Nobumichi Ohoka

发表

Development of a potent small‐molecule degrader against oncogenic BRAFV600E protein that evades paradoxical MAPK activation

M. Naito, Yoshinori Tsukumo, N. Ohoka, 2022, Cancer science.

Anti-Inflammatory Activity of Kurarinone Involves Induction of HO-1 via the KEAP1/Nrf2 Pathway

Y. Inoue, H. Hayashi, S. Hida, 2020, Antioxidants.

Development of BCR-ABL degradation inducers via the conjugation of an imatinib derivative and a cIAP1 ligand.

M. Naito, Takashi Misawa, M. Kurihara, 2016, Bioorganic & medicinal chemistry letters.

A Novel Regulatory Mechanism of the Bone Morphogenetic Protein (BMP) Signaling Pathway Involving the Carboxyl-Terminal Tail Domain of BMP Type II Receptor

A. Hata, H. Hayashi, Brandi N. Davis, 2007, Molecular and Cellular Biology.

C/EBP family transcription factors are degraded by the proteasome but stabilized by forming dimer

Takayuki Hattori, Yasumichi Inoue, Y. Inoue, 2003, Oncogene.

TRB3 suppresses adipocyte differentiation by negatively regulating PPARgamma transcriptional activity.

H. Hayashi, R. Sato, N. Ohoka, 2008, Journal of lipid research.

SNIPER(TACC3) induces cytoplasmic vacuolization and sensitizes cancer cells to Bortezomib

M. Naito, N. Cho, N. Shibata, 2017, Cancer science.

Development of small molecule chimeras that recruit AhR E3 ligase to target proteins.

M. Naito, Y. Demizu, Genichiro Tsuji, 2019, ACS chemical biology.

TRB3, a novel ER stress‐inducible gene, is induced via ATF4–CHOP pathway and is involved in cell death

H. Hayashi, K. Onozaki, N. Ohoka, 2005, The EMBO journal.

SNIPERs-Hijacking IAP activity to induce protein degradation.

M. Naito, N. Shibata, N. Ohoka, 2019, Drug discovery today. Technologies.

Critical and Functional Regulation of CHOP (C/EBP Homologous Protein) through the N-terminal Portion*

M. Kitagawa, H. Hayashi, K. Onozaki, 2007, Journal of Biological Chemistry.

Development of Agonist-Based PROTACs Targeting Liver X Receptor

T. Ohtsuki, M. Naito, Kanako Nemoto, 2021, Frontiers in Chemistry.

HNF4&agr; Increases Liver-Specific Human ATP-Binding Cassette Transporter A1 Expression and Cholesterol Efflux to Apolipoprotein A-I in Response to Cholesterol Depletion

M. Naito, R. Sato, T. Nishimaki-Mogami, 2012, Arteriosclerosis, thrombosis, and vascular biology.

Transcriptional Coactivator TAZ Negatively Regulates Tumor Suppressor p53 Activity and Cellular Senescence

Yuki Kawarada, Y. Inoue, H. Hayashi, 2020, Cells.

Degradation of Stop Codon Read-through Mutant Proteins via the Ubiquitin-Proteasome System Causes Hereditary Disorders*

Y. Gondo, M. Naito, Y. Sakuraba, 2015, The Journal of Biological Chemistry.

Periplocin and cardiac glycosides suppress the unfolded protein response

S. Iida, Y. Inoue, Yuka Itoh, 2021, Scientific Reports.

The CDK inhibitor p21 is a novel target gene of ATF4 and contributes to cell survival under ER stress

S. Ito, Y. Inoue, Keishi Fukuura, 2017, FEBS letters.

The deubiquitinating enzyme USP17 regulates c‐Myc levels and controls cell proliferation and glycolysis

Y. Inoue, H. Hayashi, N. Ohoka, 2022, FEBS letters.

Development of a Cell-penetrating Peptide that Exhibits Responsive Changes in its Secondary Structure in the Cellular Environment

M. Naito, M. Oba, Takuma Kato, 2016, Scientific Reports.

Deubiquitylase USP25 prevents degradation of BCR-ABL protein and ensures proliferation of Ph-positive leukemia cells

T. Akiyama, K. Ui-Tei, M. Naito, 2020, Oncogene.

Targeted Protein Degradation by Chimeric Small Molecules, PROTACs and SNIPERs

M. Naito, Yoshinori Tsukumo, N. Shibata, 2019, Front. Chem..

Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation

M. Naito, Ryokichi Koyama, Tomoya Sameshima, 2018, The Journal of Biological Chemistry.

Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands.

M. Naito, Ryokichi Koyama, N. Cho, 2017, Journal of medicinal chemistry.

In Vivo Knockdown of Pathogenic Proteins via Specific and Nongenetic Inhibitor of Apoptosis Protein (IAP)-dependent Protein Erasers (SNIPERs)*

M. Naito, Ryokichi Koyama, Mika Teratani, 2017, The Journal of Biological Chemistry.

Development of hybrid small molecules that induce degradation of estrogen receptor‐alpha and necrotic cell death in breast cancer cells

M. Naito, T. Nishimaki-Mogami, H. Okuda, 2013, Cancer science.

Molecular Design, Synthesis, and Evaluation of SNIPER(ER) That Induces Proteasomal Degradation of ERα.

M. Naito, M. Kurihara, N. Shibata, 2016, Methods in molecular biology.

Kurarinone from Sophora Flavescens Roots Triggers ATF4 Activation and Cytostatic Effects Through PERK Phosphorylation

Y. Inoue, Yuka Itoh, H. Hayashi, 2019, Molecules.

Dual mode of regulation of cell division cycle 25 A protein by TRB3.

M. Kitagawa, M. Nakanishi, H. Hayashi, 2010, Biological & pharmaceutical bulletin.

Anaphase-promoting complex/cyclosome-cdh1 mediates the ubiquitination and degradation of TRB3.

M. Nakanishi, H. Hayashi, K. Onozaki, 2010, Biochemical and biophysical research communications.

Development of Chimeric Molecules That Degrade the Estrogen Receptor Using Decoy Oligonucleotide Ligands.

K. Matsuno, M. Naito, Genichiro Tsuji, 2021, ACS medicinal chemistry letters.

APOLLON Protein Promotes Early Mitotic CYCLIN A Degradation Independent of the Spindle Assembly Checkpoint*

M. Naito, H. Ohata, N. Ohoka, 2013, The Journal of Biological Chemistry.

C/EBP homologous protein (CHOP) up‐regulates IL‐6 transcription by trapping negative regulating NF‐IL6 isoform

H. Hayashi, K. Onozaki, N. Ohoka, 2003, FEBS letters.

Targeted Protein Degradation by Chimeric Compounds using Hydrophobic E3 Ligands and Adamantane Moiety

M. Naito, H. Inoue, Y. Demizu, 2020, Pharmaceuticals.

The interaction with Sp1 and reduction in the activity of histone deacetylase 1 are critical for the constitutive gene expression of IL‐1α in human melanoma cells

H. Hayashi, T. Okamoto, K. Onozaki, 2008, Journal of leukocyte biology.

Anti-Tumorigenic Activity of Chrysin from Oroxylum indicum via Non-Genotoxic p53 Activation through the ATM-Chk2 Pathway

Yuka Itoh, H. Hayashi, Kan’ichiro Ishiuchi, 2018, Molecules.

Lysine-Specific Demethylase 1 (LSD1/KDM1A) Is a Novel Target Gene of c-Myc.

Y. Inoue, H. Hayashi, N. Ohoka, 2019, Biological & pharmaceutical bulletin.

Anti-Inﬂammatory Activity of Kurarinone Involves Induction of HO-1 via the KEAP1 / Nrf2 Pathway

H. Hayashi, S. Hida, Sakiko Nishikawa, 2022 .

Cancer cell death induced by novel small molecules degrading the TACC3 protein via the ubiquitin–proteasome pathway

M. Naito, N. Cho, N. Shibata, 2014, Cell Death and Disease.

The ubiquitin-specific protease USP17 prevents cellular senescence by stabilizing the methyltransferase SET8 and transcriptionally repressing p21

M. Komada, Y. Inoue, Keishi Fukuura, 2019, The Journal of Biological Chemistry.

The orphan nuclear receptor RORalpha restrains adipocyte differentiation through a reduction of C/EBPbeta activity and perilipin gene expression.

H. Hayashi, R. Sato, N. Ohoka, 2009, Molecular endocrinology.

Development of STING degrader with double covalent ligands.

Genichiro Tsuji, N. Shibata, Yosuke Demizu, 2024, Bioorganic & medicinal chemistry letters.

Binding of PDZ-RhoGEF to ATP-binding Cassette Transporter A1 (ABCA1) Induces Cholesterol Efflux through RhoA Activation and Prevention of Transporter Degradation*

M. Naito, Kazuhiro Suzuki, J. Sawada, 2010, The Journal of Biological Chemistry.

Proteasome inhibitors prevent cell death and prolong survival of mice challenged by Shiga toxin

M. Naito, T. Hamabata, K. Furukawa, 2015, FEBS open bio.

Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinase

M. Naito, Tomoya Sameshima, N. Cho, 2018, Scientific Reports.

Tributyltin chloride induces ABCA1 expression and apolipoprotein A-I-mediated cellular cholesterol efflux by activating LXRα/RXR.

M. Naito, H. Kagechika, A. Hirose, 2011, Biochemical pharmacology.

Development of a peptide-based inducer of nuclear receptors degradation.

M. Naito, Takashi Misawa, M. Kurihara, 2016, Bioorganic & medicinal chemistry letters.

Specific degradation of CRABP‐II via cIAP1‐mediated ubiquitylation induced by hybrid molecules that crosslink cIAP1 and the target protein

Yukihiro Itoh, Y. Hashimoto, M. Naito, 2011, FEBS letters.

Development of Rapid and Facile Solid‐Phase Synthesis of PROTACs via a Variety of Binding Styles

T. Kurohara, M. Naito, N. Shibata, 2022, ChemistryOpen.