J. Simpson

发表

Spinal muscular atrophy: Factors that modulate motor neurone vulnerability

J. Highley, Wen-Yo Tu, P. Heath, 2017, Neurobiology of Disease.

Review: Microglia in motor neuron disease

J. Highley, P. Heath, J. Simpson, 2020, Neuropathology and applied neurobiology.

Review: Microglia in motor neuron disease Neuropathology and Applied Neurobiology Review: Microglia in motor neuron disease

J. Highley, P. Heath, J. Simpson, 2020 .

Microarray analysis of the astrocyte transcriptome in the aging brain: relationship to Alzheimer's pathology and APOE genotype

C. Brayne, R. Raman, F. Matthews, 2011, Neurobiology of Aging.

Neuronal DNA damage response‐associated dysregulation of signalling pathways and cholesterol metabolism at the earliest stages of Alzheimer‐type pathology

M. Rattray, C. Brayne, F. Matthews, 2015, Neuropathology and applied neurobiology.

Review: Neuropathology and behavioural features of transgenic murine models of Alzheimer's disease

J. Berwick, P. Heath, J. Simpson, 2017, Neuropathology and applied neurobiology.

Metallothionein‐I/II expression associates with the astrocyte DNA damage response and not Alzheimer‐type pathology in the aging brain

C. Brayne, F. Matthews, P. Heath, 2018, Glia.

A neuronal DNA damage response is detected at the earliest stages of Alzheimer's neuropathology and correlates with cognitive impairment in the Medical Research Council's Cognitive Function and Ageing Study ageing brain cohort

C. Brayne, F. Matthews, A. Higginbottom, 2015, Neuropathology and applied neurobiology.

The epidemiological neuropathology of dementia and the implications for drug development

C. Brayne, F. Matthews, S. Wharton, 2012 .

Alterations in the blood brain barrier in ageing cerebral cortex in relationship to Alzheimer-type pathology: A study in the MRC-CFAS population neuropathology cohort

C. Brayne, F. Matthews, G. Savva, 2011, Neuroscience Letters.

Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain

C. Brayne, G. Forster, F. Matthews, 2010, Neurobiology of Aging.

Population variation in oxidative stress and astrocyte DNA damage in relation to Alzheimer‐type pathology in the ageing brain

C. Brayne, G. Forster, F. Matthews, 2010, Neuropathology and applied neurobiology.

Expression of the interferon‐γ‐inducible chemokines IP‐10 and Mig and their receptor, CXCR3, in multiple sclerosis lesions

J. Newcombe, M. Cuzner, J. Simpson, 2000, Neuropathology and applied neurobiology.

Expression of monocyte chemoattractant protein-1 and other β-chemokines by resident glia and inflammatory cells in multiple sclerosis lesions

J. Newcombe, M. Cuzner, J. Simpson, 1998, Journal of Neuroimmunology.

Age-Associated mRNA and miRNA Expression Changes in the Blood-Brain Barrier

E. Goodall, P. Heath, S. Wharton, 2019, International journal of molecular sciences.

Brain Iron Dysregulation and the Risk of Ageing White Matter Lesions

C. Brayne, P. Ince, J. Kirby, 2011, NeuroMolecular Medicine.

Review: Astrocytes in Alzheimer's disease and other age‐associated dementias: a supporting player with a central role

P. Ince, P. Heath, P. Ince, 2017, Neuropathology and applied neurobiology.

Epidemiological neuropathology: the MRC Cognitive Function and Aging Study experience.

C. Brayne, F. Matthews, G. Forster, 2011, Journal of Alzheimer's disease : JAD.

Iba-1-/CD68+ microglia are a prominent feature of age-associated deep subcortical white matter lesions

Alejandro F Frangi, J. Highley, S. Coelho, 2019, PloS one.

Differential perivascular microglial activation in the deep white matter in vascular dementia developed post‐stroke

R. Waller, J. Simpson, S. Wharton, 2022, Brain pathology.

Heterogeneity of cellular inflammatory responses in ageing white matter and relationship to Alzheimer’s and small vessel disease pathologies

J. Barnes, C. Brayne, F. Matthews, 2020, Brain pathology.

Transcriptomic Analysis of Age-Associated Periventricular Lesions Reveals Dysregulation of the Immune Response

C. Brayne, F. Matthews, P. Heath, 2020, International journal of molecular sciences.

Demonstrating a reduced capacity for removal of fluid from cerebral white matter and hypoxia in areas of white matter hyperintensity associated with age and dementia

R. Carare, N. Agarwal, R. Weller, 2020, Acta Neuropathologica Communications.

Local volume fraction distributions of axons, astrocytes, and myelin in deep subcortical white matter

Alejandro F. Frangi, Alejandro F Frangi, José María Pozo, 2018, NeuroImage.

Age‐Associated White Matter Lesions: The MRC Cognitive Function and Ageing Study

Carol Brayne, C. Brayne, S. Wharton, 2015, Brain pathology.

Oxidative Glial Cell Damage Associated with White Matter Lesions in the Aging Human Brain

C. Brayne, F. Matthews, G. Forster, 2014, Brain pathology.

Alterations of the blood–brain barrier in cerebral white matter lesions in the ageing brain

Paul G. Ince, Stephen B. Wharton, Julie E. Simpson, 2010, Neuroscience Letters.

Microarray RNA Expression Analysis of Cerebral White Matter Lesions Reveals Changes in Multiple Functional Pathways

J. O'Brien, C. Brayne, F. Matthews, 2009, Stroke.

Microglial activation in white matter lesions and nonlesional white matter of ageing brains

J. O'Brien, C. Brayne, G. Williams, 2007, Neuropathology and applied neurobiology.

White matter lesions in an unselected cohort of the elderly: astrocytic, microglial and oligodendrocyte precursor cell responses

J. O'Brien, C. Brayne, F. Matthews, 2007, Neuropathology and applied neurobiology.

White Matter Lesions in an Unselected Cohort of the Elderly: Molecular Pathology Suggests Origin From Chronic Hypoperfusion Injury

J. O'Brien, C. Brayne, F. Matthews, 2006, Stroke.

Biological and methodological complexities of beta‐amyloid peptide: Implications for Alzheimer’s disease research

L. Ferraiuolo, J. Simpson, S. Wharton, 2021, Journal of neurochemistry.

Isolation of enriched glial populations from post-mortem human CNS material by immuno-laser capture microdissection

B. Sharrack, P. Ince, P. Heath, 2012, Journal of Neuroscience Methods.

RNA-Seq Profiling of Neutrophil-Derived Microvesicles in Alzheimer’s Disease Patients Identifies a miRNA Signature That May Impact Blood–Brain Barrier Integrity

D. Blackburn, P. Heath, J. Simpson, 2022, International journal of molecular sciences.

Histological characterization of interneurons in Alzheimer's disease reveals a loss of somatostatin interneurons in the temporal cortex

S. Wharton, R. Waller, J. Simpson, 2020, Neuropathology : official journal of the Japanese Society of Neuropathology.

Alpha-synuclein mRNA expression in oligodendrocytes in MSA

A. Lees, T. Révész, J. Holton, 2014, Glia.

Brain Endothelial miR-146a Negatively Modulates T-Cell Adhesion through Repressing Multiple Targets to Inhibit NF-κB Activation

B. Sharrack, G. Michael, H. D. de Vries, 2015, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

MicroRNA‐155 negatively affects blood–brain barrier function during neuroinflammation

B. Sharrack, G. Michael, J. Simpson, 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Type 2 diabetes mellitus-associated transcriptome alterations in cortical neurones and associated neurovascular unit cells in the ageing brain

C. Brayne, F. Matthews, P. Heath, 2021, Acta neuropathologica communications.

Calcium dysregulation in relation to Alzheimer‐type pathology in the ageing brain

C. Brayne, G. Forster, F. Matthews, 2013, Neuropathology and applied neurobiology.

Expression of the β-chemokine receptors CCR2, CCR3 and CCR5 in multiple sclerosis central nervous system tissue

J. Newcombe, M. Cuzner, J. Simpson, 2000, Journal of Neuroimmunology.

Transcriptomic Profiling Reveals Discrete Poststroke Dementia Neuronal and Gliovascular Signatures

R. Kalaria, P. Heath, S. Wharton, 2022, Translational Stroke Research.

The role of chemokines in the pathogenesis of multiple sclerosis.

J. Simpson, A. Cross, K. Harkness, 1999, Advances in experimental medicine and biology.

Advanced Glycation End Product Formation in Human Cerebral Cortex Increases With Alzheimer-Type Neuropathologic Changes but Is Not Independently Associated With Dementia in a Population-Derived Aging Brain Cohort.

C. Brayne, F. Matthews, T. Minett, 2020, Journal of neuropathology and experimental neurology.

Insulin and IGF1 signalling pathways in human astrocytes in vitro and in vivo; characterisation, subcellular localisation and modulation of the receptors

P. Heath, S. Wharton, P. Ince, 2015, Molecular Brain.

Insulin and IGF 1 signalling pathways in human astrocytes in vitro and in vivo ; characterisation , subcellular localisation and modulation of thereceptors

P. Heath, S. Wharton, P. Ince, 2018 .

Extracellular Nucleotides Differentially Regulate Interleukin-1β Signaling in Primary Human Astrocytes: Implications for Inflammatory Gene Expression

C. Brosnan, Sunhee C. Lee, J. Simpson, 2001, The Journal of Neuroscience.

The Pattern of AQP4 Expression in the Ageing Human Brain and in Cerebral Amyloid Angiopathy

J. Attems, R. Carare, Colin Smith, 2020, International journal of molecular sciences.

Persistent DNA damage alters the neuronal transcriptome suggesting cell cycle dysregulation and altered mitochondrial function

P. Heath, H. Mortiboys, S. Wharton, 2021, The European journal of neuroscience.

Immuno-Laser-Capture Microdissection for the Isolation of Enriched Glial Populations from Frozen Post-Mortem Human Brain.

P. Heath, S. Wharton, J. Simpson, 2018, Methods in molecular biology.

Gene expression profiling of the astrocyte transcriptome in multiple sclerosis normal appearing white matter reveals a neuroprotective role

B. Sharrack, P. Heath, S. Wharton, 2016, Journal of Neuroimmunology.

Brain haemosiderin in older people: pathological evidence for an ischaemic origin of magnetic resonance imaging (MRI) microbleeds

C. Brayne, F. Matthews, J. Highley, 2014, Neuropathology and applied neurobiology.

The role of chemokines in the pathology of multiple sclerosis and other neuroinflammatory diseases.

J. Simpson, J. Simpson, 1999 .

DNA damage response and senescence in endothelial cells of human cerebral cortex and relation to Alzheimer's neuropathology progression: a population‐based study in the Medical Research Council Cognitive Function and Ageing Study (MRC‐CFAS) cohort

C. Brayne, F. Matthews, S. Wharton, 2014, Neuropathology and applied neurobiology.

Neuronal DNA damage response‐associated dysregulation of signalling pathways and cholesterol metabolism at the earliest stages of Alzheimer‐type pathology

C. Garwood, S. B. Wharton, L. Ratcliffe, 2015, Neuropathology and applied neurobiology.

NDRG2 Expression Correlates with Neurofibrillary Tangles and Microglial Pathology in the Ageing Brain

C. Brayne, F. Matthews, P. Heath, 2020, International journal of molecular sciences.

Insights into the pathological basis of dementia from population‐based neuropathology studies

C. Brayne, F. Matthews, P. Ince, 2023, Neuropathology and applied neurobiology.

Axonal Preservation in Deep Subcortical White Matter Lesions in the Ageing Brain

J. O'Brien, C. Brayne, F. Matthews, 2014 .

Neutrophil-Derived Microvesicle Induced Dysfunction of Brain Microvascular Endothelial Cells In Vitro

P. Heath, S. Wharton, P. Ince, 2019, International journal of molecular sciences.

Population Variation in Glial Fibrillary Acidic Protein Levels in Brain Ageing: Relationship to Alzheimer-Type Pathology and Dementia

C. Brayne, F. Matthews, G. Forster, 2009, Dementia and Geriatric Cognitive Disorders.

Loss of IGF1R in Human Astrocytes Alters Complex I Activity and Support for Neurons

Evangelia Karyka, P. Heath, H. Mortiboys, 2018, Neuroscience.

Acute effects of systemic inflammation upon the neuro-glial-vascular unit and cerebrovascular function

Chris J. Martin, J. Berwick, J. Simpson, 2019, Brain, behavior, & immunity - health.

Acute effects of systemic inflammation upon neurovascular unit and cerebrovascular function

Chris J. Martin, J. Berwick, J. Simpson, 2018, bioRxiv.

Transcriptomic Analysis of Human Astrocytes In Vitro Reveals Hypoxia-Induced Mitochondrial Dysfunction, Modulation of Metabolism, and Dysregulation of the Immune Response

P. Heath, S. Wharton, J. Simpson, 2020, International journal of molecular sciences.