C. Hill

发表

Molecular architecture of a dynamin adaptor: implications for assembly of mitochondrial fission complexes

J. Shaw, C. Hill, D. Eckert, 2010, The Journal of cell biology.

Branched ubiquitin chain binding and deubiquitination by UCH37 facilitate proteasome clearance of stress-induced inclusions

Lan Huang, C. Hill, D. Fushman, 2021, bioRxiv.

Ubiquitin recognition by the human TSG101 protein.

W. Sundquist, J. Holton, C. Hill, 2004, Molecular cell.

Ubiquitin-binding domains

Linda Hicke, C. Hill, L. Hicke, 2005, Nature Reviews Molecular Cell Biology.

Structure and Ubiquitin Binding of the Ubiquitin-interacting Motif*

R. D. Fisher, W. Sundquist, C. Hill, 2003, Journal of Biological Chemistry.

Vms1p is a release factor for the ribosome-associated quality control complex

C. Hill, J. Rutter, P. Shen, 2018, bioRxiv.

A novel SH2 recognition mechanism recruits Spt6 to the doubly phosphorylated RNA polymerase II linker at sites of transcription

T. Formosa, C. Hill, T. Parnell, 2017, eLife.

Structure of the Cdc48 segregase in the act of unfolding an authentic substrate

J. C. Price, C. Hill, J. Iwasa, 2019, Science.

The AAA ATPase Vps4 binds ESCRT-III substrates through a repeating array of dipeptide-binding pockets

W. Sundquist, C. Hill, P. Shen, 2017, eLife.

Defining polyubiquitin chain topology

C. Hill, N. Chan, C. Hill, 2001, Nature Structural Biology.

The interaction between the Spt6-tSH2 domain and Rpb1 affects multiple functions of RNA Polymerase II

T. Formosa, T. Parnell, Zaily Connell, 2021, Nucleic acids research.

Selective Kinase Inhibition Shows That Bur1 (Cdk9) Phosphorylates the Rpb1 Linker In Vivo

T. Formosa, C. Hill, S. Buratowski, 2018, Molecular and Cellular Biology.

Crystal structures of the S. cerevisiae Spt6 core and C-terminal tandem SH2 domain.

Sean J. Johnson, T. Formosa, C. Hill, 2011, Journal of molecular biology.

Molecular recognition in the HIV-1 capsid/cyclophilin A complex.

W. Sundquist, C. Hill, D. Myszka, 1997, Journal of molecular biology.

Design and characterization of ebolavirus GP prehairpin intermediate mimics as drug targets

J. Dye, A. Herbert, C. Hill, 2015, Protein science : a publication of the Protein Society.

Potent D-peptide inhibitors of HIV-1 entry

Michael S. Kay, Andrew P. VanDemark, Annie Heroux, 2007, Proceedings of the National Academy of Sciences.

Crystal structure of a biliverdin IXalpha reductase enzyme-cofactor complex.

C. Hill, J. Phillips, M. Maines, 2002, Journal of molecular biology.

UNC119 is required for G protein trafficking in sensory neurons

M. Davis, E. Jorgensen, G. Montelione, 2011, Nature Neuroscience.

Structural Basis for ESCRT-III Protein Autoinhibition

W. Sundquist, D. Myszka, J. McCullough, 2009, Nature Structural &Molecular Biology.

Crystal structure of defensin HNP-3, an amphiphilic dimer: mechanisms of membrane permeabilization.

D. Eisenberg, C. Hill, J. Yee, 1991, Science.

Direct Tests of Cytochrome Function in the Electron Transport Chain of Malaria Parasites

C. Hill, J. Wohlschlegel, F. Whitby, 2023, bioRxiv.

Characterization of Recombinant REGα, REGβ, and REGγ Proteasome Activators*

C. Hill, M. Rechsteiner, S. Johnston, 1997, The Journal of Biological Chemistry.

Inositol Hexakisphosphate Is Bound in the ADAR2 Core and Required for RNA Editing

B. Bass, C. Hill, A. Vandemark, 2005, Science.

Activation of the Anti-Oxidative Stress Response Reactivates Latent HIV-1 Through the Mitochondrial Antiviral Signaling Protein Isoform MiniMAVS

A. Spivak, C. Hill, L. Trautmann, 2021, Frontiers in Immunology.

Identification of an activation region in the proteasome activator REGalpha.

C. Hill, M. Rechsteiner, A. Clawson, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Structural insights into the catalytic mechanism of cyclophilin A

W. Sundquist, C. Hill, F. Vajdos, 2003, Nature Structural Biology.

Structure of the Spt16 Middle Domain Reveals Functional Features of the Histone Chaperone FACT*

T. Formosa, C. Hill, H. Robinson, 2013, The Journal of Biological Chemistry.

Structural and Biochemical Studies of ALIX/AIP1 and Its Role in Retrovirus Budding

R. D. Fisher, W. Sundquist, C. Hill, 2007, Cell.

Structural and functional studies of ALIX interactions with YPXnL late domains of HIV-1 and EIAV

R. D. Fisher, W. Sundquist, C. Hill, 2008, Nature Structural &Molecular Biology.

Structural basis for ubiquitin recognition by the human ESCRT-II EAP45 GLUE domain

Charles Langelier, W. Sundquist, C. Hill, 2006, Nature Structural &Molecular Biology.

X-Ray Structures of the Hexameric Building Block of the HIV Capsid

Mark Yeager, Wesley I. Sundquist, W. Sundquist, 2009, Cell.

Image reconstructions of helical assemblies of the HIV-1 CA protein

Wesley I. Sundquist, John T. Finch, W. Sundquist, 2022 .

Structure of the carboxyl-terminal dimerization domain of the HIV-1 capsid protein.

W. Sundquist, J. McCutcheon, C. Hill, 1997, Science.

Crystal Structure of Human Cyclophilin A Bound to the Amino-Terminal Domain of HIV-1 Capsid

W. Sundquist, C. Hill, F. Vajdos, 1996, Cell.

The structure of granulocyte-colony-stimulating factor and its relationship to other growth factors.

D Eisenberg, D. Eisenberg, C. Hill, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Penicillin acylase has a single-amino-acid catalytic centre

Eleanor J. Dodson, Peter C. E. Moody, C. Hill, 1996, Nature.

Crystal Structure of the Flagellar Rotor Protein FliN from Thermotoga maritima

C. Hill, D. Blair, L. Joss, 2005, Journal of bacteriology.

Structure of the Bro1 Domain Protein BROX and Functional Analyses of the ALIX Bro1 Domain in HIV-1 Budding

W. Sundquist, C. Hill, H. Robinson, 2011, PloS one.

Activation of the Retroviral Budding Factor ALIX

Jill Trewhella, Cy M. Jeffries, Wesley I. Sundquist, 2011, Journal of Virology.

Identification and Structural Characterization of the ALIX-Binding Late Domains of Simian Immunodeficiency Virus SIVmac239 and SIVagmTan-1

W. Sundquist, C. Hill, H. Robinson, 2010, Journal of Virology.

ALIX-CHMP4 interactions in the human ESCRT pathway

R. D. Fisher, W. Sundquist, C. Hill, 2008, Proceedings of the National Academy of Sciences.

Cryo-EM structure of dodecameric Vps4p and its 2:1 complex with Vta1p.

G. Jensen, W. Sundquist, Zhiheng Yu, 2008, Journal of molecular biology.

Activation of the Retroviral Budding Factor ALIX (cid:1) †

W. Sundquist, J. Trewhella, C. Hill, 2011 .

Human ESCRT-II Complex and Its Role in Human Immunodeficiency Virus Type 1 Release

R. D. Fisher, W. Sundquist, C. Hill, 2006, Journal of Virology.

Structural and biochemical characterization of Gun4 suggests a mechanism for its role in chlorophyll biosynthesis.

J. D. Reid, C. Hill, C. Hunter, 2005, Biochemistry.

Identification of dual DNA-PK MDR1 inhibitors for the potentiation of cytotoxic drug activity.

D. Jamieson, C. Hill, B. Durkacz, 2014, Biochemical pharmacology.

Structure of ATP-bound human ATP:cobalamin adenosyltransferase.

C. Hill, H. Schubert, C. Hill, 2006, Biochemistry.

Cleavage and Polyadenylation Specificity Factor 6 Is Required for Efficient HIV-1 Latency Reversal

A. Engelman, C. Hill, V. Planelles, 2021, mBio.

Crystal Structure of the Human Ubiquitin-like Protein NEDD8 and Interactions with Ubiquitin Pathway Enzymes*

C. Hill, C. Pickart, F. Whitby, 1998, The Journal of Biological Chemistry.

Structural basis for the activation of 20S proteasomes by 11S regulators

C. Hill, Ching C. Wang, E. Masters, 2000, Nature.

UBIQUITINBINDING DOMAINS

C. Hill, L. Hicke, H. Schubert, 2005 .

Structural Models for Interactions between the 20S Proteasome and Its PAN/19S Activators*

K. Ferrell, C. Hill, D. Myszka, 2009, The Journal of Biological Chemistry.

Visualization of the Cdc48 AAA+ ATPase protein unfolding pathway

C. Hill, P. Shen, H. Schubert, 2023, bioRxiv.

Structure of the C-terminal domain of FliG, a component of the rotor in the bacterial flagellar motor

C. Hill, D. Blair, F. Whitby, 1999, Nature.

Somatostatin venom analogs evolved by fish-hunting cone snails: From prey capture behavior to identifying drug leads

B. Ueberheide, C. Hill, B. Olivera, 2021, bioRxiv.

Implications for viral capsid assembly from crystal structures of HIV-1 Gag(1-278) and CA(N)(133-278).

W. Sundquist, C. Hill, H. Robinson, 2006, Biochemistry.

FACT Disrupts Nucleosome Structure by Binding H2A-H2B with Conserved Peptide Motifs.

T. Formosa, C. Hill, F. Whitby, 2015, Molecular cell.

Structural and functional studies on the extracellular domain of BST2/tetherin in reduced and oxidized conformations

W. Sundquist, C. Hill, R. Steiner, 2010, Proceedings of the National Academy of Sciences.

Crystal structures of the trimeric human immunodeficiency virus type 1 matrix protein: implications for membrane association and assembly.

W. Sundquist, C. Hill, A. M. Christensen, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Image reconstructions of helical assemblies of the HIV-1 CA protein

W. Sundquist, J. Finch, Su Li, 2000, Nature.

Structural biology of the proteasome.

C. Hill, E. Kish-Trier, C. Hill, 2013, Annual review of biophysics.

The structural and sequence homology of a family of microbial ribonucleases

C. Hill, U. Heinemann, W. Saenger, 1983 .

Symmetric and Asymmetric Receptor Conformation Continuum induced by a Novel Insulin

Ingmar B. Schäfer, J. Menting, M. Lawrence, 2022, Nature Chemical Biology.

Visualization of Insulin Receptor Activation by a Novel Insulin Analog with Elongated A Chain and Truncated B Chain

J. Menting, M. Lawrence, C. Hill, 2021 .

X-ray structure of an unusual Ca2+ site and the roles of Zn2+ and Ca2+ in the assembly, stability, and storage of the insulin hexamer.

Z. Dauter, C. Hill, E. Dodson, 1991, Biochemistry.

THE 2-ZINC INSULIN HEXAMER IS A CALCIUM-BINDING PROTEIN

M. Roy, C. Hill, G. Dodson, 1987 .

Crystal Structure of the Oxygen-dependant Coproporphyrinogen Oxidase (Hem13p) of Saccharomyces cerevisiae*

P. Labbé, Cheng Yang, J. Pflugrath, 2004, Journal of Biological Chemistry.

Active conformation of the p97-p47 unfoldase complex

C. Hill, P. Shen, Han Han, 2022, Nature Communications.

Structure of spastin bound to a glutamate-rich peptide implies a hand-over-hand mechanism of substrate translocation

W. Sundquist, M. Yeager, C. Hill, 2019, The Journal of Biological Chemistry.

Structure of Vps4 with circular peptides and implications for translocation of two polypeptide chains by AAA+ ATPases

Janet H Iwasa, Venkata P Dandey, Han Han, 2019, eLife.

Structure and mechanism of the ESCRT pathway AAA+ ATPase Vps4

C. Hill, Han Han, C. Hill, 2019, Biochemical Society transactions.

Structural basis of protein translocation by the Vps4-Vta1 AAA ATPase

W. Sundquist, C. Hill, P. Shen, 2017, eLife.

Crystal structures of adenine phosphoribosyltransferase from Leishmania donovani

C. Hill, R. Brennan, B. Ullman, 1999, The EMBO journal.

Structural basis for the specificity of ubiquitin C‐terminal hydrolases

C. Hill, R E Cohen, S. Johnston, 1999, The EMBO journal.

Proteasome activators.

C. Hill, B. Stadtmueller, C. Hill, 2011, Molecular cell.

Peptoid Residues Make Diverse, Hyperstable Collagen Triple-Helices.

T. Cheatham, C. Hill, F. Whitby, 2020, Journal of the American Chemical Society.

Structure and function of SirC from Bacillus megaterium: a metal-binding precorrin-2 dehydrogenase.

S. Rigby, H. Schubert, M. Warren, 2008, The Biochemical journal.

Structure and mechanistic implications of a uroporphyrinogen III synthase-product complex.

C. Hill, J. Phillips, A. Héroux, 2008, Biochemistry.

Structural basis for tetrapyrrole coordination by uroporphyrinogen decarboxylase

C. Hill, J. Phillips, F. Whitby, 2003, The EMBO journal.

The structure of Saccharomyces cerevisiae Met8p, a bifunctional dehydrogenase and ferrochelatase

K. Wilson, H. Schubert, M. Warren, 2002, The EMBO journal.

Crystal structure of human uroporphyrinogen decarboxylase

C. Hill, J. Phillips, F. Whitby, 1998, The EMBO journal.

Structure of the antiviral assembly inhibitor CAP-1 complex with the HIV-1 CA protein.

Chun Tang, W. Sundquist, M. Summers, 2007, Journal of molecular biology.

Protein crystallography: more surprises ahead.

D. Eisenberg, C. Hill, D. Eisenberg, 1989, Trends in biochemical sciences.

Meiotic Clade AAA ATPases: Protein Polymer Disassembly Machines.

C. Hill, N. Monroe, C. Hill, 2016, Journal of molecular biology.

Structural and mechanistic studies of VPS4 proteins

W. Sundquist, J. Holton, Ramya Viswanathan, 2005, The EMBO journal.

Structure and function of the membrane deformation AAA ATPase Vps4.

C. Hill, M. Babst, C. Hill, 2012, Biochimica et biophysica acta.

Crystal structure of alpha 1: implications for protein design.

D Eisenberg, D. Eisenberg, W. DeGrado, 1990, Science.

Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase

Andrea L. Guzman, Karen N. Allen, Jianping Ding, 2023, Science.

Crystal structure of the middle and C‐terminal domains of the flagellar rotor protein FliG

C. Hill, D. Blair, P. N. Brown, 2002, The EMBO journal.

Structural basis of ubiquitylation.

C. Hill, A. Vandemark, C. Hill, 2002, Current opinion in structural biology.

Structure of an actin-related subcomplex of the SWI/SNF chromatin remodeler

B. Cairns, M. Kasten, C. Hill, 2013, Proceedings of the National Academy of Sciences.

Structure of a new crystal form of tetraubiquitin.

C. Hill, C. Pickart, J. Thrower, 2001, Acta crystallographica. Section D, Biological crystallography.

The oligomeric state of the active Vps4 AAA ATPase.

W. Sundquist, C. Hill, D. Eckert, 2014, Journal of molecular biology.

Protein-Metabolite Interactomics Reveals Novel Regulation of Carbohydrate Metabolism

Karen N. Allen, M. V. Vander Heiden, C. Gasper, 2021, bioRxiv.

Mobilizing the proteolytic machine: cell biological roles of proteasome activators and inhibitors.

C. Hill, M. Rechsteiner, C. Hill, 2005, Trends in cell biology.

Structure-Based Optimization of Small Molecule Human Galactokinase Inhibitors.

M. Hall, J. Marugan, R. Pragani, 2021, Journal of medicinal chemistry.

Crystal structure of human uroporphyrinogen III synthase

C. Hill, J. Phillips, F. Whitby, 2001, EMBO Journal.

Novel four-disulfide insulin analog with high aggregation stability and potency† †Electronic supplementary information (ESI) available: Detailed synthesis procedure and mass spectrometry data along with biological experiment protocol. See DOI: 10.1039/c9sc04555d

C. Hill, M. Webber, F. Whitby, 2019, Chemical science.

Structural and Functional Analysis of the Spt16p N-terminal Domain Reveals Overlapping Roles of yFACT Subunits*

D. Stillman, T. Formosa, C. Hill, 2008, Journal of Biological Chemistry.

The 1.9 A structure of a proteasome-11S activator complex and implications for proteasome-PAN/PA700 interactions.

C. Hill, H. Robinson, E. Masters, 2005, Molecules and Cells.

Autoregulation of the rsc4 tandem bromodomain by gcn5 acetylation.

B. Cairns, M. Kasten, C. Hill, 2007, Molecular cell.

Purification and analysis of recombinant 11S activators of the 20S proteasome: Trypanosoma brucei PA26 and human PA28 alpha, PA28 beta, and PA28 gamma.

C. Hill, G. Pratt, E. Masters, 2005, Methods in enzymology.

The 11S regulators of 20S proteasome activity.

C. Hill, E. Masters, F. Whitby, 2002, Current topics in microbiology and immunology.

1 2 Structure of Vps 4 with circular peptides and implications for translocation of 3 two polypeptide chains by AAA + ATPases 4 5 6

W. Sundquist, C. Hill, J. Iwasa, 2019 .

Structure of Proteasome-Pba1-Pba2 Complex

T. Formosa, D. Myszka, H. Robinson, 2012 .

Structure of a Proteasome Pba1-Pba2 Complex

K. Ferrell, T. Formosa, C. Hill, 2012, The Journal of Biological Chemistry.

An asymmetric interface between the regulatory particle and core particle of the proteasome

Min Jae Lee, S. Gygi, D. Finley, 2011, Nature Structural &Molecular Biology.

Structure of a Blm10 complex reveals common mechanisms for proteasome binding and gate opening.

K. Sadre-Bazzaz, T. Formosa, C. Hill, 2010, Molecular cell.

Structure of the Blm10-20 S proteasome complex by cryo-electron microscopy. Insights into the mechanism of activation of mature yeast proteasomes.

Jack Iwanczyk, K. Sadre-Bazzaz, K. Ferrell, 2006, Journal of molecular biology.

Complex: Implications for Structure of a Proteasome Pba1-pba2

K. Ferrell, T. Formosa, D. Myszka, 2012 .

Purification and Analysis of Recombinant 11 S Activators of the 20 S Proteasome : Trypanosoma brucei PA 26 and Human PA

C. Hill, G. Pratt, E. Masters, 2005 .

The pore of activated 20S proteasomes has an ordered 7‐fold symmetric conformation

C. Hill, A. Förster, F. Whitby, 2003, The EMBO journal.

Structure of the proteasome activator REGα (PA28α)

C. Hill, M. Rechsteiner, F. Whitby, 1997, Nature.

Proteasome degradation: enter the substrate.

C. Hill, A. Förster, C. Hill, 2003, Trends in cell biology.

Structure of the proteasome activator REGalpha (PA28alpha).

C. Hill, M. Rechsteiner, F. Whitby, 1997, Nature.