L. Thomas

发表

Cytoskeletal Protein ABP-280 Directs the Intracellular Trafficking of Furin and Modulates Proprotein Processing in the Endocytic Pathway

J. Hartwig, G. Thomas, R. A. Warren, 1997, The Journal of cell biology.

Human fur gene encodes a yeast KEX2-like endoprotease that cleaves pro- beta-NGF in vivo

J. Thorner, A. Brake, R. Leduc, 1990, The Journal of cell biology.

Interaction of furin in immature secretory granules from neuroendocrine cells with the AP‐1 adaptor complex is modulated by casein kinase II phosphorylation

S. Tooze, L. Thomas, A. Dittié, 1997, The EMBO journal.

Intracellular trafficking of furin is modulated by the phosphorylation state of a casein kinase II site in its cytoplasmic tail.

G. Thomas, K. Walsh, L. Thomas, 1995, The EMBO journal.

A protein-based therapeutic for human cytomegalovirus infection.

G. Thomas, M. Jarvis, J. Nelson, 2000, Proceedings of the National Academy of Sciences of the United States of America.

HIV-1 Nef Downregulates MHC-I by a PACS-1- and PI3K-Regulated ARF6 Endocytic Pathway

G. Thomas, C. Hung, L. Thomas, 2002, Cell.

HIV-1 Nef assembles a Src family kinase-ZAP-70/Syk-PI3K cascade to downregulate cell-surface MHC-I.

K. Shokat, Z. Knight, N. Morris, 2007, Cell host & microbe.

Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Protein-induced Lysosomal Translocation of Proapoptotic Effectors Is Mediated by Phosphofurin Acidic Cluster Sorting Protein-2 (PACS-2)*

G. Gores, J. Dikeakos, S. Bronk, 2012, The Journal of Biological Chemistry.

Cell-type specific processing of neuroendocrine precursor proteins using vaccinia recombinants.

L. Thomas, E. Herbert, G. Thomas, 1988, Biochimie.

The PHD/LAP-Domain Protein M153R of Myxomavirus Is a Ubiquitin Ligase That Induces the Rapid Internalization and Lysosomal Destruction of CD4

G. McFadden, K. Früh, J. Barrett, 2003, Journal of Virology.

PACS‐2 controls endoplasmic reticulum–mitochondria communication and Bid‐mediated apoptosis

L. Wan, T. Simmen, C. Hung, 2005, The EMBO journal.

Role of PACS-1 in Trafficking of Human Cytomegalovirus Glycoprotein B and Virus Production

L. Wan, G. Thomas, C. Hung, 2003, Journal of Virology.

Caught in the act – protein adaptation and the expanding roles of the PACS proteins in tissue homeostasis and disease

T. Simmen, G. Thomas, Pushkar Shinde, 2017, Journal of Cell Science.

Identification of a pH Sensor in the Furin Propeptide That Regulates Enzyme Activation*

G. Thomas, C. Hung, L. Thomas, 2006, Journal of Biological Chemistry.

RNA-targeted therapy corrects neuronal deficits in PACS1 syndrome mice

H. Kordasiewicz, L. Thomas, S. Gingras, 2023, Research square.

A PACS‐1, GGA3 and CK2 complex regulates CI‐MPR trafficking

G. Thomas, G. Scott, L. Thomas, 2006, The EMBO journal.

[4] Use of vaccinia virus vectors to study neuropeptide processing

G. Thomas, L. Thomas, J. Vanslyke, 1995 .

Mutations within a furin consensus sequence block proteolytic release of ectodysplasin-A and cause X-linked hypohidrotic ectodermal dysplasia

N. Morris, J. Zonana, H. Bächinger, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Small Molecule Inhibition of HIV-1–Induced MHC-I Down-Regulation Identifies a Temporally Regulated Switch in Nef Action

A. Gronenborn, M. Saito, J. Dikeakos, 2010, Molecular biology of the cell.

The sorting protein PACS-2 promotes ErbB signalling by regulating recycling of the metalloproteinase ADAM17

P. Parker, M. Howell, G. Thomas, 2015, Nature Communications.

Regulation of Endosome Sorting by a Specific PP2A Isoform

M. Mumby, G. Thomas, L. Thomas, 1998, The Journal of cell biology.

PACS-1 Defines a Novel Gene Family of Cytosolic Sorting Proteins Required for trans-Golgi Network Localization

L. Wan, G. Thomas, L. Thomas, 1998, Cell.

Discovery of a diaminoquinoxaline benzenesulfonamide antagonist of HIV-1 Nef function using a yeast-based phenotypic screen

T. Smithgall, G. Thomas, B. Day, 2013, Retrovirology.

HIV-1 Nef Binds PACS-2 to Assemble a Multikinase Cascade That Triggers Major Histocompatibility Complex Class I (MHC-I) Down-regulation

Robert T. Youker, R. T. Youker, H. You, 2008, Journal of Biological Chemistry.

Preparation of recombinant vaccinia virus for expression of small GTPases.

W. Balch, L. Thomas, J. Vanslyke, 1995, Methods in enzymology.

Yeast KEX2 endopeptidase correctly cleaves a neuroendocrine prohormone in mammalian cells.

R. G. Allen, J. Thorner, D. Hruby, 1988, Science.

Rab32 uses its effector reticulon 3L to trigger autophagic degradation of mitochondria-associated membrane (MAM) proteins

T. Simmen, Megan C. Yap, N. Tahbaz, 2021, Biology Direct.

The phosphorylation state of an autoregulatory domain controls PACS‐1‐directed protein traffic

F. Gu, L. Wan, G. Thomas, 2003, The EMBO journal.

Inhibition of HIV-1 gp160-dependent membrane fusion by a furin-directed alpha 1-antitrypsin variant.

L. Thomas, G. Thomas, J. Hayflick, 1993, The Journal of biological chemistry.

AP‐1 recruitment to VAMP4 is modulated by phosphorylation‐dependent binding of PACS‐1

F. Wendler, G. Thomas, S. Tooze, 2003, EMBO reports.

PACS‐1 binding to adaptors is required for acidic cluster motif‐mediated protein traffic

F. Gu, G. Thomas, S. Tooze, 2001, The EMBO journal.

Intracellular trafficking and activation of the furin proprotein convertase: localization to the TGN and recycling from the cell surface.

G. Thomas, L. Thomas, S. Molloy, 1994, The EMBO journal.

The PC6B cytoplasmic domain contains two acidic clusters that direct sorting to distinct trans-Golgi network/endosomal compartments.

G. Thomas, L. Thomas, S. Molloy, 2000, Molecular biology of the cell.

Akt and 14-3-3 control a PACS-2 homeostatic switch that integrates membrane traffic with TRAIL-induced apoptosis.

Matthew H. Brush, H. Fu, H. Shu, 2009, Molecular cell.