Thomas Lemmin

发表

Alzheimer’s disease mutations in APP but not γ-secretase modulators affect epsilon-cleavage-dependent AICD production

M. dal Peraro, I. Hussain, F. Radtke, 2013, Nature Communications.

A 31-residue peptide induces aggregation of tau's microtubule-binding region in cells.

S. Prusiner, W. DeGrado, G. Stubbs, 2017, Nature chemistry.

Structural heterogeneity and intersubject variability of Aβ in familial and sporadic Alzheimer’s disease

S. Prusiner, W. DeGrado, L. Lannfelt, 2018, Proceedings of the National Academy of Sciences.

Structural Polymorphism of Alzheimer's β-Amyloid Fibrils as Controlled by an E22 Switch: A Solid-State NMR Study.

S. Prusiner, W. DeGrado, J. Stöhr, 2016, Journal of the American Chemical Society.

Allosteric mechanism of signal transduction in the two-component system histidine kinase PhoQ

W. DeGrado, Bruk Mensa, K. Molnar, 2021, bioRxiv.

Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G

Young Do Kwon, Tongqing Zhou, Baoshan Zhang, 2016, Cell.

Assembly of the Transmembrane Domain of E. coli PhoQ Histidine Kinase: Implications for Signal Transduction from Molecular Simulations

Matteo Dal Peraro, William F. DeGrado, Cinque S. Soto, 2013, PLoS Comput. Biol..

Palmitoylated calnexin is a key component of the ribosome–translocon complex

A. Kihara, L. Abrami, F. G. van der Goot, 2012, The EMBO journal.

XFEL structures of the influenza M2 proton channel: Room temperature water networks and insights into proton conduction

Benjamin A. Barad, O. Nureki, W. DeGrado, 2017, Proceedings of the National Academy of Sciences.

Correlating the and with two-dimensional

L. Molday, Stine A. Mikkelsen, Anna L. Vestergaard, 2014 .

Structure of the human heterodimeric transporter 4F2hc-LAT2 in complex with Anticalin, an alternative binding protein for applications in single-particle cryo-EM

D. Fotiadis, A. Skerra, T. Lemmin, 2022, Scientific Reports.

Ease.ML: A Lifecycle Management System for Machine Learning

Jiawei Jiang, Ce Zhang, Leonel Aguilar Melgar, 2021, CIDR.

Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody

C. Soto, T. Lemmin, Cinque S. Soto, 2016, Science.

Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization

John A. Robinson, A. Trkola, H. Günthard, 2021, Nature Communications.

Infrared and fluorescence assessment of the hydration status of the tryptophan gate in the influenza A M2 proton channel.

W. DeGrado, T. Troxler, F. Gai, 2016, Physical chemistry chemical physics : PCCP.

In‐Depth Analysis of Hyaline Fibromatosis Syndrome Frameshift Mutations at the Same Site Reveal the Necessity of Personalized Therapy

M. dal Peraro, A. Superti-Furga, S. Salvi, 2013, Human mutation.

RosENet: Improving Binding Affinity Prediction by Leveraging Molecular Mechanics Energies with an Ensemble of 3D Convolutional Neural Networks

Ce Zhang, Thomas Lemmin, Hussein Hassan-Harrirou, 2020, J. Chem. Inf. Model..

Structures of HIV-1-Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design

Jonathan R. McDaniel, Cinque S. Soto, U. Baxa, 2015, Nature Structural &Molecular Biology.

De novo design of a hyperstable non-natural protein-ligand complex with sub-Å accuracy.

Jeff Rawson, David N Beratan, Thomas Lemmin, 2017, Nature chemistry.

Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation.

Cinque S. Soto, B. Haynes, J. Mascola, 2017, Cell reports.

Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1

J. Mascola, Rui Chen, G. Chuang, 2018, Nature Medicine.

Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.

J. Mascola, G. Chuang, M. Sastry, 2018 .

Antibodyomics: bioinformatics technologies for understanding B‐cell immunity to HIV‐1

Peter D. Kwong, John R. Mascola, Chaim A. Schramm, 2017, Immunological reviews.

RosENet: Improving binding affinity prediction by leveraging molecular mechanics energies with a 3D Convolutional Neural Network

Ce Zhang, Thomas Lemmin, Hussein Hassan-Harrirou, 2020, bioRxiv.

Cryo-EM structure and dynamics of the green-light absorbing proteorhodopsin

D. Fotiadis, D. Kalbermatter, T. Lemmin, 2021, Nature Communications.

Structures and dynamics of the novel S1/S2 protease cleavage site loop of the SARS-CoV-2 spike glycoprotein

D. Fotiadis, D. Kalbermatter, T. Lemmin, 2020, Journal of Structural Biology: X.

Critical roles of isoleucine-364 and adjacent residues in a hydrophobic gate control of phospholipid transport by the mammalian P4-ATPase ATP8A2

M. dal Peraro, L. Molday, R. Molday, 2014, Proceedings of the National Academy of Sciences.

Compressive Sensing Using Iterative Hard Thresholding With Low Precision Data Representation: Theory and Applications

Nezihe Merve Gurel, Dan Alistarh, Ce Zhang, 2020, IEEE Transactions on Signal Processing.

A coiled coil switch mediates cold sensing by the thermosensory protein DesK

M. dal Peraro, F. Trajtenberg, A. Buschiazzo, 2015, Molecular microbiology.

Perturbations of the Straight Transmembrane α-Helical Structure of the Amyloid Precursor Protein Affect Its Processing by γ-Secretase

Matteo Dal Peraro, Patrick C. Fraering, Thomas Lemmin, 2014, The Journal of Biological Chemistry.

High-resolution structure of the amino acid transporter AdiC reveals insights into the role of water molecules and networks in oligomerization and substrate binding

D. Fotiadis, D. Kalbermatter, T. Lemmin, 2021, BMC Biology.

De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures

David Baker, Vikram Khipple Mulligan, Haifan Wu, 2017, Proceedings of the National Academy of Sciences.

Designed metalloprotein stabilizes a semiquinone radical.

W. DeGrado, Yibing Wu, T. Lemmin, 2016, Nature chemistry.