A. C. Rustan

发表

Skeletal muscle energy metabolism in obesity

A. Rustan, Abel M Mengeste, J. Lund, 2021, Obesity.

Defective Natriuretic Peptide Receptor Signaling in Skeletal Muscle Links Obesity to Type 2 Diabetes

D. Joanisse, D. Langin, Steven R Smith, 2015, Diabetes.

Uncovering human METTL12 as a mitochondrial methyltransferase that modulates citrate synthase activity through metabolite-sensitive lysine methylation

A. Ho, P. Falnes, A. Moen, 2017, Journal of Biological Chemistry.

Skeletal muscle lipid accumulation in type 2 diabetes may involve the liver X receptor pathway.

K. Højlund, H. Beck-Nielsen, G. H. Thoresen, 2005, Diabetes.

Functional expression of the thermally activated transient receptor potential channels TRPA1 and TRPM8 in human myotubes.

G. H. Thoresen, F. Haugen, A. Rustan, 2023, Journal of thermal biology.

Fatty Acids: Structures and Properties

A. C. Rustan, Jenny Lund, 2020, eLS.

Loss of lysosomal membrane protein NCU-G1 in mice results in spontaneous liver fibrosis with accumulation of lipofuscin and iron in Kupffer cells

G. H. Thoresen, M. Damme, J. Mæhlen, 2014, Disease Models & Mechanisms.

Marine n-3 fatty acids promote size reduction of visceral adipose depots, without altering body weight and composition, in male Wistar rats fed a high-fat diet

C. Drevon, J. Jensen, T. Røst, 2009, British Journal of Nutrition.

Remodeling Lipid Metabolism and Improving Insulin Responsiveness in Human Primary Myotubes

G. H. Thoresen, Steven R Smith, B. Ukropcová, 2011, PloS one.

The effect of toll-like receptor ligands on energy metabolism and myokine expression and secretion in cultured human skeletal muscle cells

G. H. Thoresen, F. Norheim, F. Haugen, 2021, Scientific Reports.

Myotubes from lean and severely obese subjects with and without type 2 diabetes respond differently to an in vitro model of exercise.

G. H. Thoresen, J. Hjelmesæth, N. Nikolić, 2015, American journal of physiology. Cell physiology.

Are cultured human myotubes far from home?

G. H. Thoresen, S. Bajpeyi, V. Aas, 2013, Cell and Tissue Research.

Insight Into the Metabolic Adaptations of Electrically Pulse-Stimulated Human Myotubes Using Global Analysis of the Transcriptome and Proteome

T. Nyman, S. Kersten, G. H. Thoresen, 2022, Frontiers in Physiology.

Increased PDK4 mRNA expression is a sensitive marker of upregulated fatty acid oxidation.

Ø. Fluge, O. Bruland, B. Bjørndal, 2019, Mitochondrion.

Energy metabolism in skeletal muscle cells from donors with different body mass index

G. H. Thoresen, S. Ellefsen, E. T. Kase, 2022, Frontiers in Physiology.

Overexpression of PGC-1α Increases Fatty Acid Oxidative Capacity of Human Skeletal Muscle Cells

G. H. Thoresen, L. Storlien, N. Nikolić, 2011, Biochemistry research international.

Effect of dietary supplementation with n-3 polyunsaturated fatty acids on physical properties and metabolism of low density lipoprotein in humans.

G. Mælandsmo, M. Nenseter, S. Lund-Katz, 1992, Arteriosclerosis and thrombosis : a journal of vascular biology.

A structurally engineered fatty acid, icosabutate, suppresses liver inflammation and fibrosis in NASH.

D. Schuppan, J. Kastelein, M. Iruarrizaga-Lejarreta, 2021, Journal of hepatology.

Impairment of adrenergically-regulated thermogenesis in brown fat of obesity-resistant mice is compensated by non-shivering thermogenesis in skeletal muscle

M. Rossmeisl, J. Kopecký, M. Vrbacký, 2023, Molecular metabolism.

Lack of the Lysosomal Membrane Protein, GLMP, in Mice Results in Metabolic Dysregulation in Liver

G. H. Thoresen, M. Damme, C. Schjalm, 2015, PloS one.

22-Hydroxycholesterols regulate lipid metabolism differently than T0901317 in human myotubes.

G. H. Thoresen, H. Nebb, E. T. Kase, 2006, Biochimica et biophysica acta.

A mitochondria-targeted fatty acid analogue influences hepatic glucose metabolism and reduces the plasma insulin/glucose ratio in male Wistar rats

B. Bjørndal, G. H. Thoresen, R. Berge, 2019, PloS one.

Tetradecylthioacetic acid attenuates dyslipidaemia in male patients with type 2 diabetes mellitus, possibly by dual PPAR‐α/δ activation and increased mitochondrial fatty acid oxidation

J. Skorve, P. Bohov, O. Gudbrandsen, 2009, Diabetes, obesity & metabolism.

The molecular structure of thio-ether fatty acids influences PPAR-dependent regulation of lipid metabolism.

Andrew D. Miller, G. H. Thoresen, A. Kamal, 2016, Bioorganic & medicinal chemistry.

Enzyme activities of intestinal triacylglycerol and phosphatidylcholine biosynthesis in Atlantic salmon (Salmo salar L.).

R. Olsen, B. Torstensen, A. Rustan, 2005, Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.

Loss of perilipin 2 in cultured myotubes enhances lipolysis and redirects the metabolic energy balance from glucose oxidation towards fatty acid oxidation

A. Kimmel, Y. Lee, G. H. Thoresen, 2017, Journal of Lipid Research.

Increased glucose utilization and decreased fatty acid metabolism in myotubes from Glmpgt/gt mice

G. H. Thoresen, E. Eftestøl, E. T. Kase, 2016, Archives of physiology and biochemistry.

Effect of serial cell passaging in the retention of fiber type and mitochondrial content in primary human myotubes

E. Ravussin, Steven R Smith, J. Covington, 2015, Obesity.

Altered Skeletal Muscle Lipase Expression and Activity Contribute to Insulin Resistance in Humans

G. Schmitz, G. Liebisch, D. Langin, 2011, Diabetes.

The small molecule SERCA activator CDN1163 increases energy metabolism in human skeletal muscle cells

G. H. Thoresen, S. Göpel, L. Eide, 2021, Current research in pharmacology and drug discovery.

Leukaemia inhibitory factor stimulates glucose transport in isolated cardiomyocytes and induces insulin resistance after chronic exposure

G. H. Thoresen, G. Christensen, G. Florholmen, 2006, Diabetologia.

Innervation and electrical pulse stimulation - in vitro effects on human skeletal muscle cells.

S. Pirkmajer, G. H. Thoresen, B. Rogelj, 2020, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

Electrical Pulse Stimulation of Cultured Human Skeletal Muscle Cells as an In Vitro Model of Exercise

G. H. Thoresen, Nataša Nikolić, Siril Skaret Bakke, 2012, PloS one.

SENP2 knockdown in human adipocytes reduces glucose metabolism and lipid accumulation, while increases lipid oxidation.

T. Nyman, G. H. Thoresen, E. T. Kase, 2023, Metabolism open.

Simvastatin Inhibits Glucose Metabolism and Legumain Activity in Human Myotubes

G. H. Thoresen, R. Solberg, A. Rustan, 2014, PloS one.

SENP2 is vital for optimal insulin signaling and insulin-stimulated glycogen synthesis in human skeletal muscle cells

G. H. Thoresen, E. T. Kase, A. Rustan, 2021, Current research in pharmacology and drug discovery.

The liver X receptor modulator 22(S)-hydroxycholesterol exerts cell-type specific effects on lipid and glucose metabolism

A. Ravna, I. Sylte, G. H. Thoresen, 2012, The Journal of Steroid Biochemistry and Molecular Biology.

Myotubes from Severely Obese Type 2 Diabetic Subjects Accumulate Less Lipids and Show Higher Lipolytic Rate than Myotubes from Severely Obese Non-Diabetic Subjects

G. H. Thoresen, J. Hjelmesæth, C. Moro, 2015, PloS one.

Oxidation of intramyocellular lipids is dependent on mitochondrial function and the availability of extracellular fatty acids.

G. H. Thoresen, K. Levin, E. Blaak, 2010, American journal of physiology. Endocrinology and metabolism.

Palmitic acid follows a different metabolic pathway than oleic acid in human skeletal muscle cells; lower lipolysis rate despite an increased level of adipose triglyceride lipase.

S. Kersten, M. Hesselink, C. Moro, 2012, Biochimica et biophysica acta.

Primary defects in lipid handling and resistance to exercise in myotubes from obese donors with and without type 2 diabetes.

G. H. Thoresen, C. Moro, N. Nikolić, 2020, Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.

Human HDL subclasses modulate energy metabolism in skeletal muscle cells

M. Lehti, E. Pirinen, H. Bakke, 2023, Journal of lipid research.

Increased triacylglycerol - Fatty acid substrate cycling in human skeletal muscle cells exposed to eicosapentaenoic acid

G. H. Thoresen, D. Ouwens, E. T. Kase, 2018, PloS one.

Metabolic switching of human myotubes is improved by n-3 fatty acids

S. Kersten, M. Hesselink, G. H. Thoresen, 2010, Journal of Lipid Research.

Metabolic switching of human skeletal muscle cells in vitro.

G. H. Thoresen, V. Aas, N. P. Hessvik, 2011, Prostaglandins, leukotrienes, and essential fatty acids.

LXR{beta} is the dominant LXR subtype in skeletal muscle regulating lipogenesis and cholesterol efflux.

S. Kersten, G. H. Thoresen, Xiufeng Xu, 2010, American journal of physiology. Endocrinology and metabolism.

Fatty Acid Incubation of Myotubes From Humans With Type 2 Diabetes Leads to Enhanced Release of β-Oxidation Products Because of Impaired Fatty Acid Oxidation

C. Drevon, R. Berge, M. Gaster, 2009, Diabetes.

Treatment of human skeletal muscle cells with inhibitors of diacylglycerol acyltransferases 1 and 2 to explore isozyme-specific roles on lipid metabolism

G. H. Thoresen, V. Zammit, E. T. Kase, 2020, Scientific Reports.

Glucose metabolism and metabolic flexibility in cultured skeletal muscle cells is related to exercise status in young male subjects

T. Ingemann-Hansen, J. Jensen, J. Wojtaszewski, 2018, Archives of physiology and biochemistry.

Glucose metabolism and metabolic flexibility in cultured skeletal muscle cells is related to exercise status in young male subjects Running title : Enhanced glucose metabolism in myotubes from trained subjects

Jesper, T. Ingemann-Hansen, E. T. Kase, 2018 .

Leukemia inhibitory factor reduces contractile function and induces alterations in energy metabolism in isolated cardiomyocytes.

G. Christensen, K. Andersson, G. Florholmen, 2004, Journal of molecular and cellular cardiology.

Effect of differentiation, de novo innervation, and electrical pulse stimulation on mRNA and protein expression of Na+,K+-ATPase, FXYD1, and FXYD5 in cultured human skeletal muscle cells

S. Pirkmajer, G. H. Thoresen, A. Chibalin, 2021, PloS one.

Pancreatic Cancer Cell-Conditioned, Human-Derived Primary Myotubes Display Increased Leucine Turnover, Increased Lipid Accumulation, and Reduced Glucose Uptake

G. H. Thoresen, E. T. Kase, A. Rustan, 2022, Metabolites.

Leptin expression in human primary skeletal muscle cells is reduced during differentiation

C. Drevon, J. Reseland, G. H. Thoresen, 2005, Journal of cellular biochemistry.

Editorial: Untangling energy metabolism in skeletal muscle: From physiology to pharmacology

S. Pirkmajer, P. García-Rovés, A. Chibalin, 2022, Frontiers in Physiology.

Benfotiamine increases glucose oxidation and downregulates NADPH oxidase 4 expression in cultured human myotubes exposed to both normal and high glucose concentrations

N. Nikolić, V. Aas, N. P. Hessvik, 2012, Genes & Nutrition.

Chronic hyperglycemia reduces substrate oxidation and impairs metabolic switching of human myotubes.

G. H. Thoresen, V. Aas, N. P. Hessvik, 2011, Biochimica et biophysica acta.

Interplay between Cultured Human Osteoblastic and Skeletal Muscle Cells: Effects of Conditioned Media on Glucose and Fatty Acid Metabolism

T. Nyman, R. Solberg, E. Belluzzi, 2023, Biomedicines.

Development of new LXR modulators that regulate LXR target genes and reduce lipogenesis in human cell models.

I. Sylte, G. H. Thoresen, P. Rongved, 2014, European journal of medicinal chemistry.

Development of three-dimensional primary human myospheres as culture model of skeletal muscle cells for metabolic studies

G. H. Thoresen, E. T. Kase, A. Rustan, 2023, Frontiers in Bioengineering and Biotechnology.