Motomu Shimaoka

发表

Conformational activation of 2 integrins, their I domains, and regulation by small molecule antagonists

Stephen C. Blacklow, Timothy A. Springer, Motomu Shimaoka, 2002, Proceedings of the Second Joint 24th Annual Conference and the Annual Fall Meeting of the Biomedical Engineering Society] [Engineering in Medicine and Biology.

Structures of the αL I Domain and Its Complex with ICAM-1 Reveal a Shape-Shifting Pathway for Integrin Regulation

Junichi Takagi, Timothy A. Springer, Motomu Shimaoka, 2003, Cell.

Therapeutic antagonists and conformational regulation of integrin function

Timothy A. Springer, Motomu Shimaoka, M. Shimaoka, 2003, Nature Reviews Drug Discovery.

Identification of the target self-antigens in reperfusion injury

Ralph Weissleder, Umar Mahmood, Motomu Shimaoka, 2006, The Journal of experimental medicine.

Sevoflurane Binds and Allosterically Blocks Integrin Lymphocyte Function-associated Antigen-1

Motomu Shimaoka, Clay Bracken, Koichi Yuki, 2010, Anesthesiology.

Directed evolution to probe protein allostery and integrin I domains of 200,000-fold higher affinity.

Motomu Shimaoka, Gang Song, Yong-Sung Kim, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Reversibly locking a protein fold in an active conformation with a disulfide bond: Integrin αL I domains with high affinity and antagonist activity in vivo

Timothy A. Springer, Motomu Shimaoka, M. Shimaoka, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Computational design of an integrin I domain stabilized in the open high affinity conformation

Junichi Takagi, Stephen L. Mayo, Timothy A. Springer, 2000, Nature Structural Biology.

Binding between the Integrin αXβ2 (CD11c/CD18) and Heparin*

Robert J. Linhardt, Timothy A. Springer, Motomu Shimaoka, 2007, Journal of Biological Chemistry.

Anti-Integrin Therapy for Multiple Sclerosis

Takayuki Okamoto, Motomu Shimaoka, Eiji Kawamoto, 2012, Autoimmune diseases.

Locking in alternate conformations of the integrin αLβ2 I domain with disulfide bonds reveals functional relationships among integrin domains

Junichi Takagi, Timothy A. Springer, Motomu Shimaoka, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Small molecule integrin antagonists that bind to the beta2 subunit I-like domain and activate signals in one direction and block them in the other.

Wei Yang, Motomu Shimaoka, Azucena Salas, 2003, Immunity.

AL-57, a ligand-mimetic antibody to integrin LFA-1, reveals chemokine-induced affinity up-regulation in lymphocytes

Dan Peer, Wei Yang, Minsoo Kim, 2006, Proceedings of the National Academy of Sciences.

Rational Design of Intercellular Adhesion Molecule-1 (ICAM-1) Variants for Antagonizing Integrin Lymphocyte Function-associated Antigen-1-dependent Adhesion*

David Baker, Tanja Kortemme, G. A. Lazar, 2006, Journal of Biological Chemistry.

Activation of leukocyte beta2 integrins by conversion from bent to extended conformations.

Thomas Walz, Yifan Cheng, Motomu Shimaoka, 2006, Immunity.

Exposure of acidic residues as a danger signal for recognition of fibrinogen and other macromolecules by integrin αxβ2

Timothy A. Springer, Motomu Shimaoka, Christopher V. Carman, 2005 .

Structure and allosteric regulation of the αXβ2 integrin I domain

Timothy A. Springer, Motomu Shimaoka, Thomas Vorup-Jensen, 2003, Proceedings of the National Academy of Sciences of the United States of America.