David Stegner

发表

Cooperative and alternate functions for STIM1 and STIM2 in macrophage activation and in the context of inflammation

B. Nieswandt, R. Schmidt, T. Vögtle, 2015, Immunity, inflammation and disease.

STIM1, STIM2, and Orai1 regulate store‐operated calcium entry and purinergic activation of microglia

J. Eilers, R. Kraft, B. Nieswandt, 2015, Glia.

STIM2 Regulates Capacitive Ca2+ Entry in Neurons and Plays a Key Role in Hypoxic Neuronal Cell Death

J. Eilers, R. Kraft, S. Meuth, 2009, Science Signaling.

Neutrophils mediate edema formation but not mechanical allodynia during zymosan‐induced inflammation

C. Denis, B. Nieswandt, K. Scholich, 2014, Journal of leukocyte biology.

STIM1 is essential for Fcgamma receptor activation and autoimmune inflammation.

B. Nieswandt, T. Vögtle, A. Braun, 2009, Blood.

Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer

Caroline L. Wilson, Patrick M. Helbling, F. Tacke, 2019, Nature Medicine.

Gray platelet syndrome and defective thrombo-inflammation in Nbeal2-deficient mice.

P. Nurden, G. Stoll, B. Nieswandt, 2013, The Journal of clinical investigation.

Coagulation factor XII induces pro-inflammatory cytokine responses in macrophages and promotes atherosclerosis in mice

A. Zernecke, K. Lorenz, B. Nieswandt, 2016, Thrombosis and Haemostasis.

Endothelial Actions of ANP Enhance Myocardial Inflammatory Infiltration in the Early Phase After Acute Infarction.

J. Fischer, M. Kuhn, H. Baba, 2016, Circulation research.

G6b-B regulates an essential step in megakaryocyte maturation

Richa Bharti, Sascha Dietrich, B. Nieswandt, 2021, bioRxiv.

Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott–Aldrich syndrome-like platelet defect

A. Fischer, J. Hartwig, P. Nurden, 2014, Nature Communications.

The Nbeal2−/− mouse as a model for the gray platelet syndrome

P. Nurden, B. Nieswandt, A. Nurden, 2013, Rare diseases.

ANXA7 Regulates Platelet Lipid Metabolism and Ca2+ Release in Arterial Thrombosis

P. Münzer, B. Walker, O. Borst, 2021, Circulation research.

Impaired αIIbβ3 Integrin Activation and Shear-Dependent Thrombus Formation in Mice Lacking Phospholipase D1

G. Stoll, M. Elvers, B. Nieswandt, 2010, Science Signaling.

Thymosin β4 is essential for thrombus formation by controlling the G-actin/F-actin equilibrium in platelets

B. Nieswandt, Z. Nagy, M. Bender, 2021, Haematologica.

Platelets and lymphocytes drive progressive penumbral tissue loss during middle cerebral artery occlusion in mice

G. Stoll, B. Nieswandt, K. Heinze, 2021, Journal of Neuroinflammation.

CD84 Links T Cell and Platelet Activity in Cerebral Thrombo-Inflammation in Acute Stroke

P. Heuschmann, G. Stoll, B. Nieswandt, 2020, Circulation research.

Size does matter: VWF in MI.

B. Nieswandt, D. Stegner, David Stegner, 2012, Blood.

Rac Inhibition Causes Impaired GPVI Signalling in Human Platelets through GPVI Shedding and Reduction in PLCγ2 Phosphorylation

S. Watson, B. Nieswandt, N. Poulter, 2022, International journal of molecular sciences.

Differentially regulated GPVI ectodomain shedding by multiple platelet-expressed proteinases.

J. Scheller, A. Chalaris, S. Rose-John, 2010, Blood.

Generation of Cardiomyocytes From Vascular Adventitia-Resident Stem Cells

M. Dickinson, S. Ergün, E. Wischmeyer, 2018, Circulation research.

XPoRting (poly)phosphates limits thrombosis.

B. Nieswandt, D. Stegner, David Stegner, 2021, Blood.

Mechanistic explanation for platelet contribution to cancer metastasis.

B. Nieswandt, S. Dütting, D. Stegner, 2014, Thrombosis research.

Platelet receptor signaling in thrombus formation

B. Nieswandt, D. Stegner, David Stegner, 2011, Journal of Molecular Medicine.

Roles of Platelet STIM1 and Orai1 in Glycoprotein VI- and Thrombin-dependent Procoagulant Activity and Thrombus Formation*

B. Nieswandt, J. Heemskerk, D. Varga-Szabó, 2010, The Journal of Biological Chemistry.

Phospholipases D1 and D2 Suppress Appetite and Protect against Overweight

G. Sumara, B. Nieswandt, D. Stegner, 2016, PloS one.

Platelets Aggregate With Neutrophils and Promote Skin Pathology in Psoriasis

K. Schäkel, M. Schindler, K. Ghoreschi, 2019, Front. Immunol..

GPVI and Thromboxane Receptor on Platelets Promote Proinflammatory Macrophage Phenotypes during Cutaneous Inflammation.

N. Ferreirós, B. Nieswandt, K. Scholich, 2017, The Journal of investigative dermatology.

Thrombopoiesis is spatially regulated by the bone marrow vasculature

B. Nieswandt, K. Heinze, S. Dütting, 2017, Nature Communications.

CLEC-2 contributes to hemostasis independently of classical hemITAM signaling in mice.

S. Watson, B. Nieswandt, Elizabeth J Haining, 2017, Blood.

expressed proteinases - Differentially regulated GPVI ectodomain shedding by multiple platelet

J. Scheller, A. Chalaris, S. Rose-John, 2011 .

Endothelial TWIK-related potassium channel-1 (TREK1) regulates immune-cell trafficking into the CNS

H. Pape, H. Wiendl, S. Meuth, 2013, Nature Medicine.

Protein kinase Cι/λ is dispensable for platelet function in thrombosis and hemostasis in mice.

M. Leitges, D. Stegner, Sarah Beck, 2017, Cellular signalling.

Impaired brain development and reduced cognitive function in phospholipase D-deficient mice

E. Hattingen, B. Nieswandt, D. Stegner, 2014, Neuroscience Letters.

Platelet glycoprotein VI promotes metastasis through interaction with cancer cell-derived Galectin-3.

T. Dandekar, P. Nurden, B. Nieswandt, 2020, Blood.

Pharmacological Inhibition of Phospholipase D Protects Mice From Occlusive Thrombus Formation and Ischemic Stroke—Brief Report

G. Stoll, B. Nieswandt, M. Frohman, 2013, Arteriosclerosis, thrombosis, and vascular biology.

Analysis of the role of von Willebrand factor, platelet glycoprotein VI-, and α2β1-mediated collagen binding in thrombus formation.

B. Nieswandt, D. Lillicrap, Kate Sponagle, 2014, Blood.

THROMBOSIS AND HEMOSTASIS Analysis of the role of von Willebrand factor , platelet glycoprotein VI-, and a 2 b 1-mediated collagen binding in thrombus formation

B. Nieswandt, D. Lillicrap, Kate Sponagle, 2014 .

BIN2 orchestrates platelet calcium signaling in thrombosis and thrombo-inflammation.

M. Sauer, G. Stoll, A. Sickmann, 2020, The Journal of clinical investigation.

Loss of Orai2-Mediated Capacitative Ca2+ Entry Is Neuroprotective in Acute Ischemic Stroke.

K. Lesch, R. Kraft, S. Meuth, 2019, Stroke.

Subthreshold IKK activation modulates the effector functions of primary mast cells and allows specific targeting of transformed mast cells

F. Greten, B. Nieswandt, T. Herdegen, 2015, Oncotarget.

STIM1 is essential for Fcreceptor activation and autoimmune inflammation

B. Nieswandt, R. Schmidt, D. Varga-Szabó, 2013 .

COVID‐19 mRNA vaccine‐associated cerebral venous thrombosis: Rare adverse event or coincidence?

D. Stegner, T. Tu, V. Chadachan, 2022, American journal of hematology.

Congenital valvular defects associated with deleterious mutations in the PLD1 gene

Milena B. Furtado, N. Rosenthal, A. Neiman, 2016, Journal of Medical Genetics.

STIM 2 Regulates Capacitive Ca 2 + Entry in Neurons and Plays a Key Role in Hypoxic Neuronal Cell Death

J. Eilers, R. Kraft, S. Meuth, 2009 .

Platelet-neutrophil aggregates promote skin pathology in psoriasis

K. Schäkel, M. Schindler, K. Ghoreschi, 2019, bioRxiv.

Comparative Analysis of Microfluidics Thrombus Formation in Multiple Genetically Modified Mice: Link to Thrombosis and Hemostasis

M. Elvers, B. Nieswandt, K. Kunzelmann, 2019, Front. Cardiovasc. Med..

Redundant functions of phospholipases D1 and D2 in platelet α‐granule release

G. Stoll, B. Nieswandt, G. Krohne, 2012, Journal of thrombosis and haemostasis : JTH.

Mapping densely packed αIIbβ3 receptors in murine blood platelets with expansion microscopy

B. Nieswandt, K. Heinze, D. Stegner, 2022, Platelets.

Foudroyant cerebral venous (sinus) thrombosis triggered through CLEC-2 and GPIIb/IIIa dependent platelet activation

A. Zernecke, G. Stoll, B. Nieswandt, 2022, Nature Cardiovascular Research.

Mapping densely packed GPIIb/IIIa receptors in murine blood platelets with expansion microscopy

B. Nieswandt, M. Aigner, K. Heinze, 2021, bioRxiv.

Mapping densely distributed membrane receptors in blood platelets with expansion microscopy

B. Nieswandt, K. Heinze, M. Meub, 2021 .

SePARating thrombosis and hemostasis?

D. Stegner, David Stegner, 2016, Thrombosis research.

Thrombus Formation in Mice Lacking Phospholipase D 1 Impaired { alpha } IIb { beta } 3 Integrin Activation and Shear-Dependent

G. Stoll, M. Elvers, B. Nieswandt, 2009 .

Role of Tyrosine Kinase Syk in Thrombus Stabilisation at High Shear

S. Watson, J. Heemskerk, Mark R Thomas, 2022, International journal of molecular sciences.

Temporal Roles of Platelet and Coagulation Pathways in Collagen- and Tissue Factor-Induced Thrombus Formation

B. Nieswandt, J. Heemskerk, D. Stegner, 2021, International journal of molecular sciences.

CK2β regulates thrombopoiesis and Ca2+-triggered platelet activation in arterial thrombosis.

P. Münzer, O. Borst, M. Gawaz, 2017, Blood.

Megakaryocyte volume modulates bone marrow niche properties and cell migration dynamics

K. Heinze, D. Stegner, Maximilian G. Gorelashvili, 2019, Haematologica.

Intravital imaging of megakaryocytes

K. Heinze, D. Stegner, David Stegner, 2020, Platelets.

Comprehensive analysis of the role of von Willebrand factor and platelet glycoprotein VI-and α 2 β 1-mediated collagen binding in thrombus formation

B. Nieswandt, D. Lillicrap, Kate Sponagle, 2014 .

Altered BCR signalling quality predisposes to autoimmune disease and a pre‐diabetic state

B. Nieswandt, M. Stehling, T. Schumacher, 2012, The EMBO journal.

PLD1 participates in BDNF-induced signalling in cortical neurons

N. Vitale, B. Nieswandt, A. Hanauer, 2015, Scientific Reports.

Experimental validation of computerised models of clustering of platelet glycoprotein receptors that signal via tandem SH2 domain proteins

Natalie S. Poulter, D. Owen, S. Watson, 2022, PLoS Comput. Biol..

Blockade of Platelet Glycoprotein Ibα Augments Neuroprotection in Orai2-Deficient Mice during Middle Cerebral Artery Occlusion

G. Stoll, B. Nieswandt, K. Heinze, 2022, International journal of molecular sciences.

FcγRIIB on liver sinusoidal endothelial cells is essential for antibody-induced GPVI ectodomain shedding in mice.

B. Nieswandt, Viola Lorenz, Michael Popp, 2016, Blood.

Platelets as Modulators of Cerebral Ischemia/Reperfusion Injury

B. Nieswandt, D. Stegner, V. Klaus, 2019, Front. Immunol..

Targeting Glycoprotein VI and the Immunoreceptor Tyrosine-Based Activation Motif Signaling Pathway

B. Nieswandt, Elizabeth J Haining, David Stegner, 2014, Arteriosclerosis, thrombosis, and vascular biology.

Munc13‐4‐mediated secretion is essential for infarct progression but not intracranial hemostasis in acute stroke

G. Stoll, B. Nieswandt, C. Kleinschnitz, 2013, Journal of thrombosis and haemostasis : JTH.

Imaging platelet biogenesis in vivo

H. Schulze, D. Stegner, David Stegner, 2018, Research and practice in thrombosis and haemostasis.

Targeted downregulation of platelet CLEC-2 occurs through Syk-independent internalization.

B. Walzog, S. Watson, B. Nieswandt, 2015, Blood.

Normal Platelet Integrin Function in Mice Lacking Hydrogen Peroxide-Induced Clone-5 (Hic-5)

B. Nieswandt, D. Stegner, Michael Popp, 2015, PloS one.

Optical Clearing of Murine Bones to Study Megakaryocytes in Intact Bone Marrow Using Light-Sheet Fluorescence Microscopy.

K. Heinze, D. Stegner, Maximilian G. Gorelashvili, 2018, Methods in molecular biology.

Pivotal Role of PDK1 in Megakaryocyte Cytoskeletal Dynamics and Polarization during Platelet Biogenesis.

P. Münzer, O. Borst, M. Gawaz, 2019, Blood.

ADAP deficiency impairs megakaryocyte polarization with ectopic proplatelet release and causes microthrombocytopenia.

P. Nurden, B. Nieswandt, M. Bender, 2018, Blood.

Corrigendum: Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott–Aldrich syndrome-like platelet defect

A. Fischer, J. Hartwig, P. Nurden, 2014, Nature Communications.

Phospholipase D is a central regulator of collagen I‐induced cytoskeletal rearrangement and podosome formation in megakaryocytes

David Stegner, Simon Stritt, Sebastian Dütting, 2014, Journal of thrombosis and haemostasis : JTH.

deficiency impairs megakaryocyte polarization with ectopic proplatelet release and causes microthrombocytopenia Short running title : Role of ADAP in platelet formation

P. Nurden, B. Nieswandt, M. Bender, 2018 .

Platelet‐derived lipids promote insulin secretion of pancreatic β cells

G. Sumara, P. Rorsman, B. Nieswandt, 2023, EMBO molecular medicine.

Stromal Interaction Molecules 1 and 2 Are Key Regulators of Autoreactive T Cell Activation in Murine Autoimmune Central Nervous System Inflammation

H. Wiendl, S. Meuth, G. Stoll, 2009, The Journal of Immunology.

Critical shifts in lipid metabolism promote megakaryocyte differentiation and proplatelet formation

P. Münzer, O. Borst, M. Gawaz, 2023, Nature Cardiovascular Research.

Neutrophil “plucking” on megakaryocytes drives platelet production and boosts cardiovascular disease

C. Gieger, I. Almendros, M. Schmidt-Supprian, 2022, Immunity.

Targeting platelet glycoprotein VI attenuates progressive ischemic brain damage before recanalization during middle cerebral artery occlusion in mice

G. Stoll, B. Nieswandt, M. Pham, 2021, Experimental Neurology.

Orai1 controls C5a‐induced neutrophil recruitment in inflammation

B. Nieswandt, R. Schmidt, T. Vögtle, 2015, European journal of immunology.

A Cdc42/RhoA regulatory circuit downstream of glycoprotein Ib guides transendothelial platelet biogenesis

P. Nurden, B. Nieswandt, S. Stritt, 2017, Nature Communications.

Cytoskeletal-based mechanisms differently regulate in vivo and in vitro proplatelet formation

C. Gachet, A. Eckly, C. Léon, 2020, Haematologica.

TMEM16F-Mediated Platelet Membrane Phospholipid Scrambling Is Critical for Hemostasis and Thrombosis but not Thromboinflammation in Mice—Brief Report

B. Nieswandt, K. Kunzelmann, J. Heemskerk, 2016, Arteriosclerosis, thrombosis, and vascular biology.

Isolation of murine bone marrow by centrifugation or flushing for the analysis of hematopoietic cells – a comparative study

I. Pleines, D. Stegner, Martha-Lena Müller, 2020, Platelets.

The bone marrow is the primary site of thrombopoiesis.

J. Italiano, K. Machlus, N. Asquith, 2023, Blood.

The Neurobeachin-like 2 Protein Regulates Mast Cell Homeostasis

B. Nieswandt, T. Kamradt, D. Stegner, 2017, The Journal of Immunology.

This information is current as Mast Cell Homeostasis The Neurobeachin-like 2 Protein Regulates

B. Nieswandt, T. Kamradt, D. Stegner, 2017 .

Cholesterol loss during glutamate‐mediated excitotoxicity

Marta Pallotto, J. Brouwers, J. Helms, 2012, The EMBO journal.

Orai1‐induced store‐operated Ca2+ entry enhances phospholipase activity and modulates canonical transient receptor potential channel 6 function in murine platelets

H. Hermanns, B. Nieswandt, S. Gambaryan, 2014, Journal of thrombosis and haemostasis : JTH.

The homophilic CD84 receptor is upregulated on platelets in COVID-19 and sepsis

B. Nieswandt, D. Weismann, H. Schulze, 2022, Thrombosis Research.

Model systems for platelet receptor shedding

B. Nieswandt, M. Bender, D. Stegner, 2017, Platelets.

Generation of a humanized FXII knock‐in mouse—A powerful model system to test novel anti‐thrombotic agents

A. Sickmann, B. Nieswandt, S. Loroch, 2021, Journal of thrombosis and haemostasis : JTH.

Targeting of a Conserved Epitope in Mouse and Human GPVI Differently Affects Receptor Function

B. Nieswandt, J. Heemskerk, D. Stegner, 2022, International journal of molecular sciences.

The humanized platelet glycoprotein VI Fab inhibitor EMA601 protects from arterial thrombosis and ischaemic stroke in mice

Stefano Navarro, S. Beck, Vanessa Göb, 2024, European heart journal.