Darlene G. Skapura

发表

Junctophilin-2 is necessary for T-tubule maturation during mouse heart development.

M. Ackerman, X. Wehrens, Long-Sheng Song, 2013, Cardiovascular research.

Retroviral insertions in the VISION database identify molecular pathways in mouse lymphoid leukemia and lymphoma

Kathryn E. Hentges, M. Justice, B. Liu, 2007, Mammalian Genome.

The Prostate Cancer Androgen Receptor Cistrome in African American Men Associates with Upregulation of Lipid Metabolism and Immune Response

M. Loda, C. Coarfa, M. Freedman, 2022, Cancer research.

Accelerated Development of Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction in an RyR2-R176Q Knockin Mouse Model

Corey L. Reynolds, X. Wehrens, L. D. de Windt, 2010, Hypertension.

Genetic inhibition of PKA phosphorylation of RyR2 prevents dystrophic cardiomyopathy

Corey L. Reynolds, X. Wehrens, S. Sarma, 2010, Proceedings of the National Academy of Sciences.

Title CaMKII-dependent phosphorylation of cardiac ryanodine receptors regulates cell death in cardiac ischemia / reperfusion injury

X. Wehrens, J. Brown, G. Rinaldi, 2014 .

Role of RyR2 Phosphorylation at S2814 During Heart Failure Progression

T. Wieland, U. Wisløff, S. Pogwizd, 2012, Circulation research.

Disrupted Junctional Membrane Complexes and Hyperactive Ryanodine Receptors After Acute Junctophilin Knockdown in Mice

Michael J Ackerman, Yoram Rudy, Wei Wang, 2011, Circulation.

CaMKII-dependent phosphorylation of cardiac ryanodine receptors regulates cell death in cardiac ischemia/reperfusion injury.

X. Wehrens, J. Brown, G. Rinaldi, 2014, Journal of molecular and cellular cardiology.

Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice.

U. Schotten, X. Wehrens, D. Dobrev, 2009, The Journal of clinical investigation.

Novel Junctophilin-2 Mutation A405S Is Associated With Basal Septal Hypertrophy and Diastolic Dysfunction

R. Pautler, M. Ackerman, X. Wehrens, 2017, JACC. Basic to translational science.

Long-term simulated microgravity causes cardiac RyR2 phosphorylation and arrhythmias in mice.

J. Sutton, X. Wehrens, P. Gershovich, 2014, International journal of cardiology.

Expression and function of Kv1.1 potassium channels in human atria from patients with atrial fibrillation

X. Wehrens, J. Noebels, D. Dobrev, 2015, Basic Research in Cardiology.

Ryanodine Receptor Phosphorylation by Calcium/Calmodulin-Dependent Protein Kinase II Promotes Life-Threatening Ventricular Arrhythmias in Mice With Heart Failure

Mark E. Anderson, D. Bers, X. Wehrens, 2010, Circulation.

Lack of UCP3 does not affect skeletal muscle mitochondrial function under lipid-challenged conditions, but leads to sudden cardiac death

X. Wehrens, L. Windt, R. Tian, 2014, Basic Research in Cardiology.

Phospholamban ablation rescues the enhanced propensity to arrhythmias of mice with CaMKII‐constitutive phosphorylation of RyR2 at site S2814

X. Wehrens, A. Mattiazzi, P. Contreras, 2016, The Journal of physiology.

Ryanodine Receptor–Mediated Calcium Leak Drives Progressive Development of an Atrial Fibrillation Substrate in a Transgenic Mouse Model

S. Nattel, X. Wehrens, D. Dobrev, 2014, Circulation.

Impaired local regulation of ryanodine receptor type 2 by protein phosphatase 1 promotes atrial fibrillation.

X. Wehrens, D. Dobrev, N. Voigt, 2014, Cardiovascular research.

Impaired local regulation of ryanodine receptor type-2 by protein phosphatase 1 promotes atrial fibrillation

X. Wehrens, Qiongling Wang, A. Quick, 2013 .

Intracellular calcium leak due to FKBP12.6 deficiency in mice facilitates the inducibility of atrial fibrillation.

X. Wehrens, D. Dobrev, M. Chelu, 2008, Heart rhythm.

Sudden Infant Death Syndrome in Mice With an Inherited Mutation in RyR2

X. Wehrens, J. Bayle, S. Sarma, 2009, Circulation. Arrhythmia and electrophysiology.

receptors(RyR2s)ishypothesizedtocontributetoarrhythmogenesisinAF,butthemolecularmechanisms areincompletelyunderstood.Here,wehaveshownthatmicewithageneticgain-of-functiondefectinRyr2 (whichwetermedRyr2 R176Q/+ mice)didnotexhibitspontaneousAFbutthatrapidatrialpacingunmasked anincreasedvulnerabilitytoA

U. Schotten, X. Wehrens, D. Dobrev, 2009 .