Nicolas Skrypek

发表

The EMT Transcription Factor ZEB2 Promotes Proliferation of Primary and Metastatic Melanoma While Suppressing an Invasive, Mesenchymal-Like Phenotype

G. Berx, J. Marine, D. Huylebroeck, 2020, Cancer Research.

Induction of DNMT3B by PGE2 and IL6 at Distant Metastatic Sites Promotes Epigenetic Modification and Breast Cancer Colonization

K. Zhao, M. Cam, Howard H. Yang, 2020, Cancer Research.

Overexpression of chemokine receptor CXCR2 and ligand CXCL7 in liver metastases from colon cancer is correlated to shorter disease-free and overall survival

S. Truant, F. Pruvot, G. Huet, 2015, Cancer science.

Epithelial-to-Mesenchymal Transition: Epigenetic Reprogramming Driving Cellular Plasticity.

G. Berx, S. Goossens, N. Vandamme, 2017, Trends in genetics : TIG.

The MUC4 mucin mediates gemcitabine resistance of human pancreatic cancer cells via the Concentrative Nucleoside Transporter family

B. Duchêne, I. Seuningen, N. Jonckheere, 2013, Oncogene.

The EGF Domains of MUC4 Oncomucin Mediate HER2 Binding Affinity and Promote Pancreatic Cancer Cell Tumorigenesis

X. Thuru, I. van Seuningen, P. Melnyk, 2021, Cancers.

Colon Cancer Cells Escape 5FU Chemotherapy-Induced Cell Death by Entering Stemness and Quiescence Associated with the c-Yes/YAP Axis

L. Ellis, F. Fan, S. Truant, 2013, Clinical Cancer Research.

ZEB2 stably represses RAB25 expression through epigenetic regulation by SIRT1 and DNMTs during epithelial-to-mesenchymal transition

G. Berx, S. Goossens, N. Vandamme, 2018, Epigenetics & Chromatin.

Mucins and tumor resistance to chemotherapeutic drugs.

I. van Seuningen, N. Skrypek, N. Jonckheere, 2014, Biochimica et biophysica acta.

Mucins and Pancreatic Cancer

I. van Seuningen, N. Skrypek, N. Jonckheere, 2010, Cancers.

The mucin MUC4 is a transcriptional and post-transcriptional target of K-ras oncogene in pancreatic cancer. Implication of MAPK/AP-1, NF-κB and RalB signaling pathways.

I. van Seuningen, N. Porchet, F. Renaud, 2015, Biochimica et biophysica acta.

The mucin MUC4 is a transcriptional and post-transcriptional target of K-ras oncogene in pancreatic cancer. Implication of MAPK/AP-1, NF- (cid:20) B and RalB signaling pathways

N. Porchet, B. Duchêne, I. Seuningen, 2020 .

Membrane-bound mucin modular domains: from structure to function.

I. van Seuningen, N. Jonckheere, F. Frénois, 2013, Biochimie.

The oncogenic receptor ErbB2 modulates gemcitabine and irinotecan/SN-38 chemoresistance of human pancreatic cancer cells via hCNT1 transporter and multidrug-resistance associated protein MRP-2

Romain Vasseur, I. van Seuningen, A. Vincent, 2015, Oncotarget.

The Mucin MUC4 and Its Membrane Partner ErbB2 Regulate Biological Properties of Human CAPAN-2 Pancreatic Cancer Cells via Different Signalling Pathways

J. Merlin, P. Dumont, A. Harris, 2012, PloS one.

Br Ief Definitive Repor T the Transcription Factor Zeb2 Regulates Development of Conventional and Plasmacytoid Dcs by Repressing Id2 Unit of Molecular and Cellular Oncology, And

Y. Saeys, B. Lambrecht, G. Berx, 2022 .

STATEMENT OF TRANSLATIONAL RELEVANCE Metastasis, chemoresistance and dormancy are the major limitations in the management of cancer patients. Here, we show that 5FU chemoresistance in human colon cancer cells preselects two distinct drug-resistant clonal populations each enriched in cells expressing

L. Ellis, F. Fan, S. Truant, 2013 .

TGF-βRII Knock-down in Pancreatic Cancer Cells Promotes Tumor Growth and Gemcitabine Resistance. Importance of STAT3 Phosphorylation on S727

I. van Seuningen, N. Skrypek, B. Duchêne, 2018, Cancers.

TGF-βRII knock-down promotes tumor growth and chemoresistance to gemcitabine of pancreatic cancer cells via phosphorylation of STAT3

N. Skrypek, B. Duchêne, I. Seuningen, 2018, bioRxiv.

Tissue Factor Induced by Epithelial-Mesenchymal Transition Triggers a Procoagulant State That Drives Metastasis of Circulating Tumor Cells.

A. Noël, G. Berx, C. Gilles, 2016, Cancer research.