Mohamed E. Shaker

发表

Celastrol ameliorates murine colitis via modulating oxidative stress, inflammatory cytokines and intestinal homeostasis.

S. A. Ashamallah, M. Houssen, Mohamed E. Shaker, 2014, Chemico-Biological Interactions.

Optimization and SAR investigation of novel 2,3-dihydropyrazino[1,2-a]indole-1,4-dione derivatives as EGFR and BRAFV600E dual inhibitors with potent antiproliferative and antioxidant activities.

Sami I. Alzarea, F. Mohamed, M. E. Shaker, 2022, Bioorganic chemistry.

Therapeutic Opportunities in Damage-Associated Molecular Pattern-Driven Metabolic Diseases.

M. E. Shaker, W. Mehal, Irma García-Martínez, 2015, Antioxidants & redox signaling.

The novel TLR9 antagonist COV08-0064 protects from ischemia/reperfusion injury in non-steatotic and steatotic mice livers.

M. E. Shaker, W. Mehal, B. Trawick, 2016, Biochemical pharmacology.

Impact of interferon β-1b, interferon β-1a and fingolimod therapies on serum interleukins-22, 32α and 34 concentrations in patients with relapsing-remitting multiple sclerosis

M. E. Shaker, Nariman M. Gameil, M. A. Abdel-Dayem, 2019, Journal of Neuroimmunology.

The novel Janus kinase inhibitor ruxolitinib confers protection against carbon tetrachloride-induced hepatotoxicity via multiple mechanisms.

M. E. Shaker, S. A. Ashamallah, Sara H. Hazem, 2014, Chemico-biological interactions.

The novel c-Met inhibitor capmatinib mitigates diethylnitrosamine acute liver injury in mice.

M. E. Shaker, S. A. Ashamallah, M. El-Mesery, 2016, Toxicology letters.

Ingestion of mannose ameliorates thioacetamide-induced intrahepatic oxidative stress, inflammation and fibrosis in rats.

M. E. Shaker, M. El-Mesery, Mohamed El-Shafey, 2021, Life sciences.

Comparison of early treatment with low doses of nilotinib, imatinib and a clinically relevant dose of silymarin in thioacetamide-induced liver fibrosis.

G. Shiha, M. E. Shaker, T. Ibrahim, 2011, European journal of pharmacology.

Comparison of imatinib, nilotinib and silymarin in the treatment of carbon tetrachloride-induced hepatic oxidative stress, injury and fibrosis.

G. Shiha, M. E. Shaker, W. Mehal, 2011, Toxicology and applied pharmacology.

Nilotinib counteracts thioacetamide‐induced hepatic oxidative stress and attenuates liver fibrosis progression

G. Shiha, H. A. Salem, T. Ibrahim, 2011, Fundamental & clinical pharmacology.

Clomiphene Citrate co-treatment with low dose urinary FSH versus urinary FSH for clomiphene resistant PCOS: randomized controlled trial

M. E. Shaker, M. Houssen, A. Gibreel, 2013, Journal of Assisted Reproduction and Genetics.

Synthesis and In Vitro Antiproliferative Activity of New 1-Phenyl-3-(4-(pyridin-3-yl)phenyl)urea Scaffold-Based Compounds

N. Omar, M. M. Al-Sanea, M. E. Shaker, 2018, Molecules.

The selective c-Met inhibitor capmatinib offsets cisplatin-nephrotoxicity and doxorubicin-cardiotoxicity and improves their anticancer efficacies.

M. E. Shaker, M. El-Mesery, Mohamed El-Shafey, 2020, Toxicology and applied pharmacology.

The c-Met inhibitor capmatinib alleviates acetaminophen-induced hepatotoxicity.

M. E. Shaker, Eman Said, A. A. Shaaban, 2020, International immunopharmacology.

The anticancer and EGFR-TK/CDK-9 dual inhibitory potentials of new synthetic pyranopyrazole and pyrazolone derivatives: X-ray crystallography, in vitro, and in silico mechanistic investigations.

M. Abdelgawad, A. Musa, Sami I. Alzarea, 2023, Journal of biomolecular structure & dynamics.

Emerging roles of tyrosine kinases in hepatic inflammatory diseases and therapeutic opportunities.

M. E. Shaker, M. El-Mesery, Sara H. Hazem, 2023, International immunopharmacology.

The contribution of sterile inflammation to the fatty liver disease and the potential therapies.

M. E. Shaker, Mohamed E. Shaker, 2022, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Mitigation of acetaminophen-induced liver toxicity by the novel phosphatidylinositol 3-kinase inhibitor alpelisib

M. El-Mesery, Sara H. Hazem, H. Gomaa, 2023, Frontiers in pharmacology.

Combining the HSP90 inhibitor TAS-116 with metformin effectively degrades the NLRP3 and attenuates inflammasome activation in rats: A new management paradigm for ulcerative colitis.

Osama A. Mohammed, Sameh Saber, G. Batiha, 2022, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

A New CDK2 Inhibitor with 3-Hydrazonoindolin-2-One Scaffold Endowed with Anti-Breast Cancer Activity: Design, Synthesis, Biological Evaluation, and In Silico Insights

M. Abdelgawad, M. M. Al-Sanea, H. Alkahtani, 2021, Molecules.

Nilotinib induces apoptosis and autophagic cell death of activated hepatic stellate cells via inhibition of histone deacetylases.

G. Shiha, M. E. Shaker, W. Mehal, 2013, Biochimica et biophysica acta.

Serum and aqueous humor concentrations of interleukin-27 in diabetic retinopathy patients

M. E. Shaker, D. Sabry, Amr M. El-Kannishy, 2018, International Ophthalmology.

Vinpocetine and Lactobacillus improve fatty liver in rats via modulating the oxidative stress, inflammation, adiponectin and gut microbiome.

A. Shata, M. E. Shaker, Sara H. Hazem, 2023, Life sciences.

The NEDD8-activating enzyme inhibition with MLN4924 sensitizes human cancer cells of different origins to apoptosis and necroptosis.

M. E. Shaker, M. El-Mesery, Sara H. Hazem, 2020, Archives of biochemistry and biophysics.

The SMAC mimetic BV6 induces cell death and sensitizes different cell lines to TNF-α and TRAIL-induced apoptosis

M. E. Shaker, M. El-Mesery, A. Elgaml, 2016, Experimental biology and medicine.

Prevention of Mother-to-Child Transmission and Early Real-Time DNA Polymerase Chain Reaction Results Among HIV-Exposed Infants in Bujumbura, Burundi

M. E. Shaker, J. Nyandwi, Sylvestre Bazikamwe, 2018, The East African health research journal.

Repression of acetaminophen-induced hepatotoxicity by a combination of celastrol and brilliant blue G.

M. E. Shaker, M. Hamed, Nariman M. Gameil, 2017, Toxicology letters.

New Sulfamethoxazole Derivatives as Selective Carbonic Anhydrase IX and XII Inhibitors: Design, Synthesis, Cytotoxic Activity and Molecular Modeling

M. Abdelgawad, A. Musa, S. N. Bukhari, 2022, Pharmaceuticals.

Digoxin mitigates diethylnitrosamine-induced acute liver injury in mice via limiting production of inflammatory mediators

M. E. Shaker, M. Hamed, A. A. Shaaban, 2022, Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society.

Polymorphisms of glutathione S-transferase π 1 and toll-like receptors 2 and 9: Association with breast cancer susceptibility.

M. E. Shaker, O. Farouk, M. Houssen, 2016, Oncology letters.

Inhibition of Bruton tyrosine kinase by acalabrutinib dampens lipopolysaccharide/galactosamine-induced hepatic damage.

M. M. Al-Sanea, M. E. Shaker, M. El-Mesery, 2020, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Assembling a Cinnamyl Pharmacophore in the C3-Position of Substituted Isatins via Microwave-Assisted Synthesis: Development of a New Class of Monoamine Oxidase-B Inhibitors for the Treatment of Parkinson’s Disease

S. Sushanth Kumar, M. Ghoneim, B. Mathew, 2023, Molecules.

Inhibition of the JAK/STAT pathway by ruxolitinib ameliorates thioacetamide-induced hepatotoxicity.

M. E. Shaker, S. A. Ashamallah, Sara H. Hazem, 2016, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Modulation of carbon tetrachloride-induced hepatic oxidative stress, injury and fibrosis by olmesartan and omega-3.

H. El-kashef, M. E. Shaker, T. Ibrahim, 2014, Chemico-biological interactions.