C. Henderson

发表

Increased Constitutive c-Jun N-terminal Kinase Signaling in Mice Lacking Glutathione S-Transferase Pi*

M. Chamberlain, C. Wolf, N. Kitteringham, 2003, Journal of Biological Chemistry.

Quantifying ERK activity in response to inhibition of the BRAFV600E-MEK-ERK cascade using mathematical modelling

Mark A. J. Chaplain, M. Chaplain, C. Henderson, 2021, British Journal of Cancer.

Activation status of the pregnane X receptor influences vemurafenib availability in humanized mouse models.

C. Wolf, C. Henderson, A. Macleod, 2015, Cancer research.

Mathematical modeling quantifies ERKactivity in response to inhibition of the BRAFV600EMEKERK cascade

Mark A. J. Chaplain, M. Chaplain, C. Wolf, 2021 .

Transgenic analysis of human drug-metabolizing enzymes: preclinical drug development and toxicology.

C. Wolf, C. Henderson, C. Henderson, 2003, Molecular interventions.

Use of Transgenic Animals in Understanding Molecular Mechanisms of Toxicity *

C. Wolf, C. Henderson, C. Henderson, 1998, The Journal of pharmacy and pharmacology.

Aryl hydrocarbon receptor is required for optimal B‐cell proliferation

B. Stockinger, M. Tolaini, C. Wolf, 2016, The EMBO journal.

Application of the in vivo oxidative stress reporter Hmox1 as mechanistic biomarker of arsenic toxicity

C. Wolf, A. Dinkova-Kostova, M. Ruchirawat, 2020, bioRxiv.

Inactivation of the Hepatic Cytochrome P450 System by Conditional Deletion of Hepatic Cytochrome P450 Reductase*

C. Wolf, M. Magnuson, I. Rosewell, 2003, The Journal of Biological Chemistry.

Regulation of JNK signaling by GSTp

M. Pincus, M. Benezra, K. Tew, 1999, The EMBO journal.

Role of cytochromes P450 1A1/2 in detoxication and activation of carcinogenic aristolochic acid I: studies with the hepatic NADPH:cytochrome P450 reductase null (HRN) mouse model.

V. Arlt, J. Mares, E. Frei, 2011, Toxicological sciences : an official journal of the Society of Toxicology.

Ubiquitin–Proteasome System Impairment and MPTP-Induced Oxidative Stress in the Brain of C57BL/6 Wild-type and GSTP Knockout Mice

C. Wolf, C. Henderson, P. Pereira, 2012, Molecular Neurobiology.

GSTπ expression mediates dopaminergic neuron sensitivity in experimental parkinsonism

Roland Wolf, Colin Henderson, Justin Boyd, 2007, Proceedings of the National Academy of Sciences.

Identification of Novel Pathways of Osimertinib Disposition and Potential Implications for the Outcome of Lung Cancer Therapy

C. Wolf, J. Huang, C. Henderson, 2018, Clinical Cancer Research.

University of Dundee Identification of novel pathways of osimertinib disposition and potential implications for the outcome of lung cancer therapy

R. Wolf, J. Huang, C. Henderson, 2018 .

Hepatic cytochrome P-450 reductase-null mice show reduced transcriptional response to quercetin and reveal physiological homeostasis between jejunum and liver.

C Roland Wolf, Gary Williamson, Sofiane Lariani, 2006, American journal of physiology. Gastrointestinal and liver physiology.

Evidence That the Capacity of Nongenotoxic Carcinogens to Induce Oxidative Stress Is Subject to Marked Variability

Amy R. Cameron, C. Wolf, L. Stanley, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes.

C. Wolf, K. Itoh, M. McMahon, 2001, Cancer research.

Identification of Novel Roles of the Cytochrome P450 System in Early Embryogenesis: Effects on Vasculogenesis and Retinoic Acid Homeostasis

C. Tickle, C. Wolf, R. Adams, 2003, Molecular and Cellular Biology.

Transcriptional Regulation of Cytochrome P450 Genes

C. Wolf, C. Henderson, E. Fraser, 2012 .

Nomenclature for alleles of the cytochrome P450 oxidoreductase gene.

M. Ingelman-Sundberg, T. Ogata, D. Nebert, 2009, Pharmacogenetics and genomics.

Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: studies with the hepatic NADPH:cytochrome P450 reductase null mouse.

V. Arlt, D. Phillips, C. Wolf, 2008, Toxicology and applied pharmacology.

Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha

C. Wolf, J. Hayes, C. Henderson, 2007, Proceedings of the National Academy of Sciences.

Cytochrome b5 Is a Major Determinant of Human Cytochrome P450 CYP2D6 and CYP3A4 Activity In Vivo

C. Wolf, L. Stanley, N. Scheer, 2015, Molecular Pharmacology.

Feedback Control of AHR Signaling Regulates Intestinal Immunity

Y. Li, B. Stockinger, A. Metidji, 2017, Nature.

Identification of P450 enzymes involved in metabolism of verapamil in humans

M. Eichelbaum, H. Kroemer, P. Beaune, 1993, Naunyn-Schmiedeberg's Archives of Pharmacology.

Novel Pathways of Ponatinib Disposition Catalyzed By CYP1A1 Involving Generation of Potentially Toxic Metabolites

C. Wolf, J. Huang, Rumen V. Kostov, 2017, The Journal of Pharmacology and Experimental Therapeutics.

Cytochrome b5 null mouse: a new model for studying inherited skin disorders and the role of unsaturated fatty acids in normal homeostasis

R. Finn, Chengli Song, C. Henderson, 2010, Transgenic Research.

Measuring in vivo responses to endogenous and exogenous oxidative stress using a novel haem oxygenase 1 reporter mouse

C. Wolf, M. McMahon, C. Henderson, 2017, The Journal of physiology.

Measuring physiological responses to stressors using a novel Hmox1 reporter mouse

C. Wolf, M. McMahon, C. Henderson, 2017, bioRxiv.

University of Dundee Measuring in vivo responses to endogenous and exogenous oxidative stress using a novel Heme Oxygenase 1 reporter mouse

C. Wolf, C. Henderson, S. Ding, 2017 .

Disruption of the glutathione transferase pi class genes.

C. Wolf, C. Henderson, C. Henderson, 2005, Methods in enzymology.

Relative expression of cytochrome P450 isoenzymes in human liver and association with the metabolism of drugs and xenobiotics.

J. S. Miles, N. Kitteringham, B. K. Park, 1992, The Biochemical journal.

Pharmacokinetics and pharmacodynamics of orally administered acetylenic tricyclic bis(cyanoenone), a highly potent Nrf2 activator with a reversible covalent mode of action

A. Dinkova-Kostova, T. Honda, Suqing Zheng, 2015, Biochemical and biophysical research communications.

The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin.

C. Wolf, M. McMahon, J. Hayes, 2000, Biochemical Society transactions.

Lactational transfer of 2,4,5,2',4',5'-hexachlorobiphenyl but not 3,4,3',4'-tetrachlorobiphenyl, induces neonatal CYP4A1.

C. Wolf, C. Henderson, J. Borlakoglu, 1993, Biochemical pharmacology.

Precision-cut tissue slices from transgenic mice as an in vitro toxicology system.

A. J. Gandolfi, C. Wolf, A. Clark, 2003, Toxicology in vitro : an international journal published in association with BIBRA.

In Vivo and In Vitro Recombinant DNA Technology as a Powerful Tool in Drug Development

C. Wolf, T. Friedberg, C. Henderson, 1999 .

Species differences in the covalent binding of [14C]tamoxifen to liver microsomes and the forms of cytochrome P450 involved.

C. Wolf, I. White, L. L. Smith, 1995, Biochemical pharmacology.

A general strategy for the expression of recombinant human cytochrome P450s in Escherichia coli using bacterial signal peptides: expression of CYP3A4, CYP2A6, and CYP2E1.

C. Wolf, B. Burchell, T. Friedberg, 1997, Archives of biochemistry and biophysics.

High variability of nitrosamine metabolism among individuals: Role of cytochromes P450 2A6 and 2E1 in the dealkylation of N‐nitrosodimethylamine and N‐nitrosodiethylamine in mice and humans

Paavo Honkakoski, H. Bartsch, M. Lang, 1993, Molecular carcinogenesis.

Cytochrome b5 impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b5/P450 reductase null (HBRN) mice

V. Arlt, D. Phillips, K. Kopka, 2018, Archives of Toxicology.

Nrf2 activation does not affect adenoma development in a mouse model of colorectal cancer

J. Griffin, C. Wolf, Ying Zhang, 2021, Communications Biology.

An Enhanced In Vivo Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC) Model for Quantification of Drug Metabolism Enzymes*

C. Wolf, P. Fallon, J. Huang, 2015, Molecular & Cellular Proteomics.

Human constitutive androstane receptor (CAR) and pregnane X receptor (PXR) support the hypertrophic but not the hyperplastic response to the murine nongenotoxic hepatocarcinogens phenobarbital and chlordane in vivo.

C. Wolf, S. Plummer, C. Elcombe, 2010, Toxicological sciences : an official journal of the Society of Toxicology.

The hepatic cytochrome P450 reductase null mouse as a tool to identify a successful candidate entity.

C. Wolf, C. Henderson, G. Pass, 2006, Toxicology letters.

Potential of in vivo stress reporter models to reduce animal use and provide mechanistic insights in toxicity studies

C. Wolf, M. McMahon, C. Henderson, 2022, F1000Research.

Sexual differentiation and regulation of cytochrome P-450-formula> CYP2C7

C. Wolf, J. Allan, A. Russell, 1992 .

In vitro metabolism of aflatoxin B1 by normal and tumorous liver tissue from Thailand.

C. Wild, C. Wolf, D. Judah, 1993, Carcinogenesis.

Divergent regulation of cytochrome P450 enzymes by morphine and pethidine: a neuroendocrine mechanism?

C. Wolf, A. Rane, C. Henderson, 1995, Molecular pharmacology.

The Hepatic Reductase Null (HRN™) and Reductase Conditional Null (RCN) mouse models as suitable tools to study metabolism, toxicity and carcinogenicity of environmental pollutants

V. Arlt, D. Phillips, C. Wolf, 2015 .

Evidence that the androgen receptor mediates sexual differentiation of mouse renal cytochrome P450 expression.

C. Wolf, C. Henderson, C. Henderson, 1991, The Biochemical journal.

Testosterone-mediated regulation of mouse renal cytochrome P-450 isoenzymes.

C. Wolf, C. S. Yang, C. Henderson, 1990, The Biochemical journal.

A Targeted in Vivo SILAC Approach for Quantification of Drug Metabolism Enzymes: Regulation by the Constitutive Androstane Receptor

C. Wolf, J. Huang, Z. Riches, 2013, Journal of proteome research.

The Imidazoacridinone Antitumor Drug, C-1311, Is Metabolized by Flavin Monooxygenases but Not by Cytochrome P450s

C. Wolf, Á. Kot-Wasik, Sébastien Ronseaux, 2011, Drug Metabolism and Disposition.

A Role for Cytochrome b5 in the In Vivo Disposition of Anticancer and Cytochrome P450 Probe Drugs in Mice

R. Finn, C. Wolf, Sébastien Ronseaux, 2014, Drug Metabolism and Disposition.

Conditional Deletion of Cytochrome P450 Oxidoreductase in the Liver and Gastrointestinal Tract: A New Model for Studying the Functions of the P450 System

R. Finn, C. Wolf, R. Wolf, 2007, Journal of Pharmacology and Experimental Therapeutics.

Cholesterol Metabolism: the Main Pathway Acting Downstream of Cytochrome P450 Oxidoreductase in Skeletal Development of the Limb

Simon R. Goodyear, C. Tickle, R. Aspden, 2009, Molecular and Cellular Biology.

Attenuation of lung fibrosis in mice with a clinically relevant inhibitor of glutathione-S-transferase π.

D. Townsend, K. Tew, C. Wolf, 2016, JCI insight.

Role of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function

A. Pandey, U. Zanger, Y. Ishii, 2018 .

Pyrethroid activity-based probes for profiling cytochrome P450 activities associated with insecticide interactions

R. Finn, J. Hemingway, B. Cravatt, 2013, Proceedings of the National Academy of Sciences.

Glutathione transferases P1/P2 regulate the timing of signaling pathway activations and cell cycle progression during mouse liver regeneration

P. Loyer, C. Rauch, F. Morel, 2015, Cell Death and Disease.

Rescue of cytochrome P450 oxidoreductase (Por) mouse mutants reveals functions in vasculogenesis, brain and limb patterning linked to retinoic acid homeostasis.

C. Tickle, P. Dollé, C. Wolf, 2007, Developmental biology.

Olaparib, Monotherapy or with Ionizing Radiation, Exacerbates DNA Damage in Normal Tissues: Insights from a New p21 Reporter Mouse

C. Wolf, M. McMahon, C. Henderson, 2016, Molecular Cancer Research.

Exacerbates DNA Damage in Normal Tissues : Insights from a New p 21 Reporter Mouse

C. Wolf, M. McMahon, C. Henderson, 2016 .

Markedly enhanced colon tumorigenesis in ApcMin mice lacking glutathione S-transferase Pi

O. Sansom, C. Wolf, C. Henderson, 2009, Proceedings of the National Academy of Sciences.

Humanizing π-Class Glutathione S-Transferase Regulation in a Mouse Model Alters Liver Toxicity in Response to Acetaminophen Overdose

Colin J. Henderson, J. Hicks, A. D. De Marzo, 2011, PloS one.

Cytochrome b5 and epoxide hydrolase contribute to benzo[a]pyrene-DNA adduct formation catalyzed by cytochrome P450 1A1 under low NADPH:P450 oxidoreductase conditions.

V. Arlt, D. Phillips, E. Frei, 2014, Toxicology.

Bioactivation of 3-aminobenzanthrone, a human metabolite of the environmental pollutant 3-nitrobenzanthrone: evidence for DNA adduct formation mediated by cytochrome P450 enzymes and peroxidases.

V. Arlt, D. Phillips, C. Wolf, 2006, Cancer letters.

Environmental pollutant and potent mutagen 3-nitrobenzanthrone forms DNA adducts after reduction by NAD(P)H:quinone oxidoreductase and conjugation by acetyltransferases and sulfotransferases in human hepatic cytosols.

B. Sopko, V. Arlt, D. Phillips, 2005, Cancer research.

Application of hepatic cytochrome b5/P450 reductase null (HBRN) mice to study the role of cytochrome b5 in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine

V. Arlt, D. Phillips, C. Wolf, 2019, Toxicology and applied pharmacology.

Deletion of Microsomal Cytochrome b5 Profoundly Affects Hepatic and Extrahepatic Drug Metabolism

R. Finn, Sébastien Ronseaux, C. Henderson, 2010, Molecular Pharmacology.

Relationship between hepatic phenotype and changes in gene expression in cytochrome P450 reductase (POR) null mice.

X. Wang, M. Chamberlain, C. Wolf, 2005, The Biochemical journal.

Glutathione-S-transferase P promotes glycolysis in asthma in association with oxidation of pyruvate kinase M2

I. Adcock, E. Wouters, C. Wolf, 2021, Redox biology.

Immunodetection of proteins by Western blotting.

C. Wolf, C. Henderson, C. Henderson, 1992, Methods in molecular biology.

Aldo-keto reductases are biomarkers of NRF2 activity and are co-ordinately overexpressed in non-small cell lung cancer

F. Carey, C. Wolf, P. Coates, 2016, British Journal of Cancer.

Pharmacologic or genetic manipulation of glutathione S-transferase P1-1 (GSTpi) influences cell proliferation pathways.

K. Tew, C. Wolf, Z. Ronai, 2001, The Journal of pharmacology and experimental therapeutics.

Cellular response to a glutathione S-transferase P1-1 activated prodrug.

K. Tew, C. Wolf, L. Rosario, 2000, Molecular pharmacology.

Increased skin tumorigenesis in mice lacking pi class glutathione S-transferases.

C. Wolf, E. Bacon, A. Smith, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Knockout and transgenic mice in glutathione transferase research

C. Wolf, C. Henderson, C. Henderson, 2011, Drug metabolism reviews.

Increased skin papilloma formation in mice lacking glutathione transferase GSTP.

P. Chakravarty, C. Wolf, A. McLaren, 2011, Cancer research.

Glutathione transferase pi plays a critical role in the development of lung carcinogenesis following exposure to tobacco-related carcinogens and urethane.

C. Wolf, O. Vassieva, P. Farmer, 2007, Cancer research.

Protein expression profiling of glutathione S‐transferase pi null mice as a strategy to identify potential markers of resistance to paracetamol‐induced toxicity in the liver

S. Pennington, C. Wolf, N. Kitteringham, 2003, Proteomics.

Pi-class glutathione S-transferase: regulation and function.

C. Wolf, E. Bacon, G. Moffat, 1998, Chemico-biological interactions.

Drug-induced chromatin accessibility changes associate with sensitivity to liver tumor promotion

K. Kapur, C. Wolf, C. Wolf, 2019, Life Science Alliance.

Defining the Contribution of CYP1A1 and CYP1A2 to Drug Metabolism Using Humanized CYP1A1/1A2 and Cyp1a1/Cyp1a2 Knockout Mice

C. Wolf, N. Scheer, C. Henderson, 2019, Drug Metabolism and Disposition.

Genetically Humanized Animal Models

I. Wilson, C. Wolf, N. Scheer, 2017 .

Cyp 2 c 70 is responsible for the species difference in bile acid metabolism between mice and humans

C. Brocker, C. Wolf, F. Gonzalez, 2016 .

Deletion of 30 Murine Cytochrome P450 Genes Results In Viable Mice With Compromised Drug Metabolism s

C. Wolf, N. Scheer, C. Henderson, 2014 .

A Role for Cytochrome b 5 in the In Vivo Disposition of Anticancer and Cytochrome P 450 Probe Drugs in Mice s

R. Finn, C. Wolf, Sébastien Ronseaux, 2013 .

DMD055277 70..77

R. Finn, C. Wolf, Sébastien Ronseaux, 2013 .

Unsaturated fatty acid regulation of cytochrome P450 expression via a CAR-dependent pathway

R. Finn, C. Wolf, C. Henderson, 2008, The Biochemical journal.

University of Dundee HDAC inhibitors increase NRF 2-signaling in tumour cells and blunt the efficacy of co-adminstered cytotoxic agents

C. Wolf, M. McMahon, C. Henderson, 2014 .

Transcription factor Nrf2 is essential for induction of NAD(P)H:quinone oxidoreductase 1, glutathione S-transferases, and glutamate cysteine ligase by broccoli seeds and isothiocyanates.

Paul J Thornalley, K. Itoh, Masayuki Yamamoto, 2004, The Journal of nutrition.

Functional Expression and Comparative Characterization of Nine Murine Cytochromes P450 by Fluorescent Inhibition Screening

C. Wolf, C. Henderson, L. Dickmann, 2008, Drug Metabolism and Disposition.

The use of transgenic animals to assess the role of metabolism in target organ toxicity.

C. Wolf, A. Clark, S. Campbell, 1998, Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement.

Uptake and effects of orally ingested polystyrene microplastic particles in vitro and in vivo

A. Lampen, A. Braeuning, R. Selb, 2019, Archives of Toxicology.

Regulation of hepatic uptake and efflux transporters in vitro

R. Weaver, G. Hawksworth, C. Henderson, 2011 .

Glutathione transferase P1: an endogenous inhibitor of allergic responses in a mouse model of asthma.

C. Wolf, P. Foster, P. Board, 2008, American journal of respiratory and critical care medicine.

The pyrrolizidine alkaloid senecionine induces CYP-dependent destruction of sinusoidal endothelial cells and cholestasis in mice

J. Hengstler, A. Lampen, A. Braeuning, 2019, Archives of Toxicology.

Editorial: Role of Protein-Protein Interactions in Metabolism: Genetics, Structure, Function

A. Pandey, U. Zanger, Y. Ishii, 2017, Front. Pharmacol..

The Role of Protein-Protein and Protein-Membrane Interactions on P450 Function

Jeffrey P. Jones, K. Berka, M. Otyepka, 2016, Drug Metabolism and Disposition.

Advances in the generation of mouse models to elucidate the pathways of drug metabolism in rodents and man

C. Wolf, N. Scheer, C. Henderson, 2009, Expert review of clinical pharmacology.

In vivo stress reporters as early biomarkers of the cellular changes associated with progeria

C. Wolf, C. Henderson, F. Inesta-Vaquera, 2022, Journal of cellular and molecular medicine.

Application of Mice Humanized for CYP2D6 to the Study of Tamoxifen Metabolism and Drug–Drug Interaction with Antidepressants

C. Wolf, C. Henderson, L. McLaughlin, 2017, Drug Metabolism and Disposition.

University of Dundee Application of Mice Humanised for Cytochrome P450 CYP2D6 to the Study of Tamoxifen Metabolism and Drug-Drug Interaction with Antidepressants

C. Wolf, K. Macleod, C. Henderson, 2016 .

Model Systems for Understanding Mechanisms of Nongenotoxic Carcinogenesis: Response.

C. Wolf, M. Schwarz, A. Braeuning, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

Phenobarbital-mediated tumor promotion in transgenic mice with humanized CAR and PXR.

C. Wolf, M. Schwarz, A. Braeuning, 2014, Toxicological sciences : an official journal of the Society of Toxicology.