Lorraine K. Morlock

发表

Installation of a cancer promoting WNT/SIX1 signaling axis by the oncofusion protein MLL-AF9

L. Lum, Jian Xu, C. Zhang, 2018, EBioMedicine.

Development of a triazole class of highly potent Porcn inhibitors.

L. Lum, N. Williams, Chuo Chen, 2016, Bioorganic & medicinal chemistry letters.

Discovery of a Neuroprotective Chemical, (S)-N-(3-(3,6-Dibromo-9H-carbazol-9-yl)-2-fluoropropyl)-6-methoxypyridin-2-amine [(−)-P7C3-S243], with Improved Druglike Properties

S. Estill, N. Williams, A. Pieper, 2014, Journal of medicinal chemistry.

Development of Dihydroxyphenyl Sulfonylisoindoline Derivatives as Liver-Targeting Pyruvate Dehydrogenase Kinase Inhibitors.

D. Chuang, Mingliang Lou, N. Williams, 2017, Journal of medicinal chemistry.

Structure-guided Development of Specific Pyruvate Dehydrogenase Kinase Inhibitors Targeting the ATP-binding Pocket*

D. Chuang, P. Scherer, N. Williams, 2013, The Journal of Biological Chemistry.

Topoisomerase II Inhibitors Induce DNA Damage-Dependent Interferon Responses Circumventing Ebola Virus Immune Evasion

S. Aguirre, A. García-Sastre, A. Fernández-Sesma, 2017, mBio.

Early detection of subclinical visual damage after blast-mediated TBI enables prevention of chronic visual deficit by treatment with P7C3-S243.

Michael G. Anderson, R. Kardon, S. Stasheff, 2014, Investigative ophthalmology & visual science.

Benzothiophene Carboxylate Derivatives as Novel Allosteric Inhibitors of Branched-chain α-Ketoacid Dehydrogenase Kinase*

D. Chuang, S. Strom, K. Dorko, 2014, The Journal of Biological Chemistry.

Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain α-ketoacid dehydrogenase kinase

D. Chuang, B. Tu, Philippe M. Campeau, 2013, Proceedings of the National Academy of Sciences.

Design and Synthesis of TASIN Analogues Specifically Targeting Colorectal Cancer Cell Lines with Mutant Adenomatous Polyposis Coli (APC).

J. Shay, N. Williams, J. D. De Brabander, 2019, Journal of medicinal chemistry.

Blockade to pathological remodeling of infarcted heart tissue using a porcupine antagonist

Sean P. Palecek, L. Lum, Y. Liu, 2017, Proceedings of the National Academy of Sciences.

A Validated Tumorgraft Model Reveals Activity of Dovitinib Against Renal Cell Carcinoma

D. Bentley, M. Ross, J. Cadeddu, 2012, Science Translational Medicine.

Development of proneurogenic, neuroprotective small molecules.

S. McKnight, S. Estill, N. Williams, 2011, Journal of the American Chemical Society.

Diet-Induced Unresolved ER Stress Hinders KRAS-Driven Lung Tumorigenesis

R. Coppari, P. Scaglioni, A. Santinelli, 2015, Cell metabolism.

The P7C3 class of neuroprotective compounds exerts antidepressant efficacy in mice by increasing hippocampal neurogenesis

J. Zigman, S. Estill, S. Osborne-Lawrence, 2014, Molecular Psychiatry.