Brian F. Clem

发表

Regulation of glucose metabolism by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases in cancer.

A. Yalçin, J. Chesney, S. Telang, 2009, Experimental and molecular pathology.

Inhibition of 6-phosphofructo-2-kinase (PFKFB3) induces autophagy as a survival mechanism

J. Chesney, S. Telang, A. Klarer, 2014, Cancer & metabolism.

Integration of flux measurements and pharmacological controls to optimize stable isotope-resolved metabolomics workflows and interpretation

P. Lorkiewicz, Yuting Zheng, Liqing He, 2019, Scientific Reports.

Clinical development of cancer therapeutics that target metabolism.

J. Chesney, S. Telang, A. Klarer, 2016, QJM : monthly journal of the Association of Physicians.

Control of Glutamine Metabolism By the Tumor Suppressor Rb

A. Lane, D. Dean, Yongqing Liu, 2013, Oncogene.

Molecular Pathways: Regulation of Metabolism by RB

J. Chesney, B. Clem, Brian F. Clem, 2012, Clinical Cancer Research.

Inhibition of 6-phosphofructo-2-kinase (PFKFB3) suppresses glucose metabolism and the growth of HER2+ breast cancer

J. Chesney, S. Telang, J. O’Neal, 2016, Breast Cancer Research and Treatment.

6-Phosphofructo-2-kinase (PFKFB3) promotes cell cycle progression and suppresses apoptosis via Cdk1-mediated phosphorylation of p27

A. Yalçin, J. Chesney, S. Telang, 2014, Cell Death and Disease.

Estradiol Stimulates Glucose Metabolism via 6-Phosphofructo-2-kinase (PFKFB3)*

J. Chesney, S. Telang, J. O’Neal, 2014, The Journal of Biological Chemistry.

Targeting 6-Phosphofructo-2-Kinase (PFKFB3) as a Therapeutic Strategy against Cancer

J. Trent, Donald M Miller, J. Chesney, 2013, Molecular Cancer Therapeutics.

Small molecule inhibition of 6-phosphofructo-2-kinase suppresses t cell activation

R. Bucala, J. Trent, J. Chesney, 2012, Journal of Translational Medicine.

Small Molecule Therapeutics Targeting 6-Phosphofructo-2-Kinase ( PFKFB 3 ) as a Therapeutic Strategy against Cancer

J. Trent, Donald M Miller, J. Chesney, 2013 .

Small-molecule inhibition of 6-phosphofructo-2-kinase activity suppresses glycolytic flux and tumor growth

John O Trent, A. Lane, A. Yalçin, 2008, Molecular Cancer Therapeutics.

Nuclear Pyruvate Kinase M2 (PKM2) Contributes to Phosphoserine Aminotransferase 1 (PSAT1)-Mediated Cell Migration in EGFR-Activated Lung Cancer Cells

M. Merchant, J. Trent, Daniel W. Wilkey, 2021, Cancers.

Targeting aspartate aminotransferase in breast cancer

A. Lane, J. Eaton, A. Simmons, 2008, Breast Cancer Research.

Discovery of a PFKFB3 inhibitor for phase I trial testing that synergizes with the B-Raf inhibitor vemurafenib

J. Chesney, S. Telang, J. O’Neal, 2014, Cancer & Metabolism.

Nuclear Targeting of 6-Phosphofructo-2-kinase (PFKFB3) Increases Proliferation via Cyclin-dependent Kinases*

A. Lane, A. Yalçin, A. Simmons, 2009, The Journal of Biological Chemistry.

Association of the mSin3A-histone deacetylase 1/2 corepressor complex with the mouse steroidogenic acute regulatory protein gene.

B. Clem, B. Clark, Brian F. Clem, 2006, Molecular endocrinology.

Phase II trial of the regulatory T cell-depleting agent, denileukin diftitox, in patients with unresectable stage IV melanoma

S. Rai, K. McMasters, Donald M Miller, 2011, BMC Cancer.

Expression of the lncRNA Maternally Expressed Gene 3 (MEG3) Contributes to the Control of Lung Cancer Cell Proliferation by the Rb Pathway

W. Lockwood, S. Dougherty, B. Clem, 2016, PloS one.

Cyclic adenosine 3',5'-monophosphate (cAMP) enhances cAMP-responsive element binding (CREB) protein phosphorylation and phospho-CREB interaction with the mouse steroidogenic acute regulatory protein gene promoter.

B. J. Clark, E. A. Hudson, B. Clem, 2005, Endocrinology.

Different thresholds of ZEB1 are required for Ras-mediated tumour initiation and metastasis

D. Dean, A. Postigo, Yongqing Liu, 2014, Nature Communications.

Rb1 family mutation is sufficient for sarcoma initiation

D. Dean, A. Postigo, Yongqing Liu, 2013, Nature Communications.

Sequential Inductions of the ZEB1 Transcription Factor Caused by Mutation of Rb and Then Ras Proteins Are Required for Tumor Initiation and Progression*

D. Dean, A. Postigo, Yongqing Liu, 2013, The Journal of Biological Chemistry.

Mouse fibroblasts lacking RB1 function form spheres and undergo reprogramming to a cancer stem cell phenotype.

M. Ratajczak, D. Dean, S. El-Naggar, 2009, Cell stem cell.

Selective inhibition of choline kinase simultaneously attenuates MAPK and PI3K/AKT signaling

A. Lane, A. Yalçin, J. Eaton, 2010, Oncogene.

The ZEB1 Transcription Factor Acts in a Negative Feedback Loop with miR200 Downstream of Ras and Rb1 to Regulate Bmi1 Expression*

D. Dean, A. Postigo, Yongqing Liu, 2013, The Journal of Biological Chemistry.

Methionine-producing tumor micro(be) environment fuels growth of solid tumors

S. Hallam, W. Lam, C. Nislow, 2023, Cellular Oncology.

Palbociclib treatment alters nucleotide biosynthesis and glutamine dependency in A549 cells

P. Lorkiewicz, S. Rai, Xinmin Yin, 2020, Cancer Cell International.

Lactate supports a metabolic-epigenetic link in macrophage polarization

K. McMasters, K. Wellen, Matthew S. Gentry, 2021, Science advances.

HNRNPA2B1 regulates tamoxifen- and fulvestrant-sensitivity and hallmarks of endocrine resistance in breast cancer cells.

N. Lehman, C. Klinge, M. Nystoriak, 2021, Cancer letters.

Loss of Rb1 Enhances Glycolytic Metabolism in Kras-Driven Lung Tumors In Vivo

P. Lorkiewicz, Xinmin Yin, R. Sun, 2020, Cancers.

Role of 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase-3 in Maintaining Redox Homeostasis and DNA Repair in Non-Small Cell Lung Cancers Under EGFR-Targeting Therapy

Xinmin Yin, Y. Imbert-Fernandez, Susan M. Dougherty, 2024, bioRxiv.

A Novel Small Molecule Antagonist of Choline Kinase-α That Simultaneously Suppresses MAPK and PI3K/AKT Signaling

A. Yalçin, J. Trent, J. Chesney, 2011, Oncogene.

Abstract 2845: The role of PSAT1 in triple negative breast cancer metastasis

C. Klinge, Susan M. Dougherty, Traci L. Kruer, 2019, Tumor Biology.

The Rb/E2F pathway and Ras activation regulate RecQ helicase gene expression.

D. Dean, S. El-Naggar, Yongqing Liu, 2008, The Biochemical journal.