A. Clark

发表

A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair.

J Wade Harper, S. Elledge, T. Kunkel, 2010, Molecular cell.

Exonuclease-1 Deletion Impairs DNA Damage Signaling and Prolongs Lifespan of Telomere-Dysfunctional Mice

T. Kunkel, P. Schirmacher, R. Greenberg, 2007, Cell.

Functional Interaction of Proliferating Cell Nuclear Antigen with MSH2-MSH6 and MSH2-MSH3 Complexes*

T. Kunkel, R. Gary, A. B. Clark, 2000, The Journal of Biological Chemistry.

Cadmium is a mutagen that acts by inhibiting mismatch repair

Jack A. Taylor, T. Kunkel, D. Gordenin, 2003, Nature Genetics.

Ribonucleotides are signals for mismatch repair of leading-strand replication errors.

T. Kunkel, S. Lujan, Jessica S. Williams, 2013, Molecules and Cells.

Mismatch Repair Balances Leading and Lagging Strand DNA Replication Fidelity

T. Kunkel, Z. Pursell, S. A. Nick McElhinny, 2012, PLoS genetics.

Inactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility.

T. Kunkel, P. Cohen, R. Kolodner, 2003, Genes & development.

Requirement for PCNA in DNA Mismatch Repair at a Step Preceding DNA Resynthesis

Asad Umar, T. Kunkel, David C. Thomas, 1996, Cell.

Increased susceptibility to UV-induced skin carcinogenesis in polymerase eta-deficient mice.

R. Kucherlapati, T. Kunkel, R. Bronson, 2006, Cancer research.

Multiple functions for the N-terminal region of Msh6

T. Kunkel, L. Deterding, K. Tomer, 2007, Nucleic acids research.

An Msh2 Point Mutation Uncouples DNA Mismatch Repair and Apoptosis

R. Kucherlapati, T. Kunkel, W. Edelmann, 2004, Cancer Research.

Mammalian Exo1 encodes both structural and catalytic functions that play distinct roles in essential biological processes

T. Kunkel, W. Edelmann, R. Sellers, 2013, Proceedings of the National Academy of Sciences.

A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers

Joshua E. Elias, John Quackenbush, S. Gygi, 2011, Nature.

Exonuclease-1 Deletion Impairs DNA Damage Signaling and Prolongs Lifespan of Telomere-Dysfunctional Mice

T. Kunkel, P. Schirmacher, R. Greenberg, 2007, Cell.

Genome instability due to ribonucleotide incorporation into DNA

Danielle L. Watt, T. Kunkel, S. A. Nick McElhinny, 2010, Nature chemical biology.

Mutagenic Processing of Ribonucleotides in DNA by Yeast Topoisomerase I

Y. Pommier, T. Kunkel, Shar-yin N. Huang, 2011, Science.

Construction of heteroduplex DNA andin vitro model for functional analysis of mismatch repair

Menghong Sun, A. B. Clark, Yi Wang, 2004 .

An Msh2 Point Mutation Uncouples DNA Mismatch Repair and Apoptosis

R. Kucherlapati, T. Kunkel, W. Edelmann, 2004, Cancer Research.

Mutator phenotypes of yeast strains heterozygous for mutations in the MSH2 gene.

T. Kunkel, D. Gordenin, M. Resnick, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Functional analysis of human MutSalpha and MutSbeta complexes in yeast.

T. Kunkel, D. Gordenin, M. Resnick, 1999, Nucleic acids research.

Mutator phenotypes of common polymorphisms and missense mutations in MSH2

T. Kunkel, A. B. Clark, K. Drotschmann, 1999, Current Biology.

Heterogeneous polymerase fidelity and mismatch repair bias genome variation and composition

T. Kunkel, P. Mieczkowski, D. Gordenin, 2014, Genome research.

Differences in genome-wide repeat sequence instability conferred by proofreading and mismatch repair defects

T. Kunkel, S. Lujan, A. B. Clark, 2015, Nucleic acids research.

Evidence that processing of ribonucleotides in DNA by topoisomerase 1 is leading-strand specific

T. Kunkel, S. Lujan, A. Chabes, 2015, Nature Structural &Molecular Biology.

A third essential DNA polymerase in S. cerevisiae

R. Hamatake, H. Araki, A. Sugino, 1990, Cell.

Genome-wide mutagenesis resulting from topoisomerase 1-processing of unrepaired ribonucleotides in DNA.

T. Kunkel, D. Fargo, Adam B. Burkholder, 2019, DNA repair.

Stimulation of Chromosomal Rearrangements by Ribonucleotides

T. Kunkel, J. L. Argueso, S. Lujan, 2015, Genetics.

Mismatch repair-independent tandem repeat sequence instability resulting from ribonucleotide incorporation by DNA polymerase ε.

T. Kunkel, G. Kissling, S. Lujan, 2011, DNA repair.

Participation of mouse DNA polymerase ι in strand-biased mutagenic bypass of UV photoproducts and suppression of skin cancer

R. Kucherlapati, T. Kunkel, W. Mcgregor, 2006, Proceedings of the National Academy of Sciences.

An Msh2 conditional knockout mouse for studying intestinal cancer and testing anticancer agents.

R. Kucherlapati, T. Kunkel, R. Bronson, 2010, Gastroenterology.

Cadmium Inhibits the Functions of Eukaryotic MutS Complexes*

T. Kunkel, A. B. Clark, A. Clark, 2004, Journal of Biological Chemistry.