Cassandra Koole

发表

The Extracellular Surface of the GLP-1 Receptor Is a Molecular Trigger for Biased Agonism

P. Sexton, A. Christopoulos, C. Reynolds, 2016, Cell.

Recent advances in understanding GLP-1R (glucagon-like peptide-1 receptor) function.

P. Sexton, A. Christopoulos, L. Miller, 2013, Biochemical Society Transactions.

Modulation of the Glucagon-Like Peptide-1 Receptor Signaling by Naturally Occurring and Synthetic Flavonoids

P. Sexton, A. Christopoulos, J. Simms, 2011, Journal of Pharmacology and Experimental Therapeutics.

Structure and Dynamics of Adrenomedullin Receptors AM1 and AM2 Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins.

P. Sexton, A. Christopoulos, C. Reynolds, 2020, ACS pharmacology & translational science.

Toward a Structural Understanding of Class B GPCR Peptide Binding and Activation.

P. Sexton, A. Christopoulos, H. Xu, 2020, Molecular cell.

O-GlcNAc engineering of GPCR peptide-agonists improves their stability and in vivo activity.

Paul M. Levine, P. Sexton, V. Katritch, 2019, Journal of the American Chemical Society.

Molecular mechanisms underlying physiological and receptor pleiotropic effects mediated by GLP‐1R activation

D. Wootten, C. Koole, K. Pabreja, 2014, British journal of pharmacology.

Structural and functional insights into the juxtamembranous amino‐terminal tail and extracellular loop regions of class B GPCRs

P. Sexton, L. Miller, M. Dong, 2014, British journal of pharmacology.

Allostery and Biased Agonism at Class B G Protein-Coupled Receptors.

P. Sexton, A. Christopoulos, L. Miller, 2017, Chemical reviews.

Phase-plate cryo-EM structure of a biased agonist-bound human GLP-1 receptor–Gs complex

W. Baumeister, P. Sexton, A. Christopoulos, 2018, Nature.

A Hydrogen-Bonded Polar Network in the Core of the Glucagon-Like Peptide-1 Receptor Is a Fulcrum for Biased Agonism: Lessons from Class B Crystal Structures

P. Sexton, A. Christopoulos, C. Reynolds, 2016, Molecular Pharmacology.

Minireview: Signal bias, allosterism, and polymorphic variation at the GLP-1R: implications for drug discovery.

P. Sexton, A. Christopoulos, L. Miller, 2013, Molecular endocrinology.

Glucagon-like peptide-1 receptor dimerization differentially regulates agonist signaling but does not affect small molecule allostery

P. Sexton, A. Christopoulos, L. Miller, 2012, Proceedings of the National Academy of Sciences.

Vascular and molecular pharmacology of the metabolically stable CGRP analogue, SAX

J. Jeppesen, P. Sexton, L. Edvinsson, 2018, European journal of pharmacology.

Allosteric Ligands of the Glucagon-Like Peptide 1 Receptor (GLP-1R) Differentially Modulate Endogenous and Exogenous Peptide Responses in a Pathway-Selective Manner: Implications for Drug Screening

P. Sexton, A. Christopoulos, L. Miller, 2010, Molecular Pharmacology.

Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor

W. Baumeister, P. Sexton, A. Christopoulos, 2018, Nature.

Polymorphism and Ligand Dependent Changes in Human Glucagon-Like Peptide-1 Receptor (GLP-1R) Function: Allosteric Rescue of Loss of Function Mutation

P. Sexton, A. Christopoulos, L. Miller, 2011, Molecular Pharmacology.

Genetically encoded photocross-linkers determine the biological binding site of exendin-4 peptide in the N-terminal domain of the intact human glucagon-like peptide-1 receptor (GLP-1R)

P. Sexton, C. Reynolds, T. Sakmar, 2017, The Journal of Biological Chemistry.

Second Extracellular Loop of Human Glucagon-like Peptide-1 Receptor (GLP-1R) Has a Critical Role in GLP-1 Peptide Binding and Receptor Activation*

P. Sexton, A. Christopoulos, L. Miller, 2011, The Journal of Biological Chemistry.

Second Extracellular Loop of Human Glucagon-like Peptide-1 Receptor (GLP-1R) Differentially Regulates Orthosteric but Not Allosteric Agonist Binding and Function*

P. Sexton, A. Christopoulos, L. Miller, 2011, The Journal of Biological Chemistry.

Two distinct domains of the glucagon-like peptide-1 receptor control peptide-mediated biased agonism

P. Sexton, A. Christopoulos, Ming-Wei Wang, 2018, The Journal of Biological Chemistry.