Dennis J. Selkoe

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The Role of APP Processing and Trafficking Pathways in the Formation of Amyloid β‐Protein a

D. Selkoe, D. Teplow, M. Citron, 1996 .

Evidence that alpha-synuclein does not inhibit phospholipase D.

D. Selkoe, S. Lindquist, A. Gitler, 2009, Biochemistry.

Evidence that the 42- and 40-amino acid forms of amyloid beta protein are generated from the beta-amyloid precursor protein by different protease activities.

D. Selkoe, M. Citron, P. Seubert, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Inhibition of Amyloid β-Protein Production in Neural Cells by the Serine Protease Inhibitor AEBSF

D. Selkoe, D. Teplow, M. Citron, 1996, Neuron.

Gene dosage of the amyloid beta precursor protein in Alzheimer's disease.

D. Selkoe, M. Podlisny, G. Lee, 1987, Science.

Selective ectodomain phosphorylation and regulated cleavage of beta‐amyloid precursor protein.

D. Selkoe, A. Hung, Dennis J. Selkoe, 1994, The EMBO journal.

Excessive production of amyloid beta-protein by peripheral cells of symptomatic and presymptomatic patients carrying the Swedish familial Alzheimer disease mutation.

B. Winblad, D. Selkoe, D. Teplow, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Microinjection of synthetic amyloid beta-protein in monkey cerebral cortex fails to produce acute neurotoxicity.

D. Selkoe, M. Frosch, I. Lieberburg, 1993, The American journal of pathology.

Assembly of the γ-Secretase Complex Involves Early Formation of an Intermediate Subcomplex of Aph-1 and Nicastrin*

D. Selkoe, M. Wolfe, W. Kimberly, 2003, Journal of Biological Chemistry.

Trafficking of cell-surface amyloid beta-protein precursor. I. Secretion, endocytosis and recycling as detected by labeled monoclonal antibody.

S. Squazzo, D. Selkoe, E. Koo, 1996, Journal of cell science.

Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s).

D. Selkoe, M. Wolfe, W. Kimberly, 2003, Biochemistry.

An amniote-like skeleton from the Early Carboniferous of Scotland

J. Clack, T. Diehl, R. Paton, 1999, Nature.

Detergent-dependent dissociation of active gamma-secretase reveals an interaction between Pen-2 and PS1-NTF and offers a model for subunit organization within the complex.

D. Selkoe, M. Wolfe, W. Kimberly, 2004, Biochemistry.

Purified recombinant insulin-degrading enzyme degrades amyloid beta-protein but does not promote its oligomerization.

D. Selkoe, M. Rosner, V. Chesneau, 2000, The Biochemical journal.

Effects of the amyloid precursor protein Glu693-->Gln 'Dutch' mutation on the production and stability of amyloid beta-protein.

D. Selkoe, D. Teplow, D. Watson, 1999, The Biochemical journal.

Fibril formation by primate, rodent, and Dutch-hemorrhagic analogues of Alzheimer amyloid beta-protein.

D. Selkoe, P. Fraser, D. Kirschner, 1992, Biochemistry.

Polarized sorting of beta-amyloid precursor protein and its proteolytic products in MDCK cells is regulated by two independent signals

D. Selkoe, D. Teplow, C. Haass, 1995, The Journal of cell biology.

Polarized secretion of beta-amyloid precursor protein and amyloid beta-peptide in MDCK cells.

D. Selkoe, D. Teplow, C. Haass, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.

D. Selkoe, J. Shen, W. Kimberly, 1998, Biochemistry.

The APP family of proteins: similarities and differences.

D. Selkoe, D. Walsh, J. Fadeeva, 2007, Biochemical Society transactions.

gamma-Secretase cleavage and binding to FE65 regulate the nuclear translocation of the intracellular C-terminal domain (ICD) of the APP family of proteins.

D. Selkoe, D. Walsh, J. Fadeeva, 2003, Biochemistry.

Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease.

D. Selkoe, M. Wolfe, W. Xia, 1999, Biochemistry.