Zheng-Hong Qin

Z. Qin, Mei Li, Wei Zhang, 2012, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Autophagy was activated in injured astrocytes and mildly decreased cell survival following glucose and oxygen deprivation and focal cerebral ischemia

Z. Qin, Jianqing Liu, Yuan-yuan Qin, 2010, Autophagy.

Targeting neuroinflammation to treat cerebral ischemia - The role of TIGAR/NADPH axis

Rui Sheng, Jia-Ying Li, Ming Zhou, 2021, Neurochemistry International.

TIGAR alleviates ischemia/reperfusion-induced autophagy and ischemic brain injury.

Yuqiang Ding, Z. Qin, Jun-chao Wu, 2019, Free radical biology & medicine.

Combination of NAD+ and NADPH Offers Greater Neuroprotection in Ischemic Stroke Models by Relieving Metabolic Stress

K. Fukunaga, Z. Qin, Jun-chao Wu, 2017, Molecular Neurobiology.

G6PD plays a neuroprotective role in brain ischemia through promoting pentose phosphate pathway.

Yuqiang Ding, Z. Qin, Zhong Chen, 2017, Free radical biology & medicine.

A TIGAR-Regulated Metabolic Pathway Is Critical for Protection of Brain Ischemia

Z. Qin, Yuan-yuan Qin, Rong Han, 2014, The Journal of Neuroscience.

Regulation of the ischemia‐induced autophagy–lysosome processes by nitrosative stress in endothelial cells

K. Fukunaga, Z. Qin, F. Han, 2011, Journal of pineal research.

The divergent roles of autophagy in ischemia and preconditioning

Z. Qin, Rui Sheng, Zheng-Hong Qin, 2015, Acta Pharmacologica Sinica.

Preservation of Cognitive Function by Lepidium meyenii (Maca) Is Associated with Improvement of Mitochondrial Activity and Upregulation of Autophagy-Related Proteins in Middle-Aged Mouse Cortex

Z. Qin, Z. Wan, Li Luo, 2016, Evidence-based complementary and alternative medicine : eCAM.

Alleviation of ischemic brain injury by exercise preconditioning is associated with modulation of autophagy and mitochondrial dynamics in cerebral cortex of female aged mice

Z. Qin, Yuan-yuan Qin, Xun Luo, 2023, Experimental Gerontology.

High intensity interval training induces dysregulation of mitochondrial respiratory complex and mitophagy in the hippocampus of middle-aged mice

Z. Qin, Guiping Wang, Li Luo, 2021, Behavioural Brain Research.

A sphingosine kinase 2-mimicking TAT-peptide protects neurons against ischemia-reperfusion injury by activating BNIP3-mediated mitophagy

Z. Qin, C. Waeber, Rui Sheng, 2020, Neuropharmacology.

Glutamate metabotropic receptor agonist 1S,3R-ACPD induces internucleosomal DNA fragmentation and cell death in rat striatum

T. Chase, Z. Qin, M. Nakai, 1997, Brain Research.

Mutant Huntingtin Impairs Vesicle Formation from Recycling Endosomes by Interfering with Rab11 Activity

Lawrence M. Lifshitz, K. Fogarty, R. Tuft, 2009, Molecular and Cellular Biology.

The Protective Effects of Cobra Venom from Naja naja atra on Acute and Chronic Nephropathy

Z. Qin, Rong Han, Shu-Zhi Wang, 2013, Evidence-based complementary and alternative medicine : eCAM.

Regulation of c‐Jun N‐terminal kinase, p38 kinase and AP‐1 DNA binding in cultured brain neurons: roles in glutamate excitotoxicity and lithium neuroprotection

D. Chuang, Z. Qin, P. Leeds, 2003, Journal of neurochemistry.

TIGAR regulates mitochondrial functions through SIRT1‐PGC1α pathway and translocation of TIGAR into mitochondria in skeletal muscle

Z. Qin, Jun-chao Wu, Wenjie Guo, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Therapeutic effect of SN50, an inhibitor of nuclear factor-κB, in treatment of TBI in mice

Z. Qin, Ran Liu, Xi-ping Chen, 2013, Neurological Sciences.

Cobratoxin inhibits pain-evoked discharge of neurons in thalamic parafascicular nucleus in rats: involvement of cholinergic and serotonergic systems.

Z. Qin, Q. Yin, Xinghong Jiang, 2009, Toxicon : official journal of the International Society on Toxinology.

Ameliorating Adriamycin-Induced Chronic Kidney Disease in Rats by Orally Administrated Cardiotoxin from Naja naja atra Venom

Yan Xie, Z. Qin, Li-min Xu, 2014, Evidence-based complementary and alternative medicine : eCAM.

Phenylephrine-Induced Cardiomyocyte Injury Is Triggered by Superoxide Generation through Uncoupled Endothelial Nitric-Oxide Synthase and Ameliorated by 3-[2-[4-(3-Chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxyindazole (DY-9836), a Novel Calmodulin Antagonist

K. Fukunaga, Z. Qin, N. Shioda, 2009, Molecular Pharmacology.

Phenylephrine-induced cardiomyocyte injury is triggered by superoxide generation through uncoupled eNOS and ameliorated by DY9836, a novel calmodulin antagonist

K. Fukunaga, Z. Qin, N. Shioda, 2008 .

Sestrin2 Protects Dopaminergic Cells against Rotenone Toxicity through AMPK-Dependent Autophagy Activation

Z. Qin, Hai-dong Xu, Rui Sheng, 2015, Molecular and Cellular Biology.

Dynamic effects of autophagy on arsenic trioxide-induced death of human leukemia cell line HL60 cells

Z. Qin, Zhong-Qin Liang, Ya-ping Yang, 2008, Acta Pharmacologica Sinica.

DRAM1 Regulates Autophagy Flux through Lysosomes

Z. Qin, Jun-chao Wu, Xing-ding Zhang, 2013, PloS one.

Blocking NF-κB nuclear translocation leads to p53-related autophagy activation and cell apoptosis.

Fang Lin, C. Xing, Bao-song Zhu, 2011, World journal of gastroenterology.

The diverse role of TIGAR in cellular homeostasis and cancer

Z. Qin, Jun-chao Wu, Xiao Yuan, 2018, Free radical research.

Autophagic and apoptotic mechanisms of curcumin-induced death in K562 cells

Z. Qin, Zhong-Qin Liang, Jun Li, 2009, Journal of Asian natural products research.

Escin-induced DNA damage promotes escin-induced apoptosis in human colorectal cancer cells via p62 regulation of the ATM/γH2AX pathway

Z. Qin, Xiao-Dong Yang, C. Xing, 2018, Acta Pharmacologica Sinica.

The Pro-Survival Role of Autophagy Depends on Bcl-2 Under Nutrition Stress Conditions

Z. Qin, Jun-chao Wu, Zhong-Qin Liang, 2013, PloS one.

Transcription factor EB is involved in autophagy-mediated chemoresistance to doxorubicin in human cancer cells

Z. Qin, Hai-dong Xu, Quan-gen Gao, 2017, Acta Pharmacologica Sinica.

Reduced nicotinamide adenine dinucleotide phosphate in redox balance and diseases: a friend or foe?

Z. Qin, Rui Sheng, Nirmala Koju, 2022, Acta Pharmacologica Sinica.

Quality control system of the endoplasmic reticulum and related diseases.

Z. Qin, Jun-chao Wu, Zhong-Qin Liang, 2006, Acta biochimica et biophysica Sinica.

Aescin-induced reactive oxygen species play a pro-survival role in human cancer cells via ATM/AMPK/ULK1-mediated autophagy

G. Wang, W. Dai, Z. Qin, 2018, Acta Pharmacologica Sinica.

Abstract. The aim of the present study was to investigate cobra neurotoxin (cobrotoxin) activity in A549 cell lines transplanted into nude mice, and to explore its molecular mechanism. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method was used to detect the growth inhibit

Yan Xie, Z. Qin, Jing-kang He, 2014 .

Exercise ameliorates the detrimental effect of chloroquine on skeletal muscles in mice via restoring autophagy flux

Z. Qin, Fang Lin, Kai Chen, 2013, Acta Pharmacologica Sinica.

Contributions of autophagic and apoptotic mechanisms to CrTX-induced death of K562 cells.

Z. Qin, Zhong-Qin Liang, Ci-hui Yan, 2006, Toxicon : official journal of the International Society on Toxinology.

NAC1 Modulates Sensitivity of Ovarian Cancer Cells to Cisplatin via Altering the HMGB1-Mediated Autophagic Response*

I. Shih, R. Patel, Jin-Ming Yang, 2011, Oncogene.

History and Current Status of Autophagy Research.

Z. Qin, Rui Sheng, Zheng-Hong Qin, 2019, Advances in experimental medicine and biology.

DRAM1 deficiency affects the organization and function of the Golgi apparatus.

Z. Qin, Jun-chao Wu, Yan Wang, 2019, Cellular signalling.

A pivotal role of FOS-mediated BECN1/Beclin 1 upregulation in dopamine D2 and D3 receptor agonist-induced autophagy activation

Z. Qin, Dong Chen, Fen Wang, 2015, Autophagy.

Autophagy, Aging, and Longevity.

Z. Qin, Li Luo, Zheng-Hong Qin, 2019, Advances in experimental medicine and biology.

Endogenous level of TIGAR in brain is associated with vulnerability of neurons to ischemic injury

Guanghui Wang, Z. Qin, F. Han, 2015, Neuroscience Bulletin.

Imbalance between CaM kinase II and calcineurin activities impairs caffeine-induced calcium release in hypertrophic cardiomyocytes.

K. Fukunaga, Z. Qin, N. Shioda, 2007, Biochemical pharmacology.

NADPH ameliorates MPTP-induced dopaminergic neurodegeneration through inhibiting p38MAPK activation

Z. Qin, Jun-chao Wu, Zhou Zhu, 2018, Acta Pharmacologica Sinica.

Mitochondrial-derived damage-associated molecular patterns amplify neuroinflammation in neurodegenerative diseases

Na Liu, Z. Qin, Yan Wang, 2022, Acta Pharmacologica Sinica.

Anti-tumor activity of CrTX in human lung adenocarcinoma cell line A549

Yan Xie, Z. Qin, Jun-chao Wu, 2011, Acta Pharmacologica Sinica.

Greater stress protein expression enhanced by combined prostaglandin A1 and lithium in a rat model of focal ischemia

Z. Qin, Jun-chao Wu, Rong Han, 2007, Acta Pharmacologica Sinica.

Autophagy is involved in cytotoxic effects of crotoxin in human breast cancer cell line MCF-7 cells

Z. Qin, Zhong-Qin Liang, Ci-hui Yan, 2007, Acta Pharmacologica Sinica.

Growth inhibitory effects and molecular mechanisms of crotoxin treatment in esophageal Eca-109 cells and transplanted tumors in nude mice

Yan Xie, Z. Qin, Jing-kang He, 2012, Acta Pharmacologica Sinica.

Bilobalide inhibits 6-OHDA-induced activation of NF-κB and loss of dopaminergic neurons in rat substantia nigra

Z. Qin, Zhong-Qin Liang, Z. Gu, 2008, Acta Pharmacologica Sinica.

Crotoxin induces apoptosis and autophagy in human lung carcinoma cells in vitro via activation of the p38MAPK signaling pathway

Chun-yu Liu, Rong Han, Hui Liang, 2014, Acta Pharmacologica Sinica.

NADPH Protects against Kainic Acid-induced Excitotoxicity via Autophagy-lysosome Pathway in Rat Striatum and Primary Cortical Neurons.

Z. Qin, Jun-chao Wu, Zhong-Qin Liang, 2020, Toxicology.

Coordination of autophagy with other cellular activities

Z. Qin, Yan Wang, Zheng-Hong Qin, 2013, Acta Pharmacologica Sinica.

Mechanisms of lysosomal proteases participating in cerebral ischemia-induced neuronal death

Huiling Zhang, Ai-Ping Qin, Zheng-Hong Qin, 2008, Neuroscience Bulletin.

A long-form α-neurotoxin from cobra venom produces potent opioid-independent analgesia

Z. Qin, Rong Han, Z. Gu, 2006, Acta Pharmacologica Sinica.

Anti-Inflammatory and Immune Regulatory Actions of Naja naja atra Venom

Z. Qin, Shu-Zhi Wang, Zheng-Hong Qin, 2018, Toxins.

Neurotoxin from Naja naja atra venom inhibits skin allograft rejection in rats.

Shu-Zhi Wang, Jian-qun Kou, Yin-li Xu, 2015, International immunopharmacology.

Suppression of Inflammation and Arthritis by Orally Administrated Cardiotoxin from Naja naja atra

Z. Qin, Shu-Zhi Wang, Jian-qun Kou, 2015, Evidence-based complementary and alternative medicine : eCAM.

Involvement of cholinergic system in suppression of formalin-induced inflammatory pain by cobratoxin

Z. Qin, Yan-li Liu, P. Reid, 2011, Acta Pharmacologica Sinica.

Suppression of complete Freund's adjuvant-induced adjuvant arthritis by cobratoxin

Z. Qin, Jun-chao Wu, Yan-li Liu, 2009, Acta Pharmacologica Sinica.

Analgesic effects of receptin, a chemically modified cobratoxin from Thailand cobra venom.

Z. Qin, Rong Han, Z. Gu, 2006, Neuroscience bulletin.

Inhibitory effect of crotoxin on the pain-evoked discharge of neurons in thalamic parafascicular nucleus in rats.

Z. Qin, Q. Yin, Xinghong Jiang, 2008, Toxicon : official journal of the International Society on Toxinology.

Effect of curcumin on the adhesion of platelets to brain microvascular endothelial cells in vitro

Z. Qin, Zhong-Qin Liang, Z. Gu, 2008, Acta Pharmacologica Sinica.

Opiate and acetylcholine-independent analgesic actions of crotoxin isolated from crotalus durissus terrificus venom.

Z. Qin, Rong Han, Z. Gu, 2006, Toxicon : official journal of the International Society on Toxinology.

The roles of the proteasome pathway in signal transduction and neurodegenerative diseases

Z. Qin, Fang Lin, Jiao-Jiao Chen, 2008, Neuroscience Bulletin.

NMDA and non-NMDA receptor-stimulated IκB-α degradation: differential effects of the caspase-3 inhibitor DEVD·CHO, ethanol and free radical scavenger OPC-14117

T. Chase, Z. Qin, M. Nakai, 2000, Brain Research.

TIGAR plays neuroprotective roles in KA-induced excitotoxicity through reducing neuroinflammation and improving mitochondrial function

Z. Qin, Jun-chao Wu, Zhong-Qin Liang, 2021, Neurochemistry International.

NADPH and Mito-Apocynin Treatment Protects Against KA-Induced Excitotoxic Injury Through Autophagy Pathway

Jun-chao Wu, Zhong-Qin Liang, Yan Wang, 2021, Frontiers in Cell and Developmental Biology.

Susceptibility of striatal neurons to excitotoxic injury correlates with basal levels of Bcl-2 and the induction of P53 and c-Myc immunoreactivity

T. Chase, D. Chuang, Z. Qin, 2005, Neurobiology of Disease.

Reduced Nicotinamide Adenine Dinucleotide Phosphate Inhibits MPTP-Induced Neuroinflammation and Neurotoxicity

Feng Qi Han, Z. Qin, Jun-chao Wu, 2018, Neuroscience.

Down‐regulation of Bcl‐2 enhances autophagy activation and cell death induced by mitochondrial dysfunction in rat striatum

K. Fukunaga, Jun-chao Wu, F. Han, 2009, Journal of neuroscience research.

TIGAR regulates DNA damage and repair through pentosephosphate pathway and Cdk5-ATM pathway

Z. Qin, Quan-gen Gao, Hao-rong Wu, 2015, Scientific Reports.

Exogenous NADPH ameliorates myocardial ischemia–reperfusion injury in rats through activating AMPK/mTOR pathway

Z. Qin, Rui Sheng, Jiang Zhu, 2019, Acta Pharmacologica Sinica.

Huntingtin Is Present in the Nucleus, Interacts with the Transcriptional Corepressor C-terminal Binding Protein, and Represses Transcription*

J. Nevins, Z. Qin, N. Aronin, 2002, The Journal of Biological Chemistry.

DRAM1 plays a tumor suppressor role in NSCLC cells by promoting lysosomal degradation of EGFR

Z. Qin, Jun-chao Wu, Haidong Xu, 2020, Cell Death & Disease.

Combined NADPH and the NOX inhibitor apocynin provides greater anti‐inflammatory and neuroprotective effects in a mouse model of stroke

Z. Qin, F. Han, Jian Wang, 2017, Free radical biology & medicine.

Downregulation of glutamate transporters is associated with elevation in extracellular glutamate concentration following rat microsphere embolism

K. Fukunaga, Z. Qin, N. Shioda, 2008, Neuroscience Letters.

Somatic autophagy of axonal mitochondria in ischemic neurons

Feng Qi Han, Z. Qin, Weiwei Hu, 2019, The Journal of cell biology.

Sphingosine kinase 2 activates autophagy and protects neurons against ischemic injury through interaction with Bcl-2 via its putative BH3 domain

Dan-dan Song, Z. Qin, C. Waeber, 2017, Cell Death & Disease.

NADPH is superior to NADH or edaravone in ameliorating metabolic disturbance and brain injury in ischemic stroke

Z. Qin, Jun-chao Wu, Zhong Chen, 2021, Acta Pharmacologica Sinica.

Reduced nicotinamide adenine dinucleotide phosphate inhibits rat platelet aggregation and p38 phosphorylation.

Z. Qin, Jun-chao Wu, Rui Sheng, 2018, Thrombosis research.

PIK3CA hypomethylation plays a key role in activation of the PI3K/AKT pathway in esophageal cancer in Chinese patients

Wei-feng Wang, Yan Xie, Zhi-hua Zhou, 2013, Acta Pharmacologica Sinica.

Structure, regulation, and biological functions of TIGAR and its role in diseases

Z. Qin, Rui Sheng, Lei Chen, 2021, Acta Pharmacologica Sinica.