P. J. Conn

发表

Prefrontal Cortex-Mediated Impairments in a Genetic Model of NMDA Receptor Hypofunction Are Reversed by the Novel M1 PAM VU6004256.

S. P. Moran, Anna L. Blobaum, C. Lindsley, 2016, ACS chemical neuroscience.

Preliminary investigation of 6,7-dihydropyrazolo[1,5-a]pyrazin-4-one derivatives as a novel series of mGlu5 receptor positive allosteric modulators with efficacy in preclinical models of schizophrenia.

J. Bartolomé-Nebreda, M. Martín-Martín, Carlos M Martínez-Viturro, 2016, Bioorganic & medicinal chemistry letters.

Identification of specific ligand-receptor interactions that govern binding and cooperativity of diverse modulators to a common metabotropic glutamate receptor 5 allosteric site.

Jens Meiler, P Jeffrey Conn, Jeffrey L. Mendenhall, 2014, ACS chemical neuroscience.

Species-Specific Involvement of Aldehyde Oxidase and Xanthine Oxidase in the Metabolism of the Pyrimidine-Containing mGlu5-Negative Allosteric Modulator VU0424238 (Auglurant)

Andrew S. Felts, Anna L. Blobaum, C. Lindsley, 2017, Drug Metabolism and Disposition.

Targeting metabotropic glutamate receptors for novel treatments of schizophrenia

S. P. Moran, P. Conn, James Maksymetz, 2017, Molecular Brain.

Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors.

K. Gregory, C. Lindsley, C. Hopkins, 2016, Chemical reviews.

Role of mGlu5 Receptors and Inhibitory Neurotransmission in M1 Dependent Muscarinic LTD in the Prefrontal Cortex: Implications in Schizophrenia.

S. P. Moran, Z. Xiang, C. Lindsley, 2017, ACS chemical neuroscience.

Discovery of (R)-(2-fluoro-4-((-4-methoxyphenyl)ethynyl)phenyl) (3-hydroxypiperidin-1-yl)methanone (ML337), an mGlu3 selective and CNS penetrant negative allosteric modulator (NAM).

Julie L. Engers, Andrew S. Felts, Cody J. Wenthur, 2013, Journal of medicinal chemistry.

A Selective Allosteric Potentiator of Metabotropic Glutamate (mGlu) 2 Receptors Has Effects Similar to an Orthosteric mGlu2/3 Receptor Agonist in Mouse Models Predictive of Antipsychotic Activity

P. Conn, R. Galici, Nicholas G Echemendia, 2005, Journal of Pharmacology and Experimental Therapeutics.

Allosteric modulation of seven transmembrane spanning receptors: theory, practice, and opportunities for central nervous system drug discovery.

Bruce J. Melancon, A. Christopoulos, C. Lindsley, 2012, Journal of medicinal chemistry.

Substituted 1-Phenyl-3-(pyridin-2-yl)urea negative allosteric modulators of mGlu5: discovery of a new tool compound VU0463841 with activity in rat models of cocaine addiction.

Andrew S. Felts, C. Lindsley, P. Conn, 2013, ACS chemical neuroscience.

"Molecular switches" on mGluR allosteric ligands that modulate modes of pharmacology.

P Jeffrey Conn, Craig W Lindsley, C. Lindsley, 2011, Biochemistry.

Discovery and Characterization of Novel Allosteric Potentiators of M1 Muscarinic Receptors Reveals Multiple Modes of Activity

C. Lindsley, H. Brown, Joy E. Marlo, 2009, Molecular Pharmacology.

mGlu 2 and mGlu 3 Negative Allosteric Modulators Divergently Potentiate Thalamocortical Transmission and Exert Rapid Antidepressant-Like Effects

Julie L. Engers, C. Lindsley, Max E. Joffe, 2019, SSRN Electronic Journal.

Application of Parallel Multiparametric Cell-Based FLIPR Detection Assays for the Identification of Modulators of the Muscarinic Acetylcholine Receptor 4 (M4)

Peter Hodder, Louis Scampavia, Franck Madoux, 2015, Journal of biomolecular screening.

Chemical modification of the M(1) agonist VU0364572 reveals molecular switches in pharmacology and a bitopic binding mode.

D. Sheffler, C. Lindsley, E. Lebois, 2012, ACS chemical neuroscience.

Further exploration of M₁ allosteric agonists: subtle structural changes abolish M₁ allosteric agonism and result in pan-mAChR orthosteric antagonism.

D. Sheffler, C. Lindsley, C. Hopkins, 2013, Bioorganic & medicinal chemistry letters.

A Novel Assay of Gi/o-Linked G Protein-Coupled Receptor Coupling to Potassium Channels Provides New Insights into the Pharmacology of the Group III Metabotropic Glutamate Receptors

Kari A. Johnson, P. Conn, C. Niswender, 2008, Molecular Pharmacology.

A Novel Selective Allosteric Modulator Potentiates the Activity of Native Metabotropic Glutamate Receptor Subtype 5 in Rat Forebrain

P Jeffrey Conn, Craig W Lindsley, C. Lindsley, 2004, Journal of Pharmacology and Experimental Therapeutics.

Heterotropic Activation of the Midazolam Hydroxylase Activity of CYP3A by a Positive Allosteric Modulator of mGlu5: In Vitro to In Vivo Translation and Potential Impact on Clinically Relevant Drug-Drug Interactions

H. Lavreysen, C. Lindsley, Margrith E. Mattmann, 2013, Drug Metabolism and Disposition.

Contribution of both M1 and M4 receptors to muscarinic agonist-mediated attenuation of the cocaine discriminative stimulus in mice

J. Wess, C. Lindsley, P. Conn, 2012, Psychopharmacology.

Attenuation of Cocaine's Reinforcing and Discriminative Stimulus Effects via Muscarinic M1 Acetylcholine Receptor Stimulation

P Jeffrey Conn, Anders Fink-Jensen, Craig Lindsley, 2010, Journal of Pharmacology and Experimental Therapeutics.

Design and Synthesis of mGlu2 NAMs with Improved Potency and CNS Penetration Based on a Truncated Picolinamide Core.

Julie L. Engers, Andrew S. Felts, Anna L. Blobaum, 2017, ACS medicinal chemistry letters.

Diverse Effects on M1 Signaling and Adverse Effect Liability within a Series of M1 Ago-PAMs.

Julie L. Engers, Anna L. Blobaum, C. Lindsley, 2017, ACS chemical neuroscience.

Biased M1 positive allosteric modulators reveal novel role of phospholipase D in M1-dependent rodent cortical plasticity

S. P. Moran, Z. Xiang, C. Lindsley, 2019, bioRxiv.

Synthesis and SAR of a mGluR5 allosteric partial antagonist lead: unexpected modulation of pharmacology with slight structural modifications to a 5-(phenylethynyl)pyrimidine scaffold.

C. Lindsley, P. Conn, Alice L. Rodriguez, 2008, Bioorganic & medicinal chemistry letters.

Allosteric Potentiators of Metabotropic Glutamate Receptor Subtype 5 Have Differential Effects on Different Signaling Pathways in Cortical Astrocytes

P. Conn, Alice L. Rodriguez, Yongqin Zhang, 2005, Journal of Pharmacology and Experimental Therapeutics.

Discovery of positive allosteric modulators for the metabotropic glutamate receptor subtype 5 from a series of N-(1,3-diphenyl-1H- pyrazol-5-yl)benzamides that potentiate receptor function in vivo.

P Jeffrey Conn, Craig W Lindsley, J. Huff, 2004, Journal of medicinal chemistry.

A Novel Selective Muscarinic Acetylcholine Receptor Subtype 1 Antagonist Reduces Seizures without Impairing Hippocampus-Dependent Learning

S. Jadhav, D. Sheffler, C. Lindsley, 2009, Molecular Pharmacology.