T. Taniguchi*

发表

T257. The Phosphodiesterase 2A Inhibitor TAK-915 Ameliorates Cognitive Impairments and Social Withdrawal in N-Methyl-D-Aspartate Receptor Antagonist-Induced Rat Models of Schizophrenia

T. Taniguchi, M. Miyamoto, Hiroki Iwashita, 2018, Biological Psychiatry.

Design and synthesis of novel human epidermal growth factor receptor 2 (HER2)/epidermal growth factor receptor (EGFR) dual inhibitors bearing a pyrrolo[3,2-d]pyrimidine scaffold.

T. Taniguchi, Toshimasa Tanaka, J. Yano, 2011, Journal of medicinal chemistry.

Direct and Regioselective Monofluorination of N-Protected Pyridone Derivatives using N-Fluorobenzenesulfonimide (NFSI).

T. Taniguchi, Fumie Sakurai, Takafumi Yukawa, 2019, Organic letters.

Discovery of an Orally Bioavailable, Brain-Penetrating, in Vivo Active Phosphodiesterase 2A Inhibitor Lead Series for the Treatment of Cognitive Disorders.

H. Oki, S. Mikami, O. Ujikawa, 2017, Journal of medicinal chemistry.

Discovery of Clinical Candidate N-((1S)-1-(3-Fluoro-4-(trifluoromethoxy)phenyl)-2-methoxyethyl)-7-methoxy-2-oxo-2,3-dihydropyrido[2,3-b]pyrazine-4(1H)-carboxamide (TAK-915): A Highly Potent, Selective, and Brain-Penetrating Phosphodiesterase 2A Inhibitor for the Treatment of Cognitive Disorders.

H. Kokubo, H. Oki, T. Taniguchi, 2017, Journal of medicinal chemistry.

Whole Genome Sequencing of Influenza A and B Viruses With the MinION Sequencer in the Clinical Setting: A Pilot Study

T. Taniguchi, K. Tamura, Y. Nishiyama, 2018, Front. Microbiol..

Design and synthesis of potent and selective pyridazin-4(1H)-one-based PDE10A inhibitors interacting with Tyr683 in the PDE10A selectivity pocket.

M. Yoshikawa, T. Hitaka, Tomoaki Hasui, 2016, Bioorganic & medicinal chemistry.

Design and synthesis of a novel 2-oxindole scaffold as a highly potent and brain-penetrant phosphodiesterase 10A inhibitor.

M. Yoshikawa, J. Kunitomo, H. Kokubo, 2015, Bioorganic & medicinal chemistry.

Discovery of 1-[2-fluoro-4-(1H-pyrazol-1-yl)phenyl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one (TAK-063), a highly potent, selective, and orally active phosphodiesterase 10A (PDE10A) inhibitor.

Hironori Kokubo, Makoto Fushimi, Kosuke Nakashima, 2014, Journal of medicinal chemistry.

Development of two fluorine-18 labeled PET radioligands targeting PDE10A and in vivo PET evaluation in nonhuman primates.

Tomoaki Hasui, T. Taniguchi, C. Halldin, 2018, Nuclear medicine and biology.

Evaluation of a novel PDE10A PET radioligand, [11C]T‐773, in nonhuman primates: Brain and whole body PET and brain autoradiography

Christer Halldin, Vladimir Stepanov, Ryuji Nakao, 2015, Synapse.

Development of a series of novel carbon-11 labeled PDE10A inhibitors.

Christer Halldin, Vladimir Stepanov, Ryuji Nakao, 2015, Journal of labelled compounds & radiopharmaceuticals.

Characterization of Binding and Inhibitory Properties of TAK-063, a Novel Phosphodiesterase 10A Inhibitor

Maki Miyamoto, Kosuke Nakashima, T. Taniguchi, 2015, PloS one.

Characterization of the binding properties of T-773 as a PET radioligand for phosphodiesterase 10A.

Christer Halldin, Vladimir Stepanov, Akihiro Takano, 2015, Nuclear medicine and biology.

Molecular Imaging of PDE10A Knockout Mice with a Novel PET Radiotracer: [11C]T-773

B. Gulyás, T. Taniguchi, C. Halldin, 2015, Molecular Imaging and Biology.

An Expedient Palladium-mediated Route to 3-Arylfurans

T. Taniguchi, K. Ogasawara, H. Nagata, 2000 .

A diastereocontrolled synthesis of (+)-febrifugine: a potent antimalarial piperidine alkaloid.

T. Taniguchi, K. Ogasawara, K. Ogasawara*, 2000, Organic letters.

Non-Carbohydrate Route to Levoglucosenone and Its Enantiomer Employing Asymmetric Dihydroxylation

T. Taniguchi, K. Ogasawara, Keiichi Nakamura, 1996 .

An expedient preparation of chiral building blocks having levoglucosenone chromophore: a new enanticontrolled route to (–)-β-multistriatin and (+)-exo-brevicomin

T. Taniguchi, H. Ohnishi, K. Ogasawara, 1996 .

A new chiral route to 5- and 6-substituted hydropyran-2-ones utilizing enantiopure 4-cumyloxy-2-cyclopenten-1-one

Masayuki Sato, M. Hayashi, K. Hanada, 2001 .