I. Pastan

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Functional characterization of a glycine 185-to-valine substitution in human P-glycoprotein by using a vaccinia-based transient expression system.

I. Pastan, M. Ramachandra, S. Ambudkar, 1996, Molecular biology of the cell.

Radioreceptor Assay of Adrenocorticotropic Hormone: New Approach to Assay of Polypeptide Hormones in Plasma

I. Pastan, R. Lefkowitz, J. Roth, 1970, Science.

Resistance to multiple chemotherapeutic agents in human cancer cells.

I. Pastan, M. Gottesman, I. Pastan, 1988, Trends in pharmacological sciences.

Acidic fibroblast growth factor-Pseudomonas exotoxin chimeric protein elicits antiangiogenic effects on endothelial cells.

I. Pastan, C. Siegall, J. Madri, 1992, Cancer research.

MDR1 gene expression in lung cancer.

I. Pastan, M. Gottesman, A. Gazdar, 1989, Journal of the National Cancer Institute.

alpha-Galactosidase A deficient mice: a model of Fabry disease.

I. Pastan, M. Gottesman, A. Kulkarni, 1997, Proceedings of the National Academy of Sciences of the United States of America.

IL-4 receptors on human medulloblastoma tumours serve as a sensitive target for a circular permuted IL-4-Pseudomonas exotoxin fusion protein

I. Pastan, R. Puri, J. Silber, 2002, British Journal of Cancer.

ATP-dependent transport of vinblastine in vesicles from human multidrug-resistant cells.

I. Pastan, M. Gottesman, I Pastan, 1988, Proceedings of the National Academy of Sciences of the United States of America.

HIV-1 protease inhibitors are substrates for the MDR1 multidrug transporter.

I. Pastan, M. Gottesman, K. Jeang, 1998, Biochemistry.

Paclitaxel chemotherapy after autologous stem-cell transplantation and engraftment of hematopoietic cells transduced with a retrovirus containing the multidrug resistance complementary DNA (MDR1) in metastatic breast cancer patients.

W. Wilson, S. Steinberg, I. Pastan, 1999, Clinical cancer research : an official journal of the American Association for Cancer Research.

Expression of a human complementary DNA for the multidrug resistance gene in murine hematopoietic precursor cells with the use of retroviral gene transfer.

P. Kantoff, I. Pastan, M. Gottesman, 1990, Journal of the National Cancer Institute.

Stability and covalent modification of P-glycoprotein in multidrug-resistant KB cells.

I. Pastan, M. Gottesman, N. Richert, 1988, Biochemistry.

Differential effects of P-glycoprotein inhibitors on NIH3T3 cells transfected with wild-type (G185) or mutant (V185) multidrug transporters.

I. Pastan, M. Gottesman, C. Cardarelli, 1995, Cancer research.

Control of DNA synthesis and mitosis in 3T3 cells by cyclic AMP.

G. S. Johnson, I. Pastan, M. Willingham, 1972, Biochemical and biophysical research communications.

Double minute chromosomes carrying the human multidrug resistance 1 and 2 genes are generated from the dimerization of submicroscopic circular DNAs in colchicine-selected KB carcinoma cells.

I. Pastan, M. Gottesman, D. Shen, 1992, Molecular biology of the cell.

Functional expression of human P-glycoprotein from plasmids using vaccinia virus-bacteriophage T7 RNA polymerase system.

C. Hrycyna, M. Gottesman, I. Pastan, 1998, Methods in enzymology.

Synaptic integration mediated by striatal cholinergic interneurons in basal ganglia function.

T Nagatsu, D. Watanabe, I. Pastan, 2000, Science.

P-glycoprotein-mediated multidrug resistance in normal and neoplastic hematopoietic cells

I. Pastan, M. Gottesman, F. Herrmann, 1994, Annals of Hematology.

Most drugs that reverse multidrug resistance also inhibit photoaffinity labeling of P-glycoprotein by a vinblastine analog.

I. Pastan, M. Gottesman, S. Akiyama, 1988, Molecular pharmacology.

Immunocytochemical localization of P170 at the plasma membrane of multidrug-resistant human cells.

M C Willingham, I H Pastan, I. Pastan, 1987, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Expression of a human multidrug resistance gene in ovarian carcinomas.

I. Pastan, M. Gottesman, J. Bourhis, 1989, Cancer research.

MDR1 RNA levels in human renal cell carcinomas: correlation with grade and prediction of reversal of doxorubicin resistance by quinidine in tumor explants.

I. Pastan, M. Gottesman, O. Yoshida, 1989, Journal of the National Cancer Institute.

Characterization of the azidopine and vinblastine binding site of P-glycoprotein.

I. Pastan, M. Gottesman, S. Currier, 1992, The Journal of biological chemistry.

Cellular and biochemical characterization of thioxanthenes for reversal of multidrug resistance in human and murine cell lines.

E. P. Bruggemann, James M. Ford, I. Pastan, 1990, Cancer research.

Transplantation of bone marrow cells from transgenic mice expressing the human MDR1 gene results in long-term protection against the myelosuppressive effect of chemotherapy in mice.

I. Aksentijevich, Lori J. Goldstein, I. Pastan, 1992, Blood.

Targeting Pseudomonas exotoxin to hematologic malignancies.

I. Pastan, R. Kreitman, I. Pastan, 1995, Seminars in cancer biology.

Kinetic evidence suggesting that the multidrug transporter differentially handles influx and efflux of its substrates.

I. Pastan, M. Gottesman, W. Stein, 1994, Molecular pharmacology.

Two different regions of P-glycoprotein [corrected] are photoaffinity-labeled by azidopine.

I. Pastan, M. Gottesman, U. Germann, 1989, The Journal of biological chemistry.

Bacterial expression of the linker region of human MDR1 P-glycoprotein and mutational analysis of phosphorylation sites.

I. Pastan, S. Ambudkar, T. Chambers, 1995, Biochemistry.

Regulation of mdr RNA levels in response to cytotoxic drugs in rodent cells.

I. Pastan, M. Gottesman, S. S. Chauhan, 1990, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

Localization of the forskolin labeling sites to both halves of P-glycoprotein: similarity of the sites labeled by forskolin and prazosin.

I. Pastan, M. Gottesman, L. Greenberger, 1994, Molecular pharmacology.