David R. Loiselle

发表

Selective roles for tumor necrosis factor alpha-converting enzyme/ADAM17 in the shedding of the epidermal growth factor receptor ligand family: the juxtamembrane stalk determines cleavage efficiency.

David C. Lee, S. Sunnarborg, C. Hinkle, 2004, The Journal of biological chemistry.

The RNA-binding protein Fus directs translation of localized mRNAs in APC-RNP granules

T. Haystead, S. Mili, I. Macara, 2013, The Journal of cell biology.

Transcription factor–driven alternative localization of Cryptococcus neoformans superoxide dismutase

D. Thiele, D. Loiselle, T. Haystead, 2021, The Journal of biological chemistry.

Optical and radioiodinated tethered Hsp90 inhibitors reveal selective internalization of ectopic Hsp90 in malignant breast tumor cells.

Philip F. Hughes, T. Haystead, L. Neckers, 2013, Chemistry & biology.

Tethered Hsp90 Inhibitors Carrying Optical or Radioiodinated Probes Reveal Selective Internalization of Ectopic Hsp90 in Malignant Breast Tumor Cells

Philip F. Hughes, L. Neckers, N. Ramanujam, 2013 .

Targeting therapy-resistant prostate cancer via a direct inhibitor of the human heat shock transcription factor 1

Philip F. Hughes, D. Thiele, Jiaoti Huang, 2020, Science Translational Medicine.

Takinib, a Selective TAK1 Inhibitor, Broadens the Therapeutic Efficacy of TNF-α Inhibition for Cancer and Autoimmune Disease.

Timothy A J Haystead, Asim K Bera, Philip F. Hughes, 2017, Cell chemical biology.

Identification of components of protein complexes.

Christoph H Borchers, Carol E Parker, C. Borchers, 2005, Methods in molecular biology.

Phosphatidylinositol 3-phosphate and Hsp70 protect Plasmodium falciparum from heat-induced cell death

D. Loiselle, J. Niles, E. Derbyshire, 2020, bioRxiv.

Pregnancy and Smoothelin-like Protein 1 (SMTNL1) Deletion Promote the Switching of Skeletal Muscle to a Glycolytic Phenotype in Human and Mice*

T. Haystead, D. Zheng, D. Loiselle, 2015, The Journal of Biological Chemistry.

Identification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70.

Philip F. Hughes, D. Thiele, David B. Darr, 2014, Chemistry & biology.

Identiﬁcation of an Allosteric Small-Molecule Inhibitor Selective for the Inducible Form of Heat Shock Protein 70

Philip F. Hughes, D. Thiele, David B. Darr, 2014 .

A highly selective Hsp90 affinity chromatography resin with a cleavable linker.

Philip F. Hughes, T. Haystead, L. Rund, 2012, Bioorganic & medicinal chemistry.

Smoothelin-like 1 Protein Regulates Myosin Phosphatase-targeting Subunit 1 Expression during Sexual Development and Pregnancy*

T. Haystead, D. Zheng, D. Loiselle, 2010, The Journal of Biological Chemistry.

The tumor suppressor folliculin inhibits lactate dehydrogenase A and regulates the Warburg effect

W. Linehan, L. Schmidt, W. Stetler-Stevenson, 2021, Nature Structural & Molecular Biology.

Genetic and pharmacological validation of TAK1 inhibition in macrophages as a therapeutic strategy to effectively inhibit TNF secretion

Philip F. Hughes, D. Loiselle, T. Haystead, 2018, Scientific Reports.

Fasnall, a Selective FASN Inhibitor, Shows Potent Anti-tumor Activity in the MMTV-Neu Model of HER2(+) Breast Cancer.

Timothy A J Haystead, Laura G. Dubois, Philip F. Hughes, 2016, Cell chemical biology.

An inducible heat shock protein 70 small molecule inhibitor demonstrates anti-dengue virus activity, validating Hsp70 as a host antiviral target.

Philip F. Hughes, T. Haystead, S. Vasudevan, 2016, Antiviral research.

ROCK1 Phosphorylates and Activates Zipper-interacting Protein Kinase*

Matthew H. Brush, T. Haystead, D. Loiselle, 2007, Journal of Biological Chemistry.

Cellular fatty acid synthase is required for late stages of HIV-1 replication

Philip F. Hughes, T. Haystead, J. Arcos, 2017, Retrovirology.

A bioorthogonal chemical reporter for fatty acid synthase–dependent protein acylation

T. Haystead, D. Loiselle, J. Yount, 2021, bioRxiv.

Smoothelin-like 1 Protein Is a Bifunctional Regulator of the Progesterone Receptor during Pregnancy*

D. Loiselle, T. Haystead, S. Lengyel, 2011, The Journal of Biological Chemistry.

Efficient detection of RNA–protein interactions using tethered RNAs

T. Haystead, I. Macara, D. Loiselle, 2011, Nucleic acids research.

Post-translational Regulation of FNIP1 Creates a Rheostat for the Molecular Chaperone Hsp90

W. Linehan, L. Schmidt, T. Haystead, 2019, Cell reports.

Progressive Rod-Cone Degeneration (PRCD) Protein Requires N-Terminal S-Acylation and Rhodopsin Binding for Photoreceptor Outer Segment Localization and Maintaining Intracellular Stability.

V. Arshavsky, N. Skiba, D. Loiselle, 2016, Biochemistry.

Phosphorylation and Ubiquitination Regulate Protein Phosphatase 5 Activity and Its Prosurvival Role in Kidney Cancer.

D. Bourboulia, A. Truman, T. Haystead, 2017, Cell reports.

The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding

Philip F. Hughes, L. Schmidt, T. Haystead, 2016, Nature Communications.