V. Holers

发表

Challenging the role of adaptive immunity in neurotrauma: Rag1(-/-) mice lacking mature B and T cells do not show neuroprotection after closed head injury.

S. Weckbach, J. T. Losacco, L. Kulik, 2012, Journal of neurotrauma.

Complement receptor 2-mediated targeting of complement inhibitors to sites of complement activation.

Stephen Tomlinson, Christian Knaak, J. Guthridge, 2003, The Journal of clinical investigation.

New therapeutic and diagnostic opportunities for injured tissue-specific targeting of complement inhibitors and imaging modalities.

J. Thurman, V. Holers, C. Atkinson, 2016, Seminars in immunology.

The structure of human CD23 and its interactions with IgE and CD21

Rebecca L. Beavil, Brian J. Sutton, V. Michael Holers, 2005, The Journal of experimental medicine.

Extended flexible linker structures in the complement chimaeric conjugate CR2-Ig by scattering, analytical ultracentrifugation and constrained modelling: implications for function and therapy.

H. E. Gilbert, S. Perkins, M. Aslam, 2006, Journal of molecular biology.

Complement C5a receptors and neutrophils mediate fetal injury in the antiphospholipid syndrome.

John D Lambris, J. Lambris, P. Casali, 2003, The Journal of clinical investigation.

Phenotypes of complement knockouts.

V. Holers, V. Holers, 2000, Immunopharmacology.

Detection of complement activation using monoclonal antibodies against C3d.

J. Thurman, D. Hourcade, J. Hannan, 2013, The Journal of clinical investigation.

Targeting mechanisms at sites of complement activation for imaging and therapy.

V. Holers, V. Holers, 2016, Immunobiology.

Structure of the Epstein-Barr virus major envelope glycoprotein

Rengasamy Asokan, M. Klein, V. Holers, 2006, Nature Structural &Molecular Biology.

Natural IgM antibodies that bind neoepitopes exposed as a result of spinal cord injury , drive secondary injury by activating complement

V. M. Holers, Hong Zhu, C. Atkinson, 2017, Journal of Neuroinflammation.

Human C3 glomerulopathy provides unique insights into complement factor H-related protein function.

V. Holers, V. Michael Holers, V. Holers, 2013, The Journal of clinical investigation.

Targeting Pathogenic Postischemic Self-Recognition by Natural IgM to Protect Against Posttransplantation Cardiac Reperfusion Injury

M. Goddard, V. M. Holers, C. Atkinson, 2015, Circulation.

The alternative pathway is required, but not alone sufficient, for retinal pathology in mouse laser-induced choroidal neovascularization.

S. Tomlinson, B. Rohrer, Kazue Takahashi, 2011, Molecular immunology.

A targeted inhibitor of the complement alternative pathway reduces RPE injury and angiogenesis in models of age-related macular degeneration.

M. Pangburn, J. Thurman, G. Gilkeson, 2010, Advances in experimental medicine and biology.

Increased B cell deletion and significantly reduced auto-antibody titre due to premature expression of human complement receptor 2 (CR2, CD21)

L. Kulik, I. Pappworth, C. Haluszczak, 2009, Molecular immunology.

Systemic activation of the complement system in patients with advanced age-related macular degeneration

A. Palestine, A. Lynch, Anne M. Lynch, 2020, European journal of ophthalmology.

Expression of Human Complement Receptor Type 2 (CD21) in Mice During Early B Cell Development Results in a Reduction in Mature B Cells and Hypogammaglobulinemia1

L. Kulik, K. Marchbank, V. Holers, 2002, The Journal of Immunology.

Epithelial secretion of C3 promotes colonization of the upper urinary tract by Escherichia coli

V. Holers, N. Sheerin, K. Abe, 2001, Nature Medicine.

Site-targeted complement inhibition by a complement receptor 2-conjugated inhibitor (mTT30) ameliorates post-injury neuropathology in mouse brains

Zhao-Xue Yu, P. Stahel, Krista Johnson, 2016, Neuroscience Letters.

Defective B cell ontogeny and humoral immune response in mice prematurely expressing human complement receptor 2 (CR2, CD21) is similar to that seen in aging wild type mice

E. Wang, V. Holers, B. Sivasankar, 2009, Molecular immunology.

Alternative Complement Pathway Activation Is Essential for Inflammation and Joint Destruction in the Passive Transfer Model of Collagen-Induced Arthritis1

J. Thurman, W. Arend, M. Carroll, 2006, The Journal of Immunology.

Generation of recombinant human C3dg tetramers for the analysis of CD21 binding and function.

D. Karp, V. M. Holers, S. Henson, 2001, Journal of immunological methods.

Mutational analysis of the complement receptor type 2 (CR2/CD21)-C3d interaction reveals a putative charged SCR1 binding site for C3d.

Rengasamy Asokan, J. Guthridge, V. Holers, 2005, Journal of molecular biology.