Kay L Wanke, 2015, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

Variation in Levels of the Lung Carcinogen NNAL and Its Glucuronides in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer

L. Le Marchand, D. Stram, S. Hecht, 2014, Cancer Epidemiology, Biomarkers & Prevention.

Urinary levels of tobacco-specific nitrosamine metabolites in relation to lung cancer development in two prospective cohorts of cigarette smokers.

Jian-Min Yuan, W. Koh, Renwei Wang, 2009, Cancer research.

Mass Spectrometric Quantitation of Nicotine, Cotinine, and 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in Human Toenails

D. Hatsukami, S. Hecht, I. Stepanov, 2006, Cancer Epidemiology Biomarkers & Prevention.

Rapid single-dose model for lung tumor induction in A/J mice by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and the effect of diet.

S. Amin, S. Hecht, G. Stoner, 1989, Carcinogenesis.

Effect of Immediate vs Gradual Reduction in Nicotine Content of Cigarettes on Biomarkers of Smoke Exposure: A Randomized Clinical Trial

Jason D. Robinson, M. al’Absi, J. Koopmeiners, 2018, JAMA.

Title Effect of immediate vs gradual reduction in nicotine content of cigarettes on biomarkers of smoke exposure a randomized clinical trial

Jason D. Robinson, J. Koopmeiners, N. Benowitz, 2018 .

Tobacco biomarkers and genetic/epigenetic analysis to investigate ethnic/racial differences in lung cancer risk among smokers

Christopher A Haiman, Daniel O Stram, Stephen S Hecht, 2018, npj Precision Oncology.

Biochemical Verification of Tobacco Use and Abstinence: 2019 Update.

Megan E. Piper, N. Benowitz, M. Jarvis, 2019, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

The reemergence of smokeless tobacco.

D. Winn, G. Connolly, S. Hecht, 1986, The New England journal of medicine.

Screening for DNA Alkylation Mono and Cross-Linked Adducts with a Comprehensive LC-MS(3) Adductomic Approach.

S. Hecht, P. Villalta, S. Balbo, 2015, Analytical chemistry.

Time course of DNA adduct formation in peripheral blood granulocytes and lymphocytes after drinking alcohol.

D. Hatsukami, S. Balbo, R. Bliss, 2012, Mutagenesis.

N2-Ethyldeoxyguanosine as a Potential Biomarker for Assessing Effects of Alcohol Consumption on DNA

P. Brennan, X. Castellsagué, P. Boffetta, 2008, Cancer Epidemiology Biomarkers & Prevention.

Effects of high dose transdermal nicotine replacement in cigarette smokers

D. Hatsukami, S. Hecht, S. Murphy, 2007, Pharmacology Biochemistry and Behavior.

Urinary concentrations of monohydroxylated polycyclic aromatic hydrocarbons in adults from the U.S. Population Assessment of Tobacco and Health (PATH) Study Wave 1 (2013–2014)

A. Hyland, D. Hatsukami, A. Calafat, 2018, Environment international.

Relationship of the oxidative damage biomarker 8-epi-prostaglandin F2&agr; to risk of lung cancer development in the Shanghai Cohort Study

Jian-Min Yuan, Renwei Wang, S. Hecht, 2018, Carcinogenesis.

Study of DNA methylation by tobacco-specific N-nitrosamines.

S. Hecht, A. Castonguay, P. Foiles, 1985, Environmental health perspectives.

Detection of 06-Methyldeoxyguanosine in Human Placental DNA1'2

S. Hecht, R. Everson, P. Foiles, 2006 .

Tobacco, e-cigarettes, and child health

S. Hecht, L. Peterson, S. Hecht, 2017, Current opinion in pediatrics.

Detection of Cotinine in Newborn Dried Blood Spots

S. Hecht, S. Ognjanovic, J. Ross, 2007, Cancer Epidemiology Biomarkers & Prevention.

Analysis of phenanthrene and benzo[a]pyrene tetraol enantiomers in human urine: relevance to the bay region diol epoxide hypothesis of benzo[a]pyrene carcinogenesis and to biomarker studies.

S. Hecht, P. Villalta, S. Carmella, 2010, Chemical research in toxicology.

Longitudinal Study of Urinary Phenanthrene Metabolite Ratios: Effect of Smoking on the Diol Epoxide Pathway

D. Hatsukami, S. Hecht, S. Carmella, 2005, Cancer Epidemiology Biomarkers & Prevention.

Safety and Efficacy of Weekly Oral Oltipraz in Chronic Smokers

M. Kelley, S. Hecht, J. Crowell, 2005, Cancer Epidemiology Biomarkers & Prevention.

Analysis of phenanthrols in human urine by gas chromatography-mass spectrometry: potential use in carcinogen metabolite phenotyping.

D. Jerina, S. Hecht, S. Carmella, 2004, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

r-1,t-2,3,c-4-Tetrahydroxy-1,2,3,4-tetrahydrophenanthrene in human urine: a potential biomarker for assessing polycyclic aromatic hydrocarbon metabolic activation.

D. Jerina, S. Hecht, S. Carmella, 2003, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

Nicotine Metabolite Ratio Predicts Smoking Topography and Carcinogen Biomarker Level

C. Lerman, N. Benowitz, R. Tyndale, 2011, Cancer Epidemiology, Biomarkers & Prevention.

Influence of bay-region methyl group on formation of 5-methylchrysene dihydrodiol epoxide:DNA adducts in mouse skin.

E. LaVoie, S. Hecht, D. Hoffmann, 1982, Cancer research.

Identification and quantification of phenanthrene ortho-quinones in human urine and their association with lipid peroxidation.

K. Luo, S. Hecht, S. Carmella, 2020, Environmental pollution.

Synthesis of Fjord region diol epoxides as potential ultimate carcinogens of dibenzo[a,l]pyrene.

S. Amin, S. Hecht, J. M. Lin, 1994, Chemical research in toxicology.

Tobacco smoke carcinogens and breast cancer

S. Hecht, S. Hecht, 2002, Environmental and molecular mutagenesis.

Application of a High-Resolution Mass-Spectrometry-Based DNA Adductomics Approach for Identification of DNA Adducts in Complex Mixtures

S. Hecht, P. Villalta, S. Balbo, 2014, Analytical chemistry.

Effects of chronic ethanol consumption on the metabolism and carcinogenicity of N'-nitrosonornicotine in F344 rats.

S. Hecht, A. Castonguay, A. Rivenson, 1984, Cancer research.

Differential effect of chronic ethanol consumption on the carcinogenicity of N-nitrosopyrrolidine and N'-nitrosonornicotine in male Syrian golden hamsters.

E. Wynder, S. Hecht, G. Mccoy, 1981, Cancer research.

Dose-dependent detoxication of the airborne pollutant benzene in a randomized trial of broccoli sprout beverage in Qidong, China.

A. Muñoz, J. Groopman, S. Hecht, 2019, The American journal of clinical nutrition.

Rapid and Sustainable Detoxication of Airborne Pollutants by Broccoli Sprout Beverage: Results of a Randomized Clinical Trial in China

A. Muñoz, J. Groopman, S. Hecht, 2014, Cancer Prevention Research.

Carcinogen biomarkers related to smoking and upper aerodigestive tract cancer

S. Hecht, F. Chung, S. Murphy, 1993, Journal of cellular biochemistry. Supplement.

Quantitative Liquid Chromatography-Nanoelectrospray Ionization-High Resolution Tandem Mass Spectrometry Analysis of Acrolein-DNA Adducts and Etheno-DNA Adducts in Oral Cells from Cigarette Smokers and Non-smokers.

S. Hecht, V. Guidolin, S. Balbo, 2020, Chemical research in toxicology.

Analysis of DNA and protein adducts of benzo[a]pyrene in human tissues using structure-specific methods.

S. Hecht, G. Boysen, S. Hecht, 2003, Mutation research.

Children's exposure to environmental tobacco smoke: using diverse exposure metrics to document ethnic/racial differences.

T. Church, K. Sexton, S. Hecht, 2003, Environmental health perspectives.

Metabolites of a tobacco-specific lung carcinogen in the urine of elementary school-aged children.

T. Church, K. Sexton, S. Hecht, 2001, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

Tumorigenicity of Fjord Region Diol Epoxides of Polycyclic Aromatic Hydrocarbons

S. Amin, D. Desai, S. Hecht, 1996 .

Effects of anti-7,8-dihydroxy-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene on human small airway epithelial cells and the protective effects of myo-inositol.

S. Hecht, K. Iijima, H. Jyonouchi, 1999, Carcinogenesis.

Tumorigenicity and metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol enantiomers and metabolites in the A/J mouse.

S. Hecht, P. Upadhyaya, M. Wang, 1999, Carcinogenesis.

Presence of the carcinogen N'-nitrosonornicotine in the urine of some users of oral nicotine replacement therapy products.

B. Lindgren, D. Hatsukami, S. Hecht, 2009, Cancer research.

New and traditional smokeless tobacco: comparison of toxicant and carcinogen levels.

D. Hatsukami, S. Hecht, I. Stepanov, 2008, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

Extensive Metabolic Activation of the Tobacco-Specific Carcinogen 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone in Smokers

D. Hatsukami, S. Hecht, S. Carmella, 2008, Cancer Epidemiology Biomarkers & Prevention.

Mandated lowering of toxicants in cigarette smoke: a description of the World Health Organization TobReg proposal

K. Straif, P. Hainaut, M. Jarvis, 2008, Tobacco Control.

Exposure to nicotine and a tobacco-specific carcinogen increase with duration of use of smokeless tobacco

D. Hatsukami, S. Hecht, S. Murphy, 2008, Tobacco Control.

It Is Time to Regulate Carcinogenic Tobacco-Specific Nitrosamines in Cigarette Tobacco

S. Hecht, S. Hecht, 2014, Cancer Prevention Research.

Smokeless tobacco brand switching: a means to reduce toxicant exposure?

D. Hatsukami, J. Ebbert, S. Hecht, 2007, Drug and alcohol dependence.

Smoking behaviour and toxin exposure during six weeks use of a potential reduced exposure product: Omni

S. Hecht, J. Hughes, P. Callas, 2004, Tobacco Control.

Carcinogen derived biomarkers: applications in studies of human exposure to secondhand tobacco smoke

S. Hecht, S. Hecht, 2004, Tobacco Control.

Smokeless tobacco reduction: preliminary study of tobacco-free snuff versus no snuff.

D. Hatsukami, J. Ebbert, S. Hecht, 2008, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

Temporal stability of urinary and plasma biomarkers of tobacco smoke exposure among cigarette smokers

T. Church, K. Anderson, S. Hecht, 2010, Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.

D. Hatsukami, S. Hecht, A. Joseph, 2005, Cancer Epidemiology Biomarkers & Prevention.

Metabolites of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in smokers' urine.

S. Hecht, S. Carmella, S. Akerkar, 1993, Cancer research.

Determination of Hemoglobin and Serum Albumin Adducts of Benzo[a]Pyrene by Gas Chromatography-Mass Spectrometry in Humans and Their Relation to Exposure and to other Biological Markers

S. Hecht, A. John, B. Schoket, 1999 .

Erratum: Biomarkers to assess the utility of potential reduced exposure tobacco products (Nicotine and Tobacco Research vol. 8 (2) (169-191))

D. Hatsukami, N. Benowitz, S. Rennard, 2006 .

2'-Hydroxylation of nicotine by cytochrome P450 2A6 and human liver microsomes: formation of a lung carcinogen precursor.

S. Hecht, P. Villalta, S. Murphy, 2000, Proceedings of the National Academy of Sciences of the United States of America.

A Randomized Controlled Trial of Progressively Reduced Nicotine Content Cigarettes on Smoking Behaviors, Biomarkers of Exposure, and Subjective Ratings

K. Tang, S. Hecht, M. Mercincavage, 2016, Cancer Epidemiology, Biomarkers & Prevention.

Metabolites of the Polycyclic Aromatic Hydrocarbon Phenanthrene in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer

C. Haiman, L. Le Marchand, D. Stram, 2016, PloS one.

Identification of adducts formed by pyridyloxobutylation of deoxyguanosine and DNA by 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanone, a chemically activated form of tobacco specific carcinogens.

Shana J Sturla, Yongli Shi, Stephen S Hecht, 2003, Chemical research in toxicology.

Comparative tumorigenicity and DNA methylation in F344 rats by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N-nitrosodimethylamine.

S. Hecht, A. Castonguay, A. Rivenson, 1986, Cancer research.

The Association of a Tobacco-Specific Biomarker and Cigarette Consumption and Its Dependence on Host Characteristics

J. Lubin, D. Hatsukami, S. Hecht, 2007, Cancer Epidemiology Biomarkers & Prevention.

Relationships between Cigarette Consumption and Biomarkers of Tobacco Toxin Exposure

Stephen S. Hecht, Sharon E. Murphy, Dorothy K. Hatsukami, 2005, Cancer Epidemiology Biomarkers & Prevention.

Reduced nicotine content cigarettes and use of alternative nicotine products: exploratory trial

M. al’Absi, D. Hatsukami, P. Shields, 2017, Addiction.

Exposure to a Tobacco-Specific Lung Carcinogen in Adolescent versus Adult Smokers

Emily B Zylla, W. Riley, B. Lindgren, 2008, Cancer Epidemiology Biomarkers & Prevention.

Cigarette Smokers vs. Co-users of Cannabis and Cigarettes: Exposure to Toxicants.

M. al’Absi, D. Hatsukami, S. Hecht, 2020, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

Tobacco‐specific N‐nitrosamine exposures and cancer risk in the Shanghai cohort study: Remarkable coherence with rat tumor sites

Jian-Min Yuan, Renwei Wang, S. Hecht, 2014, International journal of cancer.

Distribution and metabolism of N'-nitrosonornicotine in the miniature pig.

S. Hecht, L. Domellöf, H. Tjälve, 1987, Carcinogenesis.

Nicotine-derived N-nitrosamines and tobacco-related cancer: current status and future directions.

S. Hecht, D. Hoffmann, S. Hecht, 1985, Cancer research.

Effects of watercress consumption on urinary metabolites of nicotine in smokers.

S. Hecht, S. Murphy, S. Carmella, 1999, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

Quantitation of 4-oxo-4-(3-pyridyl)butanoic acid and enantiomers of 4-hydroxy-4-(3-pyridyl)butanoic acid in human urine: A substantial pathway of nicotine metabolism.

D. Hatsukami, S. Hecht, J. B. Hochalter, 1999, Chemical research in toxicology.

More than 500 trillion molecules of strong carcinogens per cigarette: use in product labelling?

S. Hecht, S. Hecht, 2011, Tobacco Control.

Research opportunities related to establishing standards for tobacco products under the Family Smoking Prevention and Tobacco Control Act.

S. Hecht, S. Hecht, 2012, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

Exposure to the carcinogen 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK) in smokers from 3 populations with different risks of lung cancer

L. Le Marchand, S. Hecht, C. Caberto, 2009, International journal of cancer.

High Level of Tobacco Carcinogen–Derived DNA Damage in Oral Cells Is an Independent Predictor of Oral/Head and Neck Cancer Risk in Smokers

B. Lindgren, D. Hatsukami, S. Khariwala, 2017, Cancer Prevention Research.

Prediagnostic levels of urinary 8-epi-prostaglandin F2α and prostaglandin E2 metabolite, biomarkers of oxidative damage and inflammation, and risk of hepatocellular carcinoma.

Jian-Min Yuan, Renwei Wang, S. Hecht, 2019, Carcinogenesis.

Clinical Trial of 2-Phenethyl Isothiocyanate as an Inhibitor of Metabolic Activation of a Tobacco-Specific Lung Carcinogen in Cigarette Smokers

Jian-Min Yuan, D. Hatsukami, Renwei Wang, 2016, Cancer Prevention Research.

O-300 Phase I chemoprevention trial of oltipraz in smokers

J. Crowell, R. Santella, R. Bergan, 2003 .

Tobacco Smoke Exposure in Nonsmoking Hospitality Workers before and after a State Smoking Ban

B. Lindgren, D. Hatsukami, S. Murphy, 2010, Cancer Epidemiology, Biomarkers & Prevention.

Kinetics of DNA Adduct Formation in the Oral Cavity after Drinking Alcohol

D. Hatsukami, S. Hecht, S. Balbo, 2012, Cancer Epidemiology, Biomarkers & Prevention.

Quantitation of an acetaldehyde adduct in human leukocyte DNA and the effect of smoking cessation.

D. Hatsukami, S. Hecht, P. Villalta, 2007, Chemical research in toxicology.

New aspects of DNA adduct formation by the carcinogens crotonaldehyde and acetaldehyde.

S. Hecht, P. Villalta, E. McIntee, 2001, Advances in experimental medicine and biology.

Analysis and Identification of 2'-Deoxyadenosine-Derived Adducts in Lung and Liver DNA of F-344 Rats Treated with the Tobacco-Specific Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and Enantiomers of its Metabolite 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol.

S. Hecht, P. Villalta, E. Carlson, 2018, Chemical research in toxicology.

Comparative Levels of O6-Methylguanine, Pyridyloxobutyl-, and Pyridylhydroxybutyl-DNA Adducts in Lung and Liver of Rats Treated Chronically with the Tobacco-Specific Carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone

B. Lindgren, S. Hecht, P. Upadhyaya, 2009, Drug Metabolism and Disposition.

Effects of benzyl isothiocyanate and phenethyl isothiocyanate on DNA adduct formation by a mixture of benzo[a]pyrene and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J mouse lung.

S. Hecht, G. Boysen, P. Upadhyaya, 2002, Carcinogenesis.

DNA adduct formation from tobacco-specific N-nitrosamines.

S. Hecht, S. Hecht, 1999, Mutation research.

Evidence for an important role of DNA pyridyloxobutylation in rat lung carcinogenesis by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone: effects of dose and phenethyl isothiocyanate.

S. Hecht, P. Foiles, M. E. Staretz, 1997, Cancer research.

Biomarkers for human uptake and metabolic activation of tobacco-specific nitrosamines.

S. Hecht, S. Murphy, S. Carmella, 1994, Cancer research.

A/J mouse lung tumorigenesis by the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its inhibition by arylalkyl isothiocyanates.

S. Hecht, F. Chung, M. Morse, 1991, Experimental lung research.

Chapter 11 – Nitrosamines derived from nicotine and other tobacco alkaloids

S. Hecht, A. Tricker, S. Hecht, 1999 .

Relevance of Nicotine-Derived N-Nitrosamines in Tobacco Carcino-Genesis

S. Hecht, F. Chung, D. Hoffmann, 1991 .

Induction of respiratory tract tumors in Syrian golden hamsters by a single dose of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and the effect of smoke inhalation.

S. Hecht, J. Adams, D. Hoffmann, 1983, Carcinogenesis.

Metabolism in the F344 rat of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco-specific carcinogen.

S. Hecht, C. B. Chen, C. H. B. Chen, 1980, Cancer research.

A STUDY OF CHEMICAL CARCINOGENESIS. 14. HYDROLYSIS OF MODEL COMPOUNDS FOR α-HYDROXYLATION OF THE CARCINOGENS N-NITROSOPYRROLIDINE AND N′-NITROSONORNICOTINE

S. Hecht, C. B. Chen, S. Hecht, 1979 .

Evidence for 4-(3-pyridyl)-4-oxobutylation of DNA in F344 rats treated with the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N'-nitrosonornicotine.

S. Hecht, T. Spratt, N. Trushin, 1988, Carcinogenesis.

Effects of alpha-deuterium substitution on the mutagenicity of 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK).

S. Hecht, A. Castonguay, D. Lin, 1983, Carcinogenesis.

Evaluation of toxicant and carcinogen metabolites in the urine of e-cigarette users versus cigarette smokers.

Delshanee Kotandeniya, D. Hatsukami, S. Hecht, 2015, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

Analysis of Total 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanol in Smokers' Blood

S. Hecht, P. Villalta, S. Carmella, 2005, Cancer Epidemiology Biomarkers & Prevention.

Tobacco‐specific nitrosamines in smokeless tobacco products marketed in India

Stephen S Hecht, P. C. Gupta, S. Hecht, 2005, International journal of cancer.

Metabolic activation of the tobacco carcinogen 4-(methylnitrosamino)-(3-pyridyl)-1-butanone by cytochrome P450 2A13 in human fetal nasal microsomes.

S. Hecht, S. Murphy, Qing-Yu Zhang, 2005, Chemical research in toxicology.

Urinary Metabolites of a Tobacco-Specific Lung Carcinogen in Nonsmoking Hospitality Workers

D. Hatsukami, S. Hecht, S. Murphy, 2005, Cancer Epidemiology Biomarkers & Prevention.

Tobacco-Specific Nitrosamines and Their Pyridine-N-glucuronides in the Urine of Smokers and Smokeless Tobacco Users

S. Hecht, I. Stepanov, S. Hecht, 2005, Cancer Epidemiology Biomarkers & Prevention.

Cytochrome P450 enzymes as catalysts of metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco specific carcinogen.

S. Hecht, S. Murphy, J. Jalas, 2005, Chemical research in toxicology.

Stereoselective metabolism and tissue retention in rats of the individual enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), metabolites of the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).

S. Hecht, C. Zimmerman, P. Upadhyaya, 2004, Carcinogenesis.

Effects of cruciferous vegetable consumption on urinary metabolites of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in singapore chinese.

S. Hecht, Mimi C. Yu, K. Arakawa, 2004, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

Identification of O2-substituted pyrimidine adducts formed in reactions of 4-(acetoxymethylnitrosamino)- 1-(3-pyridyl)-1-butanone and 4-(acetoxymethylnitros- amino)-1-(3-pyridyl)-1-butanol with DNA.

S. Hecht, P. Villalta, S. Sturla, 2004, Chemical research in toxicology.

Metabolites of a tobacco-specific lung carcinogen in nonsmoking casino patrons.

K. Anderson, S. Hecht, R. Bliss, 2003, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

Analysis of total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in human urine.

S. Hecht, S. Carmella, Shaomei Han, 2003, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

Stereospecific deuterium substitution attenuates the tumorigenicity and metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK).

Stephen S Hecht, S. Hecht, L. Peterson, 2003, Chemical research in toxicology.

Synthesis of stereospecifically deuterated 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) iastereomers and metabolism by A/J mouse lung microsomes and cytochrome p450 2A5.

S. Hecht, J. Jalas, S. Hecht, 2003, Chemical research in toxicology.

Identification of adducts produced by the reaction of 4-(acetoxymethylnitrosamino)-1-(3-pyridyl)-1-butanol with deoxyguanosine and DNA.

N. Tretyakova, S. Hecht, P. Villalta, 2003, Chemical research in toxicology.

Metabolism and pharmacokinetics of N'-nitrosonornicotine in the patas monkey.

S. Hecht, C. Zimmerman, P. Upadhyaya, 2002, Drug metabolism and disposition: the biological fate of chemicals.

Human urinary carcinogen metabolites: biomarkers for investigating tobacco and cancer.

S. Hecht, S. Hecht, 2002, Carcinogenesis.

Analysis of tobacco-specific nitrosamines in Moldovan cigarette tobacco.

S. Hecht, G. Duca, S. Carmella, 2002, Journal of agricultural and food chemistry.

Analysis of N- and O-glucuronides of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in human urine.

S. Hecht, S. Carmella, P. Upadhyaya, 2002, Chemical research in toxicology.

Metabolites of a tobacco-specific lung carcinogen in nonsmoking women exposed to environmental tobacco smoke.

K. Anderson, S. Hecht, R. Bliss, 2001, Journal of the National Cancer Institute.

Formation and metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol enantiomers in vitro in mouse, rat and human tissues.

F. Guengerich, S. Hecht, S. Carmella, 2000, Carcinogenesis.

A tobacco‐specific carcinogen in the fetus

S. Hecht, S. Carmella, A. Milunsky, 2000, Prenatal diagnosis.

Metabolism of N'-nitrosonornicotine enantiomers by cultured rat esophagus and in vivo in rats.

S. Hecht, E. McIntee, S. Hecht, 2000, Chemical research in toxicology.

Stereochemistry of metabolites of a tobacco-specific lung carcinogen in smokers' urine.

S. Hecht, S. Carmella, P. Upadhyaya, 1999, Cancer research.

Quantitation of urinary metabolites of a tobacco-specific lung carcinogen after smoking cessation.

D. Hatsukami, S. Hecht, S. Murphy, 1999, Cancer research.

Stereoselective metabolism of nicotine and tobacco-specific N-nitrosamines to 4-hydroxy-4-(3-pyridyl)butanoic acid in rats.

S. Hecht, N. Trushin, S. Hecht, 1999, Chemical research in toxicology.

Comparative metabolism of the tobacco-related carcinogens benzo[a]pyrene, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol, and N'- nitrosonornicotine in human hepatic microsomes.

S. Amin, F. Guengerich, S. Hecht, 1997, Drug metabolism and disposition: the biological fate of chemicals.

Analysis of human urine for pyridine-N-oxide metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco-specific lung carcinogen.

S. Hecht, S. Carmella, S. Akerkar, 1997, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

Inhibitory effects of 6-phenylhexyl isothiocyanate on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone metabolic activation and lung tumorigenesis in rats.

S. Amin, D. Desai, S. Hecht, 1996, Carcinogenesis.

Complete inhibition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced rat lung tumorigenesis and favorable modification of biomarkers by phenethyl isothiocyanate.

S. Hecht, S. Carmella, A. Rivenson, 1996, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

Metabolites of a tobacco-specific nitrosamine, 4-(methylnitrosamino)- 1-(3-pyridyl)-1-butanone (NNK), in the urine of smokeless tobacco users: relationship between urinary biomarkers and oral leukoplakia.

S. Hecht, G. Stoner, Randall Harris, 1996, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

Effects of watercress consumption on metabolism of a tobacco-specific lung carcinogen in smokers.

S. Hecht, F. Chung, S. Carmella, 1995, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

Evidence supporting the role of DNA pyridyloxobutylation in rat nasal carcinogenesis by tobacco-specific nitrosamines.

S. Hecht, A. Rivenson, N. Trushin, 1994, Cancer research.

A tobacco-specific lung carcinogen in the urine of men exposed to cigarette smoke.

S. Hecht, S. Murphy, D. Hoffmann, 1993, The New England journal of medicine.

Identification of 4-(methylnitrosamino)-1-[3-(6-hydroxypyridyl)]-1-butanone as a urinary metabolite of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in rodents.

S. Amin, D. Desai, S. Hecht, 1993, Chemical research in toxicology.

Pyridyloxobutyl DNA adducts inhibit the repair of O6-methylguanine.

S. Hecht, L. Peterson, X. K. Liu, 1993, Cancer research.

Metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in the patas monkey: pharmacokinetics and characterization of glucuronide metabolites.

L. Anderson, S. Hecht, J. Rice, 1993, Carcinogenesis.

Quantitation of microsomal alpha-hydroxylation of the tobacco-specific nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

S. Hecht, L. Peterson, R. Mathew, 1991, Cancer research.

Mass spectrometric analysis of tobacco-specific nitrosamine-DNA adducts in smokers and nonsmokers.

J. Resau, S. Hecht, G. Stoner, 1991, Chemical research in toxicology.

Evaluation of cysteine adduct formation in rat hemoglobin by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and related compounds.

S. Hecht, T. Spratt, S. Carmella, 1990, Cancer research.

Mass spectrometric analysis of tobacco-specific nitrosamine hemoglobin adducts in snuff dippers, smokers, and nonsmokers.

S. Hecht, M. Kagan, S. Carmella, 1990, Cancer research.

Dose-response study of DNA and hemoglobin adduct formation by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in F344 rats.

S. Hecht, S. Murphy, D. Hoffmann, 1990, Cancer research.

Investigations of metabolic precursors to hemoglobin and DNA adducts of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

S. Hecht, L. Peterson, S. Carmella, 1990, Carcinogenesis.

Effects of deuterium substitution on the tumorigenicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in A/J mice.

S. Hecht, C. Choi, N. Trushin, 1990, Carcinogenesis.

Cell specificity for the pulmonary metabolism of tobacco-specific nitrosamines in the Fischer rat.

C M White, S. Belinsky, S. Hecht, 1989, Carcinogenesis.

Analysis for N2-(pyridyloxobutyl)deoxyguanosine adducts in DNA of tissues exposed to tritium-labeled 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N'-nitrosonornicotine.

S. Hecht, T. Spratt, N. Trushin, 1989, Chemical research in toxicology.

A study of tobacco carcinogenesis. XLII. Bioassay in A/J mice of some structural analogues of tobacco-specific nitrosamines.

S. Hecht, A. Abbaspour, D. Hoffman, 1988, Cancer letters.

DNA and hemoglobin alkylation by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and its major metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in F344 rats.

S. Hecht, N. Trushin, S. Hecht, 1988, Carcinogenesis.

Detection of O6-methyldeoxyguanosine in human placental DNA.

S. Hecht, R. Everson, P. Foiles, 1988, Cancer research.

Formation of hemoglobin adducts upon treatment of F344 rats with the tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N'-nitrosonornicotine.

S. Hecht, S. Carmella, S. Hecht, 1987, Cancer research.

Effects of alpha-deuterium substitution on the tumorigenicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in F344 rats.

S. Hecht, A. Castonguay, A. Rivenson, 1987, Carcinogenesis.

Metabolism of tobacco-specific N-nitrosamines by cultured human tissues.

S. Hecht, G. Stoner, H. Schut, 1983, Proceedings of the National Academy of Sciences of the United States of America.

Comparative carcinogenicity in F344 rats and Syrian golden hamsters of N'-nitrosonornicotine and N'-nitrosonornicotine-1-N-oxide.

S. Hecht, Y. Maeura, R. Young, 1983, Cancer letters.

Tissue distribution of the tobacco-specific carcinogen 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone and its metabolites in F344 rats.

S. Hecht, H. Tjälve, A. Castonguay, 1983, Cancer research.

Comparative carcinogenicity and metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and N'-nitrosonornicotine in Syrian golden hamsters.

S. Hecht, D. Hoffmann, A. Castonguay, 1981, Cancer research.

METABOLIC β-HYDROXYLATION AND N-OXIDATION OF N′-NITROSONORNICOTINE

S. Hecht, Chi‐hong B. Chen, D. Hoffmann, 1981 .

Comparative carcinogenicity in F344 rats of the tobacco-specific nitrosamines, N'-nitrosonornicotine and 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone.

S. Hecht, D. Hoffmann, C. B. Chen, 1980, Cancer research.

Metabolic α-Hydroxylation of the Tobacco-specific Carcinogen, N′-Nitrosonornicotine

S. Hecht, D. Hoffmann, C. H. B. Chen, 1978 .

Tobacco-specific nitrosamines: formation from nicotine in vitro and during tobacco curing and carcinogenicity in strain A mice.

S. Hecht, T. Tso, Chi‐hong B. Chen, 1978, Journal of the National Cancer Institute.

A study of tobacco carcinogenesis. XIV. Effects of N'-nitrosonornicotine and N'-nitrosonanabasine in rats.

E. Wynder, R. Maronpot, S. Hecht, 1975, Journal of the National Cancer Institute.

Cytochrome P450 2A-catalyzed metabolic activation of structurally similar carcinogenic nitrosamines: N'-nitrosonornicotine enantiomers, N-nitrosopiperidine, and N-nitrosopyrrolidine.

S. Hecht, S. Murphy, Hansen L Wong, 2005, Chemical research in toxicology.

Dose-response study of the carcinogenicity of tobacco-specific N-nitrosamines in F344 rats

S. Amin, S. Hecht, D. Hoffmann, 2004, Journal of Cancer Research and Clinical Oncology.

Disposition of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in bile duct-cannulated rats: stereoselective metabolism and tissue distribution.

S. Hecht, S. Carmella, C. Zimmerman, 2002, Carcinogenesis.

Quantitation of metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone after cessation of smokeless tobacco use.

D. Hatsukami, S. Hecht, S. Carmella, 2002, Cancer research.

Metabolism of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone by cultured monkey lung explants.

L. Anderson, S. Hecht, P. Nerurkar, 2000, Drug metabolism and disposition: the biological fate of chemicals.

Synthesis of tobacco-specific N-nitrosamines and their metabolites and results of related bioassays.

S. Amin, D. Desai, S. Hecht, 1996, Critical reviews in toxicology.

Evidence that a hemoglobin adduct of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone is a 4-(3-pyridyl)-4-oxobutyl carboxylic acid ester.

S. Hecht, S. Carmella, S. S. Kagan, 1992, Chemical research in toxicology.

Hemoglobin adducts as biomarkers of exposure to and metabolic activation of carcinogenic tobacco-specific nitrosamines.

S. Hecht, S. Murphy, S. Carmella, 1991, Biomedical and environmental sciences : BES.

A study of snuff carcinogenesis.

D. Hoffmann, A. Rivenson, K. Brunnemann, 1987, IARC scientific publications.

Investigations on the molecular dosimetry of tobacco-specific N-nitrosamines.

S. Hecht, F. Chung, J. Rubín, 1987, IARC scientific publications.

Comparative mutagenicity of 4-(carbethoxynitrosamino)-4-(3-pyridyl)butanal and 4-(carbethoxynitrosamino)-1-(3-pyridyl)-1-butanone, model compounds for alpha-hydroxylation of N'-nitrosonornicotine.

S. Hecht, D. Lin, S. Hecht, 1986, Carcinogenesis.

Kinetics of DNA methylation by the tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in F344 rats.

S. Hecht, A. Castonguay, R. Tharp, 1984, IARC scientific publications.

Effects of α-deuterium substitution on the mutagenicity of 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK)1

S. Hecht, A. Castonguay, D. Lin, 1983 .

Metabolism of N'-nitrosonornicotine by cultured rat esophagus.

G. Williams, S. Hecht, B. Reiss, 1982, Carcinogenesis.

Regiospecificity in the metabolism of the homologous cyclic nitrosamines, N'-nitrosonornicotine and N'-nitrosoanabasine.

S. Hecht, R. Young, S. Hecht, 1982, Carcinogenesis.

Chemical studies on tobacco smoke LXVIII. Analysis of volatile and tobacco-specific nitrosamines in tobacco products.

S. Hecht, J. Adams, D. Hoffmann, 1980, IARC scientific publications.

A study of tobacco carcinogenesis. XV. Effects of N'-nitrosonornicotine and N'-nitrosoanabasine in Syrian golden hamsters.

S. Hecht, J. Hilfrich, D. Hoffmann, 1977, Cancer letters.

Pyridylhydroxybutyl and pyridyloxobutyl DNA phosphate adduct formation in rats treated chronically with enantiomers of the tobacco-specific nitrosamine metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol

S. Hecht, P. Villalta, I. Stepanov, 2017, Mutagenesis.

The relevance of tobacco-specific nitrosamines to human cancer.

D Hoffmann, S. Hecht, D. Hoffmann, 1989, Cancer surveys.

Biomarkers of Exposure and Potential Harm among Natural American Spirit Smokers.

D. Hatsukami, S. Hecht, E. Donny, 2019, Tobacco regulatory science.

Tobacco-Specific Nitrosamines (NNAL, NNN, NAT, and NAB) Exposures in the US Population Assessment of Tobacco and Health (PATH) Study Wave 1 (2013-2014).

A. Hyland, B. Xia, D. Hatsukami, 2020, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

Tobacco‐specific N‐nitrosamines and polycyclic aromatic hydrocarbons in cigarettes smoked by the participants of the Shanghai Cohort Study

Jian-Min Yuan, Renwei Wang, S. Hecht, 2016, International journal of cancer.

Origin in tobacco smoke of N'-nitrosonornicotine, a tobacco-specific carcinogen.

S. Hecht, D. Hoffmann, M. Dong, 1977, Journal of the National Cancer Institute.

Inositol hexaphosphate inhibits cell transformation and activator protein 1 activation by targeting phosphatidylinositol-3' kinase.

S. Hecht, C. Huang, W. Ma, 1997, Cancer research.

Effects of benzyl isothiocyanate and phenethyl isothiocyanate on benzo[a]pyrene metabolism and DNA adduct formation in the A/J mouse.

S. Hecht, H. Liang, M. Wang, 2000, Carcinogenesis.

Metabolism and DNA Adduct Formation of Tobacco-Specific N-Nitrosamines

S. Hecht, Yupeng Li, S. Hecht, 2022, International journal of molecular sciences.

Quantitation of a minor enantiomer of phenanthrene tetraol in human urine: correlations with levels of overall phenanthrene tetraol, benzo[a]pyrene tetraol, and 1-hydroxypyrene.

S. Hecht, S. Carmella, J. B. Hochalter, 2011, Chemical research in toxicology.

Quantitation of N-acetyl-S-(9,10-dihydro-9-hydroxy-10-phenanthryl)-L-cysteine in human urine: comparison with glutathione-S-transferase genotypes in smokers.

S. Hecht, P. Villalta, P. Upadhyaya, 2006, Chemical research in toxicology.

Metabolism of 5-methylchrysene and 6-methylchrysene by human hepatic and pulmonary cytochrome P450 enzymes.

H. Yamazaki, S. Amin, F. Guengerich, 1996, Cancer research.

Nicotine-derived JV-Nitrosamines and Tobacco-related Cancer: Current Status and Future Directions1

S. Hecht, D. Hoffmann, S. Hecht, 2006 .

Metabolic Activation of Chrysene by Human Hepatic and Pulmonary Cytochrome P450 Enzymes

H. Yamazaki, S. Amin, F. Guengerich, 1996 .

Chemical Carcinogens: In Vitro Metabolism and Activation

S. Hecht, E. J. L. Voie, S. Hecht, 1981 .

INHIBITION OF CARCINOGENESIS BY ISOTHIOCYANATES*

S. Hecht, S. Hecht, 2000, Drug metabolism reviews.

Effects of dietary compounds on alpha-hydroxylation of N-nitrosopyrrolidine and N'-nitrosonornicotine in rat target tissues.

S. Hecht, F. Chung, J. Vitarius, 1984, Cancer research.

Effects of Dietary Compounds on a-Hydroxylation of JV-Nitrosopyrrolidine and A/'-Nitrosonornicotine in Rat Target Tissues1

S. Hecht, F. Chung, A. Juchatz, 2006 .

Tobacco specific nitrosamines: Carcinogenicity, metabolism, and possible role in human cancer

S. Hecht, D. Hoffmann, A. Castonguay, 1983 .

Anthocyanins, anthocyanin derivatives, and colorectal cancer

T. Huang, S. Hecht, G. Stoner, 2013 .

Quality assurance and harmonization for targeted biomonitoring measurements of environmental organic chemicals across the Children's Health Exposure Analysis Resource laboratory network.

D. Barr, S. Hecht, P. Parsons, 2021, International journal of hygiene and environmental health.

A Randomized Clinical Trial Examining the Effects of Instructions for Electronic Cigarette Use on Smoking-Related Behaviors, and Biomarkers of Exposure.

B. Lindgren, D. Hatsukami, P. Shields, 2019, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

A Randomized Clinical Trial of Snus Examining the Effect of Complete Versus Partial Cigarette Substitution on Smoking-Related Behaviors, and Biomarkers of Exposure.

B. Lindgren, D. Hatsukami, P. Shields, 2019, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

Tobacco-Specific Nitrosamines: Occurrence, Formation, Carcinogenicity, and Metabolism

S. Hecht, D. Hoffmann, C. H. B. Chen, 2002 .

4 – Tobacco Carcinogenesis

E. Wynder, S. Hecht, D. Hoffmann, 1978 .

Bioassay for carcinogenicity of 3,2'-dimethyl-4-nitrosobiphenyl, O-nitrosotoluene, nitrosobenzene and the corresponding amines in Syrian golden hamsters.

E. Fiala, S. Hecht, K. El-Bayoumy, 1983, Cancer letters.

Carcinogenicity of tobacco-specific N-nitrosamines (TSNA): the role of the vascular network in the selection of target organs.

S. Hecht, D. Hoffmann, A. Rivenson, 1991, Critical reviews in toxicology.

N-nitroso-N-methyldodecylamine and N-nitroso-N-methyltetradecylamine in hair-care products.

S. Hecht, J. Wenninger, J. Morrison, 1982, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

N-Nitroso-N-methyldodecylamine and N-nitroso-N-methyltetradecylamine in household dishwashing liquids.

S. Hecht, J. Morrison, S. Hecht, 1982, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Nicotine: a precursor for carcinogens.

E. LaVoie, S. Hecht, D. Hoffmann, 1985, Cancer letters.

A study of tobacco carcinogenesis. XIII. Tumor-promoting subfractions of the weakly acidic fraction.

R. Maronpot, S. Hecht, D. Hoffmann, 1975, Journal of the National Cancer Institute.

Anthocyanins and Cancer Prevention

S. Hecht, G. Stoner, Li‐Shu Wang, 2012, Natural Products for Cancer Chemoprevention.

Opportunities for evaluating chemical exposures and child health in the United States: the Environmental influences on Child Health Outcomes (ECHO) Program

M. Karagas, T. Woodruff, R. Fry, 2020, Journal of Exposure Science & Environmental Epidemiology.

Advances in Tobacco Carcinogenesis

S. Hecht, D. Hoffmann, S. Hecht, 1990 .

Chemical Carcinogens in Tobacco

E. Wynder, S. Hecht, D. Hoffmann, 1987 .

Synthesis and mutagenicity of modified chrysenes related to the carcinogen, 5-methylchrysene.

S. Hecht, D. Hoffmann, M. Loy, 2002, Journal of medicinal chemistry.

Stereochemical assignment of (E)- and (Z)-2-(1-naphthyl)-1-phenylpropene and their photocyclization to 5-methylchrysene

S. Hecht, E. Eisenbraun, C. E. Browne, 1978 .

A study of chemical carcinogenesis 4. Synthesis of the carbon-14 labelled carcinogens 5-methylchrysene, 2-methyl-aniline and 3-methyl-2-naphthylamine

S. Hecht, D. Hoffmann, Loui Weiss, 1978 .

Aspartame consumption in relation to childhood brain tumor risk: results from a case-control study.

S. Preston‐Martin, E. Holly, J. Gurney, 1997, Journal of the National Cancer Institute.

Identification of New Markers of Alcohol-Derived DNA Damage in Humans

S. Hecht, V. Guidolin, A. Carrá, 2021, Biomolecules.

Urinary levels of volatile organic carcinogen and toxicant biomarkers in relation to lung cancer development in smokers.

Jian-Min Yuan, Renwei Wang, S. Hecht, 2012, Carcinogenesis.

32P-postlabeling analysis of 1-nitropyrene-DNA adducts in female Sprague-Dawley rats.

S. Hecht, K. El-Bayoumy, A. K. Roy, 1989, Carcinogenesis.

Progress and challenges in selected areas of tobacco carcinogenesis.

S. Hecht, S. Hecht, 2008, Chemical research in toxicology.

Chemopreventive agents modulate the protein expression profile of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo[a]pyrene-induced lung tumors in A/J mice.

S. Hecht, Yunqian Pan, F. Kassie, 2007, Carcinogenesis.

Indole-3-carbinol inhibits 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone plus benzo(a)pyrene-induced lung tumorigenesis in A/J mice and modulates carcinogen-induced alterations in protein levels.

S. Hecht, R. Scherber, F. Kassie, 2007, Cancer research.

Mercapturic Acids Derived from the Toxicants Acrolein and Crotonaldehyde in the Urine of Cigarette Smokers from Five Ethnic Groups with Differing Risks for Lung Cancer

C. Haiman, L. Le Marchand, D. Stram, 2015, PloS one.

Detection of DNA and globin adducts of polynuclear aromatic hydrocarbon diol epoxides by gas chromatography-mass spectrometry and -3H-CH3I postlabeling of released tetraols.

S. Amin, S. Hecht, A. Melikian, 1996, Chemical research in toxicology.

Urinary tobacco smoke-constituent biomarkers for assessing risk of lung cancer.

Jian-Min Yuan, S. Hecht, L. Butler, 2014, Cancer research.

Synthesis and Fluorescence Spectra of Structural Analogues of Potential Benzo[b]fluoranthene-DNA Adducts

S. Amin, S. Hecht, K. Huie, 1985 .

Pilot study on lower nitrosamine smokeless tobacco products compared with medicinal nicotine.

D. Hatsukami, S. Hecht, S. Murphy, 2007, Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco.

Metabolic Activation and DNA Interactions of Carcinogenic N-Nitrosamines to Which Humans Are Commonly Exposed

S. Hecht, Yupeng Li, S. Hecht, 2022, International journal of molecular sciences.

Increased Levels of the Acrolein Metabolite 3-Hydroxypropyl Mercapturic Acid in the Urine of e-Cigarette Users.

B. Lindgren, D. Hatsukami, S. Hecht, 2022, Chemical research in toxicology.

Ethylation and methylation of hemoglobin in smokers and non-smokers.

D. Hatsukami, J. Gurney, S. Hecht, 2002, Carcinogenesis.

Association of urinary biomarkers of smoking-related toxicants with lung cancer incidence in smokers: The Multiethnic Cohort Study.

L. Le Marchand, D. Stram, Sungshim L Park, 2022, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

Urinary levels of the tobacco-specific carcinogen N'-nitrosonornicotine and its glucuronide are strongly associated with esophageal cancer risk in smokers.

Jian-Min Yuan, Renwei Wang, S. Hecht, 2011, Carcinogenesis.

Anthocyanins in Black Raspberries Prevent Esophageal Tumors in Rats

J. Lechner, S. Hecht, G. Stoner, 2009, Cancer Prevention Research.

Induction of liver tumors in F344 rats by crotonaldehyde.

S. Hecht, T. Tanaka, F. Chung, 1986, Cancer research.

Safety evaluation of substituted thiophenes used as flavoring ingredients.

Sean V. Taylor, Christie L Harman, S. Fukushima, 2017, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Oral Cell DNA Adducts as Potential Biomarkers for Lung Cancer Susceptibility in Cigarette Smokers.

S. Hecht, S. Hecht, 2017, Chemical research in toxicology.

Clues to the Etiology of Childhood Brain Cancer: N-Nitroso Compounds, Polyomaviruses, and Other Factors of Interest

A. Olshan, J. Gurney, S. Hecht, 2001, Cancer investigation.

Racial/Ethnic Differences in Lung Cancer Incidence in the Multiethnic Cohort Study: An Update.

C. Haiman, L. Le Marchand, D. Stram, 2019, Journal of the National Cancer Institute.

Lung tumorigenesis suppressing effects of a commercial kava extract and its selected compounds in A/J mice.

S. Hecht, Lei Wang, M. G. O’Sullivan, 2011, The American journal of Chinese medicine.

Analysis of pyridyloxobutyl and pyridylhydroxybutyl DNA adducts in extrahepatic tissues of F344 rats treated chronically with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol.

B. Lindgren, S. Hecht, P. Villalta, 2009, Chemical research in toxicology.

Effects of phenethyl isothiocyanate on the tissue distribution of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and metabolites in F344 rats.

S. Hecht, M. E. Staretz, S. Hecht, 1995, Cancer research.