J. Kelly

J. Kelly, Y. Sekijima, Maria T A Dendle, 2006, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.

The V122I cardiomyopathy variant of transthyretin increases the velocity of rate-limiting tetramer dissociation, resulting in accelerated amyloidosis

J. Kelly, J. Buxbaum, X. Jiang, 2001, Proceedings of the National Academy of Sciences of the United States of America.

The core trisaccharide of an N-linked glycoprotein intrinsically accelerates folding and enhances stability

Chi‐Huey Wong, J. Kelly, E. Powers, 2009, Proceedings of the National Academy of Sciences.

Antibody Domain Exchange Is an Immunological Solution to Carbohydrate Cluster Recognition

Ping Zhu, Renate Kunert, Pauline M. Rudd, 2003, Science.

Structural and energetic basis of carbohydrate-aromatic packing interactions in proteins.

H. Dyson, Chi‐Huey Wong, Wentao Chen, 2013, Journal of the American Chemical Society.

Protein Native-State Stabilization by Placing Aromatic Side Chains in N-Glycosylated Reverse Turns

Chi-Huey Wong, Martin Gruebele, M. Gruebele, 2011, Science.

Biochemical Properties of Highly Neuroinvasive Prion Strains

E. Masliah, C. Sigurdson, P. Liberski, 2012, PLoS pathogens.

Individual and collective contributions of chaperoning and degradation to protein homeostasis in E. coli.

L. Gierasch, J. Kelly, E. Powers, 2015, Cell reports.

Trans-Suppression of Misfolding in an Amyloid Disease

J. Kelly, Per Hammarström, F. Schneider, 2001, Science.

A chemical approach to elucidate tin mechanism of transthyretin and β-protein amyloid fibril formation

P. Lansbury, J. Kelly, J. Kelly, 1994 .

Toward the molecular mechanism(s) by which EGCG treatment remodels mature amyloid fibrils.

J. Kelly, N. Grimster, Jiyong Lee, 2013, Journal of the American Chemical Society.

AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin

I. Graef, I. Wilson, M. Liedtke, 2013, Proceedings of the National Academy of Sciences.

Mechanisms of transthyretin cardiomyocyte toxicity inhibition by resveratrol analogs.

J. Kelly, Sungwook Choi, S. Bourgault, 2011, Biochemical and biophysical research communications.

Long-term effects of tafamidis for the treatment of transthyretin familial amyloid polyneuropathy

Teresa Coelho, R. Labaudinière, J. Kelly, 2013, Journal of Neurology.

Conformational differences between the wild type and V30M mutant transthyretin modulate its binding to genistein: implications to tetramer stability and ligand-binding.

J. Kelly, I. Polikarpov, D. Foguel, 2010, Journal of structural biology.

Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidoses.

Steven M. Johnson, Ian A Wilson, I. Wilson, 2010, Current opinion in structural biology.

Genistein, a natural product from soy, is a potent inhibitor of transthyretin amyloidosis.

J. Kelly, T. Foss, N. S. Green, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Native state kinetic stabilization as a strategy to ameliorate protein misfolding diseases: a focus on the transthyretin amyloidoses.

Steven M. Johnson, J. Kelly, R. L. Wiseman, 2005, Accounts of chemical research.

Native state stabilization by NSAIDs inhibits transthyretin amyloidogenesis from the most common familial disease variants

J. Kelly, Y. Sekijima, Sean R. Miller, 2004, Laboratory Investigation.

Hydration and packing are crucial to amyloidogenesis as revealed by pressure studies on transthyretin variants that either protect or worsen amyloid disease.

J. Kelly, H. Lashuel, D. Foguel, 2003, Journal of molecular biology.

Pharmacologic Approaches for Adapting Proteostasis in the Secretory Pathway to Ameliorate Protein Conformational Diseases.

J. Kelly, J. Kelly, 2019, Cold Spring Harbor perspectives in biology.

Modulating protein quality control

J. Kelly, R. L. Wiseman, L. Plate, 2016, eLife.

Phosphatase Inhibition Delays Translational Recovery

J. Kelly, R. L. Wiseman, R. Wiseman, 2011, Science.

and Prognosis Progress − Ameliorate Protein Misfolding and Aggregation Diseases Chemical and Biological Approaches for Adapting Proteostasis to service

S. Lindquist, J. Kelly, J. Kelly, 2011 .

Structural Characterization of Cardiac ex vivo Transthyretin Amyloid: Insight into Transthyretin Misfolding Pathway in vivo.

R. Griffin, J. Kelly, I. Hung, 2020, Biochemistry.

NMR Measurements Reveal the Structural Basis of Transthyretin Destabilization by Pathogenic Mutations.

H. Dyson, P. Wright, J. Kelly, 2018, Biochemistry.

Localized structural fluctuations promote amyloidogenic conformations in transthyretin.

H. Dyson, P. Wright, J. Kelly, 2013, Journal of molecular biology.

A glimpse of a possible amyloidogenic intermediate of transthyretin

D. Wemmer, J. Kelly, H. Lashuel, 2000, Nature Structural Biology.

Influence of the N‐terminal domain on the aggregation properties of the prion protein

J. Kelly, E. Powers, Kristen N Frankenfield, 2005, Protein science : a publication of the Protein Society.

Tafamidis concentration required for transthyretin stabilisation in cerebrospinal fluid

J. Kelly, E. Powers, T. Coelho, 2023, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.

Tafamidis polyneuropathy amelioration requires modest increases in transthyretin stability even though increases in plasma native TTR and decreases in non-native TTR do not predict response

J. Kelly, E. Powers, J. Fernandes, 2022, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.

ATF6 Activation Reduces Amyloidogenic Transthyretin Secretion through Increased Interactions with Endoplasmic Reticulum Proteostasis Factors

J. Kelly, Joseph C. Genereux, R. L. Wiseman, 2022, bioRxiv.

Blinded potency comparison of transthyretin kinetic stabilisers by subunit exchange in human plasma

J. Kelly, E. Powers, Ryan J. Paxman, 2020, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.

Brain Permeable Tafamidis Amide Analogs for Stabilizing TTR and Reducing APP Cleavage.

P. Greengard, Weilin Sun, J. Kelly, 2020, ACS medicinal chemistry letters.

Predictive model of response to tafamidis in hereditary ATTR polyneuropathy.

E. Powers, J. Fernandes, T. Coelho, 2019, JCI insight.

Cerebrospinal fluid and vitreous body exposure to orally administered tafamidis in hereditary ATTRV30M (p.TTRV50M) amyloidosis patients

J. Kelly, T. Coelho, C. Monteiro, 2018, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.

Fluorescence Turn-On Folding Sensor To Monitor Proteome Stress in Live Cells

Wentao Chen, J. Kelly, Yu Liu, 2015, Journal of the American Chemical Society.

A fluorogenic aryl fluorosulfate for intraorganellar transthyretin imaging in living cells and in Caenorhabditis elegans.

I. Wilson, J. Kelly, Yvonne S. Eisele, 2015, Journal of the American Chemical Society.

Fluorogenic small molecules requiring reaction with a specific protein to create a fluorescent conjugate for biological imaging–what we know and what we need to learn

I. Wilson, J. Kelly, E. Powers, 2014, Biopolymers.

Stilbene vinyl sulfonamides as fluorogenic sensors of and traceless covalent kinetic stabilizers of transthyretin that prevent amyloidogenesis.

I. Wilson, J. Kelly, Joseph C. Genereux, 2013, Journal of the American Chemical Society.

Bifunctional coumarin derivatives that inhibit transthyretin amyloidogenesis and serve as fluorescent transthyretin folding sensors.

I. Wilson, J. Kelly, Sungwook Choi, 2013, Chemical communications.

Aromatic sulfonyl fluorides covalently kinetically stabilize transthyretin to prevent amyloidogenesis while affording a fluorescent conjugate.

I. Wilson, E. Powers, N. Grimster, 2013, Journal of the American Chemical Society.

Development of Therapeutic Strategies for the Transthyretin Amyloidoses

J. Kelly, E. Powers, C. Fearns, 2013 .

A competition assay to identify amyloidogenesis inhibitors by monitoring the fluorescence emitted by the covalent attachment of a stilbene derivative to transthyretin.

J. Kelly, Sungwook Choi, J. Kelly, 2011, Bioorganic & medicinal chemistry.

A substructure combination strategy to create potent and selective transthyretin kinetic stabilizers that prevent amyloidogenesis and cytotoxicity.

Steven M. Johnson, I. Wilson, J. Kelly, 2010, Journal of the American Chemical Society.

Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma.

I. Wilson, J. Kelly, Sungwook Choi, 2010, Nature chemical biology.

Toward optimization of the linker substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies.

Steven M. Johnson, I. Wilson, J. Kelly, 2008, Journal of medicinal chemistry.

Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors.

Steven M. Johnson, I. Wilson, J. Kelly, 2008, Journal of medicinal chemistry.

Potent and selective structure-based dibenzofuran inhibitors of transthyretin amyloidogenesis: kinetic stabilization of the native state.

Steven M. Johnson, K. Chiang, E. Powers, 2005, Journal of the American Chemical Society.

Kinetic stabilization of the native state by protein engineering: implications for inhibition of transthyretin amyloidogenesis.

I. Wilson, J. Kelly, R. L. Wiseman, 2005, Journal of molecular biology.

Kinetic stabilization of an oligomeric protein by a single ligand binding event.

Steven M. Johnson, Ian A Wilson, I. Wilson, 2005, Journal of the American Chemical Society.

Bisaryloxime ethers as potent inhibitors of transthyretin amyloid fibril formation.

Steven M. Johnson, J. Sacchettini, K. Chiang, 2005, Journal of medicinal chemistry.

Hydroxylated polychlorinated biphenyls selectively bind transthyretin in blood and inhibit amyloidogenesis: rationalizing rodent PCB toxicity.

J. Sacchettini, S. Safe, J. Kelly, 2004, Chemistry & biology.

Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis.

James C Sacchettini, J. Sacchettini, J. Kelly, 2004, Journal of medicinal chemistry.

Synthesis and characterization of potent bivalent amyloidosis inhibitors that bind prior to transthyretin tetramerization.

J. Sacchettini, J. Kelly, S. Palaninathan, 2003, Journal of the American Chemical Society.

Benzoxazoles as transthyretin amyloid fibril inhibitors: synthesis, evaluation, and mechanism of action.

J. Sacchettini, J. Kelly, K. Chiang, 2003, Angewandte Chemie.

Prevention of Transthyretin Amyloid Disease by Changing Protein Misfolding Energetics

J. Kelly, E. Powers, R. L. Wiseman, 2003, Science.

Anion shielding of electrostatic repulsions in transthyretin modulates stability and amyloidosis: insight into the chaotrope unfolding dichotomy.

J. Kelly, P. Hammarström, S. Deechongkit, 2001, Biochemistry.

Evaluating the binding selectivity of transthyretin amyloid fibril inhibitors in blood plasma

J. Kelly, Michael I Dorrell, Michael I. Dorrell, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Synthesis and evaluation of inhibitors of transthyretin amyloid formation based on the non-steroidal anti-inflammatory drug, flufenamic acid.

Scott A. Peterson, J. Kelly, P. Baures, 1999, Bioorganic & medicinal chemistry.

Synthesis and evaluation of anthranilic acid-based transthyretin amyloid fibril inhibitors.

J. Kelly, V. Oza, Vibha B. Oza, 1999, Bioorganic & medicinal chemistry letters.

Guanidine hydrochloride-induced denaturation and refolding of transthyretin exhibits a marked hysteresis: equilibria with high kinetic barriers.

J. Kelly, H. Lashuel, J. Mcculloch, 1997, Biochemistry.

Amyloid diseases: abnormal protein aggregation in neurodegeneration.

P. Lansbury, J. Kelly, E. Koo, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Localized Thermodynamic Coupling between Hydrogen Bonding and Microenvironment Polarity Substantially Stabilizes Proteins

Jianmin Gao, D. A. Bosco, J. Kelly, 2009, Nature Structural &Molecular Biology.

Toward quantification of protein backbone–backbone hydrogen bonding energies: An energetic analysis of an amide‐to‐ester mutation in an α‐helix within a protein

Jianmin Gao, J. Kelly, 2008, Protein science : a publication of the Protein Society.

Amide-to-E-olefin versus amide-to-ester backbone H-bond perturbations: Evaluating the O-O repulsion for extracting H-bond energies.

J. Kelly, J. Bieschke, Jianmin Gao, 2006, Journal of the American Chemical Society.

Alzheimer's Abeta peptides containing an isostructural backbone mutation afford distinct aggregate morphologies but analogous cytotoxicity. Evidence for a common low-abundance toxic structure(s)?

J. Kelly, J. Bieschke, Yanwen Fu, 2008, Biochemistry.

The 8 and 5 kDa fragments of plasma gelsolin form amyloid fibrils by a nucleated polymerization mechanism, while the 68 kDa fragment is not amyloidogenic.

E. Powers, W. Balch, Isaac T. Yonemoto, 2009, Biochemistry.

Heparin accelerates gelsolin amyloidogenesis.

J. Kelly, R. Linhardt, W. Balch, 2006, Biochemistry.

Metalloendoprotease cleavage triggers gelsolin amyloidogenesis

John D. Venable, J. Yates, J. Kelly, 2005, The EMBO journal.

A cross‐strand Trp–Trp pair stabilizes the hPin1 WW domain at the expense of function

Amelia A. Fuller, J. Kelly, M. Jäger, 2007, Protein science : a publication of the Protein Society.

Mechanisms of Transthyretin Inhibition of β-Amyloid Aggregation In Vitro

P. Wright, Xin Zhang, J. Kelly, 2013, The Journal of Neuroscience.

A biomimetic synthesis of thiazolines using hexaphenyloxodiphosphonium trifluoromethanesulfonate.

J. Kelly, S. You, H. Razavi, 2003, Angewandte Chemie.

Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue.

I. Wilson, B. Cravatt, Wentao Chen, 2016, Journal of the American Chemical Society.

Unfolded protein response activation reduces secretion and extracellular aggregation of amyloidogenic immunoglobulin light chain

Lisa M. Ryno, J. Kelly, R. L. Wiseman, 2014, Proceedings of the National Academy of Sciences.

Stress-independent activation of XBP1s and/or ATF6 reveals three functionally diverse ER proteostasis environments.

Lisa M. Ryno, A. Su, J. Yates, 2013, Cell reports.

Translation efficiency is maintained at elevated temperature in Escherichia coli

David H Burkhardt, David H. Burkhardt, J. Kelly, 2017, The Journal of Biological Chemistry.

Translation efficiency is maintained at elevated temperature in E. coli

David H Burkhardt, David H. Burkhardt, J. Kelly, 2017, bioRxiv.

N-terminal Domains Elicit Formation of Functional Pmel17 Amyloid Fibrils*

D. Fowler, J. Kelly, G. Raposo, 2009, The Journal of Biological Chemistry.

Characterization of the WW Domain of Human Yes-associated Protein and Its Polyproline-containing Ligands*

Scott A. Peterson, M. Sudol, J. Kelly, 1997, The Journal of Biological Chemistry.

Metabolite-initiated protein misfolding may trigger Alzheimer's disease.

R. Lerner, J. Nieva, J. Kelly, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Toward assessing the position-dependent contributions of backbone hydrogen bonding to beta-sheet folding thermodynamics employing amide-to-ester perturbations.

J. Kelly, P. Dawson, S. Deechongkit, 2004, Journal of the American Chemical Society.

The oxidative stress metabolite 4-hydroxynonenal promotes Alzheimer protofibril formation.

J. Kelly, E. Powers, J. Bieschke, 2007, Biochemistry.

2,2,2-Triphenyl-4,5-(2',2"-biphenylene)-1,3,2-dioxaphospholane: an effective reagent for converting diols, amino alcohols, and especially mercapto alcohols to the corresponding heterocycles

S. Evans, P. Robinson, J. Kelly, 1986 .

Fourier transform infrared spectroscopy provides a fingerprint for the tetramer and for the aggregates of transthyretin.

J. Kelly, Y. Cordeiro, D. Foguel, 2006, Biophysical journal.

Inhibiting transthyretin amyloid fibril formation via protein stabilization.

Scott A. Peterson, J. Kelly, S. Peterson, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Deducing the presence of proteins and proteoforms in quantitative proteomics

J. Yates, J. Kelly, S. Martínez-Bartolomé, 2018, Nature Communications.

Structure-based design and analysis of SuFEx chemical probes.

J. Kelly, L. Jones, J. Kelly, 2020, RSC medicinal chemistry.

Isofagomine- and 2,5-anhydro-2,5-imino-D-glucitol-based glucocerebrosidase pharmacological chaperones for Gaucher disease intervention.

Chi‐Huey Wong, J. Kelly, A. Sawkar, 2007, Journal of medicinal chemistry.

Chemical chaperones and permissive temperatures alter localization of Gaucher disease associated glucocerebrosidase variants.

Klaus-Peter Zimmer, J. Kelly, W. Balch, 2006, ACS chemical biology.

The Yin-Yang of Sirtuins

J. Kelly, A. Dillin, J. Kelly, 2007, Science.

WW: An isolated three‐stranded antiparallel β‐sheet domain that unfolds and refolds reversibly; evidence for a structured hydrophobic cluster in urea and GdnHCl and a disordered thermal unfolded state

M. Sudol, J. Kelly, E. Koepf, 2008, Protein science : a publication of the Protein Society.

Protein misfolding diseases : current and emerging principles and therapies

C. Dobson, J. Kelly, M. Ramirez-Alvarado, 2010 .

A fundamental protein property, thermodynamic stability, revealed solely from large-scale measurements of protein function

S. Fields, D. Fowler, C. Araya, 2012, Proceedings of the National Academy of Sciences.

Semi-quantitative models for identifying potent and selective transthyretin amyloidogenesis inhibitors.

Steven M. Johnson, I. Wilson, E. Powers, 2017, Bioorganic & medicinal chemistry letters.

Mechanism of Action and Clinical Application of Tafamidis in Hereditary Transthyretin Amyloidosis

R. Labaudinière, D. Judge, M. Maurer, 2016, Neurology and Therapy.

Screening transthyretin amyloid fibril inhibitors: characterization of novel multiprotein, multiligand complexes by mass spectrometry.

H. M. Petrassi, L. Greene, C. Robinson, 2002, Structure.

Inhibiting transthyretin conformational changes that lead to amyloid fibril formation.

Scott A. Peterson, T. Klabunde, J. Sacchettini, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Glycosylation of the enhanced aromatic sequon is similarly stabilizing in three distinct reverse turn contexts

E. Powers, D. Powers, J. L. Price, 2011, Proceedings of the National Academy of Sciences.

Enhanced Aromatic Sequons Increase Oligosaccharyltransferase Glycosylation Efficiency and Glycan Homogeneity.

Wentao Chen, E. Powers, A. Dell, 2015, Chemistry & biology.

Divergent Proteome Reactivity Influences Arm-Selective Activation of Pharmacological Endoplasmic Reticulum Proteostasis Regulators

J. Kelly, E. Powers, R. L. Wiseman, 2023, bioRxiv.

Age-dependent cognitive dysfunction in untreated hereditary transthyretin amyloidosis

J. Kelly, S. Cavaco, J. Fernandes, 2018, Journal of Neurology.

Compromised mutant EFEMP1 secretion associated with macular dystrophy remedied by proteostasis network alteration

S. Kaushal, J. Kelly, W. Balch, 2011, Molecular biology of the cell.

Context-dependent effects of asparagine glycosylation on Pin WW folding kinetics and thermodynamics.

M. Gruebele, E. Powers, Y. Levy, 2010, Journal of the American Chemical Society.

Sequence determinants of thermodynamic stability in a WW domain—An all‐β‐sheet protein

J. Kelly, M. Jäger, Maria T A Dendle, 2009, Protein science : a publication of the Protein Society.

Light Chain Stabilization: A Therapeutic Approach to Ameliorate AL Amyloidosis

J. Kelly, G. Morgan, J. Buxbaum, 2021, Hemato.

A circulating, disease-specific, mechanism-linked biomarker for ATTR polyneuropathy diagnosis and response to therapy prediction

R. Labaudinière, J. Kelly, T. Coelho, 2021, Proceedings of the National Academy of Sciences.

Disruption of the CD loop by Enzymatic Cleavage Promotes the Formation of Toxic Transthyretin Oligomers through a Common Transthyretin Misfolding Pathway.

R. Griffin, J. Kelly, K. Lim, 2020, Biochemistry.

Peptide probes detect misfolded transthyretin oligomers in plasma of hereditary amyloidosis patients

B. Cravatt, J. Kelly, Yvonne S. Eisele, 2017, Science Translational Medicine.

Transthyretin Proteins Regulate Angiogenesis by Conferring Different Molecular Identities to Endothelial Cells*

J. Kelly, J. Becker, P. Marcelino, 2013, The Journal of Biological Chemistry.

Potent Kinetic Stabilizers That Prevent Transthyretin-Mediated Cardiomyocyte Proteotoxicity

I. Graef, I. Wilson, E. Powers, 2011, Science Translational Medicine.

Human-Murine Transthyretin Heterotetramers Are Kinetically Stable and Non-amyloidogenic

J. Kelly, E. Santelli, J. Pascual, 2008, Journal of Biological Chemistry.

Cell based screening of inhibitors of transthyretin aggregation.

J. Koziol, J. Kelly, J. Buxbaum, 2006, Biochemical and biophysical research communications.

Retention of misfolded mutant transthyretin by the chaperone BiP/GRP78 mitigates amyloidogenesis.

J. Kelly, B. Jonsson, B. Ghafouri, 2006, Journal of molecular biology.

Partitioning conformational intermediates between competing refolding and aggregation pathways: insights into transthyretin amyloid disease.

J. Kelly, E. Powers, R. L. Wiseman, 2005, Biochemistry.

Support for the multigenic hypothesis of amyloidosis: The binding stoichiometry of retinol-binding protein, vitamin A, and thyroid hormone influences transthyretin amyloidogenicity in vitro

J. Kelly, Joleen T. White, J. Kelly, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Lovastatin ameliorates α-synuclein accumulation and oxidation in transgenic mouse models of α-synucleinopathies

E. Masliah, J. Kelly, E. Rockenstein, 2010, Experimental Neurology.

Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis

J. Kelly, R. L. Wiseman, D. Thuerauf, 2019, Nature Communications.

Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins

J. Kelly, E. Powers, R. L. Wiseman, 2018, eLife.

The unfolded protein response regulator ATF6 promotes mesodermal differentiation

S. Tsang, J. Kelly, E. Powers, 2018, Science Signaling.

Influence of hPin1 WW N‐terminal domain boundaries on function, protein stability, and folding

H. Nguyen, M. Gruebele, J. Kelly, 2007, Protein science : a publication of the Protein Society.

Engineering a β-sheet protein toward the folding speed limit

Martin Gruebele, Marcus Jäger, H. Nguyen, 2005 .

Tuning the free-energy landscape of a WW domain by temperature, mutation, and truncation

H. Nguyen, M. Gruebele, A. Moretto, 2003, Proceedings of the National Academy of Sciences of the United States of America.

The folding mechanism of a -sheet: the WW domain1

Jason C. Crane, Martin Gruebele, Marcus Jäger, 2001 .

Mapping the transition state of the WW domain β-sheet

M. Gruebele, J. Kelly, E. Koepf, 2000 .

Pharmacological stabilization of the native state of full-length immunoglobulin light chains to treat light chain amyloidosis.

J. Kelly, G. Morgan, I. Wilson, 2023, Current opinion in chemical biology.

Discovery of Potent Coumarin-Based Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains Using Structure-Based Design.

H. M. Petrassi, I. Wilson, J. Kelly, 2021, Journal of medicinal chemistry.

Structural basis for the stabilization of amyloidogenic immunoglobulin light chains by hydantoins.

L. Kay, I. Wilson, Stefano Forli, 2020, Bioorganic & medicinal chemistry letters.

Stabilization of amyloidogenic immunoglobulin light chains by small molecules

Steven J Brown, L. Kay, I. Wilson, 2019, Proceedings of the National Academy of Sciences.

Tafamidis for transthyretin familial amyloid polyneuropathy

R. Labaudinière, J. Kelly, P. Lozeron, 2012, Neurology.

Role of domain interactions in the aggregation of full-length immunoglobulin light chains

L. Kay, J. Kelly, G. Morgan, 2018, Proceedings of the National Academy of Sciences.

The Kinetic Stability of a Full-Length Antibody Light Chain Dimer Determines whether Endoproteolysis Can Release Amyloidogenic Variable Domains.

J. Kelly, G. Morgan, J. Kelly, 2016, Journal of molecular biology.

Partial denaturation of transthyretin is sufficient for amyloid fibril formation in vitro.

J. Kelly, W. Colón, J. Kelly, 1992, Biochemistry.

The role of protein thermodynamics and primary structure in fibrillogenesis of variable domains from immunoglobulin light-chains.

L. Kay, J. Kelly, G. Morgan, 2019, Journal of the American Chemical Society.

Amyloid Fibrils Trigger the Release of Neutrophil Extracellular Traps (NETs), Causing Fibril Fragmentation by NET-associated Elastase*

J. Kelly, D. Foguel, C. Braga, 2012, The Journal of Biological Chemistry.

Secretion of amyloidogenic gelsolin progressively compromises protein homeostasis leading to the intracellular aggregation of proteins

J. Kelly, W. Balch, M. Wood, 2009, Proceedings of the National Academy of Sciences.

Structural insight into pH-induced conformational changes within the native human transthyretin tetramer.

James C Sacchettini, J. Sacchettini, J. Kelly, 2008, Journal of molecular biology.

Kinetic stabilization of an oligomeric protein under physiological conditions demonstrated by a lack of subunit exchange: implications for transthyretin amyloidosis.

J. Kelly, R. L. Wiseman, R. Wiseman, 2005, Biochemistry.

Energetic Characteristics of the New Transthyretin Variant A25T May Explain Its Atypical Central Nervous System Pathology

T. Tokuda, J. Kelly, Y. Shimizu, 2003, Laboratory Investigation.

potential to treat a variety of human protein misfolding diseases.

J. Kelly, R. L. Wiseman, L. Plate, 2016 .

ERdj3 is an endoplasmic reticulum degradation factor for mutant glucocerebrosidase variants linked to Gaucher's disease.

J. Yates, J. Kelly, Joseph C. Genereux, 2014, Chemistry & biology.

Context-dependent contributions of backbone hydrogen bonding to β-sheet folding energetics

Philip E. Dawson, Martin Gruebele, H. Nguyen, 2004, Nature.

Backbone-Backbone H-Bonds Make Context-Dependent Contributions to Protein Folding Kinetics and Thermodynamics: Lessons from Amide-to-Ester Mutations.

J. Kelly, E. Powers, S. Deechongkit, 2005, Advances in protein chemistry.

Genetic ablation of N‐linked glycosylation reveals two key folding pathways for R345W fibulin‐3, a secreted protein associated with retinal degeneration

J. Kelly, J. Hulleman, J. Kelly, 2015, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

An experimental survey of the transition between two-state and downhill protein folding scenarios

Amelia A. Fuller, Martin Gruebele, Peter Wipf, 2008, Proceedings of the National Academy of Sciences.

Synthesis of a negatively charged dibenzofuran-based beta-turn mimetic and its incorporation into the WW miniprotein-enhanced solubility without a loss of thermodynamic stability.

J. Kelly, S. Deechongkit, R. Kaul, 2002, Journal of the American Chemical Society.

Pathological and functional amyloid formation orchestrated by the secretory pathway.

J. Kelly, W. Balch, M. E. Huff, 2003, Current opinion in structural biology.

Gelsolin domain 2 Ca2+ affinity determines susceptibility to furin proteolysis and familial amyloidosis of finnish type.

J. Kelly, W. Balch, L. Page, 2003, Journal of molecular biology.

Furin initiates gelsolin familial amyloidosis in the Golgi through a defect in Ca2+ stabilization

J. Kelly, W. Balch, J. Matteson, 2001, The EMBO journal.

Applications of Enzyme Biotechnology

J. Kelly, T. Baldwin, J. Kelly, 1991, Industry-University Cooperative Chemistry Program Symposia.

The integration of cell and chemical biology in protein folding

J. Kelly, W. Balch, J. Kelly, 2006, Nature chemical biology.

Examining the structural and functional roles of the β-turn region in neuropeptide Y

J. Kelly, John W. Taylor, Wentao Zhang, 2004, Letters in Peptide Science.

β-Sheet folding mechanisms from perturbation energetics

H. Nguyen, M. Gruebele, J. Kelly, 2006 .

Phosphomonoesters and phosphodiesters derived from the photohydrolysis of 2-methoxy-5-nitrophenyl substituted phosphotriesters

J. Kelly, N. Graciani, Daniel S. Swanson, 1995 .

Pathogenesis of and therapeutic strategies to ameliorate the transthyretin amyloidoses.

J. Kelly, S. Ikeda, Y. Sekijima, 2008, Current pharmaceutical design.

Deducing the presence of proteins and proteoforms in quantitative proteomics

J. Yates, J. Kelly, S. Martínez-Bartolomé, 2018, Nature Communications.

Amino acids that specify structure through hydrophobic clustering and histidine-aromatic interactions lead to biologically active peptidomimetics.

J. Kelly, N. Graciani, K. Tsang, 1994, Bioorganic & medicinal chemistry.

Templates That Induce .alpha.-Helical, .beta.-Sheet, and Loop Conformations

Joel P. Schneider, J. Kelly, J. Schneider, 1995 .

Regulated in Development and DNA Damage Response 1 Deficiency Impairs Autophagy and Mitochondrial Biogenesis in Articular Cartilage and Increases the Severity of Experimental Osteoarthritis

J. Kelly, M. Lotz, O. Alvarez-Garcia, 2017, Arthritis & rheumatology.

Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis

D. Thuerauf, C. Glembotski, L. Plate, 2018, Nature Communications.

Stress-independent activation of XBP1s and/or ATF6 reveals three functionally diverse ER proteostasis environments.

Lisa M. Ryno, A. Su, Chunlei Wu, 2013, Cell reports.

Probing the folding transition state structure of the villin headpiece subdomain via side chain and backbone mutagenesis.

J. Kelly, F. Gai, Michelle R Bunagan, 2009, Journal of the American Chemical Society.

Structure-function-folding relationship in a WW domain.

Yan Zhang, Martin Gruebele, Joseph P Noel, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Proteostasis Regulators and Pharmacologic Chaperones Synergize to Correct Protein Misfolding Diseases

J. Yates, D. Ong, J. Kelly, 2009 .

Unfolded protein response‐induced ERdj3 secretion links ER stress to extracellular proteostasis

Lisa M. Ryno, R. Kaufman, J. Kelly, 2015, The EMBO journal.

Clinical Trial for Ttr Amyloidosis Using Diflunisal

R. Falk, M. Skinner, J. Kelly, 2007 .

R104H may suppress transthyretin amyloidogenesis by thermodynamic stabilization, but not by the kinetic mechanism characterizing T119 interallelic trans-suppression

J. Kelly, R. L. Wiseman, Y. Sekijima, 2006, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.

Design and Rationale the SCAN‐MP (Screening for Cardiac Amyloidosis With Nuclear Imaging in Minority Populations) Study

A. Einstein, M. Maurer, J. Kelly, 2023, Journal of the American Heart Association.

Stereoelectronic Effects in Stabilizing Protein–N-Glycan Interactions Revealed by Experiment and Machine Learning

J. Kelly, E. Powers, Louis Noodleman, 2021, Nature Chemistry.

Residues Comprising the Enhanced Aromatic Sequon Influence Protein N-Glycosylation Efficiency.

Chi‐Huey Wong, Hwai I. Yang, J. Kelly, 2017, Journal of the American Chemical Society.

Identifying protein stabilizing ligands using GroEL.

M. Fisher, Gregory L. Bomhoff, I. Haque, 2010, Biopolymers.