Jacqueline Naylor

发表

Resolution of NASH and hepatic fibrosis by the GLP-1R/GcgR dual-agonist Cotadutide via modulating mitochondrial function and lipogenesis.

M. Larsen, O. McGuinness, L. Jermutus, 2020, Nature metabolism.

Peptide-YY3-36/glucagon-like peptide-1 combination treatment of obese diabetic mice improves insulin sensitivity associated with recovered pancreatic β-cell function and synergistic activation of discrete hypothalamic and brainstem neuronal circuitries

J. Hecksher-Sørensen, O. McGuinness, Jotham Austin, 2021, Molecular metabolism.

Pharmacological antagonism of the incretin system protects against diet-induced obesity

D. D’Alessio, B. Finan, Jonathan E. Campbell, 2019, Molecular metabolism.

Stereo-selective inhibition of transient receptor potential TRPC5 cation channels by neuroactive steroids

K. Muraki, M. Amer, D. Beech, 2011, British journal of pharmacology.

Controlling the bioactivity of a peptide hormone in vivo by reversible self-assembly

David Baker, M. Welland, P. Vicini, 2017, Nature Communications.

Development of an orally delivered GLP-1 receptor agonist through peptide engineering and drug delivery to treat chronic disease

J. Subramony, P. Tyagi, Yue Huang, 2021, Scientific Reports.

TRPM3 channel stimulated by pregnenolone sulphate in synovial fibroblasts and negatively coupled to hyaluronan

P. Emery, Coziana Ciurtin, D. Beech, 2010, BMC musculoskeletal disorders.

TRPC channel activation by extracellular thioredoxin

P. Emery, Coziana Ciurtin, K. Porter, 2008, Nature.

Generation of antibodies that are externally acting isoform-specific inhibitors of ion channels.

D. Beech, J. Naylor, Jacqueline Naylor, 2013, Methods in molecular biology.

GVI phospholipase A2 role in the stimulatory effect of sphingosine-1-phosphate on TRPC5 cationic channels

S. Tumova, D. Beech, Jing Li, 2011, Cell calcium.

Development and characterisation of a novel glucagon like peptide-1 receptor antibody

F. Reimann, F. Gribble, M. Coghlan, 2017, Diabetologia.

Gut check on diabesity: leveraging gut mechanisms for the treatment of type 2 diabetes and obesity

M. Coghlan, D. Baker, J. Trevaskis, 2017, Current opinion in pharmacology.

Self-assembled GLP-1/glucagon peptide nanofibrils prolong inhibition of food intake

M. Welland, A. L. Gomes dos Santos, Myriam M. Ouberai, 2023, Frontiers in endocrinology.

Engineering of a GLP-1 analogue peptide/anti-PCSK9 antibody fusion for type 2 diabetes treatment

J. Osbourn, A. Celeste, C. Rondinone, 2018, Scientific Reports.

A Sphingosine-1–Phosphate–Activated Calcium Channel Controlling Vascular Smooth Muscle Cell Motility

A. Cheong, K. Porter, K. Muraki, 2006, Circulation research.

Function and pharmacology of TRPM3 ion channel

J. Naylor, Jacqueline Naylor, 2008 .

Randomised, phase 1, dose-finding study of MEDI4166, a PCSK9 antibody and GLP-1 analogue fusion molecule, in overweight or obese patients with type 2 diabetes mellitus

L. Morrow, G. Carlson, P. Ambery, 2018, Diabetologia.

Inhibition of endothelial cell Ca2+ entry and transient receptor potential channels by Sigma-1 receptor ligands

R. Bon, D. O'regan, K. Porter, 2013, British journal of pharmacology.

Gut-derived GIP activates central Rap1 to impair neural leptin sensitivity during overnutrition

Q. Mo, M. Fukuda, K. Williams, 2019, The Journal of clinical investigation.

Extracellular Ion Channel Inhibitor Antibodies

D. Beech, J. Naylor, Jacqueline Naylor, 2009 .

Production of a specific extracellular inhibitor of TRPM3 channels

C. Milligan, D. Beech, J. Naylor, 2008, British journal of pharmacology.

Sensing of Lysophospholipids by TRPC5 Calcium Channel*

David J Beech, K. Muraki, C. Benham, 2006, Journal of Biological Chemistry.

TRPC5 Channel Sensitivities to Antioxidants and Hydroxylated Stilbenes*

D. O'regan, K. Porter, K. Muraki, 2010, The Journal of Biological Chemistry.

Use of CRISPR/Cas9-engineered INS-1 pancreatic β cells to define the pharmacology of dual GIPR/GLP-1R agonists.

M. Coghlan, M. Snaith, D. Baker, 2016, The Biochemical journal.

Rapid and Contrasting Effects of Rosiglitazone on Transient Receptor Potential TRPM3 and TRPC5 Channels

Victoria A. L. Seymour, C. Milligan, D. Beech, 2011, Molecular Pharmacology.

Use of the Site-Specific Retargeting Jump-In Platform Cell Line to Support Biologic Drug Discovery

Ling Huang, T. Wilkinson, N. Tigue, 2015, Journal of biomolecular screening.

Automated Acoustic Dispensing for the Serial Dilution of Peptide Agonists in Potency Determination Assays.

J. Naylor, D. Hornigold, Christopher Brankin, 2016, Journal of visualized experiments : JoVE.

Use of the Site-Specific Retargeting Jump-In Platform Cell Line to Support Biologic Drug Discovery

Ling Huang, T. Wilkinson, N. Tigue, 2015, Journal of biomolecular screening.

Pregnenolone Sulphate- and Cholesterol-Regulated TRPM3 Channels Coupled to Vascular Smooth Muscle Secretion and Contraction

David J Beech, Stephen B Wheatcroft, Bing Hou, 2010, Circulation research.

Pregnenolone sulphate-independent inhibition of TRPM3 channels by progesterone

C. Fishwick, D. O'regan, K. Porter, 2012, Cell calcium.

Robotic multiwell planar patch-clamp for native and primary mammalian cells

Mark L Dallas, Jing Li, Chris Peers, 2009, Nature Protocols.