David Eastwood

发表

Monoclonal antibody TGN1412 trial failure explained by species differences in CD28 expression on CD4+ effector memory T‐cells

M. Wadhwa, C. Bird, R. Stebbings, 2010, British journal of pharmacology.

Effect of Formaldehyde Inactivation on Poliovirus

Javier Martin, D. Eastwood, G. Dunn, 2014, Journal of Virology.

Severity of the TGN1412 trial disaster cytokine storm correlated with IL-2 release

M. Wadhwa, P. Dilger, C. Bird, 2013, British journal of clinical pharmacology.

After TGN1412: Recent developments in cytokine release assays

R. Thorpe, R. Stebbings, D. Eastwood, 2012, Journal of immunotoxicology.

Monoclonal antibody TGN1412 trial failure explained by species differences in CD28

M. Wadhwa, R. Stebbings, L. Findlay, 2010 .

Cytokine release assays for the prediction of therapeutic mAb safety in first-in man trials — Whole blood cytokine release assays are poorly predictive for TGN1412 cytokine storm

R. Thorpe, S. Sethu, R. Stebbings, 2015, Journal of immunological methods.

“Cytokine Storm” in the Phase I Trial of Monoclonal Antibody TGN1412: Better Understanding the Causes to Improve PreClinical Testing of Immunotherapeutics

M. Wadhwa, P. Dilger, C. Bird, 2007, The Journal of Immunology.

Higher mass meningococcal group C-tetanus toxoid vaccines conjugated with carbodiimide correlate with greater immunogenicity.

J. Derrick, R. Stebbings, D. Eastwood, 2020, Vaccine.

Reply to the Response from Babette Wolf et al. to our Letter to the Editor: How predictive are in vitro assays for cytokine release syndrome in vivo? A comparison of methods reveals worrying differences in sensitivity and frequency of response

R. Thorpe, R. Stebbings, L. Findlay, 2013 .

Comparison of novel methods for predicting the risk of pro-inflammatory clinical infusion reactions during monoclonal antibody therapy.

M. Wadhwa, C. Bird, R. Thorpe, 2011, Journal of immunological methods.

Cytokine release assays for the prediction of therapeutic mAb safety in first-in man trials — Whole blood cytokine release assays are poorly predictive for TGN1412 cytokine storm

T. Dougall, David Eastwood, Robin Thorpe, 2015, Journal of immunological methods.

How predictive are in vitro assays for cytokine release syndrome in vivo? A comparison of methods reveals worrying differences in sensitivity and frequency of response.

R. Thorpe, R. Stebbings, L. Findlay, 2013, Cytokine.

Antibody C Region Influences TGN1412-like Functional Activity In Vitro

P. Parren, R. Thorpe, C. Ball, 2012, The Journal of Immunology.

Endothelial cells co-stimulate peripheral blood mononuclear cell responses to monoclonal antibody TGN1412 in culture.

M. Wadhwa, C. Bird, R. Thorpe, 2011, Cytokine.

Improved in vitro methods to predict the in vivo toxicity in man of therapeutic monoclonal antibodies including TGN1412.

R. Thorpe, J. Hood, C. Ball, 2010, Journal of immunological methods.