Yimin Qian

Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-Ras mutation and p53 deletion.

S. Sebti, A. Hamilton, Jiazhi Sun, 1995, Cancer research.

Protein geranylgeranylation, not farnesylation, is required for the G1 to S phase transition in mouse fibroblasts.

S. Sebti, A. Hamilton, T. Mcguire, 1996, Oncogene.

Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: combination therapy with the cytotoxic agents cisplatin, Taxol, and gemcitabine.

S. Sebti, A. Hamilton, Jiazhi Sun, 1999, Cancer research.

Design and synthesis of non-peptide Ras CAAX mimetics as potent farnesyltransferase inhibitors.

S. Sebti, A. Hamilton, Y. Qian, 1996, Journal of medicinal chemistry.

Design and structural requirements of potent peptidomimetic inhibitors of p21ras farnesyltransferase.

S. Sebti, A. Hamilton, Y. Qian, 1994, The Journal of biological chemistry.