Kendall A. Smith

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Interleukin‐2 Deficient Mice: A New Model to Study Autoimmunity and Self‐Tolerance

Kendall A. Smith, I. Horak, A. Ma, 1995, Immunological reviews.

Low-dose daily interleukin-2 immunotherapy: accelerating immune restoration and expanding HIV-specific T-cell immunity without toxicity.

K. Smith, Kendall A. Smith, 2001, AIDS.

Innate lymphoid cells support regulatory T cells in the intestine through interleukin-2

J. Kelsen, R. Baldassano, Kendall A. Smith, 2019, Nature.

PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cells.

G. Freeman, Kendall A. Smith, R. Ahmed, 2013, The Journal of clinical investigation.

Single-cell quantification of IL-2 response by effector and regulatory T cells reveals critical plasticity in immune response

Michael W. Sneddon, G. Altan-Bonnet, Kendall A. Smith, 2010, Molecular systems biology.

Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy

J. Lisziewicz, E. Rosenberg, R. Siliciano, 1999, Nature Medicine.

Determining to Divide: How Do Cells Decide?

Kendall A. Smith, Kendall A. Smith, 2005, Journal of biological physics.

The quantal theory of how the immune system discriminates between "self and non-self"

Kendall A. Smith, Kendall A. Smith, 2004, Medical immunology.

The quantal theory of immunity

Kendall A. Smith, Kendall A. Smith, 2006, Cell Research.

Vaccination of Macaques with Long-Standing SIVmac251 Infection Lowers the Viral Set Point After Cessation of Antiretroviral Therapy1

D. Montefiori, Kendall A. Smith, D. Venzon, 2002, The Journal of Immunology.

Following the cytokine signaling pathway to leukemogenesis: a chronology.

Kendall A. Smith, J. Griffin, James D Griffin, 2008, The Journal of clinical investigation.

Long term culture of tumour-specific cytotoxic T cells

Kendall A. Smith, S. Gillis, Kendall A. Smith, 1977, Nature.

Glucocorticoid-Induced Inhibition of T Cell Growth Factor Production

G. Crabtree, Kendall A. Smith, S. Gillis, 1979, The Journal of Immunology.

The molecular mechanisms of regulatory T cell immunosuppression

Kendall A. Smith, Kendall A. Smith, 2012, Front. Immun..

The molecular mechanisms of regulatoryT cell immunosuppression

Kendall A. Smith, P. Pandiyan, H. Waldmann, 2011 .

T cell growth factor: parameters of production and a quantitative microassay for activity.

Kendall A. Smith, K. Smith, S. Gillis, 1978, Journal of immunology.

SIVmac 251 in Macaques Chronically Infected with T Cells + and CD 8 + Virus ( SIV )-Specific CD 4 Vaccine-Boosted Simian Immunodeficiency Contrasting Effects of Low-Dose IL-2 on

Kendall A. Smith, D. Venzon, A. Hryniewicz, 2005 .

Prolonged interleukin-2Ralpha expression on virus-specific CD8+ T cells favors terminal-effector differentiation in vivo.

W. Haining, R. Ahmed, V. Kalia, 2010, Immunity.

A monoclonal antibody that appears to recognize the receptor for human T-cell growth factor; partial characterization of the receptor

T. Waldmann, W. Leonard, W. Greene, 1982, Nature.

Conditional IL-2 Gene Deletion: Consequences for T Cell Proliferation

Kendall A. Smith, Z. Popmihajlov, Dong Xu, 2012, Front. Immun..

The roles of c‐rel and interleukin‐2 in tolerance: a molecular explanation of self–nonself discrimination

Kendall A. Smith, H. Liou, Kendall A. Smith, 2011, Immunology and cell biology.

The quantal theory of immunity and the interleukin‐2‐dependent negative feedback regulation of the immune response

Kendall A. Smith, Z. Popmihajlov, Kendall A. Smith, 2008, Immunological reviews.

Negative Feedback Regulation of T Cells via Interleukin-2 and FOXP3 Reciprocity

Kendall A. Smith, Z. Popmihajlov, Kendall A. Smith, 2008, PloS one.

Contrasting Effects of Low-Dose IL-2 on Vaccine-Boosted Simian Immunodeficiency Virus (SIV)-Specific CD4+ and CD8+ T Cells in Macaques Chronically Infected with SIVmac251

Kendall A. Smith, D. Venzon, A. Hryniewicz, 2005, The Journal of Immunology.

c-Rel is crucial for lymphocyte proliferation but dispensable for T cell effector function.

Kendall A. Smith, K. Smith, H. Liou, 1999, International immunology.

Identification of Cellular Sources of IL-2 Needed for Regulatory T Cell Development and Homeostasis

M. Farrar, Kendall A. Smith, B. Blazar, 2018, The Journal of Immunology.

Treg-mediated "Active Suppression" of T Cell Proliferation

Kendall A. Smith, Kendall A. Smith, 2010 .

This information is current as and Homeostasis Needed for Regulatory T Cell Development Identification of Cellular Sources of IL-2

Kendall A. Smith, B. Blazar, K. B. Vang, 2018 .

Toward a molecular understanding of adaptive immunity: a chronology – part II

Kendall A. Smith, Kendall A. Smith, 2012, Front. Immun..

Interleukin 2 receptor‐targeted cytotoxicity. Receptor binding requirements for entry of a diphtheria toxin‐related interleukin 2 fusion protein into cells

Kendall A. Smith, T. Strom, K. Itoh, 1990, European journal of immunology.

The Role of IL-2 in the Generation of Immune Responses In Vivo

Kendall A. Smith, Kendall A. Smith, 2010 .

The Role of the IL-2r Chains in IL-2 Signaling, Consumption and Suppression of T Cell Proliferation

Kendall A. Smith, Kendall A. Smith, 2010 .

Quantitation, Specificity, and Biological Relevance*

Kendall A. Smith, A. Munck, R. Robb, 1981 .

The in vitro generation and sustained culture of nude mouse cytolytic T- lymphocytes

Kendall A. Smith, K. Smith, S. Gillis, 1979, The Journal of experimental medicine.

T‐Cell Growth Factor

Kendall A. Smith, Kendall A. Smith, 1980, Immunological reviews.

CHAPTER 1 – INTERLEUKIN 2: A 10-YEAR PERSPECTIVE

Kendall A. Smith, Kendall A. Smith, 1988 .

Triggering of the T3-Ti antigen-receptor complex results in clonal T-cell proliferation through an interleukin 2-dependent autocrine pathway.

E. Reinherz, Kendall A. Smith, S. Meuer, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Cytokine gene activation and modified responsiveness to interleukin-2 in the blood of tuberculosis patients.

W. Rom, G. Kaplan, E. Sampaio, 1993, The Journal of infectious diseases.

Immunotherapy with Canarypox Vaccine and Interleukin-2 for HIV-1 Infection: Termination of a Randomized Trial

Kendall A. Smith, Z. Popmihajlov, M. Lesser, 2007, PLoS clinical trials.

Manipulating both the inhibitory and stimulatory immune system towards the success of therapeutic vaccination against chronic viral infections

R. Ahmed, S. Ha, K. Araki, 2008, Immunological reviews.

The continuing HIV vaccine saga: naked emperors alongside fairy godmothers

Kendall A. Smith, 2005, Medical immunology.

Thalidomide Exerts Its Inhibitory Action on Tumor Necrosis Factor oe by Enhancing m R N A Degradation

Kendall A. Smith, G. Kaplan, A. Moreira, 2003 .

Louis Pasteur, the Father of Immunology?

Kendall A. Smith, Kendall A. Smith, 2012, Front. Immun..

Glucocorticoid-induced inhibition of T cell growth factor production. I. The effect on mitogen-induced lymphocyte proliferation.

G. Crabtree, K. Smith, S. Gillis, 1979, Journal of immunology.

Glucocorticoid receptors and glucocorticoid sensitivity of mitogen stimulated and unstimulated human lymphocytes

G. Crabtree, Kendall A. Smith, A. Munck, 1977, Nature.

Toward a Molecular Understanding of Adaptive Immunity: A Chronology, Part III

Kendall A. Smith, Kendall A. Smith, 2014, Front. Immunol..

Medical immunology: a new journal for a new subspecialty

Kendall A. Smith, Kendall A. Smith, 2002, Medical immunology.

Rational Immunotherapy with Interleukin 2

Kendall A. Smith, G. Kaplan, Z. Cohn, 1992, Bio/Technology.

Differentiation of T cell lymphokine gene expression: the in vitro acquisition of T cell memory

Kendall A. Smith, S. Ehlers, K. Smith, 1991, The Journal of experimental medicine.

T-Cell Growth Factor, a Lymphocytotrophic Hormone

Kendall A. Smith, Kendall A. Smith, 1983 .

PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program

C. Klein, G. Freeman, W. Leonard, 2022, Nature.

Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor.

Ian A Wilson, I. Wilson, Kendall A. Smith, 2006, Proceedings of the National Academy of Sciences of the United States of America.

The structure of IL2 bound to the three chains of the IL2 receptor and how signaling occurs

Kendall A. Smith, Kendall A. Smith, 2006, Medical immunology.

The effect of T cell growth factor on the generation of cytolytic T cells.

Kendall A. Smith, K. Smith, S. Gillis, 1978, Journal of immunology.

DNA array analysis of interleukin-2-regulated immediate/early genes

Kendall A. Smith, C. Beadling, Kendall A. Smith, 2002, Medical immunology.

A monoclonal antibody, anti-Tac, blocks the action and membrane binding of human interleukin-2 (IL-2)

T. Waldmann, W. Leonard, W. Greene, 1982 .

Cytokine response gene 8 (CR8) regulates the cell cycle G1-S phase transition and promotes cellular survival

Kendall A. Smith, C. Beadling, A. Cereseto, 2001, Oncogene.

IN-VITRO GLUCOCORTICOID STUDIES FOR PREDICTING RESPONSE TO GLUCOCORTICOID THERAPY IN ADULTS WITH MALIGNANT LYMPHOMA

C. Bloomfield, Kendall A. Smith, A. Munck, 1980, The Lancet.

Prognostic significance of the Philadelphia chromosome in acute lymphocytic leukemia

C. Bloomfield, Kendall A. Smith, R. Brunning, 1980 .

Introduction — The Evolution of Our Understanding of the Immune System

Kendall A. Smith, Kendall A. Smith, 2010 .

Lymphopenia, Autoimmunity and the Regulatory T Cell (Treg)

Kendall A. Smith, Kendall A. Smith, 2010 .

Both interleukin 2 and a second T cell-derived factor in EL-4 supernatant have activity as differentiation factors in IgM synthesis

W. Paul, Kendall A. Smith, E. Shevach, 1984, The Journal of experimental medicine.

Are the IL-2 Receptors Expressed in the Murine Fetal Thymus Functional?

D. Longo, Kendall A. Smith, D. Pardoll, 1990, Developmental immunology.

Commentary: "The role ofT3 surface molecules in the activation of human cells: a two-stimulus requirement for IL-2 production reflects events occurring at a pretranslational level"

E. Reinherz, Kendall A. Smith, Russell-Ephraim P. Engleman, 2015 .

T‐CELL GROWTH FACTOR‐MEDIATED T‐CELL PROLIFERATION *

Kendall A. Smith, F. Ruscetti, S. Gillis, 1979, Annals of the New York Academy of Sciences.

The Molecular Basis for Quantal IL-2/IL-2R Signaling of Cell Cycle Progression — The IL-2/Receptor Interaction

Kendall A. Smith, Kendall A. Smith, 2010 .

Evidence that the level of the p55 component of the interleukin (IL) 2 receptor can control IL 2 responsiveness in a murine IL 3‐dependent cell

K. Arai, Kendall A. Smith, R. Mulligan, 1990, European journal of immunology.

The Variability of Cell Cycle Progression and the Competence and Progression Phases of the Cell Cycle

Kendall A. Smith, Kendall A. Smith, 2010 .

The Discovery of T Cell–B Cell Cooperation

N. Mitchison, Kendall A. Smith, 2014, Front. Immunol..

The Pathogenesis of Leukemia — Loss of Normal Quantal Growth Control

Kendall A. Smith, Kendall A. Smith, 2010 .

T-cell Growth Factor-Dependent Leukemic Cell Growth: Therapeutic Implications

Kendall A. Smith, Kendall A. Smith, 1982 .

Interleukin 2 Immunoassay Using Monoclonal Antibodies

Kendall A. Smith, R. Budd, Kendall A. Smith, 1986, Bio/Technology.

Cytokine response gene 6 induces p21 and regulates both cell growth and arrest

Kendall A. Smith, C. Beadling, A. Cereseto, 1999, Oncogene.

Edward Jenner and the Small Pox Vaccine

Kendall A. Smith, Kendall A. Smith, 2011, Front. Immun..

Glucocorticoids inhibit expression of Fc receptors on the human granulocytic cell line HL-60

G. Crabtree, Kendall A. Smith, A. Munck, 1979, Nature.

Low-Dose Daily Subcutaneous Interleukin-2 in Combination with Highly Active Antiretroviral Therapy in HIV + Patients: A Randomized Controlled Trial

Kendall A. Smith, R. Murphy, C. Cohen, 2000, HIV clinical trials.

Lymphocyte activating factor promotes T-cell growth factor production by cloned marine lymphoma cells

Kendall A. Smith, K. Gilbride, M. Favata, 1980, Nature.

Revisiting the 1986 molecular cloning of interleukin 6

Kendall A. Smith, N. Gascoigne, Kendall A. Smith, 2014 .

Regulation of the rate of cell cycle progression in quiescent cytolytic T cells by T cell growth factor: Analysis by flow microfluorometry

Kendall A. Smith, R. Sékaly, H. Macdonald, 1984, Journal of cellular physiology.

Smallpox: can we still learn from the journey to eradication?

Kendall A. Smith, Kendall A. Smith, 2013, The Indian journal of medical research.

Frontiers in Immunology – Grand Challenges

Kendall A. Smith, 2010, Front. Immun..

Wanted, an Anthrax vaccine: Dead or Alive?

Kendall A. Smith, Kendall A. Smith, 2005, Medical immunology.